Allele Dmel\stau¹

General Information
Symbol	Dmel\stau¹	Species	D. melanogaster
Name		FlyBase ID	FBal0016164
Feature type	allele	Associated gene	Dmel\stau
Also Known As	stau^HL, stau^HL54

Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Schupbach and Wieschaus, 1986, Kraut and Levine, 1991, Crauk and Dostatni, 2005)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference No molecular modification is detectable in Southern blots. (St. Johnston et al., 1991)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| maternal effect (Hay et al., 1990) lethal \| maternal effect \| recessive (Lehmann and Nusslein-Volhard, 1991) male sterile \| maternal effect (Hay et al., 1990)
Phenotype Manifest In
	abdominal segment (Schupbach and Wieschaus, 1986) pole cell (Schupbach and Wieschaus, 1986)
Detailed Description
	Statement Reference Heterozygous females with mama¹ are fertile. (Doane, 1996) Shallow gradient of bcd protein with reduced amounts in anterior regions. The gt posterior domain is abolished and the anterior domain is shifted anteriorly. (Kraut and Levine, 1991) Absence of posterior pole plasm, polar granules and pole cells. (Lehmann and Nusslein-Volhard, 1991) Does not interact with RpII140^wimp maternal effect. (Parkhurst and Ish-Horowicz, 1991) Embryos lack pole cells. Large amounts of vas protein are expressed in early stages of oogenesis. Perinuclear localization is reduced in favour of additional protein in the cytoplasm: vas protein fails to distribute asymmetrically. Cleavage embryos have uniform vas protein distribution, the protein disappears by early gastrulation. (Lasko and Ashburner, 1990) Homozygous females produce embryos that fail to form pole cells, lack polar granules normally found at the posterior pole, and have deletions of abdominal segments. The embryos also show a tor-like head deletion. (Schupbach and Wieschaus, 1986) Embryos from homozygous stau¹ mothers have normal abdomen, hatch and survive to adulthood. Embryos from mothers transheterozygous for stau¹ over a deletion of stau have severe abdominal deletions. (Schupbach and Wieschaus, 1986) weak allele maternal-effect lethal Embryos from homozygous mothers exhibit a so-called 'grandchildless-knirps' phenotype; all eggs lack polar granules and no pole cells are formed; most embryos show variable deletions of abdominal segments, whereby segment A4 is deleted most frequently; larger deletions may delete segments A2 through A7; in extreme cases, anterior parts of segment A1 become fused to posterior parts of segment A8, but telson elements are always present and relatively normal. In addition, embryos show deletions of the anterior-most head structures and the cephalic furrow is shifted anteriorly at gastrulation. Analysis of germ-line clones indicates that the mutation is germ-line autonomous (Schupbach and Wieschaus, 1986).
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference stau¹ is an enhancer of neuroanatomy defective phenotype of Hsap\ATXN8OS^{CTG112.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mutsuddi et al., 2004)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	1507 stau¹ cn¹ bw¹/CyO
Kyoto	106354 stau¹ cn¹ bw¹/CyO
Notes on Origin
Discoverer

Comments
	Cytoplasmic transplantation of wild type plasm into the abdominal region restores normal abdominal development. (Lehmann and Nusslein-Volhard, 1991) Germline mosaic analysis shows that stau is required in the germline. (Schupbach and Wieschaus, 1986)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	stau¹ (Sofola et al., 2007, Christensen et al., 2007.10.29, Christensen et al., 2008.4.15) stau^HL54 (Doane, 1996, Parkhurst and Ish-Horowicz, 1991, Kraut and Levine, 1991, Jack and McGinnis, 1990) stau^HL (Crauk and Dostatni, 2005, Houchmandzadeh et al., 2002, Gao et al., 1996, Liang et al., 1994, Ding et al., 1994, Lehmann and Nusslein-Volhard, 1991, St. Johnston et al., 1991, Lasko and Ashburner, 1990, Tearle and Nusslein-Volhard, 1987, Schupbach and Wieschaus, 1986, Schupbach and Wieschaus, 1986, He et al., 2008) stau^HLS4 (Hay et al., 1990)
Name Synonym
Secondary FlyBase IDs

References ( 24 )

Generate a list of	All references relating to this allele ( 24 )

List References by type	Research paper ( 19 ) Review ( 1 ) Personal communication to FlyBase ( 2 ) Letter ( 1 ) Stock list ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
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Allele Dmel\stau1

Allele Dmel\stau¹