Allele Dmel\Su(H)¹

General Information
Symbol	Dmel\Su(H)¹	Species	D. melanogaster
Name		FlyBase ID	FBal0016302
Feature type	allele	Associated gene	Dmel\Su(H)

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	spontaneous, ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Schweisguth and Posakony, 1992) loss of function allele (de Celis et al., 1996)
Mutagen	ethyl methanesulfonate (O'Donnell et al., 1977) spontaneous (Ashburner et al., 1999.10.12)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal (with Su(H)^EG37) (Ma et al., 2009) lethal \| pupal stage \| recessive (Schweisguth and Posakony, 1992) lethal \| recessive (O'Donnell et al., 1977)
Phenotype Manifest In
	embryonic/larval lymph gland (with Su(H)^IB115) (Tokusumi et al., 2010) eye-antennal disc (Schweisguth and Posakony, 1992) plasmatocyte (with Su(H)^IB115) (Tokusumi et al., 2010) sensory mother cell (Schweisguth and Posakony, 1992) wing (de Celis et al., 1996) wing disc (Schweisguth and Posakony, 1992)
Detailed Description
	Statement Reference Su(H)[1]/Su(H)[IB115] mutant tissues exhibit a loss of ptc-positive prohemocytes and the overproduction of differentiated plasmatocytes. By contrast, an increase is not observed in the crystal cell population in Su(H)[1]/Su(H)[IB115] mutant lymph glands. (Tokusumi et al., 2010) Dorsal, ventral and dorsoventral clones that extend to the wing margin produce extensive scalloping. (de Celis et al., 1996) Lethality during the first day of pupal development. Supernumerary cells stained in mutant imaginal discs have adopted a sensory organ precursor (SOP) fate instead of the epidermal fate they would normally express. The excess SOPs arise from the proneural clusters of potential precursor cels that appear in the imaginal discs during the development of wild type bristles. The wing pouch region of the wing imaginal disc and the retinal field of the eye-antennal imaginal disc are dramatically reduced. Identical phenotype is seen when transheterozygous with Df(2L)TE35BC-24, Su(H)^IB115, Su(H)² or Su(H)⁸. (Schweisguth and Posakony, 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference Su(H)[+]/Su(H)¹ is a non-enhancer of neuroanatomy defective \| dominant \| adult stage phenotype of Gl¹ (Ma et al., 2009) Su(H)[+]/Su(H)¹ is a non-enhancer of neurophysiology defective \| dominant \| adult stage phenotype of Gl¹ (Ma et al., 2009)
Suppressor of
Statement Reference Su(H)[+]/Su(H)¹ is a suppressor of lethal \| pupal stage phenotype of Eps-15^EP2513 (Tang et al., 2005) Su(H)[+]/Su(H)¹ is a suppressor of visible \| dominant phenotype of gcm^Pyx (Popkova et al., 2012) Su(H)[+]/Su(H)¹ is a suppressor of visible phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006)
Phenotype Manifest In
NOT Enhancer of
Statement Reference Su(H)[+]/Su(H)¹ is a non-enhancer of giant fiber neuron phenotype of Gl¹ (Ma et al., 2009)
Suppressor of
Statement Reference Su(H)[+]/Su(H)¹ is a suppressor of chaeta \| supernumerary phenotype of gcm^Pyx (Popkova et al., 2012) Su(H)[+]/Su(H)¹ is a suppressor of wing vein \| ectopic phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006)
Other
Statement Reference Su(H)[+]/Su(H)¹, da² has follicle cell phenotype (Smith et al., 2002) Su(H)¹, da² has follicle cell phenotype (Smith et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Su(H)[1]/+ does not enhance the morphological or electrophysiological defects of the giant fiber axons of Gl[1]/+ flies. (Ma et al., 2009) Su(H)[1] heterozygosity suppresses the lethality found in Eps-15[EP2513] homozygotes. These flies do not exhibit any apparent morphological or behavioral defects. (Tang et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 5 )
Bloomington	418 Su(H)¹ whd¹ l(2)Su(H)¹/SM5 417 Su(H)¹/In(2L)Cy, In(2R)Cy, Cy¹ pr¹
Kyoto	105901 Su(H)¹ whd¹ l(2)Su(H)¹/SM5 101508 In(2L)Cy In(2R)Cy Cy¹ pr¹ / Su(H)¹ 105900 Su(H)¹/In(2L)Cy, In(2R)Cy, Cy¹ pr¹
Notes on Origin
Discoverer	Plunkett, Sep. 1924.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	DM-15 (O'Donnell et al., 1977) Su(H) (Smith et al., 2002) Su(H)¹ (Christensen and Cook, 2007.5.8, Tsuda et al., 2006, Tokusumi et al., 2010, Tang et al., 2005, Ma et al., 2009, Oishi et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 19 )
Research paper	Popkova et al., 2012, PLoS Genet. 8(12): e1003159 Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515] Tokusumi et al., 2010, Development 137(21): 3561--3568 Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis. [FBrf0212074] Ma et al., 2009, BMC Genet. 10: 77 A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation. [FBrf0209456] Oishi et al., 2006, Hum. Mol. Genet. 15(4): 543--553 Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. [FBrf0190828] Tsuda et al., 2006, EMBO J. 25(13): 3191--3202 An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. [FBrf0194300] Tang et al., 2005, Mol. Cell. Biol. 25(8): 2899--2909 Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. [FBrf0184155] Smith et al., 2002, Development 129(13): 3255--3267 daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila. [FBrf0148972] Cooper et al., 2000, Dev. Biol. 221(2): 390--403 Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes. [FBrf0127044] Eastman et al., 1997, Mol. Cell. Biol. 17(9): 5620--5628 Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. [FBrf0098234] de Celis et al., 1996, Development 122(1): 359--369 Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. [FBrf0086228] de Celis et al., 1996, Development 122(9): 2719--2728 Functional relationships between N, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. [FBrf0090023] Schweisguth and Posakony, 1992, Cell 69: 1199--1212 Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. [FBrf0055545] Ashburner, 1982, Genetics 101: 447--459 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for Alcohol dehydrogenase. [FBrf0038053] O'Donnell et al., 1977, Genetics 86: 553--566 Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. [FBrf0030161] Nash, 1970, Genetics 64: 471--479 The mutational basis for the 'allelic' modifier mutants, Enhancer and Suppressor of Hairless of Drosophila melanogaster. [FBrf0021572] Nash, 1965, Genet. Res. (Camb.) 6: 175--189 The expression of 'Hairless' in Drosophila and the role of two closely linked modifiers of opposite effect. [FBrf0016985] Plunkett, 1926, J. exp. Zool. 46: 181--244 The interaction of genetic and environmental factors in development. [FBrf0001495]
Personal communication to FlyBase	Christensen and Cook, 2007.5.8, Isolation and characterization of Df(2L)BSC299. Isolation and characterization of Df(2L)BSC299. [FBrf0198999] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]

Allele Dmel\Su(H)1

Allele Dmel\Su(H)¹