FB2025_02 , released April 17, 2025
Allele: Dmel\stg6
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General Information
Symbol
Dmel\stg6
Species
D. melanogaster
Name
FlyBase ID
FBal0016178
Feature type
allele
Associated gene
Dmel\stg
Associated Insertion(s)
Carried in Construct
Also Known As
stg9A, stg9A19
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Hartenstein and Posakony, 1990)

loss of function allele

(Edgar and Datar, 1996)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No visible eye defects are seen in heterozygous stg6 mutant flies.

      (Hong et al., 2008)

      In those embryos that are incubated at the restrictive temperature of 29oC before the division of the ganglion mother cell into RP2/sib, the ganglion mother cell assumes an RP2 identity. In the aCC/pCC lineage, the ganglion mother cell assumes an aCC identity. A 30 minute delay into G2 entry is also found in these embryos.

      (Wai et al., 1999)

      Cells in homozygous clones induced in the wing pouch of the wing disc divide slowly when maintained at a semi-permissive temperature and become enlarged. These cells are gradually lost from the disc epithelium.

      (Neufeld et al., 1998)

      Embryos derived from germ line clones proceed through cycles 1-13 normally.

      (Edgar and Datar, 1996)

      Postblastoderm cell divisions do take place in homozygous embryos, but at a lower frequency than in wild-type. The length of the cell cycle, in particular the length of the mitotic phase is increased.

      (Hartenstein and Posakony, 1990)

      Mutants show a nonspecific reduction in the number of differentiated cuticular structures.

      (Edgar and O'Farrell, 1989)

      weak allele

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      stg6/stg[+] is an enhancer of visible | adult stage | heat sensitive phenotype of Hsap\YWHAGhs.cHa

      (Hong et al., 2008)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Hsap\YWHAGhs.cHa, stg6/stg[+] has eye | heat sensitive phenotype

      (Hong et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Heterozygous stg6 induces a rough eye phenotype when flies expressing Hsap\YWHAGhs.cHa are heat-shocked at 37[o]C for 30 minutes every 7.5 hours from the third instar stage. 8.96% of flies have a rough eye compared to only 1.61% in the absence of stg6 and 1.39% in wild type controls. No eye defects are seen in heterozygous stg6.

      (Hong et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (8)