FB2025_01 , released February 20, 2025
Allele: Dmel\su(f)1
Open Close
General Information
Symbol
Dmel\su(f)1
Species
D. melanogaster
Name
FlyBase ID
FBal0016266
Feature type
allele
Associated gene
Dmel\su(f)
Associated Insertion(s)
Carried in Construct
Also Known As
su(f)
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
Progenitor genotype
Cytology
Description

restriction map normal; Mitcheson, Simonelig, Williams and O'Hare (1993)

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A low frequency of individuals homozygous for Bpt1 and lz37 have small eye spots, the frequency is enhanced in the presence of su(f)1.

      (Duus et al., 1992)

      Non-lethal. Homozygotes show moderate enhancement of the wa phenotype at 29oC, and stronger enhancement at 21oC. Homozygotes show almost complete suppression of f1 penetrance, and essentially no reduction in bristle size. Enhances the lz37 phenotype and suppresses the lz1 phenotype.

      (Fitch et al., 1992)

      su(f)6/su(f)1 and su(f)3/su(f)1 shows a Minute-like phenotype at 24-25oC and results in lethality at 29-30oC.

      (Schalet, 1972)

      Wild type in appearance with normal viability and fertility when raised at 25oC; however, both su(f) flies raised at 29-30oC and su(f) flies heterozygous with a su(f)- deletion raised at 25oC display the Minute-like syndrome. The same phenotype is seen in combinations with su(f)2 and su(f)6 raised at 29oC. su(f) heterozygous with a su(f)- deletion is lethal when raised at 29oC; viability also temperature-sensitive in combination with su(f)3 and su(f)5 (Schalet and Lefevre, 1976). su(f) enhances wa; wa su(f) eyes nearly white at 25oC and white at 18oC but apricot in flies raised at 29oC; suppresses lz1 and enhances lz37 at all temperatures. Increases the accumulation of gypsy transcript, suggesting that the wild-type allele represses gypsy (Parkhurst and Corces, 1986); protein binding to a negative regulatory sequence of gypsy is reduced in nuclear extracts from su(f) pupae compared with those from wild type, again suggesting gypsy repression by su(f)+ (Mazo, Mizrokhi, Karavanov, Sedkov, Krichevskaha and Ilyn, 1989). viable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      su(f)4/su(f)1, w1 has abnormal eye color phenotype

      (Schalet, 1972)

      su(f)4/su(f)1, wa has abnormal eye color phenotype

      (Schalet, 1972)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      su(f)1 is an enhancer of phenotype of lz37

      (Fitch et al., 1992)

      su(f)1 is an enhancer of phenotype of wa

      (Fitch et al., 1992, Lindsley and Grell, 1968)

      su(f)1 is an enhancer of phenotype of wric

      (Rabinow and Birchler, 1990, Mount et al., 1988)

      su(f)1 is an enhancer of phenotype of waM

      (Mount et al., 1988)

      su(f)1 is an enhancer of phenotype of waR84e19

      (Mount et al., 1988)

      su(f)1 is an enhancer of phenotype of waR84h

      (Mount et al., 1988)

      su(f)1 is an enhancer of phenotype of wa59k13

      su(f)1 is an enhancer of phenotype of wa57i

      su(f)1 is an enhancer of phenotype of wa58l

      su(f)1 is an enhancer of phenotype of wM

      su(f)1 is an enhancer of phenotype of wa59k9

      su(f)1 is an enhancer of phenotype of wa59k1

      su(f)1 is an enhancer of phenotype of lz71b

      Suppressor of
      Statement
      Reference

      su(f)1 is a suppressor of phenotype of lz1

      (Fitch et al., 1992)

      su(f)1 is a suppressor of phenotype of f1

      (Schalet and Lefevre, 1973, Schalet, 1972)

      su(f)1 is a suppressor of phenotype of f67a

      su(f)1 is a suppressor of phenotype of wgd

      NOT Suppressor of
      Statement
      Reference

      su(f)1 is a non-suppressor of phenotype of whd81b6

      (Rabinow and Birchler, 1990)

      su(f)1 is a non-suppressor of phenotype of whd81b11

      (Rabinow and Birchler, 1990)

      su(f)1 is a non-suppressor of phenotype of whd81b25

      (Rabinow and Birchler, 1990)

      su(f)1 is a non-suppressor of phenotype of fH

      su(f)1 is a non-suppressor of phenotype of f51a

      su(f)1 is a non-suppressor of phenotype of fX1

      su(f)1 is a non-suppressor of phenotype of fX2

      su(f)1 is a non-suppressor of phenotype of fX4

      su(f)1 is a non-suppressor of phenotype of fX3

      Other
      Statement
      Reference

      su(f)4/su(f)1, w1 has pigment cell phenotype

      (Schalet, 1972)

      su(f)4/su(f)1, wa has pigment cell phenotype

      (Schalet, 1972)

      su(f)1, wa has pigment cell phenotype

      (Schalet, 1972)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      f1 su(f)2/f1 su(f)1 and f1 su(f)4/f1 su(f)1 flies are f+.

      (Schalet and Lefevre, 1973)

      Suppresses the f1 phenotype; f1 su(f)4 males and females are f+ at 17-18oC. f1 su(f)4/f1 su(f)1 females are f+, like f1 su(f)1/f1 su(f)1, at all temperatures. f1 su(f)2/f1 su(f)1 females are f+ at 24-25oC. f1 su(f)2/f5 su(f)1 females show suppression of the f mutant phenotype similar to that seen in f1 su(f)1/f5 su(f)1 females at 24-25oC. At 20-30oC, the f1 su(f)2/f5 su(f)1 combination shows suppression of the f mutant phenotype but bristles are Minute-like. wa su(f)1 flies have apricot coloured eyes at 29-30oC, at 24-25oC the eyes are near white and at 17-18oC the eyes are indistinguishable from white. w1 su(f)4/wa su(f)1 females have a w1 phenotype at 24-25oC.

      (Schalet, 1972)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      su(f)2

      (Schalet, 1972)
      Rescued by

      su(f)1 is rescued by su(f)+t6.4

      (Simonelig et al., 1996)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (8)
      Notes on Origin
      Discoverer

      Whittinghill, 4th July 1937.

      Comments
      Comments

      su(f)1 is an enhancer of lz37.

      (Duus et al., 1992)

      Strength of enhancement of the wa phenotype: su(f)1 > su(f)12 > su(f)8 > su(f)4. Strength of suppression of the f1 phenotype: su(f)1 > su(f)4 > su(f)12 > su(f)8.

      (Fitch et al., 1992)

      su(f)1 has no significant effect on level of Adh transcript but the relative level of Adhr transcript is increased, the extent of this increase is greater in conditions (high temperature) which result in a more severe su(f) phenotype.

      (Brogna and Ashburner, 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      su(f)
      (Schalet and Lefevre, 1973, Schalet, 1972)
      su(f)1
      suW(f)
      Name Synonyms
      Secondary FlyBase IDs
        References (18)