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General Information
Symbol
Dmel\st1
Species
D. melanogaster
Name
FlyBase ID
FBal0016127
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
st
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

7.6kb 412 insertion (in opposite orientation to st transcription) at nucleotide -803 within exon 4.

Insertion of 7.6kb DNA, with no obvious similarity to known transposable elements, between positions -1.7 and -0.8.

Insertion components
412{}st1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

st1 and st1/Df(3L)ED4606 mutant adults show a significant and progressive decrease in climbing ability, as compared to controls. Unlike controls, both these mutant adults show a significant and progressive decrease in the number of PPL1 neurons (decreases observed from from day 3 to days 18 and 21, respectively) when raised at 29[o], but not at 25[o]C, as compared to controls.

Mutant flies have significantly fewer synaptic vesicles in the terminals of the photoreceptor cells R1-R6 in the lamina. However, in contrast to the absolute numbers of synaptic vesicles, the profile density is not significantly different from wild type. There is no significant difference in the normalized number of single-headed capitate projection profiles in the photoreceptor terminals, but the number of multiple-headed capitate projection profiles is higher than normal.

Male homozygous st1 flies are undistinguishable from wild-type flies in their sensitivity to enflurane. This effect is true whether enflurane resistance is measured in regular light or red light.

Eye colour: light yellow, with st14.

Malpighian tubule colour: pale yellow.

Eye color autonomous in larval optic discs transplanted into wild-type hosts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

st1 has short lived phenotype, non-enhanceable by cn1

Suppressed by
Statement
Reference

st1 has decreased cell number | adult stage | progressive | heat sensitive phenotype, suppressible by cn1

NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

st1 is a non-suppressor of chemical resistant | dominant | male phenotype of bw1

Other
Phenotype Manifest In
Suppressed by
Statement
Reference

st1 has dopaminergic PPL1 neuron | progressive | heat sensitive phenotype, suppressible by cn1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The increased resistance of bw1 homozygous males to enflurane is not enhanced or suppressed by st1/st1. bw1/+, st1/+ males from bw1, st1 homozygous mothers show increased resistance to halothane when tested under red light but not when tested under white light. A maternal effect is necessary for this phenotype as it is not seen in bw1/+, st1/+ males from bw1, st1 homozygous fathers.

Eye colour: white with lz51d.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (2)
Stocks (634)
Notes on Origin
Discoverer

Richards, 18th Nov. 1916.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (29)