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General Information
Symbol
Dmel\su(Hw)7
Species
D. melanogaster
Name
FlyBase ID
FBal0016324
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
su(Hw)f
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G14306189A

Reported nucleotide change:

G2377A

Amino acid change:

C525Y | su(Hw)-PA; C525Y | su(Hw)-PB; C525Y | su(Hw)-PC

Reported amino acid change:

C?Y

Comment:

Reported nucleotide numbering from FBrf0048095.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The first Cys residue of zinc finger 10 is changed to Tyr.

Point mutation in one of the Zn fingers which retains some ability to bind DNA.

Point mutation in one of the zinc fingers.

Nucleotide substitution: G2377A. Amino acid replacement: C?Y. Substitution in the tenth zinc finger.

Mutation of one of the zinc fingers.

Southern blot normal.

Point mutation.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

su(Hw)7/Df(3R)su(Hw)-A1933 transheterozygous females are fertile but show loss of the gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes).

P{SUPor-P} induced double strand breakage repair is increased about twofold in a su(Hw)V/su(Hw)7 background compared to wild-type. This phenotype is also seen in flies derived from su(Hw)V/su(Hw)7 parents.

Partial suppression of the y2 phenotype.

su(Hw)2/su(Hw)7 heterozygotes almost completely suppress the "Hw" phenotype acHw-1+R5, extra macrochaetae are seen on the pleura and postnotum. This was accompanied by a 2--3 fold reduction of ac RNA, sc RNA levels were unchanged. A positive correlation can be seen between increased levels of ac transcripts and the appearance of the "Hw" phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
Enhancer of
Statement
Reference

su(Hw)7/su(Hw)V is an enhancer of visible phenotype of sc5

Suppressor of
Statement
Reference

su(Hw)7/su(Hw)V is a suppressor of visible phenotype of apf00451

su(Hw)7/su(Hw)V is a suppressor | partially of visible phenotype of scms1

su(Hw)7/su(Hw)V is a suppressor | partially of visible phenotype of scms2

NOT Suppressor of
Statement
Reference

su(Hw)7/su(Hw)V is a non-suppressor of visible phenotype of apP1\loxP.MCP-PRE.MM

Other
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

su(Hw)7/su(Hw)V is a non-enhancer of scutellar bristle phenotype of scV2

Suppressor of
Statement
Reference

su(Hw)7/su(Hw)V is a suppressor of wing phenotype of apf00451

su(Hw)7/su(Hw)V is a suppressor of ocellar bristle phenotype of scms2

su(Hw)7/su(Hw)V is a suppressor of ocellar bristle phenotype of scms1

su(Hw)7, su(Hw)V, su(Hw)Δ706-736 is a suppressor of phenotype of y2

su(Hw)7, su(Hw)V, su(Hw)Δ853-880 is a suppressor of phenotype of y2

su(Hw)Δ673-943, su(Hw)7, su(Hw)V is a suppressor of phenotype of y2

su(Hw)7, su(Hw)V, su(Hw)Δ2-203.673-943 is a suppressor of phenotype of y2

su(Hw)7, su(Hw)V, su(Hw)Δ738-780 is a suppressor of phenotype of y2

su(Hw)7, su(Hw)V, su(Hw)Δ782-944 is a suppressor of phenotype of y2

su(Hw)7 is a suppressor of pigment cell phenotype of wE.BR.BR

su(Hw)7/su(Hw)[+] is a suppressor of phenotype of ctMRpN30

su(Hw)7 is a suppressor of phenotype of ctK

su(Hw)7 is a suppressor of phenotype of yD-CTLR

su(Hw)7 is a suppressor of phenotype of yD-786

su(Hw)7 is a suppressor of phenotype of yD-CLTR

su(Hw)7 is a suppressor of wing phenotype of rsP1

su(Hw)7 is a suppressor of wing phenotype of rsP2

NOT Suppressor of
Statement
Reference

su(Hw)7/su(Hw)V is a non-suppressor of wing phenotype of apP1\loxP.MCP-PRE.MM

su(Hw)7/su(Hw)V is a non-suppressor of humeral bristle phenotype of scms2

su(Hw)7/su(Hw)V is a non-suppressor of humeral bristle phenotype of scms1

su(Hw)7, su(Hw)V, su(Hw)wt is a non-suppressor of phenotype of y2

su(Hw)7, su(Hw)V, su(Hw)Δ2-203 is a non-suppressor of phenotype of y2

su(Hw)7, su(Hw)Δ656-705, su(Hw)V is a non-suppressor of phenotype of y2

su(Hw)7, su(Hw)V, su(Hw)Δ881-944 is a non-suppressor of phenotype of y2

Other
Statement
Reference

In(1)sc8, su(Hw)7/su(Hw)V has mesothoracic tergum & microchaeta phenotype

In(1)y3P, su(Hw)7/su(Hw)V has mesothoracic tergum & microchaeta phenotype

In(1)scV2, su(Hw)7/su(Hw)V has mesothoracic tergum & microchaeta phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Introduction of su(Hw)V/su(Hw)7 restores viability to bgm38f-ex animals.

A su(Hw)V/su(Hw)7 background almost completely suppresses the wing defects seen in apf00451 mutant flies.

A su(Hw)V/su(Hw)7 mutant background has no effect on the wing defects seen in aploxP.MCP-PRE.MM mutant flies.

A su(Hw)V/su(Hw)7 background is unable to suppress the enhancer blocking seen in flies expressing y62D.DNR. The same light wing blade and body pigmentation is seen as is seen in y62D.DNR alone.

wScer\FRT.S.P1\loxP.S flies carrying su(Hw)V/su(Hw)7 tend to have lighter eye pigmentation than wScer\FRT.S.P1\loxP.S flies.

wP1\loxP.S.dW.Scer\FRT.S flies carrying su(Hw)V/su(Hw)7 tend to have darker eye pigmentation than wP1\loxP.S.dW.Scer\FRT.S flies.

wΔS.dW.Scer\FRT.S flies carrying su(Hw)V/su(Hw)7 tend to have lighter eye pigmentation than wΔS.dW.Scer\FRT.S flies.

Body colour: flies carrying yEye125bpYSW.Scer\FRT.P1\loxP (in a y- background) have wild-type levels of pigmentation if they are also carrying su(Hw)V/su(Hw)7. In(1)y3P ; su(Hw)V/su(Hw)7 animals show loss of a number of bristles. Bristle pigmentation is normal in these animals. In(1)scV2 ; su(Hw)V/su(Hw)7 animals show loss of a number of bristles. Bristle pigmentation shows mild variegation in these animals; about half the bristles are yellow. In(1)sc8 ; su(Hw)V/su(Hw)7 animals show loss of a number of bristles. Bristle pigmentation is normal in these animals. sc5 ; su(Hw)V/su(Hw)7 animals show loss of a number of bristles. Bristle pigmentation is normal in these animals.

Pigmentation of y1/y1; yP1\loxP.su(Hw)BR-y-AS-C.-900 animals is largely unaffected by a su(Hw)7/Df(3R)su(Hw)V background.

In a su(Hw)V/su(Hw)7 background, the adbdominal phenotype of Abd-BFab7-2.gypsy\su(Hw)BR-340/+ males reverts to that seen in Fab-72 flies.

su(Hw)2/su(Hw)7 heteroallelic combination strongly suppresses gypsy insertions.

su(Hw)V/su(Hw)7 restores wild type coloration to y-800, y-800R, y-1868, y+660R and y+660.

Dominant suppressor of ctK and ctMRpN30, but suppression is less complete than for su(Hw)V.

Heterozygotes with su(Hw)2 suppress oblique truncated wing of rsP1 and rsP2. Effect on rsP1 is recessive. Effect on rsP2 is semidominant. Suppression not temperature-dependent as previously reported (Cramer DIS 55:197 ).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Neither su(Hw)A2663 nor su(Hw)A460 complements su(Hw)7, a separation-of-function alleles that only affects the gypsy insulator function (assayed through body, wing and bristle phenotypes induced by mutations in the y, ct and f genes), this allele is complemented by su(Hw)M393 (a separation-of-function allele that impairs female fertility).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (48)