Allele Dmel\su(Hw)³

General Information
Symbol	Dmel\su(Hw)³	Species	D. melanogaster
Name		FlyBase ID	FBal0016320
Feature type	allele	Associated gene	Dmel\su(Hw)
Also Known As	su(Hw)^69k

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References deletion 3R:10,132,395..10,132,398 comment=4bp deletion (-/CACA) predicted to cause frame shift at position aa405 and premature translation stop. (Weedmark, 2008.10.21)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 4bp deletion (-/CACA) in exon 2 (nucleotide positions 1912-1915). This is predicted to cause a frame shift at amino acid residue 405 and premature truncation of the C-terminal region, including several zinc fingers and the mod(mdg4)67.2 interacting region. (Weedmark, 2008.10.21) Southern blot normal
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Parkhurst et al., 1988)
Phenotype Manifest In

Detailed Description
	Statement Reference su(Hw)³ cancels the effect of mod(mdg4)^ul on trans repression of y gene expression. (Georgiev and Corces, 1995)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	su(Hw)³ is rescued by su(Hw)^+t9.5 (Parkhurst et al., 1988) su(Hw)³ is rescued by su(Hw)^+t18 (Parkhurst et al., 1988)
Comments	Mutant phenotype was rescued by P element mediated transformation of the wild type gene. (Parkhurst et al., 1988)
Stocks ( 2 )
Bloomington	672 su(Hw)³/MKRS
Kyoto	106033 su(Hw)³/MKRS
Notes on Origin
Discoverer	Grell.

Comments
	Strong su(Hw) allele. (Georgiev and Corces, 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	su(Hw)³ (Christensen et al., 2008.4.15, Weedmark, 2008.10.21) su(Hw)^69k (Georgiev and Corces, 1995, Harrison et al., 1989, Parkhurst et al., 1988, )
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Bushey and Locke, 2004, Genetics 168(3): 1395--1411 Mutations in Su(var)205 and Su(var)3-7 suppress P-element-dependent silencing in Drosophila melanogaster. [FBrf0180280] Georgiev and Corces, 1995, Proc. Natl. Acad. Sci. U.S.A. 92(11): 5184--5188 The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog. [FBrf0082023] Harrison et al., 1989, Dev. Genet. 10: 239--248 The gypsy retrotransposon of Drosophila melanogaster: mechanisms of mutagenesis and interaction with the suppressor of Hairy-wing locus. [FBrf0049522] Parkhurst et al., 1988, Genes Dev. 2: 1205--1215 The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein. [FBrf0048095] Rutledge et al., 1988, Genetics 119: 391--397 Genetic interactions of modifier genes and modifiable alleles in Drosophila melanogaster. [FBrf0048208] Modolell et al., 1983, Proc. Natl. Acad. Sci. U.S.A. 80: 1678--1682 Drosophila melanogaster mutations suppressible by the suppressor of Hairy-wing are insertions of a 7.3-kilobase mobile element. [FBrf0040116]
Personal communication to FlyBase	Christensen et al., 2008.4.15, Isolation and characterization of Df(3R)BSC487. Isolation and characterization of Df(3R)BSC487. [FBrf0204515] Weedmark, 2008.10.21, Molecular data on su(Hw)[3] allele. Molecular data on su(Hw)[3] allele. [FBrf0206261]

Allele Dmel\su(Hw)3

Allele Dmel\su(Hw)³