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General Information
Symbol
Dmel\SxlfP7B0
Species
D. melanogaster
Name
FlyBase ID
FBal0016694
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Sxl7BO, Sxl7B0, SxlfP7BO, Df(1)Sxl7BO, Sxlnull
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Deletion for the entire Sxl transcription unit.
Deletion of Sxl.
Small deletion removing most of the Sxl transcription unit and some upstream sequences.
Deletion that deletes the entire Sxl locus and no flanking loci.
Deficiency of the Sxl locus.
The entire Sxl gene is deleted.
Deletion of DNA extending at least 13kb distal to coordinate 0 (coordinates according to FBrf0042036). No P-element sequences remain.
appears to be deleted for the entire Sxl transcription unit. deletion of >50 kb; deletion from SxlfPb
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
SxlfP7B0 heterozygous females do not display any decrease in viability compared to controls.
SxlfP7B0 heterozygotes are viable.
Female viability is not compromised in a cross between wild-type females and SxlfP7B0 males.
The viability of females carring SxlN.Hsp83.T:Ecol\lacZ is further reduced if they are also heterozygous for SxlfP7B0. Females carrying two copies of SxlN.Hsp83.T:Ecol\lacZ and heterozygous for SxlfP7B0 have reduced viability compared to females carrying one copy of SxlN.Hsp83.T:Ecol\lacZ and heterozygous for SxlfP7B0.
SxlfP7B0 is unable to suppress the sex comb defect seen in homozygous male U2af3806751 flies.
SxlfP7B0/Df(1)N19 double heterozygous females have reduced viability; only 29% survive compared to control flies. Viability is recovered if the SxlfP7B0/Df(1)N19 females also carry Dp(1;3)JC153 or SxlM1. SxlfP7B0 shows no female-specific lethal interaction with Df(1)E128 or Df(1)os1A2. SxlfP7B0/+ ; In(2LR)Scorv1LTE35B-4R/+ females have reduced viability at 29oC.
Homozygous clones induced at blastoderm survive, differentiating male structures. Lethal in heterozygous combination with Df(1)N71 or Df(1)svr.
Interacts with RpII140wimp maternal effect.
SxlfP7B0/snf1 female progeny are more viable at lower temperatures. SxlfP7B0/snf1 flies showed some somatic sexual transformation: male sex combs among normal female bristles. SxlfP7B0/snf1 flies were always female sterile as expression of Sxl+ in the germline is required for female fertility. At 29oC the ovarian tumours of SxlfP7B0/snf heterozygotes are snf-like (egg chambers have no nurse-like cells) and at 20oC they are Sxl-like (egg chambers have an excessive number of nurse cells).
Fails to complement Sxl alleles that are defective in somatic function, suggesting that this allele probably eliminates all known somatic functions. Fails to complement Sxlf2, an allele defective in germline function.
nulls female-lethal male viable male-fertile males display normal male sexual behavior.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference
SxlfP7B0 has lethal | female phenotype, non-suppressible by snf[+]/da[+]/snfJ210/da2
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
When da2 or FlaccA heterozygous mothers are crossed to SxlfP7B0/Y fathers only 53% and 38%, respectively, of the expected SxlfP7B0/+ female progeny survive to adulthood.
SxlfP7B0;msl-2227/Df(2L)Exel7016 females do not display any decrease in viability compared to controls. Ime4Δ22-3;SxlfP7B0 double heterozygous daughters from Ime4Δ22-3 mutant females show strongly reduced female viability and tumorous ovaries (no decrease in viability or ovarian defects are observed in the presence of maternal wild-type copy of Ime4). The reduced viability phenotype can be fully rescued by combination with msl-2227/Df(2L)Exel7016 although these females frequently show signs of sexual transformation and display male-specific features such as sex-combs, which are mosaic to various degrees. SxlfP7B0;YT521-BMI02006 double heterozygous daughters from YT521-BMI02006 mutant females show reduced viability and sexual transformations such as male abdominal pigmentation.
Ime4null/+, SxlfP7B0/+ females, but not males, exhibit severely reduced survival to hatching, as compared to controls.
Removing one copy of Rbp9P2690 during oogenesis in combination with zygotic heterozygosity for SxlfP7B0 results in female lethality. No female lethality is seen in the reverse cross. This female lethality is suppressed when msl-31 is also zygotically removed.
Females trans-heterozygous for SxlfP7B0 and dm1 are approximately two-thirds as viable as their dm1/+ siblings. Females trans-heterozygous for SxlfP7B0 and dmP0 are approximately two-thirds as viable as their dmP0/+ siblings. Females trans-heterozygous for SxlfP7B0 and dmP1 are approximately two-thirds as viable as their dmP1/+ siblings. SxlN.Hsp83.T:Ecol\lacZ females that are trans-heterozygous for SxlfP7B0 and dm1 are two-thirds as viable as their SxlN.Hsp83.T:Ecol\lacZ SxlfP7B0/+ sisters. Transgenic females trans-heterozygous for Df(1)dm75e19 and SxlfP7B0 are only half as viable as SxlfP7B0 female siblings.
SxlfP7B0 suppresses the semi-lethality of homozygous cav2248 males. In progeny from Su(var)2055 heterozygous females crossed to SxlfP7B0/Y males, female viability is dramatically reduced. The effect of Su(var)2055 is strictly maternal; no significant reduction in female viability is observed in the reciprocal cross. In progeny from Su(var)2054 heterozygous females crossed to SxlfP7B0/Y males, female viability is dramatically reduced. In progeny from Su(var)2052 heterozygous females crossed to SxlfP7B0/Y males, female viability is reduced.
The viability of SxlfP7B0/+ females is significantly reduced if they also carry one maternally-derived copy of msl-1L60, msl-21 or msl-31. The viability of SxlfP7B0/+ females is not affected if they also carry one maternally-derived copy of mle1. The almost complete lethality of SxlfP7B0/+ females carrying a maternally-derived copy of msl-31 is significantly rescued (to 98.7% viability) by a maternally-derived copy of SxlM1.
The female progeny of fl(2)d1/+ females mated to SxlfP7B0/Y males show only 65.3% viability. The female progeny of fl(2)d2/+ females mated to SxlfP7B0/Y males show only 87.4% viability. The female progeny of snfJ210/+ females mated to SxlfP7B0/Y males show only 83.6% viability. The female progeny of snfJ210/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 27.6% viability. The female progeny of snfJ210/+ ; fl(2)d2/+ females mated to SxlfP7B0/Y males show only 74.4% viability. The female progeny of snf148/+ females mated to SxlfP7B0/Y males show only 48.0% viability. The female progeny of snf148/+ ; fl(2)d1/+ females mated to SxlfP7B0/Y males show only 11.1% viability. The female progeny of snf148/+ ; fl(2)d2/+ females mated to SxlfP7B0/Y males show only 45.6% viability. The female progeny of snfJ210/+ ; snf5MER females mated to SxlfP7B0/Y males show 98% viability. The female progeny of snfJ210/+ ; fl(2)d1/+ ; snf5MER females mated to SxlfP7B0/Y males show 16.1% viability. The female progeny of snfJ210/+ ; fl(2)d2/+ ; snf5MER females mated to SxlfP7B0/Y males show 79.3% viability. The female progeny of U2af38ΔE18/+ females mated to SxlfP7B0/Y males are completely viable. The female progeny of U2af38ΔE18/fl(2)d1 females mated to SxlfP7B0/Y males show only 25.8% viability. The female progeny of U2af38ΔE18/fl(2)d2 females mated to SxlfP7B0/Y males show only 90.1% viability.
If snf148/snf148, SxlcF1.otu females are crossed with SxlfP7B0 males only 6% of her SxlfP7B0/+ daughters survive. When mothers heterozygous for both snfJ210 and snRNP70K02107 are crossed with SxlfP7B0 males, a significant reduction in viability is seen in SxlfP7B0/+ daughters. When mothers heterozygous for both snfJ210 and U2af38ΔE18 are crossed with SxlfP7B0 males, a significant reduction in viability is seen in SxlfP7B0/+ daughters. When mothers heterozygous for both snfJ210 and U2af50XR15 are crossed with SxlfP7B0 males, no significant reduction in viability is seen in SxlfP7B0/+ daughters.
The preferential sensitivity of males to the lethal effects of expression of runScer\UAS.cLa under the control of Scer\GAL4nos.PG is not suppressed by SxlfP7B0.
When embryos are also mutant for nosBN, the germ cells form two clusters instead of the one they form in single mutants for nosBN.
Female SxlfP7B0/+ embryos are fully viable if their mothers are heterozygous for da2, 80% viable if their mothers are heterozygous for snfJ210, but only 7% viable if their mothers are heterozygous for both da2 and snfJ210. The weak interaction between SxlfP7B0 and snfJ210 is enhanced by Df(2R)Su(z)3-1.iy, Aats-aspTW6, Aats-aspTW3, Aats-asp12-21R, Aats-asp1 or Aats-asp25-1R; the viability of female SxlfP7B0/+ embryos derived from mothers heterozygous for snfJ210 and one of Df(2R)Su(z)3-1.iy, Aats-aspTW6, Aats-aspTW3, Aats-asp12-21R, Aats-asp1 or Aats-asp25-1R is reduced. The weak interaction between SxlfP7B0 and snfJ210 is enhanced by Aats-trp03559, Aats-trp4420, Aats-trpP-74, Aats-trpP-28B or Df(3R)by10; the viability of female SxlfP7B0/+ embryos derived from mothers heterozygous for snfJ210 and one of Aats-trp03559, Aats-trp4420, Aats-trpP-74, Aats-trpP-28B or Df(3R)by10 is reduced.
Lethal in female double heterozygous combination with fl(1)3535. Females doubly heterozygous for fl(1)3546 and SxlfP7B0 show 2.1% viability. Lethality of fl(1)3546/SxlfP7B0 females can occur at embryonic or larval stages. The viability of SxlfP7B0 in female double heterozygous combination with l(1)4343 is reduced.
Female lethal-synergistic interactions with snf- mutations.
Heterozygous females from snfe8H mothers die, with same phenotype as shown by dying Sxl mutants. This phenotype can be suppressed if the embryo carries the constitutive SxlM4 or SxlM1 allele.
The number of vitellogenic eggs produced by ovoD2 heterozygous females is increased by SxlfP7B0.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Partially rescues
Comments
Partially rescues the otherwise complete lethality of SxlFL.Hsp83 and SxlN.Hsp83males.
SxlF1.hs cannot rescue the lethal phenotype. One copy of the moderate class of SxlF1.hs insertion at 25oC causes high numbers of intersex individuals, this number drops slightly at 29oC. All values are higher than individuals carrying the insertion in an Sxl+ background. This same pattern is demonstrated with one copy of a strong SxlF1.hs insertion class but the number of intersexes are less.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
Isolated on the basis of its failure to complement Sxlf9.
Does not interfere with transcription of the locus.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (11)
References (48)