Allele Dmel\ss^aP88

General Information
Symbol	Dmel\ss^aP88	Species	D. melanogaster
Name		FlyBase ID	FBal0016120
Feature type	allele	Associated gene	Dmel\ss

Allele class	loss of function allele
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Duncan et al., 1998)
Mutagen	X ray
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Break falls between coordinate +20 and (approximately) +17kb on the ss molecular map, within the ss transcription unit. (Duncan et al., 1998)
Caused by aberration	In(3LR)P88 (Struhl, 1982, Duncan et al., 1998, Kirpichnikova, 1992)
Carried on aberration	TM6 (FlyBase Curators, 2006-, Lindsley and Zimm, 1992) TM6-23 (FlyBase Curators, 2006-) TM6AbdA-lacZ (FlyBase Curators, 2006-) TM6-EEFLAT (FlyBase Curators, 2006-) TM6-Est-C^S (FlyBase Curators, 2006-) TM6-h¹ (FlyBase Curators, 2006-) TM6-Idh^S (FlyBase Curators, 2006-) TM6-su(Hw)⁵ (FlyBase Curators, 2006-) TM6-Ubx⁺ (FlyBase Curators, 2006-) TM6-Ue (FlyBase Curators, 2006-) TM6-UW23-1 (FlyBase Curators, 2006-) TM6-vYa (FlyBase Curators, 2006-) TM6-y⁺ (FlyBase Curators, 2006-)
Cytology
Phenotypic Data
Phenotypic Class
	flightless \| recessive (Kirpichnikova, 1992) visible \| homeotic (Duncan et al., 1998) visible \| homeotic \| recessive (Kirpichnikova, 1992) visible \| recessive (Struhl, 1982)
Phenotype Manifest In
	antenna (Duncan et al., 1998, Struhl, 1982) arista (Kirpichnikova, 1992, Struhl, 1982) macrochaeta (Duncan et al., 1998, Struhl, 1982) mesothoracic tarsal segment \| distal \| ectopic (Kirpichnikova, 1992) tarsal segment (Duncan et al., 1998, Struhl, 1982) third segment of antenna (Struhl, 1982)
Detailed Description
	Statement Reference Null phenotype. Antennal transformations, reduction in bristle size and tarsal deletions. (Duncan et al., 1998) ss^aP88 in combination with ss^a, ss^aB, ss^ax or ss^a40a produces transformation of the arista to distal mesothoracic tarsus. The expressivity of the phenotype decreases with increasing temperature in ss^aB/ss^aP88 flies. A high proportion of ss^a40a/ss^aP88 or ss^a/ss^aP88 flies produce an ectopic tarsal response to chemical stimulation at 25^oC. ss^a/ss^aP88 and ss^ax/ss^aP88 flies usually cannot fly, although ss^aB/ss^aP88 and ss^a40a/ss^aP88 flies often show some flight ability. (Kirpichnikova, 1992) ss^aC3/ss^aP88 flies are viable and fertile, and have a modest aristapedia phenotype; the proximal portion of the arista is swollen and carries bracted bristles characteristic of the tarsus. Bracted bristles are also found on the distal portion of the third antennal segment. ss^a/ss^aP88 flies have an aristapedia phenotype; the arista and part of the third antennal segment are transformed into a well formed distal leg carrying 2 claws and 3 to 4 tarsal segments. ss^aP88 is viable in transheterozygous combination with either ss^aC6, ss^aC10, ss^aC11, ss^aC13, Df(3R)ss-a or ss^aC16, and gives the following phenotype; flies show complete transformation of the distal antenna to distal tarsus. Bristles show and extreme and consistent spineless phenotype. Fusions of most of the tarsal segments of the legs and also of the transformed aristapedia tarsus are seen. ss^aP88 is viable in transheterozygous combination with either ss^aC5, ss^aC7, ss^aC8, ss^aC9, ss^aC12 or ss^aC14 producing flies with an aristapedia phenotype. (Struhl, 1982) strong allele
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 7 )
Kyoto	103319 Fdh^nNC1 / TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹ 101608 Df(3R)cu, Sb¹ / TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹ 103350 Df(3R)L127 / TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹ ; Dp(3;1)B152 101631 e^s ca^nd1 / TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹ 103301 Df(3L)st4, st⁴ gl² e⁴ / TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹ 101763 th¹ st¹ pb¹ p^p cu¹ kar¹ su(Hw)² jvl¹ ss¹ Ubx^bx-1 sr¹ gl¹ / TM6, (Hn^P) ss^aP88 Ubx^bx-34e Ubx^P15 e¹ 103359 SM1, al² Cy¹ cn² sp² Pgk⁴ Pgi⁴ / Pgk² Pgi² ; TM6, Hn^P ss^aP88 Ubx^bx-34e Ubx^P15 e¹ Men⁴ ry^el-F Aldox-1^L4 Mdh2^* / Men⁶ ry^el-S Aldox-1³ Mdh2^*
Notes on Origin
Discoverer	E.B. Lewis

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	ss^aP88 ss^P88 unnamed (Kirpichnikova, 1992, Struhl, 1982)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Duncan et al., 1998, Genes Dev. 12(9): 1290--1303 Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. [FBrf0102306] Kirpichnikova, 1992, Annls Sci. nat., Zool. Biol. anim. 13e serie 13(1): 47--52 The relationship of behavioral pleiotropic effects produced by mutations at the spineless-aristapedia locus in Drosophila. [FBrf0055395] Struhl, 1982, Genetics 102: 737--749 Spineless-aristapedia: a homeotic gene that does not control the development of specific compartments in Drosophila. [FBrf0038072]
FlyBase analysis	FlyBase Curators, 2006-, Balancer summary information. Balancer summary information. [FBrf0189689]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\ssaP88

Allele Dmel\ss^aP88