Allele Dmel\sw¹

General Information
Symbol	Dmel\sw¹	Species	D. melanogaster
Name		FlyBase ID	FBal0016648
Feature type	allele	Associated gene	Dmel\sw

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	fertile \| reduced (Boylan and Hays, 2002) lethal (with sw²) (Lindsley and Zimm, 1992) lethal (with sw⁵) (Lindsley and Zimm, 1992) lethal (with sw⁶) (Lindsley and Zimm, 1992) lethal (with sw⁷) (Lindsley and Zimm, 1992) lethal \| heat sensitive (with Df(1)mal3) (Boylan and Hays, 2002) lethal \| pupal stage (with sw¹⁵) (Lindsley and Zimm, 1992) neuroanatomy defective \| larval stage (with sw¹²²⁹) (Zheng et al., 2008) viable (Boylan and Hays, 2002) visible (Boylan and Hays, 2002) visible (with sw^Dic-1) (Boylan and Hays, 2002) visible (with sw^Dic-2) (Boylan and Hays, 2002) visible (with sw^Dic-3) (Boylan and Hays, 2002)
Phenotype Manifest In
	cystic bulge (Ghosh-Roy et al., 2005) dendritic arborizing neuron (with sw¹²²⁹) (Zheng et al., 2008) eye (Schalet and Finnerty, 1968, Boylan and Hays, 2002, Lindsley and Zimm, 1992) nucleus & spermatid (Ghosh-Roy et al., 2005) ommatidium (Boylan and Hays, 2002) wing (Schalet and Finnerty, 1968, Lindsley and Zimm, 1992, Mortin and Lefevre, 1981) wing (with sw^Dic-1) (Boylan and Hays, 2002) wing (with sw^Dic-2) (Boylan and Hays, 2002) wing (with sw^Dic-3) (Boylan and Hays, 2002) wing margin (Boylan and Hays, 2002) wing vein (Boylan and Hays, 2002)
Detailed Description
	Statement Reference Dendritic arborization neurons show an altered distribution of Golgi outposts in sw[1229]/sw[1] larvae compared to controls. Golgi outposts can be seen moving from the soma into the axon and travelling anterogradely and retrogradely within the axon. (Zheng et al., 2008) About 60% of the actin nuclear bundles and individualization complexes are disrupted in the testis of sw¹ hemizygous males. The F-actin density in the investment cones is not significantly different from wild-type spermatids. (Ghosh-Roy et al., 2005) sw^Dic-2/sw¹ flies have a mild wing phenotype at 28^oC. Mutant flies have a variable wing phenotype, including defects in wing venation and incised margins, reduced fertility and rough eyes. (Boylan and Hays, 2002) Above 23^oC, most sw¹ flies have spread and incised wings with irregular veins; eyes reduced and roughened. Male expression more extreme than female. RK2 at 28^oC. (Lindsley and Zimm, 1992) +/Df(1)mal10 and +/sw¹ exhibit short-wing phenotype in presence of RpII215^Ubl. (Mortin and Lefevre, 1981) 15% of males eclose at 25^oC; show wing and eye abnormalities; above 31^oC, sw¹ is lethal. At 17^oC, most flies are wild type; at 14^oC, all are wild type. (Schalet and Finnerty, 1968)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference sw¹/sw[+] is an enhancer of visible \| dominant phenotype of Gl¹ (Boylan and Hays, 2002)
Other
Statement Reference ctp^DIIA82, sw¹ has lethal phenotype (Ghosh-Roy et al., 2005) ctp^ins1, sw¹ has lethal phenotype (Ghosh-Roy et al., 2005) Gl¹, sw¹ has lethal phenotype (Boylan and Hays, 2002, Boylan and Hays, 2002)
Phenotype Manifest In
Enhanced by
Statement Reference sw¹ has cystic bulge phenotype, enhanceable by ctp^exc39 (Ghosh-Roy et al., 2005) sw¹ has nucleus & spermatid phenotype, enhanceable by ctp^exc39 (Ghosh-Roy et al., 2005)
Enhancer of
Statement Reference sw¹/sw[+] is an enhancer of ommatidium phenotype of Gl¹ (Boylan and Hays, 2002)
Additional Comments
Genetic Interactions
Statement Reference ctp^exc39; sw¹/Y mutants are viable at 25^oC. The double mutants show a slight enhancement of the disruption of individualization complexes seen in both single mutants. Almost all ctp^ins1; sw¹/Y and ctp^DIIA82; sw¹/Y males fail to emerge, at either 25^oC or 18^oC. (Ghosh-Roy et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	sw³ (Lindsley and Zimm, 1992)
Fails to complement	sw^Dic-1 (Boylan and Hays, 2002) sw^Dic-2 (Boylan and Hays, 2002) sw^Dic-3 (Boylan and Hays, 2002)
Rescued by	sw¹/sw^Dic-1 is rescued by sw^+t11 (Boylan and Hays, 2002) sw¹/sw^Dic-3 is rescued by sw^+t11 (Boylan and Hays, 2002) sw¹ is rescued by sw^+t11 (Boylan and Hays, 2002) sw^Dic-2/sw¹ is rescued by sw^+t11 (Boylan and Hays, 2002)
Comments
Stocks ( 3 )
Bloomington	4175 sw¹ 175 y¹ pn¹ w¹ cm¹ ct⁶ sn³ oc¹ ras² v¹ dy¹ g² f¹ os^o car¹ sw¹/In(1)sc^S1, In(1)dl-49, y^c4 sc^S1 v^Of B¹
Kyoto	105772 y¹ pn¹ w¹ cm¹ ct⁶ sn³ oc¹ ras² v¹ dy¹ g² f¹ os^o car¹ sw¹/In(1)sc^S1, In(1)dl-49, y^c4 sc^S1 v^Of B¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	dic^ts (Zheng et al., 2008) sw¹ (Cook et al., 2008.9.3, Cook et al., 2008.9.3, Ghosh-Roy et al., 2005, Christensen et al., 2008.10.20, Cook and Cook, 2010.2.17, Xiong et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Xiong et al., 2010, J. Cell Biol. 191(1): 211--223 Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. [FBrf0211939] Zheng et al., 2008, Nat. Cell Biol. 10(10): 1172--1180 Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. [FBrf0206898] Ghosh-Roy et al., 2005, Mol. Biol. Cell 16(7): 3107--3116 Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila. [FBrf0188025] Boylan and Hays, 2002, Genetics 162(3): 1211--1220 The gene for the intermediate chain subunit of cytoplasmic Dynein is essential in Drosophila. [FBrf0155472] Mortin and Lefevre, 1981, Chromosoma 82(2): 237--247 An RNA polymerase II-mutation in Drosophila melanogaster that mimics ultrabithorax. [FBrf0035975] Schalet and Finnerty, 1968, D. I. S. 43: 128--129 The arrangement of genes in the proximal region of the X chromosome of Drosophila melanogaster. [FBrf0019285] Eker, 1939, J. Genet. 38: 201--227 Further studies on the effect of temperature on the manifestation of the short-wing gene in Drosophila melanogaster. [FBrf0004724] Eker, 1935, J. Genet. 30: 357--368 The short-wing gene in Drosophila melanogaster, and the effect of temperature on its manifestation. [FBrf0003138]
Personal communication to FlyBase	Cook and Cook, 2010.2.17, Isolation and characterization of Df(1)BSC872. Isolation and characterization of Df(1)BSC872. [FBrf0210083] Christensen et al., 2008.10.20, Isolation and characterization of Df(1)BSC648. Isolation and characterization of Df(1)BSC648. [FBrf0206125] Cook et al., 2008.9.3, Isolation and characterization of Df(1)BSC586. Isolation and characterization of Df(1)BSC586. [FBrf0205899] Cook et al., 2008.9.3, Isolation and characterization of Df(1)BSC587. Isolation and characterization of Df(1)BSC587. [FBrf0205900]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\sw1

Allele Dmel\sw¹