FB2025_01 , released February 20, 2025
Allele: Dmel\Su(H)1
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General Information
Symbol
Dmel\Su(H)1
Species
D. melanogaster
Name
FlyBase ID
FBal0016302
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Schweisguth and Posakony, 1992)

loss of function allele

(de Celis et al., 1996)
Mutagen
spontaneous
(Ashburner et al., 1999.10.12)
ethyl methanesulfonate
(O'Donnell et al., 1977)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Schimke immuno-osseous dysplasia
      modeled by Marcal1UAS.cBa
      (Morimoto et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Su(H)1/Su(H)IB115 mutant tissues exhibit a loss of ptc-positive prohemocytes and the overproduction of differentiated plasmatocytes. By contrast, an increase is not observed in the crystal cell population in Su(H)1/Su(H)IB115 mutant lymph glands.

      (Tokusumi et al., 2010)

      Dorsal, ventral and dorsoventral clones that extend to the wing margin produce extensive scalloping.

      (de Celis et al., 1996)

      Lethality during the first day of pupal development. Supernumerary cells stained in mutant imaginal discs have adopted a sensory organ precursor (SOP) fate instead of the epidermal fate they would normally express. The excess SOPs arise from the proneural clusters of potential precursor cels that appear in the imaginal discs during the development of wild type bristles. The wing pouch region of the wing imaginal disc and the retinal field of the eye-antennal imaginal disc are dramatically reduced. Identical phenotype is seen when transheterozygous with Df(2L)TE35BC-24, Su(H)IB115, Su(H)2 or Su(H)8.

      (Schweisguth and Posakony, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Su(H)[+]/Su(H)1 is a non-enhancer of abnormal neurophysiology | adult stage | dominant phenotype of DCTN1-p150Gl-1

      (Ma et al., 2009)

      Su(H)[+]/Su(H)1 is a non-enhancer of abnormal neuroanatomy | adult stage | dominant phenotype of DCTN1-p150Gl-1

      (Ma et al., 2009)
      Suppressor of
      Statement
      Reference

      Su(H)[+]/Su(H)1 is a suppressor of visible | dominant phenotype of gcmPyx

      (Popkova et al., 2012)

      Su(H)[+]/Su(H)1 is a suppressor of visible | adult stage phenotype of Hsap\ATXN1LUAS.Tag:FLAG

      (Tong et al., 2011)

      Su(H)[+]/Su(H)1 is a suppressor of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

      (Oishi et al., 2006)

      Su(H)[+]/Su(H)1 is a suppressor of lethal | pupal stage phenotype of Eps-15EP2513

      (Tang et al., 2005)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Su(H)[+]/Su(H)1 is a non-enhancer of giant fiber neuron phenotype of DCTN1-p150Gl-1

      (Ma et al., 2009)
      Suppressor of
      Statement
      Reference

      Su(H)[+]/Su(H)1 is a suppressor of chaeta | increased number phenotype of gcmPyx

      (Popkova et al., 2012)

      Su(H)[+]/Su(H)1 is a suppressor of wing blade phenotype of Hsap\ATXN1LUAS.Tag:FLAG

      (Tong et al., 2011)

      Su(H)[+]/Su(H)1 is a suppressor of wing vein L5 phenotype of Hsap\ATXN1LUAS.Tag:FLAG

      (Tong et al., 2011)

      Su(H)[+]/Su(H)1 is a suppressor of posterior crossvein phenotype of Hsap\ATXN1LUAS.Tag:FLAG

      (Tong et al., 2011)

      Su(H)[+]/Su(H)1 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

      (Oishi et al., 2006)
      Other
      Statement
      Reference

      Su(H)1, da2 has follicle cell phenotype

      (Smith et al., 2002)

      Su(H)[+]/Su(H)1, da2 has follicle cell phenotype

      (Smith et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Su(H)1/+ does not enhance the morphological or electrophysiological defects of the giant fiber axons of Gl1/+ flies.

      (Ma et al., 2009)

      Su(H)1 heterozygosity suppresses the lethality found in Eps-15EP2513 homozygotes. These flies do not exhibit any apparent morphological or behavioral defects.

      (Tang et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference

      The wing vein L5 thickening characteristic for adult females expressing Hsap\ATXN1LScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4hh.PU can be suppressed by combination with Su(H)1/+, while the loss of posterior crossvein is only partially restored.

      (Tong et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (5)
      Notes on Origin
      Discoverer

      Plunkett, Sep. 1924.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (26)