FlyBase Allele Report: Dmel\Sxl[fP7B0]

General Information

Symbol

Dmel\Sxl^fP7B0

Species

D. melanogaster

Name

FlyBase ID

FBal0016694

Feature type

allele

Associated gene

Dmel\Sxl

Associated Insertion(s)

Carried in Construct

Also Known As

Sxl^7BO, Sxl^7B0, Sxl^fP7BO, Df(1)Sxl^7BO, Sxl^null

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Oliver et al., 1993)

loss of function allele

Mutagen

PM hybrid dysgenesis

(Salz et al., 1987)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Sxl^fPb

(Salz et al., 1987)

Cytology

Nature of the lesion

Statement

Reference

Deletion for the entire Sxl transcription unit.

(Granadino et al., 1997)

Deletion of Sxl.

(Zhu et al., 1997)

Small deletion removing most of the Sxl transcription unit and some upstream sequences.

(Samuels et al., 1994)

Deletion that deletes the entire Sxl locus and no flanking loci.

(Bell et al., 1991)

Deficiency of the Sxl locus.

(Granadino et al., 1991)

The entire Sxl gene is deleted.

(Torres and Sanchez, 1991)

Deletion of DNA extending at least 13kb distal to coordinate 0 (coordinates according to FBrf0042036). No P-element sequences remain.

(Salz et al., 1987)

appears to be deleted for the entire Sxl transcription unit. deletion of >50 kb; deletion from Sxl^fPb

Caused by aberration

Df(1)Sxl^fP7B0

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sex-determination | female | somatic clone

(Granadino et al., 1991)

lethal | female | recessive

(Granadino et al., 1991)

lethal | recessive

(Bell et al., 1991)

viable

(Kappes et al., 2011)

viable, with Sxl^N.Hsp83.lacZ

(Kappes et al., 2011)

viable | male

(Anand et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sxl^fP7B0 heterozygous females do not display any decrease in viability compared to controls.

(Haussmann et al., 2016)

Sxl^fP7B0 heterozygotes are viable.

(Kappes et al., 2011)

Female viability is not compromised in a cross between wild-type females and Sxl^fP7B0 males.

(Li et al., 2011)

The viability of females carring Sxl^{N.Hsp83.T:Ecol\lacZ} is further reduced if they are also heterozygous for Sxl^fP7B0. Females carrying two copies of Sxl^{N.Hsp83.T:Ecol\lacZ} and heterozygous for Sxl^fP7B0 have reduced viability compared to females carrying one copy of Sxl^{N.Hsp83.T:Ecol\lacZ} and heterozygous for Sxl^fP7B0.

(Deshpande et al., 1999)

Sxl^fP7B0 is unable to suppress the sex comb defect seen in homozygous male U2af38⁰⁶⁷⁵¹ flies.

(Rudner et al., 1996)

Sxl^fP7B0/Df(1)N19 double heterozygous females have reduced viability; only 29% survive compared to control flies. Viability is recovered if the Sxl^fP7B0/Df(1)N19 females also carry Dp(1;3)JC153 or Sxl^M1. Sxl^fP7B0 shows no female-specific lethal interaction with Df(1)E128 or Df(1)os1A2. Sxl^fP7B0/+ ; In(2LR)Sco^rv1LTE35B-4^R/+ females have reduced viability at 29^oC.

(Sanchez et al., 1994)

Homozygous clones induced at blastoderm survive, differentiating male structures. Lethal in heterozygous combination with Df(1)N71 or Df(1)svr.

(Granadino et al., 1991)

Interacts with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Sxl^fP7B0/snf¹ female progeny are more viable at lower temperatures. Sxl^fP7B0/snf¹ flies showed some somatic sexual transformation: male sex combs among normal female bristles. Sxl^fP7B0/snf¹ flies were always female sterile as expression of Sxl⁺ in the germline is required for female fertility. At 29^oC the ovarian tumours of Sxl^fP7B0/snf heterozygotes are snf-like (egg chambers have no nurse-like cells) and at 20^oC they are Sxl-like (egg chambers have an excessive number of nurse cells).

(Oliver et al., 1988)

Fails to complement Sxl alleles that are defective in somatic function, suggesting that this allele probably eliminates all known somatic functions. Fails to complement Sxl^f2, an allele defective in germline function.

(Salz et al., 1987)

nulls female-lethal male viable male-fertile males display normal male sexual behavior.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by fl(2)d^unspecified/fl(2)d^unspecified

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Mettl14^SK1/Mettl14[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Ythdc1[+]/Ythdc1^NP1

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Ythdc1^NP3/Ythdc1[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Ythdf^NP3/Ythdf[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by da[+]/da²

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by Df(2R)Su(z)3-1.iy/+

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by TrpRS[+]/TrpRS^P-74

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by TrpRS^P-28B/TrpRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by Df(3R)by10/+

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by AspRS^TW6/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by AspRS^TW3/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by AspRS^12-21R/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by AspRS¹/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by AspRS^25-1R/AspRS[+]

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by TrpRS[+]/TrpRS⁰³⁵⁵⁹

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype, enhanceable | maternal effect by TrpRS[+]/TrpRS⁴⁴²⁰

(Stitzinger et al., 1999)

NOT Enhanced by

Statement

Reference

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, non-enhanceable by Ythdf^NP1/Ythdf[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, non-enhanceable by Ythdf^NP2/Ythdf[+]

(Kan et al., 2017)

Suppressed by

Statement

Reference

Mettl3^Delta22-3, Sxl[+]/Sxl^fP7B0 has partially lethal - majority die | female | maternal effect phenotype, suppressible by Df(2L)Exel7016/msl-2²²⁷

(Haussmann et al., 2016)

Sxl^fP7B0 has viable phenotype, suppressible | partially by Myc^P0

(Kappes et al., 2011)

Sxl^fP7B0 has viable phenotype, suppressible | partially by Myc^P1

(Kappes et al., 2011)

Sxl^N.Hsp83.lacZ, Sxl^fP7B0 has viable phenotype, suppressible | partially by Myc^dm-1

(Kappes et al., 2011)

Sxl^fP7B0 has viable phenotype, suppressible | partially by Df(1)dm75e19

(Kappes et al., 2011)

Sxl^fP7B0 has viable phenotype, suppressible | partially by Myc^dm-1

(Kappes et al., 2011)

Su(var)205⁵, Sxl^fP7B0 has partially lethal - majority die | dominant | maternal effect phenotype, suppressible by cav²²⁴⁸

(Li et al., 2011)

Su(var)205⁵, Sxl^fP7B0 has partially lethal - majority die | dominant | maternal effect phenotype, suppressible by cav¹

(Li et al., 2011)

Sxl^fP7B0 has lethal | female phenotype, suppressible by da[+]/da²

(Stitzinger et al., 1999)

Sxl^fP7B0 has lethal | female phenotype, suppressible | partially by snf[+]/snf^J210

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, fl(1)35⁴⁶ has partially lethal | female phenotype, suppressible | partially by Dp(1;3)sn^13a1

(Anand et al., 1998)

NOT suppressed by

Statement

Reference

Sxl^fP7B0 has lethal | female phenotype, non-suppressible by snf[+]/da[+]/snf^J210/da²

(Stitzinger et al., 1999)

Suppressor of

Statement

Reference

Sxl^fP7B0 is a suppressor of partially lethal - majority die | dominant | male limited phenotype of cav²²⁴⁸

(Li et al., 2011)

Sxl^fP7B0 is a suppressor | partially of decreased fecundity | dominant | female phenotype of ovo^D2

(Oliver et al., 1990)

NOT Suppressor of

Statement

Reference

Sxl^fP7B0 is a non-suppressor of lethal | embryonic stage phenotype of Scer\GAL4^nos.PG, run^UAS.cLa

(Tracey et al., 2000)

Other

Statement

Reference

Flacc^A, Sxl[+]/Sxl^fP7B0 has partially lethal | female | parental effect phenotype

(Guo et al., 2018)

Sxl[+]/Sxl^fP7B0, da² has partially lethal | female | parental effect phenotype

(Guo et al., 2018)

Df(2L)BSC111/Mettl14^SK1, Sxl^fP7B0 has abnormal sex-determination phenotype

(Kan et al., 2017)

Mettl14^SK1, Sxl^fP7B0 has abnormal sex-determination | dominant phenotype

(Kan et al., 2017)

Mettl14^SK1, Sxl[+]/Sxl^fP7B0 has increased cell number | oogenesis | oogenesis phenotype

(Kan et al., 2017)

Ythdc1^NP3/Df(3L)ED208, Sxl^fP7B0 has abnormal sex-determination phenotype

(Kan et al., 2017)

Sxl^fP7B0, Ythdc1^NP3 has abnormal sex-determination phenotype

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, Ythdc1^NP3 has increased cell number | oogenesis | oogenesis phenotype

(Kan et al., 2017)

Ythdc1^NP2/Df(3L)ED208, Sxl^fP7B0 has abnormal sex-determination phenotype

(Kan et al., 2017)

Sxl^fP7B0, Ythdc1^NP2 has abnormal sex-determination phenotype

(Kan et al., 2017)

Sxl^fP7B0, Ythdc1^NP1 has abnormal sex-determination phenotype

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype

(Kan et al., 2017)

Mettl3^Delta22-3, Sxl[+]/Sxl^fP7B0 has partially lethal - majority die | female | maternal effect phenotype

(Haussmann et al., 2016)

Mettl3^Delta22-3, Sxl[+]/Sxl^fP7B0 has neoplasia | female | maternal effect phenotype

(Haussmann et al., 2016)

Df(2L)Exel7016/msl-2²²⁷, Mettl3^Delta22-3, Sxl[+]/Sxl^fP7B0 has abnormal sex-determination | female | adult stage phenotype

(Haussmann et al., 2016)

Sxl[+]/Sxl^fP7B0, Ythdc1^MI02006 has partially lethal - majority live | female | maternal effect phenotype

(Haussmann et al., 2016)

Sxl[+]/Sxl^fP7B0, Ythdc1^MI02006 has abnormal sex-determination | female | maternal effect phenotype

(Haussmann et al., 2016)

Mettl3^null, Sxl[+]/Sxl^fP7B0 has partially lethal - majority die | female limited phenotype

(Lence et al., 2016)

Rbp9^P2690, Sxl^fP7B0 has partially lethal - majority die | maternal effect | female limited phenotype

(Zaharieva et al., 2015)

Su(var)205⁴, Sxl^fP7B0 has partially lethal - majority die | dominant | maternal effect phenotype

(Li et al., 2011)

Su(var)205⁵, Sxl^fP7B0 has partially lethal - majority die | dominant | maternal effect phenotype

(Li et al., 2011)

Su(var)205², Sxl^fP7B0 has partially lethal - majority die | dominant | maternal effect phenotype

(Li et al., 2011)

Sxl[+]/Sxl^fP7B0, msl-1^L60 has partially lethal - majority die | female | maternal effect phenotype

(Gladstein et al., 2010)

Sxl[+]/Sxl^fP7B0, msl-2¹ has partially lethal - majority die | female | maternal effect phenotype

(Gladstein et al., 2010)

Sxl[+]/Sxl^fP7B0, msl-3¹ has lethal | female | maternal effect phenotype

(Gladstein et al., 2010)

Sxl^fP7B0, snRNP-U1-70K⁰²¹⁰⁷, snf^J210 has lethal phenotype

(Nagengast et al., 2003)

Sxl^cF1.otu, Sxl^fP7B0, snf¹⁴⁸ has lethal phenotype

(Nagengast et al., 2003)

Sxl^fP7B0/Sxl^cF1.otu, snf¹⁴⁸ has lethal phenotype

(Nagengast et al., 2003)

Sxl^fP7B0, U2af38^ΔE18, snf^J210 has lethal phenotype

(Nagengast et al., 2003)

Sxl^fP7B0, da[+]/da² has viable | female phenotype

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female phenotype

(Stitzinger et al., 1999)

Sxl[+]/Sxl^fP7B0, snf^J210 has partially lethal | female | maternal effect phenotype

(Stitzinger et al., 1999)

Sxl^fP7B0, fl(1)35³⁵ has lethal | dominant | female phenotype

(Anand et al., 1998)

Sxl^fP7B0, fl(1)35⁴⁶ has lethal | dominant | female phenotype

(Anand et al., 1998)

Sxl^fP7B0, l(1)43⁴³ has partially lethal | female phenotype

(Anand et al., 1998)

Sxl^fP7B0, snf^e8H has lethal | recessive | female | maternal effect phenotype

(Albrecht and Salz, 1993)

Sxl^fP7B0, snf^e8H has lethal | dominant | female phenotype

(Albrecht and Salz, 1993)

Phenotype Manifest In

Other

Statement

Reference

Mettl14^SK1, Sxl[+]/Sxl^fP7B0 has spectrosome | oogenesis phenotype

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, Ythdc1^NP3 has spectrosome | oogenesis phenotype

(Kan et al., 2017)

Mettl3^Delta22-3, Sxl[+]/Sxl^fP7B0 has ovary | maternal effect phenotype

(Haussmann et al., 2016)

Df(2L)Exel7016/msl-2²²⁷, Mettl3^Delta22-3, Sxl[+]/Sxl^fP7B0 has sex comb | ectopic | female phenotype

(Haussmann et al., 2016)

Sxl^fP7B0, nos^BN has germline cell phenotype

(Deshpande et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

When da² or Flacc^A heterozygous mothers are crossed to Sxl^fP7B0/Y fathers only 53% and 38%, respectively, of the expected Sxl^fP7B0/+ female progeny survive to adulthood.

(Guo et al., 2018)

Sxl^fP7B0;msl-2²²⁷/Df(2L)Exel7016 females do not display any decrease in viability compared to controls.

Ime4^Δ22-3;Sxl^fP7B0 double heterozygous daughters from Ime4^Δ22-3 mutant females show strongly reduced female viability and tumorous ovaries (no decrease in viability or ovarian defects are observed in the presence of maternal wild-type copy of Ime4). The reduced viability phenotype can be fully rescued by combination with msl-2²²⁷/Df(2L)Exel7016 although these females frequently show signs of sexual transformation and display male-specific features such as sex-combs, which are mosaic to various degrees.

Sxl^fP7B0;YT521-B^MI02006 double heterozygous daughters from YT521-B^MI02006 mutant females show reduced viability and sexual transformations such as male abdominal pigmentation.

(Haussmann et al., 2016)

Ime4^null/+, Sxl^fP7B0/+ females, but not males, exhibit severely reduced survival to hatching, as compared to controls.

(Lence et al., 2016)

Removing one copy of Rbp9^P2690 during oogenesis in combination with zygotic heterozygosity for Sxl^fP7B0 results in female lethality. No female lethality is seen in the reverse cross. This female lethality is suppressed when msl-3¹ is also zygotically removed.

(Zaharieva et al., 2015)

Females trans-heterozygous for Sxl^fP7B0 and dm¹ are approximately two-thirds as viable as their dm¹/+ siblings.

Females trans-heterozygous for Sxl^fP7B0 and dm^P0 are approximately two-thirds as viable as their dm^P0/+ siblings.

Females trans-heterozygous for Sxl^fP7B0 and dm^P1 are approximately two-thirds as viable as their dm^P1/+ siblings.

Sxl^{N.Hsp83.T:Ecol\lacZ} females that are trans-heterozygous for Sxl^fP7B0 and dm¹ are two-thirds as viable as their Sxl^{N.Hsp83.T:Ecol\lacZ} Sxl^fP7B0/+ sisters.

Transgenic females trans-heterozygous for Df(1)dm75e19 and Sxl^fP7B0 are only half as viable as Sxl^fP7B0 female siblings.

(Kappes et al., 2011)

Sxl^fP7B0 suppresses the semi-lethality of homozygous cav²²⁴⁸ males.

In progeny from Su(var)205⁵ heterozygous females crossed to Sxl^fP7B0/Y males, female viability is dramatically reduced. The effect of Su(var)205⁵ is strictly maternal; no significant reduction in female viability is observed in the reciprocal cross.

In progeny from Su(var)205⁴ heterozygous females crossed to Sxl^fP7B0/Y males, female viability is dramatically reduced.

In progeny from Su(var)205² heterozygous females crossed to Sxl^fP7B0/Y males, female viability is reduced.

(Li et al., 2011)

The viability of Sxl^fP7B0/+ females is significantly reduced if they also carry one maternally-derived copy of msl-1^L60, msl-2¹ or msl-3¹.

The viability of Sxl^fP7B0/+ females is not affected if they also carry one maternally-derived copy of mle¹.

The almost complete lethality of Sxl^fP7B0/+ females carrying a maternally-derived copy of msl-3¹ is significantly rescued (to 98.7% viability) by a maternally-derived copy of Sxl^M1.

(Gladstein et al., 2010)

The female progeny of fl(2)d¹/+ females mated to Sxl^fP7B0/Y males show only 65.3% viability.

The female progeny of fl(2)d²/+ females mated to Sxl^fP7B0/Y males show only 87.4% viability.

The female progeny of snf^J210/+ females mated to Sxl^fP7B0/Y males show only 83.6% viability.

The female progeny of snf^J210/+ ; fl(2)d¹/+ females mated to Sxl^fP7B0/Y males show only 27.6% viability.

The female progeny of snf^J210/+ ; fl(2)d²/+ females mated to Sxl^fP7B0/Y males show only 74.4% viability.

The female progeny of snf¹⁴⁸/+ females mated to Sxl^fP7B0/Y males show only 48.0% viability.

The female progeny of snf¹⁴⁸/+ ; fl(2)d¹/+ females mated to Sxl^fP7B0/Y males show only 11.1% viability.

The female progeny of snf¹⁴⁸/+ ; fl(2)d²/+ females mated to Sxl^fP7B0/Y males show only 45.6% viability.

The female progeny of snf^J210/+ ; snf^5MER females mated to Sxl^fP7B0/Y males show 98% viability.

The female progeny of snf^J210/+ ; fl(2)d¹/+ ; snf^5MER females mated to Sxl^fP7B0/Y males show 16.1% viability.

The female progeny of snf^J210/+ ; fl(2)d²/+ ; snf^5MER females mated to Sxl^fP7B0/Y males show 79.3% viability.

The female progeny of U2af38^ΔE18/+ females mated to Sxl^fP7B0/Y males are completely viable.

The female progeny of U2af38^ΔE18/fl(2)d¹ females mated to Sxl^fP7B0/Y males show only 25.8% viability.

The female progeny of U2af38^ΔE18/fl(2)d² females mated to Sxl^fP7B0/Y males show only 90.1% viability.

(Penn et al., 2008)

If snf¹⁴⁸/snf¹⁴⁸, Sxl^cF1.otu females are crossed with Sxl^fP7B0 males only 6% of her Sxl^fP7B0/+ daughters survive. When mothers heterozygous for both snf^J210 and snRNP70K⁰²¹⁰⁷ are crossed with Sxl^fP7B0 males, a significant reduction in viability is seen in Sxl^fP7B0/+ daughters. When mothers heterozygous for both snf^J210 and U2af38^ΔE18 are crossed with Sxl^fP7B0 males, a significant reduction in viability is seen in Sxl^fP7B0/+ daughters. When mothers heterozygous for both snf^J210 and U2af50^XR15 are crossed with Sxl^fP7B0 males, no significant reduction in viability is seen in Sxl^fP7B0/+ daughters.

(Nagengast et al., 2003)

The preferential sensitivity of males to the lethal effects of expression of run^Scer\UAS.cLa under the control of Scer\GAL4^nos.PG is not suppressed by Sxl^fP7B0.

(Tracey et al., 2000)

When embryos are also mutant for nos^BN, the germ cells form two clusters instead of the one they form in single mutants for nos^BN.

(Deshpande et al., 1999)

Female Sxl^fP7B0/+ embryos are fully viable if their mothers are heterozygous for da², 80% viable if their mothers are heterozygous for snf^J210, but only 7% viable if their mothers are heterozygous for both da² and snf^J210. The weak interaction between Sxl^fP7B0 and snf^J210 is enhanced by Df(2R)Su(z)3-1.iy, Aats-asp^TW6, Aats-asp^TW3, Aats-asp^12-21R, Aats-asp¹ or Aats-asp^25-1R; the viability of female Sxl^fP7B0/+ embryos derived from mothers heterozygous for snf^J210 and one of Df(2R)Su(z)3-1.iy, Aats-asp^TW6, Aats-asp^TW3, Aats-asp^12-21R, Aats-asp¹ or Aats-asp^25-1R is reduced. The weak interaction between Sxl^fP7B0 and snf^J210 is enhanced by Aats-trp⁰³⁵⁵⁹, Aats-trp⁴⁴²⁰, Aats-trp^P-74, Aats-trp^P-28B or Df(3R)by10; the viability of female Sxl^fP7B0/+ embryos derived from mothers heterozygous for snf^J210 and one of Aats-trp⁰³⁵⁵⁹, Aats-trp⁴⁴²⁰, Aats-trp^P-74, Aats-trp^P-28B or Df(3R)by10 is reduced.

(Stitzinger et al., 1999)

Lethal in female double heterozygous combination with fl(1)35³⁵. Females doubly heterozygous for fl(1)35⁴⁶ and Sxl^fP7B0 show 2.1% viability. Lethality of fl(1)35⁴⁶/Sxl^fP7B0 females can occur at embryonic or larval stages. The viability of Sxl^fP7B0 in female double heterozygous combination with l(1)43⁴³ is reduced.

(Anand et al., 1998)

Female lethal-synergistic interactions with snf^- mutations.

(Salz and Flickinger, 1996)

Heterozygous females from snf^e8H mothers die, with same phenotype as shown by dying Sxl mutants. This phenotype can be suppressed if the embryo carries the constitutive Sxl^M4 or Sxl^M1 allele.

(Albrecht and Salz, 1993)

The number of vitellogenic eggs produced by ovo^D2 heterozygous females is increased by Sxl^fP7B0.

(Oliver et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Sxl^dlf

(Anand et al., 1998)

Partially rescues

Sxl^fP7B0 partially rescues Sxl^FL.Hsp83

(Yanowitz et al., 1999)

Comments

Partially rescues the otherwise complete lethality of Sxl^FL.Hsp83 and Sxl^N.Hsp83males.

(Yanowitz et al., 1999)

Sxl^F1.hs cannot rescue the lethal phenotype. One copy of the moderate class of Sxl^F1.hs insertion at 25^oC causes high numbers of intersex individuals, this number drops slightly at 29^oC. All values are higher than individuals carrying the insertion in an Sxl⁺ background. This same pattern is demonstrated with one copy of a strong Sxl^F1.hs insertion class but the number of intersexes are less.

(Bell et al., 1991)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58489

y¹ pn¹ w¹ Sxl^M8/Df(1)Sxl^fP7B0, y¹ pn¹ w¹ Sxl^fP7B0

Notes on Origin

Discoverer

Comments

Isolated on the basis of its failure to complement Sxl^f9.

(Salz et al., 1987)

Does not interfere with transcription of the locus.

(Albrecht and Salz, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Df(1)Sxl^7BO

(Oliver et al., 1994, Oliver et al., 1993, Oliver et al., 1990)

Df(1)Sxl^fp7BO

Df(Sxl)fP7BO

(Bopp et al., 1991)

Sxl^7B0

(Haussmann et al., 2016, Zaharieva et al., 2015, Nagengast et al., 2003, Yanowitz et al., 1999, Zhu et al., 1997, Granadino et al., 1996, Rudner et al., 1996, Salz and Flickinger, 1996, Samuels et al., 1994, Albrecht and Salz, 1993, Granadino et al., 1991, Parkhurst and Ish-Horowicz, 1991, Torres and Sanchez, 1991, Oliver et al., 1988)

Sxl^7BO

(Guo et al., 2018, Kan et al., 2017, Lence et al., 2016, Kappes et al., 2011, Johnson et al., 2010, Penn et al., 2008, Chaouki and Salz, 2006, Andrews and Oliver, 2002, Deshpande et al., 1999, Deshpande et al., 1999, Stitzinger et al., 1999, Anand et al., 1998, Sanchez et al., 1994, Granadino et al., 1992, Oliver et al., 1990)

Sxl^f7BO

(Salz et al., 1987)

Sxl^fP7B0

(Gladstein et al., 2010, Pal Bhadra et al., 2006, Horabin, 2005)

Sxl^fP7BO

(Li et al., 2011, Vied and Horabin, 2001, Granadino et al., 1997, Bopp et al., 1991)

Sxl^fP7bo

(Cline, 2014.11.10, Cline et al., 1999, Hager and Cline, 1997)

Sxl^null

(Haussmann et al., 2016, Zaharieva et al., 2015)

Sxl[7BO]

(Tracey et al., 2000)

Name Synonyms

Secondary FlyBase IDs

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