Allele Dmel\Su(var)2-1¹

General Information
Symbol	Dmel\Su(var)2-1¹	Species	D. melanogaster
Name		FlyBase ID	FBal0016489
Feature type	allele	Associated gene	Dmel\Su(var)2-1
Also Known As	Su(var)2-1⁰¹, Suvar(2)1⁰¹, Su-var(2)1⁰¹, S-var(2)1⁰¹

Allele class	antimorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	antimorphic allele - genetic evidence (Sinclair et al., 1992)
Mutagen	spontaneous (Reuter et al., 1983, Sinclair et al., 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (Reuter et al., 1983) lethal \| recessive (Sinclair et al., 1992) non-suppressor of variegation \| dominant, with P{hsp26-pt-T}118E-10 (Sun et al., 2000) suppressor of variegation, with In(1)w^m4h (Laible et al., 1997, Buchner et al., 2000) suppressor of variegation \| dominant (Reuter et al., 1983) suppressor of variegation \| dominant, with In(1)w^m4 (Sinclair et al., 1992) suppressor of variegation \| dominant, with In(1)w^m4h (Dorn et al., 1993, Westphal and Reuter, 2002) suppressor of variegation \| dominant, with P{hsp26-pt-T}39C-12 (Sun et al., 2000) suppressor of variegation \| dominant, with P{hsp26-pt-T}39C-42 (Sun et al., 2000) suppressor of variegation \| dominant, with P{hsp26-pt-T}118E-3 (Sun et al., 2000) suppressor of variegation \| dominant, with P{hsp26-pt-T}118E-19 (Sun et al., 2000) suppressor of variegation \| dominant, with P{hsp26-pt-T}118E-25-5 (Sun et al., 2000) suppressor of variegation \| dominant, with P{hsp26-pt-T}CG2316^39C-34 (Sun et al., 2000)
Phenotype Manifest In
	pigment cell (Buchner et al., 2000)
Detailed Description
	Statement Reference Heterozygotes show no effect on crossing over between kni and p^p. (Westphal and Reuter, 2002) In X/O males carnitine compounds have a lethal interaction. (Fanti et al., 1994) mod(mdg4)^neo129 suppresses the strong dominant suppressor effect. (Dorn et al., 1993) Suppresses In(1)w^m4 and T(2;3)Sb^V and enhances the variegation phenotype of In(2R)bw^VDe2. Homozygous embryos are semi-viable. The effect of the Su(var)2-1¹ allele is slightly reduced in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin). The extent of hemizygous lethality is dramatically enhanced in the presence of extra heterochromatin (attachedXX/Y females) whereas the lethality did not occur in the absence of the Y (X/O males). (Sinclair et al., 1992) Dominant suppressor effect for position-effect variegation. Homozygous lethal and semi-sterile in males. (Reuter et al., 1983)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)[+]/mod(mdg4)⁰⁵ (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)[+]/mod(mdg4)^R32 (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰³/mod(mdg4)[+] (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰⁴/mod(mdg4)[+] (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰⁶/mod(mdg4)[+] (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)⁰⁷/mod(mdg4)[+] (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)^142Δ32/mod(mdg4)[+] (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹ has suppressor of variegation phenotype, suppressible by mod(mdg4)^neo129/mod(mdg4)[+] (Buchner et al., 2000)
Enhancer of
Statement Reference Su(var)2-1[+], Su(var)2-1[+], Su(var)2-1¹, Su(var)2-1^v9 is an enhancer of eye color defective phenotype of Su(var)2-1[+]:, /lt¹/lt¹¹ (Clegg et al., 1998) Su(var)2-1[+], Su(var)208[+], Su(var)2-1¹, Su(var)208^unspecified is an enhancer of eye color defective phenotype of lt¹/lt¹¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)2-1^v9 is an enhancer of eye color defective \| recessive phenotype of lt¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)2-1^v9 is an enhancer of eye color defective \| recessive phenotype of lt¹¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)208^unspecified is an enhancer of eye color defective \| recessive phenotype of lt¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)208^unspecified is an enhancer of eye color defective \| recessive phenotype of lt¹¹ (Clegg et al., 1998) Su(var)2-1¹ is an enhancer of eye color defective phenotype of lt¹/lt¹¹ (Clegg et al., 1998)
Other
Statement Reference E(lt^v)319³¹⁹, Su(var)2-1¹, lt¹¹ has eye color defective phenotype (Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1¹, lt¹¹ has viable phenotype (Clegg et al., 1998) Su(var)2-1¹, rl^unspecified has visible phenotype (Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹, Su(var)205^unspecified, rl^unspecified has visible phenotype (Sinclair et al., 2000, Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹, Su(var)208^unspecified, rl^unspecified has visible phenotype (Sinclair et al., 2000, Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹/Su(var)2-1²¹⁶, rl^unspecified has visible phenotype (Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹/Su(var)2-1^v9, lt¹ has lethal \| male \| partially \| recessive phenotype (Clegg et al., 1998) Su(var)2-1¹/Su(var)2-1^v9, lt¹¹ has lethal \| male \| partially \| recessive phenotype (Clegg et al., 1998)
Phenotype Manifest In
Enhancer of
Statement Reference Su(var)2-1[+], Su(var)2-1[+], Su(var)2-1¹, Su(var)2-1^v9 is an enhancer of pigment cell phenotype of Su(var)2-1[+]:, /lt¹/lt¹¹ (Clegg et al., 1998) Su(var)2-1[+], Su(var)208[+], Su(var)2-1¹, Su(var)208^unspecified is an enhancer of pigment cell phenotype of lt¹/lt¹¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)2-1^v9 is an enhancer of pigment cell phenotype of lt¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)2-1^v9 is an enhancer of pigment cell phenotype of lt¹¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)208^unspecified is an enhancer of pigment cell phenotype of lt¹ (Clegg et al., 1998) Su(var)2-1¹/Su(var)208^unspecified is an enhancer of pigment cell phenotype of lt¹¹ (Clegg et al., 1998) Su(var)2-1¹ is an enhancer of pigment cell phenotype of lt¹/lt¹¹ (Clegg et al., 1998)
Suppressor of
Statement Reference Su(var)2-1¹ is a suppressor \| partially of adult mesothoracic segment \| ectopic phenotype of E(z)^Trm (Bajusz et al., 2001) Su(var)2-1¹ is a suppressor \| partially of adult metathoracic segment phenotype of E(z)^Trm (Bajusz et al., 2001) Su(var)2-1¹ is a suppressor \| partially of adult prothoracic segment phenotype of E(z)^Trm (Bajusz et al., 2001) Su(var)2-1¹ is a suppressor of phenotype of Ubp64E^Evar1 (Henchoz et al., 1996)
Other
Statement Reference E(lt^v)319³¹⁹, Su(var)2-1¹, lt¹¹ has pigment cell phenotype (Clegg et al., 1998) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)[+]/mod(mdg4)⁰⁵ has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)[+]/mod(mdg4)^R32 has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)⁰³/mod(mdg4)[+] has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)⁰⁴/mod(mdg4)[+] has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)⁰⁶/mod(mdg4)[+] has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)⁰⁷/mod(mdg4)[+] has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)^142Δ32/mod(mdg4)[+] has pigment cell phenotype (Buchner et al., 2000) In(1)w^m4h, Su(var)2-1¹, mod(mdg4)^neo129/mod(mdg4)[+] has pigment cell phenotype (Buchner et al., 2000) Su(var)2-1¹, rl^unspecified has eye phenotype (Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹, Su(var)205^unspecified, rl^unspecified has eye phenotype (Sinclair et al., 2000, Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹, Su(var)208^unspecified, rl^unspecified has eye phenotype (Sinclair et al., 2000, Sinclair et al., 2000, Sinclair et al., 2000) Su(var)2-1¹/Su(var)2-1²¹⁶, rl^unspecified has eye phenotype (Sinclair et al., 2000, Sinclair et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference Su(var)205^unspecified shows semi-lethality with Su(var)2-1¹ in females with a Y chromosome. (Sinclair et al., 2000) Eye pigmentation in lt¹¹/lt¹ flies is reduced if the flies are also carrying Su(var)208^unspecified/Su(var)2-1¹ or Su(var)2-1^v9/Su(var)2-1¹. XY lt¹¹/lt¹; Su(var)2-1^v9/Su(var)2-1¹ males have reduced viability, which is restored in XO males. Eye pigmentation is reduced and viability is essentially wild-type in lt¹¹/+ flies that are also carrying or Su(var)2-1^v9 and E(lt^v)319³¹⁹. (Clegg et al., 1998) The effect of loss of one copy of Su(var)2-1¹ can be rescued by P-element mediated transformation with Su(var)3-7. (Reuter et al., 1990)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments	non-complementing
Stocks ( 4 )
Bloomington	6232 In(1)w^m4h; Su(var)2-1¹/In(2L)t, In(2R)Cy, Cy¹ amos^Roi-1 pr¹ cn¹ 6265 In(1)w^m4h; Su(var)2-1¹ sna^Sco/In(2L)t, In(2R)Cy, Cy¹ amos^Roi-1 pr¹ cn¹; ry⁵⁰⁶
Kyoto	108691 In(1)w^m4h; Su(var)2-1¹/In(2L)t, In(2R)Cy, Cy¹ amos^Roi-1 pr¹ cn¹ 103360 In(1)w^m4h ; Su(var)2-1¹ sna^Sco / In(2L)t In(2R)Cy, Cy¹ amos^Roi-1 pr¹ cn¹ ; ry⁵⁰⁶
Notes on Origin
Discoverer

Comments
	Used as the genetic background in a screen to identify enhancers of PEV. (Dorn et al., 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Su(var)2-1⁰¹ (Erhardt et al., 2003, Boivin et al., 2003, Westphal and Reuter, 2002, Hwang et al., 2001, Gvozdev et al., 2000, Zhao et al., 2001, Sun et al., 2000, Buchner et al., 2000, Naumova et al., 2000, ) Su(var)2-1¹ Su(var)2-101 (Netter et al., 1998) Su(var)2⁰¹ (Martin-Morris et al., 1997) Suvar(2)1⁰¹ (Sinclair et al., 2000, Clegg et al., 1998, Reuter and Spierer, 1992, Sinclair et al., 1992) Su-var(2)1⁰¹ (Elgin, 1996, Fanti et al., 1995, Schlossherr et al., 1994, Dorn et al., 1993) Su-var(2)101 (Fauvarque and Dura, 1993) S-var(2)1⁰¹ (Weiler and Wakimoto, 1995, Fanti et al., 1994)
Name Synonym
Secondary FlyBase IDs
	FBal0030276
References ( 31 )

Generate a list of	All references relating to this allele ( 31 )

List References by type	Research paper ( 25 ) Review ( 4 ) Abstract ( 2 )
Recent research papers (0)
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Allele Dmel\Su(var)2-11

Allele Dmel\Su(var)2-1¹