Allele Dmel\Su(var)3-9²

General Information
Symbol	Dmel\Su(var)3-9²	Species	D. melanogaster
Name		FlyBase ID	FBal0016558
Feature type	allele	Associated gene	Dmel\Su(var)3-9
Also Known As	Su(var)3-9⁰²

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Ebert et al., 2004, Zhang et al., 2006)
Mutagen	ethyl methanesulfonate (Reuter et al., 1986)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: C427Y. (Krauss et al., 2006) Point mutation. (Ebert et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	suppressor of variegation \| dominant, with In(1)w^m4h (Reuter et al., 1986, Tschiersch et al., 1994) viable (Reuter et al., 1986)
Phenotype Manifest In

Detailed Description
	Statement Reference Strong suppressors of bw and w position effect variegation (PEV). (Tschiersch et al., 1994) Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4h. (Reuter et al., 1986)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Su(var)3-9[+]/Su(var)3-9² is a suppressor \| partially of lethal \| recessive phenotype of JIL-1^z2 (Deng et al., 2007) Su(var)3-9¹/Su(var)3-9² is a suppressor \| partially of lethal \| recessive phenotype of JIL-1^z2 (Deng et al., 2007)
Phenotype Manifest In
Suppressor of
Statement Reference Su(var)3-9[+]/Su(var)3-9² is a suppressor \| partially of polytene chromosome phenotype of JIL-1^z2 (Deng et al., 2007) Su(var)3-9¹/Su(var)3-9² is a suppressor \| partially of polytene chromosome phenotype of JIL-1^z2 (Deng et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference The lethality of JIL-1^z2 homozygotes is significantly suppressed by one copy of Su(var)3-9² (50.7% viability). The lethality of JIL-1^z2 homozygotes is significantly suppressed by Su(var)3-9¹/Su(var)3-9² (55.8% viability). The abnormal polytene chromosome morphology seen in JIL-1^z2 homozygous third instar larvae is partially suppressed by Su(var)3-9²/+ or Su(var)3-9¹/Su(var)3-9²; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants. (Deng et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	6210 In(1)w^m4; Su(var)3-9²/TM3, Sb¹ Ser¹
Kyoto	108676 Su(var)3-9²/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer

Comments
	Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)w^m4h, and a dominant enhancer of position effect variegation, E(var)c101¹. (Reuter et al., 1986)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	2 (Krauss et al., 2006) Su(var)3-9⁰² (Ebert et al., 2004, Brower-Toland et al., 2009) Su(var)3-9² (Boeke et al., 2011, Deng et al., 2007, Scaria et al., 2008, Skora and Spradling, 2010, Zhang et al., 2008) Su(var)3-902 (Netter et al., 1998) Su(var)² (Scaria et al., 2008) Su-var(3)9⁰² (Reuter et al., 1986) Su-var(3)902 (Fauvarque and Dura, 1993)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Boeke et al., 2011, PLoS ONE 6(6): e20761 The RNA Helicase Rm62 Cooperates with SU(VAR)3-9 to Re-Silence Active Transcription in Drosophila melanogaster. [FBrf0213941] Skora and Spradling, 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7389--7394 Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. [FBrf0210662] Brower-Toland et al., 2009, Genetics 181(4): 1303--1319 Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster. [FBrf0207712] Scaria et al., 2008, Mech. Dev. 125(7): 646--661 Two components of the Myb complex, DMyb and Mip130, are specifically associated with euchromatin and degraded during prometaphase throughout development. [FBrf0205473] Zhang et al., 2008, Dev. Cell 14(4): 481--493 Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos. [FBrf0204622] Deng et al., 2007, Genetics 177(1): 79--87 Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase. [FBrf0200626] Krauss et al., 2006, BMC Evol. Biol. 6: 18 The evolution of the histone methyltransferase gene Su(var)3-9 in metazoans includes a fusion with and a re-fission from a functionally unrelated gene. [FBrf0189765] Zhang et al., 2006, Development 133(2): 229--235 The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. [FBrf0190333] Ebert et al., 2004, Genes Dev. 18(23): 2973--2983 Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. [FBrf0180260] Netter et al., 1998, Genetics 149(1): 257--275 white+ transgene insertions presenting a dorsal/ventral pattern define a single cluster of homeobox genes that is silenced by the polycomb-group proteins in Drosophila melanogaster. [FBrf0102846] Tschiersch et al., 1994, EMBO J. 13(16): 3822--3831 The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. [FBrf0076431] Fauvarque and Dura, 1993, Genes Dev. 7(8): 1508--1520 polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. [FBrf0058522] Reuter et al., 1986, Mol. Gen. Genet. 202(3): 481--487 Third chromosome suppressor of position-effect variegation loci in Drosophila melanogaster. [FBrf0045055]

Allele Dmel\Su(var)3-92

Allele Dmel\Su(var)3-9²