Allele Dmel\Su(var)2-1²¹³

General Information
Symbol	Dmel\Su(var)2-1²¹³	Species	D. melanogaster
Name		FlyBase ID	FBal0016501
Feature type	allele	Associated gene	Dmel\Su(var)2-1

Allele class	antimorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	antimorphic allele - genetic evidence (Sinclair et al., 1992)
Mutagen	ethyl methanesulfonate (Sinclair et al., 1983, Sinclair et al., 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Sinclair et al., 1983, Sinclair et al., 1992) suppressor of variegation \| dominant, with In(1)w^m4 (Sinclair et al., 1983) suppressor of variegation \| dominant, with In(2R)bw^VDe2 (Sinclair et al., 1983) suppressor of variegation \| dominant, with T(2;3)Sb^V (Sinclair et al., 1983)
Phenotype Manifest In

Detailed Description
	Statement Reference No maternal effects seen in w⁺ eye pigment levels in non-suppressor bearing offspring of Su(var)2-1 females. Removal of segments of heterochromatin from the genome by loss of the Y chromosome abolishes the suppression of the position effect variegation phenotype. The effect of the Su(var)2-1²¹³ allele is reduced in heterozygotes with Df(2R)M41A10 (which lacks 2R heterochromatin). The extent of hemizygous lethality is dramatically enhanced in the presence of extra heterochromatin (attachedXX/Y females) whereas the lethality did not occur in the absence of the Y (X/O males). (Sinclair et al., 1992) Dominant suppressor of position effect variegation in eye pigment caused by In(1)w^m4 or In(2R)bw^VDe2. Dominant suppressor of position effect variegation at the Sb locus caused by T(2;3)Sb^V. The suppressor effect on the variegation caused by In(1)w^m4 is substantially reduced or eliminated entirely in male XO flies lacking a Y chromosome. (Sinclair et al., 1983) homozygous lethal
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference Su(var)2-1²¹³, rl^unspecified has visible phenotype (Sinclair et al., 2000, Sinclair et al., 2000)
Phenotype Manifest In
Other
Statement Reference Su(var)2-1²¹³, rl^unspecified has eye phenotype (Sinclair et al., 2000, Sinclair et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Su(var)2-1²¹³ Su(var)213 (Sinclair et al., 1983, ) Suvar(2)1²¹³ (Sinclair et al., 2000)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Sinclair et al., 2000, Genetica 109(1-2): 9--18 Essential genes in autosomal heterochromatin of Drosophila melanogaster. [FBrf0135800] Sinclair et al., 1992, Genetics 130: 333--344 A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster. [FBrf0056214] Sinclair et al., 1983, Mol. Gen. Genet. 191(2): 326--333 Genes which suppress position effect variegation in Drosophila melanogaster are clustered. [FBrf0039952]

Allele Dmel\Su(var)2-1213

Allele Dmel\Su(var)2-1²¹³