Allele Dmel\Su(var)3-9⁶

General Information
Symbol	Dmel\Su(var)3-9⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0016562
Feature type	allele	Associated gene	Dmel\Su(var)3-9
Also Known As	Su(var)3-9⁰⁶

Allele class
Mutagen	ethyl methanesulfonate, X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Reuter et al., 1986) X ray (Tschiersch et al., 1994, Westphal and Reuter, 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of an approximately 6kb DNA fragment. (Westphal and Reuter, 2002) Insertion of unknown DNA. (Tschiersch et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	enhancer of variegation, with P{hsp26-pt-T}39C-12 (Haynes et al., 2007) enhancer of variegation, with P{hsp26-pt-T}gw^39C-33 (Haynes et al., 2007) enhancer of variegation \| dominant, with P{hsp26-pt-T}39C-12 (Brower-Toland et al., 2009) enhancer of variegation \| dominant, with P{hsp26-pt-T}118E-25-5 (Brower-Toland et al., 2009) non-suppressor of variegation (Cryderman et al., 2011) non-suppressor of variegation \| dominant, with P{RS3}pan^CB-5204-3 (Phalke et al., 2009) non-suppressor of variegation \| dominant, with P{RS5}5-HA-1902 (Phalke et al., 2009) non-suppressor of variegation \| dominant, with P{RS5}5-HA-1992 (Phalke et al., 2009) non-suppressor of variegation \| dominant, with T(2;3)V21-P{lacW}92E.x3 (Phalke et al., 2009) suppressor of variegation (Schotta et al., 2002) suppressor of variegation, with P{hsp26-pt-T}39C-3 (Haynes et al., 2007) suppressor of variegation, with P{hsp26-pt-T}39C-27 (Haynes et al., 2007) suppressor of variegation, with P{hsp26-pt-T}118E-10 (Haynes et al., 2007) suppressor of variegation, with P{T1(-FRT)}T190-177 (Haynes et al., 2006) suppressor of variegation, with P{T1}T190-177 (Haynes et al., 2006) suppressor of variegation \| dominant (Fagegaltier et al., 2009) suppressor of variegation \| dominant, with In(1)w^m4 (Phalke et al., 2009) suppressor of variegation \| dominant, with In(1)w^m4h (Reuter et al., 1986, Dorn et al., 1993, Tschiersch et al., 1994) suppressor of variegation \| dominant, with P{hsp26-pt-T}39C-2 (Brower-Toland et al., 2009) suppressor of variegation \| dominant, with P{hsp26-pt-T}118E-10 (Brower-Toland et al., 2009) suppressor of variegation \| dominant, with P{hsp26-pt-T}118E-28a, P{hsp26-pt-T}118E-28b (Brower-Toland et al., 2009) viable (Reuter et al., 1986, Brower-Toland et al., 2009)
Phenotype Manifest In
	polytene chromosome (Demakova et al., 2007, Brower-Toland et al., 2009) polytene chromosome chromocenter (Demakova et al., 2007)
Detailed Description
	Statement Reference Su(var)3-9[6] does not suppress the position effect variegation of the w gene that is seen in the P{hsp26-pt-T}Dyrk3[118E-15] insertion. (Cryderman et al., 2011) Su(var)3-9[6] can be maintained as a homozygous stock, although homozygotes are less healthy and fecund than wild type. The fourth chromosome appears hypercondensed in polytene chromosomes of mutant salivary glands. (Brower-Toland et al., 2009) Su(var)3-9[6]/+ completely suppresses the position effect variegation of the Sb[1] allele that is seen in the T(2;3)Sb[V] chromosome. Su(var)3-9[6]/Su(var)3-9[6] suppresses the position effect variegation of the w gene that is seen in the In(1)w[m4] chromosome. (Fagegaltier et al., 2009) Su(var)3-9[6] dominantly suppresses variegation of the w gene caused by In(1)w[m4]. Su(var)3-9[6] does not dominantly suppress variegation of the w gene caused by P{RS5}5-HA-1902, P{RS5}5-HA-1992 or P{RS3}pan[CB-5204-3]. (Phalke et al., 2009) The chromocenter is unusually large and appears more decondensed than normal in the salivary gland polytene chromosomes of homozygous mutants. Region 20A-F of the In(1)w^m4h salivary gland polytene chromosome acquires a distinct banding pattern in the Su(var)3-9⁶ mutant background; in contrast to the one or two bands usually seen a Su(var)3-9⁺ background, up to 14-18 bands are seen. In addition, a large pseudopuff is seen in the area of the 20F-3C eu-heterochromatin junction. (Demakova et al., 2007) Su(var)3-9⁶ flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177. (Haynes et al., 2006) Heterozygotes show a suppression of the position effect variegation seen in In(1)w^m4. This phenotype dominates the enhancement of PEV caused by the loss of a Y chromosome. (Schotta et al., 2002) Heterozygotes show no effect on crossing over between kni and p^p. (Westphal and Reuter, 2002) Strong suppressors of bw and w position effect variegation (PEV). (Tschiersch et al., 1994) mod(mdg4)^neo129 suppresses the strong dominant suppressor effect. (Dorn et al., 1993) Dominant suppressor of position effect variegation at the w locus caused by In(1)w^m4h. (Reuter et al., 1986)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference Su(var)3-9⁶ has suppressor of variegation phenotype, non-enhanceable by Su(var)3-7^+t10.4 (Schotta et al., 2002) Su(var)3-9⁶ has suppressor of variegation phenotype, non-enhanceable by Su(var)205^+tSa (Schotta et al., 2002)
Suppressor of
Statement Reference Su(var)3-9[+]/Su(var)3-9⁶ is a suppressor \| partially of lethal \| recessive phenotype of JIL-1^z2 (Deng et al., 2007) Su(var)3-9⁶/Su(var)3-9⁶ is a suppressor of lethal \| recessive phenotype of egg¹⁴⁷³ (Brower-Toland et al., 2009, Brower-Toland et al., 2009)
Other
Statement Reference G9a^{dsRNA.hp.Scer\UAS}, Scer\GAL4^Act5C.PU, Su(var)3-9⁶ has viable phenotype (Brower-Toland et al., 2009)
Phenotype Manifest In
Suppressor of
Statement Reference Su(var)3-9[+]/Su(var)3-9⁶ is a suppressor \| partially of polytene chromosome phenotype of JIL-1^z2 (Deng et al., 2007)
Other
Statement Reference Su(var)3-9⁶, egg[+]/egg²³⁵ has polytene chromosome phenotype (Brower-Toland et al., 2009) Su(var)3-9⁶, egg¹⁴⁷³ has polytene chromosome phenotype (Brower-Toland et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference Polytene chromosomes in egg[1473] ; Su(var)3-9[6] double mutant larval salivary glands are less condensed than normal and the chromocenter is ill defined. egg[235]/+ reduces condensation of polytene chromosome 4 in Su(var)3-9[6] mutants. The chromosome is often broader and shorter than in wild type. (Brower-Toland et al., 2009) The most proximal part of region 20 of the salivary gland polytene X chromosomes appears decompacted in SuUR^ES Su(var)3-9⁶ double mutants. (Demakova et al., 2007) The lethality of JIL-1^z2 homozygotes is significantly suppressed by one copy of Su(var)3-9⁶ (60.7% viability). The abnormal polytene chromosome morphology seen in JIL-1^z2 homozygous third instar larvae is partially suppressed by Su(var)3-9⁶/+ or Su(var)3-9⁶/Su(var)3-9⁶; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants. (Deng et al., 2007) The combination of Su(var)3-9⁶ and either Su(var)3-7^+t10.4 or Su(var)205^+tSa leads to a Su(var)3-9⁶ like position effect variegation (PEV) phenotype - i.e. suppression of PEV in In(1)w^m4. (Schotta et al., 2002) Su(var)3-9⁶ Df(3R)Ace-HD1 double mutants show an increase in crossing over between kni and p^p. Su(var)205⁵ Su(var)3-9⁶ double heterozygotes show an increase in crossing over between kni and p^p. (Westphal and Reuter, 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Su(var)3-9⁶ is rescued by Su(var)3-9^+t11.5 (Schotta et al., 2002)
Partially rescued by	Su(var)3-9⁶ is partially rescued by Su(var)3-9^{Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^Sgs3.PD (Demakova et al., 2007)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)w^m4h, and a dominant enhancer of position effect variegation, E(var)c101¹. (Reuter et al., 1986)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Su(var)3-9⁰⁶ (Swaminathan et al., 2005, Perrini et al., 2004, Ebert et al., 2004, Danzer and Wallrath, 2004, Kunert et al., 2003, Schotta et al., 2002, Li et al., 2003, Czermin et al., 2002, Westphal and Reuter, 2002, Demakova et al., 2007, Haynes et al., 2007, Haynes et al., 2006, Koryakov et al., 2011, Deng et al., 2007, Seum et al., 2007, Cai et al., 2008, Brower-Toland et al., 2009, Johansson et al., 2007, Gracheva et al., 2009, Phalke et al., 2009, Hofmann et al., 2009, Cryderman et al., 2011) Su(var)3-9⁶ su(var)3.9⁶ (Fagegaltier et al., 2009) Su-var(3)9⁰⁶ (Reuter et al., 1986)
Name Synonym
Secondary FlyBase IDs

References ( 26 )

Generate a list of	All references relating to this allele ( 26 )

List References by type	Research paper ( 26 )
Recent research papers ( 2 )
	Cryderman et al., 2011, Transcription 2(2): 95--99 Heterochromatin protein 1a is required for an open chromatin structure. [FBrf0213370] Koryakov et al., 2011, Chromosome Res. 19(2): 235--249 The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster. [FBrf0213472] Show all research papers ...

Allele Dmel\Su(var)3-96

Allele Dmel\Su(var)3-9⁶