A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\Tb1

General Information
SymbolDmel\Tb1SpeciesD. melanogaster
NameFlyBase IDFBal0016730
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\Tb
Allele class
Mutagennitrogen mustard
hide Nature of the Allele
Allele class
Mutagen
nitrogen mustard
(Craymer, 1980)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Carried on aberration
      TM6B-UZ
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6bT8LZ
      (FlyBase Curators, 2006-)
      TM6B-vHa
      (FlyBase Curators, 2006-)
      TM6B-vGb
      (FlyBase Curators, 2006-)
      TM6B-vDAa
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-P{Crew}
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-y+
      (FlyBase Curators, 2006-)
      TM6B-P{HZ2.7}3
      (Beitel, 2004.9.21)
      TM6B-P{Dfd-EYFP}3
      (FlyBase Curators, 2006-, Beitel, 2005.3.25)
      TM6C-ST
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-vGa
      (FlyBase Curators, 2006-)
      TM6B-ryCBTb1
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6C-cu1
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1999.7.19)
      TM6B-Tb
      (Lindsley and Zimm, 1992)
      TM6B-TD
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-BT
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      SM6a-TM6B
      (FlyBase Curators, 2006-, Basu et al., 1999)
      TM6B-gT
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TSTL14
      (FlyBase Curators, 2006-)
      TM6B.Scr-lacZ
      (FlyBase Curators, 2006-)
      TM6B-rT
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6C-AST
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-rTc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      T(2;3)SM6b-TM6B
      (Kreber, 2004.7.20)
      TM6C-ryCB
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1999.7.19)
      TM6B-Tc
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      TM6B-Sb1
      (FlyBase Curators, 2006-)
      TM6B-pXp
      (FlyBase Curators, 2006-)
      CyO-TM6B
      (FlyBase Curators, 2006-)
      TM6B-P{Dfd-GMR-nvYFP}4
      (Beitel, 2007.4.20)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      viable
      (Lindsley and Zimm, 1992)
      visible | dominant
      (Craymer, 1980, Lindsley and Zimm, 1992)
      fertile
      (Lindsley and Zimm, 1992)
      hide Phenotype Manifest In
      larval tracheal system
      (Lindsley and Zimm, 1992)
      larva
      (Lindsley and Zimm, 1992)
      pupa
      (Lindsley and Zimm, 1992)
      adult
      (Lindsley and Zimm, 1992)
      hide Detailed Description
      Statement
      Reference
      Larvae, pupae and adult are short and thickset. RK1 from first instar through pupa, RK2 as adult.
      (Craymer, 1980)
      Larvae, pupae and adults are shorter and thicker than wild-type in both heterozygotes and homozygotes (not separable). Mutant larvae are distinguishable from wild-type on the basis of reduced length and tortuous tracheal trunks. Classification is reliable in larvae and pupae but not adults.
      (Lindsley and Zimm, 1992)
      Tb[1] mutant pupae exhibit a reduced cuticle axial ratio (length\width), without any defects in viability or fertility. At the pupal stage Tb[1] mutants exhibit an axial ratio of 2.0 (compared to 3.5 in wild-type).
      (Guan et al., 2006)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 1352 )
      Bloomington
      624
      Tb1
      1794
      TM1/TM6B, Tb1
      2182
      Df(3R)CP1/TM6B, Tb1
      7295
      Df(3L)3C7/TM6B, Tb1
      3617
      Df(3L)kto2/TM6B, Tb1
      3626
      T(2;3)P607/TM6B, Tb1
      5797
      Df(3R)GC14/TM6B, Tb1
      7002
      Df(3L)1-16/TM6B, Tb1
      Kyoto
      106015
      Tb1
      106732
      Df(3R)CP1/TM6B, Tb1
      106780
      Df(3R)Cha7/TM6B, Tb1
      108428
      Df(3R)GC14/TM6B, Tb1
      hide Notes on Origin
      Discoverer
      Auerbach.
      hide Comments
      "nitrogen mustard" was stated as tentative.
      (Craymer, 1980)
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      Tb1
      (Guan, 2006, Guan et al., 2006)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 13 )
        Research paper
        Guan et al., 2006, Proc. Natl. Acad. Sci. USA 103(45): 16794--16799
        Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. [FBrf0195309]
        Basu et al., 1999, J. Cell Biol. 146(1): 13--28
        Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. [FBrf0109303]
        Craymer, 1980, D. I. S. 55: 197--200
        [New mutants report.] [FBrf0063385]
        Auerbach, 1943, D. I. S. 17: 48--50
        Chemically induced mutations and rearrangements. [FBrf0005917]
        Supplementary material
        Guan, 2006, Proc. Natl. Acad. Sci. USA 103(45):
        [FBrf0200374]
        Personal communication to FlyBase
        Beitel, 2007.4.20, P{Dfd-GMR-nvYFP} insertions and balancer variants.
        P{Dfd-GMR-nvYFP} insertions and balancer variants. [FBrf0197896]
        Beitel, 2005.3.25, P{Dfd-EYFP}3 insertion.
        P{Dfd-EYFP}3 insertion. [FBrf0182566]
        Beitel, 2004.9.21, Info from Greg Beitel.
        Info from Greg Beitel. [FBrf0179869]
        Kreber, 2004.7.20, T(2;3)SM6b-TM6B.
        T(2;3)SM6b-TM6B. [FBrf0178900]
        Bloomington Drosophila Stock Center, 2001.8.28, Balancer Variants.
        Balancer Variants. [FBrf0138610]
        Bloomington Drosophila Stock Center, 1999.7.19, New TM6C balancer for curation.
        New TM6C balancer for curation. [FBrf0109360]
        FlyBase analysis
        FlyBase Curators, 2006-, Balancer summary information.
        Balancer summary information. [FBrf0189689]
        Book
        Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
        The Genome of Drosophila melanogaster. [FBrf0066905]