FB2025_01 , released February 20, 2025
Allele: Dmel\su(f)4
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General Information
Symbol
Dmel\su(f)4
Species
D. melanogaster
Name
FlyBase ID
FBal0016269
Feature type
allele
Associated gene
Dmel\su(f)
Associated Insertion(s)
Carried in Construct
Also Known As
su(f)pb, su(f)R-9-18, R-9-18
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Perrimon et al., 1989, Schalet and Lefevre, 1973)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G3490A. Amino acid replacement: G?R. Coordinates from FBrf0058525.

(Simonelig et al., 1996)

restriction map normal; Mitcheson, Simonelig, Williams and O'Hare (1993)

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:23,100,742..23,100,742 [+]
Nucleotide change:

G23100742A

Reported nucleotide change:

G3490A

Amino acid change:

G632R | su(f)-PE; G664R | su(f)-PF; G632R | su(f)-PG

Reported amino acid change:

G?R

Comment:

Reported coordinates from FBrf0058525.

(Simonelig et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18oC a small proportion of individuals eclose showing thread-like, pale yellow bristles and hairs and wrinkled wings.

      (Simonelig et al., 1996)

      Hemizygous males survive at low temperatures and show no enhancement of the wa phenotype and strong suppression of f1 penetrance.

      (Fitch et al., 1992)

      Lethality occurs during larval or pupal stages. Homozygous germline clones display no maternal effect. Embryos derived from heterozygous mothers exhibit neither CNS or PNS defects.

      (Perrimon et al., 1989)

      su(f)4 flies die at the time of puparium formation at 24-25oC. At 17-18oC, the flies are viable, have thread-like pale yellow bristles and hairs, dark pigment at the dorsal anterior portion of the thorax and somewhat wrinkled or curled wings. Males do not appear sufficiently energetic to mate. su(f)4/su(f)2 flies are viable at 17-18oC, 24-25oC and 29-30oC, and are normal for the "pale bristles" phenotype. su(f)4/su(f)6 females are fully viable and normal at 17-18oC, vary in viability and show a broad streak of dark pigment on the thorax at 24-25oC, but die some time before puparium formation at 29-30oC. su(f)4/su(f)3 females are fully viable at 17-18oC, and some of the bristles and hairs show the "pale bristles" phenotype, although the texture of the wings appears normal.

      (Schalet and Lefevre, 1973)

      Lethal at 24-25o and 29-30oC. Fully viable (but weak) at 17-18oC provided overcrowding is prevented. Body colour: bristles and hairs are pale yellow, dark pigment on the thorax is usually concentrated at the dorsal anterior region. Bristles are thread-like. Wings are curled or wrinkled. su(f)4/su(f)3 flies die at about the time of puparium formation at 24-25oC. At 17-18oC they are fully viable, with some bristles and hairs of all individuals showing the su(f)4 phenotype and the texture of the wings appearing abnormal. su(f)4/su(f)6 females are fully viable and normal at 17-18oC. At 24-25oC, they vary in viability, show a broad streak of dark pigment on the thorax which is sometimes concentrated at the dorsal anterior region and have wings which sometimes stick up and out. At 29-30oC, they die just prior to puparium formation. su(f)4/su(f)8 females are fully viable and normal at 17-18oC and 24-25oC, but are fully viable and Minute-like at 29-30oC. su(f)4/Df(1)D43L1 females die at about the time of puparium formation at 24-25oC, but die just prior to eclosion at 17-18oC.

      (Schalet, 1972)

      Temperature-sensitive lethal. Lethality at late pupal stage; homozygous germ-line clones show no maternal effect in homozygous germ-line clones; also, no zygotic effects on development of peripheral or central nervous systems (Perrimon, Smouse and Miklos, 1989).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      su(f)4 has lethal phenotype, non-enhanceable by Scer\GAL4da.G32/Hsap\CSTF3UAS.cBa

      (Benoit et al., 2002)
      NOT suppressed by
      Statement
      Reference

      su(f)4 has lethal phenotype, non-suppressible by Scer\GAL4da.G32/Hsap\CSTF3UAS.cBa

      (Benoit et al., 2002)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      su(f)4 is an enhancer of phenotype of wa

      (Fitch et al., 1992)

      su(f)4 is an enhancer of phenotype of lz37

      (Schalet, 1972)
      Suppressor of
      Statement
      Reference

      su(f)4 is a suppressor of phenotype of f1

      (Simonelig et al., 1996, Schalet and Lefevre, 1973, Schalet, 1972)
      Other
      Statement
      Reference

      su(f)4/su(f)1, w1 has pigment cell phenotype

      (Schalet, 1972)

      su(f)4, wa has pigment cell phenotype

      (Schalet, 1972)

      su(f)4/su(f)1, wa has pigment cell phenotype

      (Schalet, 1972)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      f1 su(f)4/f1 su(f)1 flies are f+. su(f)4/su(f)2 flies show a good but not complete suppression of f1.

      (Schalet and Lefevre, 1973)

      Suppresses the f1 phenotype; f1 su(f)4 males and females are f+ at 17-18oC. f1 su(f)4/f1 su(f)1 females are f+, like f1 su(f)1/f1 su(f)1, at all temperatures. su(f)4/su(f)2 females are fully viable, show a good but not complete suppression of f1 and are normal for the su(f)4 phenotype at all temperatures. Enhances the wa phenotype; w1 su(f)4/wa su(f)1 females have a w1 phenotype at 24-25oC. wa su(f)4/Y males have an eye colour intermediate between that of w1 and wa at 17-18oC. Enhances the phenotype of lz37 males at 17-18oC.

      (Schalet, 1972)
      Xenogenetic Interactions
      Statement
      Reference

      su(f)4 lethality is unaffected by Hsap\CSTF3Scer\UAS.cBa; Scer\GAL4da.G32.

      (Benoit et al., 2002)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lifschytz.

      Comments
      Comments

      May be the only pale-bristle allele. One other allele of this type was found by Dale Grace as a sex-lined lethal (Schalet).

      Complements: stnA16-1-49. Complements: intro16-3-4. Complements: intro17-410. Complements: intro16-2-9. Complements: sph16-2-9.

      (Munoz, 2004.1.5)

      Maternal germline clonal analysis demonstrates there is no maternal effect.

      (Perrimon et al., 1989)

      Strength of enhancement of the f1 penetrance: su(f)1 > su(f)12 > su(f)8 > su(f)4. Strength of suppression of the f1 phenotype: su(f)1 > su(f)4 > su(f)12 > su(f)8.

      (Fitch et al., 1992)

      At 18oC su(f)4 is allelic to su(f)1. At 25oC su(f)4 complements su(f)26, su(f)5, su(f)2 and su(f)6 and fails to complement su(f)19, su(f)16-185, su(f)28, su(f)27, su(f)25, su(f)3 and su(f)4. At 30oC the only exception is that su(f)4 fails to complement su(f)6, in addition su(f)4 complements su(f)13 and su(f)12. su(f)4 exhibits a unique pattern of complementation compared to other su(f) alleles. The allelic state of z has no effect on complementation behaviour.

      (Simonelig et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (17)