FB2025_01 , released February 20, 2025
Allele: Dmel\sta2
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General Information
Symbol
Dmel\sta2
Species
D. melanogaster
Name
FlyBase ID
FBal0016162
Feature type
allele
Associated gene
Dmel\sta
Associated Insertion(s)
Carried in Construct
Also Known As
stalt3
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Melnick et al., 1993, Biyasheva et al., 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae can survive to the third instar stage although they show a considerable delay in development. These third instar larvae tend to die early if they are left in the food, but they can survive in a humid chamber as relatively under-developed third instar larvae for up to 2 weeks after their heterozygous siblings have emerged from the pupal case. The larvae then gradually die without forming a puparium. The hematopoietic organs are considerably enlarged in aged larvae, with the maximum hyperplasia occurring in the first lobes. The hematopoietic organs retain a globular and compact structure. Imaginal discs are small. Melanotic masses are not seen.

      (Torok et al., 1999)

      The lethal period of development starts at the first larval instar and lasts the whole period of development, with a peak at the prepupal stage. Pupariation is delayed for 60-80 hours and is abnormal; some animals do not show pupal moulting and die at the stage of gas-bubble formation, others die at the stage of eye pigmentation and bristle formation. Those surviving to imago formation generally die before or at the moment of eclosion, while the 2-5% that manage to eclose live for only a few days. Injection of ecdysterone into homozygous 140 hour larvae partially normalises development; puparium formation is not delayed, but subsequent development stops and the imago does not eclose.

      (Biyasheva et al., 1991)

      Fertility is unaffected.

      (Mazina et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      sta2 has lethal | larval stage | recessive phenotype, enhanceable by RpS21k16814

      (Torok et al., 1999)
      Enhancer of
      Statement
      Reference

      sta2 is an enhancer of lethal | larval stage | recessive phenotype of RpS21k16814

      (Torok et al., 1999)

      Dp(1;3)sta/sta2 is an enhancer of visible | dominant phenotype of RpS21k16814

      (Torok et al., 1999)

      sta1/sta2 is an enhancer of visible | dominant phenotype of RpS21k16814

      (Torok et al., 1999)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Dp(1;3)sta/sta2 is an enhancer of macrochaeta phenotype of RpS21k16814

      (Torok et al., 1999)

      sta1/sta2 is an enhancer of macrochaeta phenotype of RpS21k16814

      (Torok et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sta2/Y ; RpS21k16814/RpS21k16814 animals die as first to second instar larvae. sta2/Y ; RpS21k16814/+ and sta2/sta2 ; RpS21k16814/+ animals die as first to second instar larvae. sta2/+ ; RpS21k16814/RpS21k16814 third instar larvae are larger in size and have much larger overgrown imaginal discs than RpS21k16814/RpS21k16814 larvae. The leg discs tend to fuse together and the hematopoietic organs are larger than in RpS21k16814/RpS21k16814 larvae. The sta2/+ ; RpS21k16814/RpS21k16814 third instar larvae are more active than RpS21k16814/RpS21k16814 third instar larvae. The bristle phenotype of RpS21k16814/+ heterozygotes is enhanced by sta2; Dp(1;3)sta/+ or sta1/sta2.

      (Torok et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      sta2 is rescued by sta+t4.4

      (Melnick et al., 1993)
      Comments

      Mutant phenotype can be resuced by P-element mediated introduction of a wild type copy of sta.

      (Melnick et al., 1993)

      in combination with variegating translocation (T(1;2)dorvar7) produces incised wing margins, small rough eyes with missing facets and missing head macrochaetae (Demakova and Belyaeva, 1988).

      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      lt3
      (Belyaeva et al., 1982)
      sta2
      stal3
      stalt3
      (Biyasheva et al., 1991, Mazina et al., 1991, Mazina et al., 1990, Demakova and Belyaeva, 1988)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)