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General Information
Symbol
Dmel\Su(var)3-91
Species
D. melanogaster
Name
FlyBase ID
FBal0016557
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(var)3-901, 3-91
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Animals homozygous for In(1)wm4 and heterozygous for Su(var)3-91 have red eyes.

One copy of Su(var)3-91 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Su(var)3-91 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

Heterozygotes show no effect on crossing over between kni and pp.

Suppresses the position effect variegation at the w locus caused by In(1)wm4 and suppresses the position effect variegation at the bw locus caused by In(2R)bwVDe2. Does not effect position effect variegation at the bw locus caused by Byron or the position effect variegation of w seen in the P{wAR}41A insertion.

Strong suppressors of bw and w position effect variegation (PEV).

Dominant suppressor of position effect variegation at the w locus caused by In(1)wm4h.

homozygous viable homozygous fertile

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Su(var)3-91/Su(var)3-9[+] is a suppressor of partially lethal - majority live phenotype of ctA, lncRNA:flamA

Su(var)3-91/Su(var)3-9[+] is a suppressor of enhancer of variegation | dominant phenotype of Kdm510424

Su(var)3-91/Su(var)3-9[+] is a suppressor | partially of lethal | recessive phenotype of JIL-1z2

Su(var)3-91/Su(var)3-9[+] is a suppressor | partially of lethal phenotype of JIL-1z60/JIL-1z2

Su(var)3-91 is a suppressor of eye color defective phenotype of wA

Phenotype Manifest In
Enhancer of
Statement
Reference

Su(var)3-91/Su(var)3-9[+] is an enhancer of neuron phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU

Suppressor of
Statement
Reference

Su(var)3-91/Su(var)3-9[+] is a suppressor | partially of polytene chromosome phenotype of JIL-1z2

Additional Comments
Genetic Interactions
Statement
Reference

flamA, ctA double homozygotes display significant mortality during the pharate stage as compared to controls, which is suppressed by Su(var)3-91 heterozygosity.

The Scer\GAL4GMR.PU, HersScer\UAS.T:Zzzz\FLAG rough eye phenotype is significantly enhanced by Su(var)3-91.

Su(var)3-91/+ suppresses the ability of lid10424/+ to enhance the variegation at the w locus which is seen in the In(1)wm4 chromosome.

The lethality of JIL-1z2 homozygotes is significantly suppressed by one copy of Su(var)3-91 (87.4% viability).

The lethality of JIL-1z2 homozygotes is significantly suppressed by Su(var)3-91/Su(var)3-92 (55.8% viability).

The abnormal polytene chromosome morphology seen in JIL-1z2 homozygous third instar larvae is partially suppressed by Su(var)3-91/+ or Su(var)3-91/Su(var)3-92; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants.

JIL-1z2/JIL-1z60 flies that have one copy of the Su(var)3-91 allele show greater levels of survival compared to those that carry two wild-type copies of Su(var)3-9.

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males.

Xenogenetic Interactions
Statement
Reference

Heterozygous Su(var)3-91 enhances the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS induced neuronal apoptosis.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)wm4h, and a dominant enhancer of position effect variegation, E(var)c1011.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (6)
References (26)