embryonic/first instar larval cuticle & embryonic head | germ-line clone
eye disc & neuron | somatic clone | cell autonomous
proneural cluster & dorsal mesothoracic disc
Su(H)2 Sox154AA/Su(H)8 Sox154AA; Su(H)RC-ΔASE mutants show a more dramatic socket differentiation defect than either single mutant. Most of the double mutant bristles have a convex (rather than concave) socket-shaft cuticular interface. Dome of these bulbous socket structures extend one or more small cuticular projections, while others extend one or two distinctly shaft-like structures.
The neurogenic phenotype, but not the wing development phenotype, of Su(H)2/Su(H)8 is strongly suppressed by either HLHm7Scer\UAS.cdCa or E(spl)Scer\UAS.cNa driven by Scer\GAL4klu-G410. The wing development phenotype of Su(H)2/Su(H)8 is not suppressed by either Nint.SH.Scer\UAS or DlScer\UAS.cHa, or SerScer\UAS.cSa in combination with vgScer\UAS.cKa, driven by Scer\GAL4dpp.blk1. The wing development phenotype of Su(H)2/Su(H)8 is also not suppressed by HE31.
Partially suppresses the Tom8 phenotype - Su(H)8/+ ; Tom8/Tom8 pharate adults show almost completely everted head structures. The larval lethality and small eye-antennal disc phenotype of Su(H)8 homozygotes can be partially rescued by Tom8 - Su(H)8/Su(H)8 ; Tom8/+ animals develop to the pupal stage with pharate adults showing partially everted heads.
The addition of Su(H)2/Su(H)8 has no effect on the proneural cluster phenotype in the wing disc seen in NECNΔ10-12.Scer\UAS/Scer\GAL4ptc-559.1 discs. Expression of Ncdc10.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4ptc-559.1 has no effect on the Su(H)8/Su(H)2 proneural cluster phenotype in the wing disc.
Scer\GAL4dpp.blk1-mediated or Scer\GAL4ptc-559.1-mediated expression of vgScer\UAS.cKa substantially rescues the wing blade phenotype. Scer\GAL4dpp.blk1-mediated expression of wgScer\UAS.cGa does not rescue loss of wing tissue.
When expression of Su(H)Scer\UAS.cKa is driven by Scer\GAL4dpp.blk1 in a Su(H)2/Su(H)8 mutant the wing pouch size defect is rescued. When expression of Su(H)Scer\UAS.cKa is driven by Scer\GAL4klu-G410 in a Su(H)2/Su(H)8 mutant the neurogenesis and wing pouch size defects are rescued.