FB2022_02, released March 29, 2022

Allele: Dmel\st1

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General Information
Symbol
Dmel\st1
Species
D. melanogaster
Name
FlyBase ID
FBal0016127
Feature type
allele
Associated gene
Dmel\st
Associated Insertion(s)
412{}st1
Carried in Construct
Also Known As
st
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(ten Have et al., 1995, Tearle et al., 1989)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology

      Polytene chromosomes normal.

      Nature of the lesion
      Statement
      Reference

      7.6kb 412 insertion (in opposite orientation to st transcription) at nucleotide -803 within exon 4.

      (ten Have et al., 1995)

      Insertion of 7.6kb DNA, with no obvious similarity to known transposable elements, between positions -1.7 and -0.8.

      (Tearle et al., 1989)
      Insertion components
      412{}st1
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Cunningham et al., 2018)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by cn1
      (Cunningham et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      st1 and st1/Df(3L)ED4606 mutant adults show a significant and progressive decrease in climbing ability, as compared to controls. Unlike controls, both these mutant adults show a significant and progressive decrease in the number of PPL1 neurons (decreases observed from from day 3 to days 18 and 21, respectively) when raised at 29[o], but not at 25[o]C, as compared to controls.

      (Cunningham et al., 2018)

      Mutant flies have significantly fewer synaptic vesicles in the terminals of the photoreceptor cells R1-R6 in the lamina. However, in contrast to the absolute numbers of synaptic vesicles, the profile density is not significantly different from wild type. There is no significant difference in the normalized number of single-headed capitate projection profiles in the photoreceptor terminals, but the number of multiple-headed capitate projection profiles is higher than normal.

      (Borycz et al., 2008)

      Male homozygous st1 flies are undistinguishable from wild-type flies in their sensitivity to enflurane. This effect is true whether enflurane resistance is measured in regular light or red light.

      (Campbell and Nash, 2001)

      Eye colour: light yellow, with st14.

      (Tearle et al., 1989)

      Malpighian tubule colour: pale yellow.

      (Beadle, 1937)

      Eye color autonomous in larval optic discs transplanted into wild-type hosts.

      (Beadle and Ephrussi, 1936)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      st1 has abnormal locomotor behavior | adult stage | progressive phenotype, non-enhanceable by cn1

      (Cunningham et al., 2018)

      st1 has short lived phenotype, non-enhanceable by cn1

      (Cunningham et al., 2018)
      Suppressed by
      Statement
      Reference

      st1 has decreased cell number | adult stage | progressive | heat sensitive phenotype, suppressible by cn1

      (Cunningham et al., 2018)
      NOT Enhancer of
      Statement
      Reference

      st1 is a non-enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of cn1

      (Cunningham et al., 2018)

      st1 is a non-enhancer of chemical resistant | dominant | male phenotype of bw1

      (Campbell and Nash, 2001)
      NOT Suppressor of
      Statement
      Reference

      st1 is a non-suppressor of chemical resistant | dominant | male phenotype of bw1

      (Campbell and Nash, 2001)
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      st1 has dopaminergic PPL1 neuron | progressive | heat sensitive phenotype, suppressible by cn1

      (Cunningham et al., 2018)
      Other
      Statement
      Reference

      lz51d, st1 has pigment cell phenotype

      (Arvelighetsinstitutten, University)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased resistance of bw1 homozygous males to enflurane is not enhanced or suppressed by st1/st1. bw1/+, st1/+ males from bw1, st1 homozygous mothers show increased resistance to halothane when tested under red light but not when tested under white light. A maternal effect is necessary for this phenotype as it is not seen in bw1/+, st1/+ males from bw1, st1 homozygous fathers.

      (Campbell and Nash, 2001)

      Eye colour: white with lz51d.

      (Arvelighetsinstitutten, University)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      st1 is partially rescued by Scer\GAL4ple.PF/stUAS.Venus

      (Cunningham et al., 2018)
      Comments
      Images (2)
      Stocks (655)
      Notes on Origin
      Discoverer

      Richards, 18th Nov. 1916.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (31)