Allele Dmel\Tb1
| General Information | |||
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| Symbol | Dmel\Tb1 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0016730 | |
| Feature type | allele | Associated gene | Dmel\Tb |
| Allele class | |||
| Mutagen | nitrogen mustard | ||
Recent Updates
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| Description |
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| FB2013_03 |
Stocks
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| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mutations Mapped to the Genome | |||
Type Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference | ||
| Carried on aberration | |||
| Cytology | |||
Phenotypic Data
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Phenotypic Class
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Phenotype Manifest In
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Detailed Description
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Statement Reference Larvae, pupae and adults are shorter and thicker than wild-type in both heterozygotes and homozygotes (not separable). Mutant larvae are distinguishable from wild-type on the basis of reduced length and tortuous tracheal trunks. Classification is reliable in larvae and pupae but not adults. Larvae, pupae and adult are short and thickset. RK1 from first instar through pupa, RK2 as adult. | |||
External Data
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Interactions
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Phenotypic Class
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Suppressor of | |||
Statement Reference | |||
NOT Suppressor of | |||
Statement Reference | |||
Phenotype Manifest In
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Suppressor of | |||
Statement Reference Tb+/Tb1 is a suppressor | partially of embryonic/larval peripheral nervous system phenotype of GlcAT-Pbrv1 | |||
NOT Suppressor of | |||
Statement Reference | |||
Additional Comments
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Genetic Interactions
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Statement Reference A Tb[1] heterozygous background suppresses the ventral nerve cord extension found in GlcAT-P[brv1] homozygous mutant L3 larvae, however, these double mutants still exhibit extension compared to wild-type controls. This demonstrates that the ventral nerve cord extension correlates with the total length of the larva, suggesting that in GlcAT-P[brv1] mutants the ventral nerve cord expands as a consequence of increased tension from shorter peripheral nerves or trachea, possibly due to some growth retardation of larval peripheral nerves or trachea. One copy of Tb[1] in a Mmp1[2] mutant background partially rescues the tracheal break phenotype seen in Mmp1[2] homozygotes (55% of larva have tracheal breaks compared to 93%).
The angle between the transverse connective and the dorsal trunk is reduced in Tb[1] Mmp1[2] double mutants compared to homozygous Mmp1[2] mutants but is still greater than in wild type.
No homozygous Mmp1[2] larvae survive to pupariation, whereas 29% of Tb[1] Mmp1[2] double mutants survive beyond the larval stages.
The failure of the taenidial distance to increase from the early to late third instar stages that is seen in Mmp1[2] mutants is still present in flies that also carry one copy of Tb[1]. | |||
Xenogenetic Interactions
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Statement Reference | |||
Complementation & Rescue Data
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| Comments | |||
Stocks
( 3053 ) | |||
| Bloomington | 624 1794 | ||
| Kyoto | 106732 106780 108428 107131 | ||
Notes on Origin
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| Discoverer | Auerbach. | ||
Comments
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"nitrogen mustard" was stated as tentative. | |||
External Crossreferences & Linkouts
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| Other Crossreferences | |||
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Synonyms & Secondary IDs
( 2 ) | |||
| Reported As | |||
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| Name Synonym | |||
| Secondary FlyBase IDs | |||
References
( 17 ) | |||
| Research paper |
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| Supplementary material |
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| Personal communication to FlyBase |
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| FlyBase analysis |
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| Book |
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Recent Updates
External Crossreferences & Linkouts