Open Close
General Information
Symbol
Dmel\SxlfPb
Species
D. melanogaster
Name
FlyBase ID
FBal0016696
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P element insertion.

Insertion of P-element on the 5' side of the gene, at coordinate 0 (coordinates according to FBrf0042036).

Insertion of P-element into the Sxl gene.

Insertion components
P{}SxlfPb
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A P-insertion-induced lethal hypomorphic allele with the unusual distinction of displaying a mosaic intersex phenotype in homozygous mutant diplo-X clones induced by mitotic recombination; hence, appears to be defective in the cellular maintenance of the female sexual commitment. Under dysgenic conditions, can mutate further to less extreme or to more extreme condition. Partially complements Sxlf7,M1, generating masculinized individuals; partially complements Sxlf2593, generating sterile females; fully complements Sxlf9.

Partial loss-of-function allele. Only partially complemented by Sxlf7,M1. Fully complements Sxlf9 and Sxlf2. Homozygous germline clones develop normally.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference

SxlfPb is a non-suppressor of decreased fecundity | dominant | female phenotype of ovoD2

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The number of vitellogenic eggs produced by ovoD2 heterozygous females is not increased by SxlfPb.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Nuclei of SxlfPb/Sxlf2593 larvae exhibit binding of the msl gene products to the paired X chromosomes but no Sxl binding.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
SxlfPb
Name Synonyms
Secondary FlyBase IDs
    References (7)