FB2025_01 , released February 20, 2025
Allele: Dmel\su(f)2
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General Information
Symbol
Dmel\su(f)2
Species
D. melanogaster
Name
FlyBase ID
FBal0016267
Feature type
allele
Associated gene
Dmel\su(f)
Associated Insertion(s)
Carried in Construct
Also Known As
su(f)3DES, 3DES
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
diethyl sulfate
(Perrimon et al., 1989, Schalet and Lefevre, 1973, Lifschytz and Falk, 1968)
ethyl methanesulfonate
(Lifschytz and Falk, 1968)
Progenitor genotype
Cytology
Description

Nucleotide substitution at position 3606 (coordinates from FBrf0058525) that changes the AG consensus dinucleotide at the 3' splice site of intron 8 to TG.

(Simonelig et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:23,100,858..23,100,858 [+]
Nucleotide change:

A23100858T

Reported nucleotide change:

A3606T

Comment:

Mutation in the splice acceptor site for intron 8.

(Simonelig et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethality occurs during larval or pupal stages. Homozygous germline clones display cell lethality. Embryos derived from heterozygous mothers exhibit neither CNS or PNS defects.

      (Perrimon et al., 1989)

      su(f)4/su(f)2 flies are viable at 17-18oC, 24-25oC and 29-30oC, and are normal for the "pale bristles" phenotype.

      (Schalet and Lefevre, 1973)

      su(f)4/su(f)2 females are fully viable, show a good but not complete suppression of f1 and are normal for the su(f)4 phenotype at all temperatures.

      (Schalet, 1972)

      Homozygotes lethal at the larval stage; homozygous germ-line clones don't survive; no effect on development of peripheral or central nervous systems (Perrimon, Smouse, and Miklos, 1989). wa displays dilute apricot pigmentation in su(f)1/su(f)2 flies raised at 25oC but white eyes when raised at 18oC (Schalet and Lefevre, 1976). su(f)2 shown to be proximal to su(f)1 by recombination (Schalet).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      su(f)2 is a suppressor of phenotype of f1

      (Schalet and Lefevre, 1973, Schalet, 1972)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      su(f)2 lethality is unaffected by Hsap\CSTF3Scer\UAS.cBa; Scer\GAL4da.G32.

      (Benoit et al., 2002)

      f1 su(f)2/f1 su(f)1 flies are f+. su(f)4/su(f)2 flies show a good but not complete suppression of f1.

      (Schalet and Lefevre, 1973)

      f1 su(f)2/f1 su(f)1 females are f+ at 24-25oC. f1 su(f)2/f5 su(f)1 females show suppression of the f mutant phenotype similar to that seen in f1 su(f)1/f5 su(f)1 females at 24-25oC. At 20-30oC, the f1 su(f)2/f5 su(f)1 combination shows suppression of the f mutant phenotype but bristles are Minute-like.

      (Schalet, 1972)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      su(f)4

      (Schalet, 1972)
      Fails to complement

      su(f)1

      (Schalet, 1972)
      Rescued by

      su(f)2 is rescued by su(f)UAS.cAa/Scer\GAL4da.G32

      (Benoit et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lifschytz.

      Comments
      Comments

      Complements: stnA16-1-49. Complements: intro16-3-4. Complements: intro17-410. Complements: intro16-2-9. Complements: sph16-2-9.

      (Munoz, 2004.1.5)

      su(f)26, su(f)5 and su(f)2 exhibit the same pattern of complementation; complement su(f)4, su(f)13 and su(f)12. The allelic state of z has no effect on complementation behaviour.

      (Simonelig et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      References (16)