Deletion for the entire Sxl transcription unit.
Deletion of Sxl.
Small deletion removing most of the Sxl transcription unit and some upstream sequences.
Deletion that deletes the entire Sxl locus and no flanking loci.
Deficiency of the Sxl locus.
The entire Sxl gene is deleted.
Deletion of DNA extending at least 13kb distal to coordinate 0 (coordinates according to FBrf0042036). No P-element sequences remain.
appears to be deleted for the entire Sxl transcription unit. deletion of >50 kb; deletion from SxlfPb
SxlfP7B0 heterozygous females do not display any decrease in viability compared to controls.
SxlfP7B0 heterozygotes are viable.
Female viability is not compromised in a cross between wild-type females and SxlfP7B0 males.
The viability of females carring SxlN.Hsp83.T:Ecol\lacZ is further reduced if they are also heterozygous for SxlfP7B0. Females carrying two copies of SxlN.Hsp83.T:Ecol\lacZ and heterozygous for SxlfP7B0 have reduced viability compared to females carrying one copy of SxlN.Hsp83.T:Ecol\lacZ and heterozygous for SxlfP7B0.
SxlfP7B0 is unable to suppress the sex comb defect seen in homozygous male U2af3806751 flies.
SxlfP7B0/Df(1)N19 double heterozygous females have reduced viability; only 29% survive compared to control flies. Viability is recovered if the SxlfP7B0/Df(1)N19 females also carry Dp(1;3)JC153 or SxlM1. SxlfP7B0 shows no female-specific lethal interaction with Df(1)E128 or Df(1)os1A2. SxlfP7B0/+ ; In(2LR)Scorv1LTE35B-4R/+ females have reduced viability at 29oC.
Interacts with RpII140wimp maternal effect.
SxlfP7B0/snf1 female progeny are more viable at lower temperatures. SxlfP7B0/snf1 flies showed some somatic sexual transformation: male sex combs among normal female bristles. SxlfP7B0/snf1 flies were always female sterile as expression of Sxl+ in the germline is required for female fertility. At 29oC the ovarian tumours of SxlfP7B0/snf heterozygotes are snf-like (egg chambers have no nurse-like cells) and at 20oC they are Sxl-like (egg chambers have an excessive number of nurse cells).
nulls female-lethal male viable male-fertile males display normal male sexual behavior.
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, enhanceable by fl(2)dunspecified/fl(2)dunspecified
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, enhanceable by Mettl14SK1/Mettl14[+]
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, enhanceable by Ythdc1[+]/Ythdc1NP1
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, enhanceable by Ythdc1NP3/Ythdc1[+]
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, enhanceable by YthdfNP3/Ythdf[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by da[+]/da2
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by Df(2R)Su(z)3-1.iy/+
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by TrpRS[+]/TrpRSP-74
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by TrpRSP-28B/TrpRS[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by Df(3R)by10/+
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by AspRSTW6/AspRS[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by AspRSTW3/AspRS[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by AspRS12-21R/AspRS[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by AspRS1/AspRS[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by AspRS25-1R/AspRS[+]
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by TrpRS[+]/TrpRS03559
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | maternal effect | female phenotype, enhanceable | maternal effect by TrpRS[+]/TrpRS4420
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, non-enhanceable by YthdfNP1/Ythdf[+]
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype, non-enhanceable by YthdfNP2/Ythdf[+]
Mettl3Delta22-3, Sxl[+]/SxlfP7B0 has partially lethal - majority die | female | maternal effect phenotype, suppressible by Df(2L)Exel7016/msl-2227
SxlfP7B0 has viable phenotype, suppressible by Df(1)dm75e19
SxlN.Hsp83.lacZ, SxlfP7B0 has viable phenotype, suppressible | partially by Mycdm-1
Su(var)2055, SxlfP7B0 has partially lethal - majority die | dominant | maternal effect phenotype, suppressible by cav2248
Su(var)2055, SxlfP7B0 has partially lethal - majority die | dominant | maternal effect phenotype, suppressible by cav1
Sxl[+]/SxlfP7B0, fl(1)3546 has partially lethal | female phenotype, suppressible | partially by Dp(1;3)sn13a1
SxlfP7B0 is a suppressor of partially lethal - majority die | dominant | male limited phenotype of cav2248
SxlfP7B0 is a suppressor of decreased fecundity | dominant | female phenotype of ovoD2
SxlfP7B0 is a non-suppressor of lethal | embryonic stage phenotype of Scer\GAL4nanos.PG, runUAS.cLa
Sxl[+]/SxlfP7B0, da2 has partially lethal | female | parental effect phenotype
FlaccA, Sxl[+]/SxlfP7B0 has partially lethal | female | parental effect phenotype
Sxl[+]/SxlfP7B0, da3 has abnormal sex-determination phenotype
Df(2L)BSC111/Mettl14SK1, SxlfP7B0 has abnormal sex-determination phenotype
Mettl14SK1, SxlfP7B0 has abnormal sex-determination | dominant phenotype
Mettl14SK1, Sxl[+]/SxlfP7B0 has increased cell number | oogenesis phenotype
Ythdc1NP3/Df(3L)ED208, SxlfP7B0 has abnormal sex-determination phenotype
SxlfP7B0, Ythdc1NP3 has abnormal sex-determination phenotype
Sxl[+]/SxlfP7B0, Ythdc1NP3 has increased cell number | oogenesis phenotype
Ythdc1NP2/Df(3L)ED208, SxlfP7B0 has abnormal sex-determination phenotype
SxlfP7B0, Ythdc1NP2 has abnormal sex-determination phenotype
SxlfP7B0, Ythdc1NP1 has abnormal sex-determination phenotype
Mettl3Delta22-3, Sxl[+]/SxlfP7B0 has partially lethal - majority die | female | maternal effect phenotype
Mettl3Delta22-3, Sxl[+]/SxlfP7B0 has neoplasia | female | maternal effect phenotype
Df(2L)Exel7016/msl-2227, Mettl3Delta22-3, Sxl[+]/SxlfP7B0 has abnormal sex-determination | female | adult stage phenotype
Sxl[+]/SxlfP7B0, Ythdc1MI02006 has partially lethal - majority live | female | maternal effect phenotype
Sxl[+]/SxlfP7B0, Ythdc1MI02006 has abnormal sex-determination | female | maternal effect phenotype
Mettl3null, Sxl[+]/SxlfP7B0 has partially lethal - majority die | female limited phenotype
Rbp9P2690, SxlfP7B0 has partially lethal - majority die | maternal effect | female limited phenotype
Su(var)2052, SxlfP7B0 has partially lethal - majority die | dominant | maternal effect phenotype
Su(var)2054, SxlfP7B0 has partially lethal - majority die | dominant | maternal effect phenotype
Su(var)2055, SxlfP7B0 has partially lethal - majority die | dominant | maternal effect phenotype
Sxl[+]/SxlfP7B0, msl-21 has partially lethal - majority die | female | maternal effect phenotype
Sxl[+]/SxlfP7B0, msl-31 has lethal | female | maternal effect phenotype
Sxl[+]/SxlfP7B0, msl-1L60 has partially lethal - majority die | female | maternal effect phenotype
SxlcF1.otu, SxlfP7B0, snf148 has lethal phenotype
SxlfP7B0/SxlcF1.otu, snf148 has lethal phenotype
SxlfP7B0, snRNP-U1-70K02107, snfJ210 has lethal phenotype
SxlfP7B0, U2af38ΔE18, snfJ210 has lethal phenotype
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | female phenotype
Sxl[+]/SxlfP7B0, snfJ210 has partially lethal | female | maternal effect phenotype
SxlfP7B0, l(1)4343 has partially lethal | female phenotype
Mettl14SK1, Sxl[+]/SxlfP7B0 has spectrosome | oogenesis phenotype
Sxl[+]/SxlfP7B0, Ythdc1NP3 has spectrosome | oogenesis phenotype
Mettl3Delta22-3, Sxl[+]/SxlfP7B0 has ovary | maternal effect phenotype
Df(2L)Exel7016/msl-2227, Mettl3Delta22-3, Sxl[+]/SxlfP7B0 has sex comb | ectopic | female phenotype
SxlfP7B0, nanosBN has germline cell phenotype
SxlfP7B0;msl-2227/Df(2L)Exel7016 females do not display any decrease in viability compared to controls.
Ime4Δ22-3;SxlfP7B0 double heterozygous daughters from Ime4Δ22-3 mutant females show strongly reduced female viability and tumorous ovaries (no decrease in viability or ovarian defects are observed in the presence of maternal wild-type copy of Ime4). The reduced viability phenotype can be fully rescued by combination with msl-2227/Df(2L)Exel7016 although these females frequently show signs of sexual transformation and display male-specific features such as sex-combs, which are mosaic to various degrees.
SxlfP7B0;YT521-BMI02006 double heterozygous daughters from YT521-BMI02006 mutant females show reduced viability and sexual transformations such as male abdominal pigmentation.
Females trans-heterozygous for SxlfP7B0 and dm1 are approximately two-thirds as viable as their dm1/+ siblings.
Females trans-heterozygous for SxlfP7B0 and dmP0 are approximately two-thirds as viable as their dmP0/+ siblings.
Females trans-heterozygous for SxlfP7B0 and dmP1 are approximately two-thirds as viable as their dmP1/+ siblings.
SxlN.Hsp83.T:Ecol\lacZ females that are trans-heterozygous for SxlfP7B0 and dm1 are two-thirds as viable as their SxlN.Hsp83.T:Ecol\lacZ SxlfP7B0/+ sisters.
Transgenic females trans-heterozygous for Df(1)dm75e19 and SxlfP7B0 are only half as viable as SxlfP7B0 female siblings.
SxlfP7B0 suppresses the semi-lethality of homozygous cav2248 males.
In progeny from Su(var)2055 heterozygous females crossed to SxlfP7B0/Y males, female viability is dramatically reduced. The effect of Su(var)2055 is strictly maternal; no significant reduction in female viability is observed in the reciprocal cross.
In progeny from Su(var)2054 heterozygous females crossed to SxlfP7B0/Y males, female viability is dramatically reduced.
In progeny from Su(var)2052 heterozygous females crossed to SxlfP7B0/Y males, female viability is reduced.
The viability of SxlfP7B0/+ females is significantly reduced if they also carry one maternally-derived copy of msl-1L60, msl-21 or msl-31.
The viability of SxlfP7B0/+ females is not affected if they also carry one maternally-derived copy of mle1.
The almost complete lethality of SxlfP7B0/+ females carrying a maternally-derived copy of msl-31 is significantly rescued (to 98.7% viability) by a maternally-derived copy of SxlM1.
The female progeny of fl(2)d1/+ females mated to SxlfP7B0/Y males show only 65.3% viability.
The female progeny of fl(2)d2/+ females mated to SxlfP7B0/Y males show only 87.4% viability.
The female progeny of snfJ210/+ females mated to SxlfP7B0/Y males show only 83.6% viability.
The female progeny of snfJ210/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 27.6% viability.
The female progeny of snfJ210/+ ; fl(2)d2/+ females mated to SxlfP7B0/Y males show only 74.4% viability.
The female progeny of snf148/+ females mated to SxlfP7B0/Y males show only 48.0% viability.
The female progeny of snf148/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 11.1% viability.
The female progeny of snf148/+ ; fl(2)d2/+ females mated to SxlfP7B0/Y males show only 45.6% viability.
The female progeny of snfJ210/+ ; snf5MER females mated to SxlfP7B0/Y males show 98% viability.
The female progeny of snfJ210/+ ; fl(2)d1/+ ; snf5MER females mated to SxlfP7B0/Y males show 16.1% viability.
The female progeny of snfJ210/+ ; fl(2)d2/+ ; snf5MER females mated to SxlfP7B0/Y males show 79.3% viability.
The female progeny of U2af38ΔE18/+ females mated to SxlfP7B0/Y males are completely viable.
The female progeny of U2af38ΔE18/fl(2)d1 females mated to SxlfP7B0/Y males show only 25.8% viability.
The female progeny of U2af38ΔE18/fl(2)d2 females mated to SxlfP7B0/Y males show only 90.1% viability.
If snf148/snf148, SxlcF1.otu females are crossed with SxlfP7B0 males only 6% of her SxlfP7B0/+ daughters survive. When mothers heterozygous for both snfJ210 and snRNP70K02107 are crossed with SxlfP7B0 males, a significant reduction in viability is seen in SxlfP7B0/+ daughters. When mothers heterozygous for both snfJ210 and U2af38ΔE18 are crossed with SxlfP7B0 males, a significant reduction in viability is seen in SxlfP7B0/+ daughters. When mothers heterozygous for both snfJ210 and U2af50XR15 are crossed with SxlfP7B0 males, no significant reduction in viability is seen in SxlfP7B0/+ daughters.
The preferential sensitivity of males to the lethal effects of expression of runScer\UAS.cLa under the control of Scer\GAL4nos.PG is not suppressed by SxlfP7B0.
Female SxlfP7B0/+ embryos are fully viable if their mothers are heterozygous for da2, 80% viable if their mothers are heterozygous for snfJ210, but only 7% viable if their mothers are heterozygous for both da2 and snfJ210. The weak interaction between SxlfP7B0 and snfJ210 is enhanced by Df(2R)Su(z)3-1.iy, Aats-aspTW6, Aats-aspTW3, Aats-asp12-21R, Aats-asp1 or Aats-asp25-1R; the viability of female SxlfP7B0/+ embryos derived from mothers heterozygous for snfJ210 and one of Df(2R)Su(z)3-1.iy, Aats-aspTW6, Aats-aspTW3, Aats-asp12-21R, Aats-asp1 or Aats-asp25-1R is reduced. The weak interaction between SxlfP7B0 and snfJ210 is enhanced by Aats-trp03559, Aats-trp4420, Aats-trpP-74, Aats-trpP-28B or Df(3R)by10; the viability of female SxlfP7B0/+ embryos derived from mothers heterozygous for snfJ210 and one of Aats-trp03559, Aats-trp4420, Aats-trpP-74, Aats-trpP-28B or Df(3R)by10 is reduced.
Lethal in female double heterozygous combination with fl(1)3535. Females doubly heterozygous for fl(1)3546 and SxlfP7B0 show 2.1% viability. Lethality of fl(1)3546/SxlfP7B0 females can occur at embryonic or larval stages. The viability of SxlfP7B0 in female double heterozygous combination with l(1)4343 is reduced.
Female lethal-synergistic interactions with snf- mutations.
SxlfP7B0 partially rescues SxlFL.Hsp83
Partially rescues the otherwise complete lethality of SxlFL.Hsp83 and SxlN.Hsp83males.
SxlF1.hs cannot rescue the lethal phenotype. One copy of the moderate class of SxlF1.hs insertion at 25oC causes high numbers of intersex individuals, this number drops slightly at 29oC. All values are higher than individuals carrying the insertion in an Sxl+ background. This same pattern is demonstrated with one copy of a strong SxlF1.hs insertion class but the number of intersexes are less.
Isolated on the basis of its failure to complement Sxlf9.
Does not interfere with transcription of the locus.