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General Information
Symbol
Dmel\su(r)1
Species
D. melanogaster
Name
FlyBase ID
FBal0016334
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G9199541A

Reported nucleotide change:

G?A

Amino acid change:

G193E | su(r)-PC

Reported amino acid change:

G193E

Comment:

The reported amino acid change is from Figure 4 of FBrf0192211 and does not agree with the G203E location reported in the text.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

Amino acid replacement: G193E.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous males are hypersensitive to 5-fluorouracil compared to control flies.

Suppresses both the phenotypic effects and the female sterility of all r alleles; also suppresses the r phenocopying and lethal effects of 6-azauracil administration. Little or no dihydrouracil dehydrogenase activity. Thought to interfere with pyrimidine catabolism. Unable to degrade uracil and extremely sensitive to exogenous pyrimidine. Enhances the expression of dp and net and causes b flies to have very black bodies, darker than wild type, especially along the wing veins; forms synthetic lethals in combination with tt and whd.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

su(r)1 is a suppressor of visible phenotype of rC

Other
Phenotype Manifest In
Suppressor of
Statement
Reference

su(r)1 is a suppressor of wing phenotype of rC

su(r)1 is a suppressor of phenotype of runspecified

Additional Comments
Genetic Interactions
Statement
Reference

su(r)1, rC; b1 mutants show wild-type freezing responses in 60% of flies and exhibit a delayed response in only 20% of flies.

Suppressor effect on the pyrimidine requiring mutant r is due to a block in the catabolic pathway of pyrimidines.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)