A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Tb1

General Information
SymbolDmel\Tb1SpeciesD. melanogaster
NameFlyBase IDFBal0016730
Feature typealleleAssociated geneDmel\Tb
Allele class
Mutagennitrogen mustard
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Description
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What does this section not display?
This section does not currently display links that were removed or gene model changes.
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FB2013_03
Stocks
Df(3L)XG1/TM3, P{w[+mW.hs]=Thb8-lacZ}WD1, Sb[1] Ser[1]
R[1] D[1] red[1] Sb[1]/TM6
FBst0043348
FBst0043659
FBst0043657
FBst0043347
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
nitrogen mustard
(Craymer, 1980)
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
 
 
Carried on aberration
CyO-TM6B
(FlyBase Curators, 2006-)
SM6a-TM6B
(FlyBase Curators, 2006-, Basu et al., 1999)
T(2;3)SM6b-TM6B
(Kreber, 2004.7.20)
TM6B.Scr-lacZ
(FlyBase Curators, 2006-)
TM6bT8LZ
(FlyBase Curators, 2006-)
TM6B-BT
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-gT
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-P{Crew}
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-P{Dfd-EYFP}3
(FlyBase Curators, 2006-, Beitel, 2005.3.25)
TM6B-P{Dfd-GMR-nvYFP}4
(Beitel, 2007.4.20)
TM6B-P{HZ2.7}3
(Beitel, 2004.9.21)
TM6B-pXp
(FlyBase Curators, 2006-)
TM6B-rT
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-rTc
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-ryCBTb1
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-Sb1
(FlyBase Curators, 2006-)
TM6B-Tb
(Lindsley and Zimm, 1992)
TM6B-Tc
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-TD
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-UZ
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-vDAa
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6B-vGa
(FlyBase Curators, 2006-)
TM6B-vGb
(FlyBase Curators, 2006-)
TM6B-vHa
(FlyBase Curators, 2006-)
TM6B-y+
(FlyBase Curators, 2006-)
TM6C-AST
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TM6C-cu1
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1999.7.19)
TM6C-ryCB
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1999.7.19)
TM6C-ST
(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
TSTL14
(FlyBase Curators, 2006-)
Cytology
hide Phenotypic Data
hide Phenotypic Class
fertile
(Lindsley and Zimm, 1992)
size defective | dominant | larval stage
(Glasheen et al., 2010)
small body | larval stage
(Pandey et al., 2011)
viable
(Lindsley and Zimm, 1992)
visible | dominant
(Craymer, 1980, Lindsley and Zimm, 1992)
hide Phenotype Manifest In
adult
(Lindsley and Zimm, 1992)
embryonic/larval dorsal trunk
(Glasheen et al., 2010)
embryonic/larval peripheral nervous system
(Pandey et al., 2011)
embryonic/larval tracheal system
(Lindsley and Zimm, 1992)
larva
(Lindsley and Zimm, 1992)
pupa
(Lindsley and Zimm, 1992)
hide Detailed Description
Statement
Reference
Tb[1] larvae are considerably shorter along the anterior-posterior axis than wild-type. Although the length of the Tb[1] ventral nerve cord is comparable to wild-type, peripheral nerves are shorter in Tb[1] larvae.
(Pandey et al., 2011)
Heterozygous Tb[1] mutant larvae have short bodies and long tracheal tubes compared to wild type. The intertaenidial distance in Tb[1] heterozygotes is similar to wild type.
(Glasheen et al., 2010)
Tb1 mutant pupae exhibit a reduced cuticle axial ratio (length\width), without any defects in viability or fertility. At the pupal stage Tb1 mutants exhibit an axial ratio of 2.0 (compared to 3.5 in wild-type).
(Guan et al., 2006)
Larvae, pupae and adults are shorter and thicker than wild-type in both heterozygotes and homozygotes (not separable). Mutant larvae are distinguishable from wild-type on the basis of reduced length and tortuous tracheal trunks. Classification is reliable in larvae and pupae but not adults.
(Lindsley and Zimm, 1992)
Larvae, pupae and adult are short and thickset. RK1 from first instar through pupa, RK2 as adult.
(Craymer, 1980)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideSuppressor of
Statement
Reference
Tb+/Tb1 is a suppressor | partially of lethal | larval stage phenotype of Mmp12
(Glasheen et al., 2010)
Tb+/Tb1 is a suppressor | partially of neuroanatomy defective phenotype of GlcAT-Pbrv1
(Pandey et al., 2011)
hideNOT Suppressor of
Statement
Reference
Tb+/Tb1 is a non-suppressor of size defective | late third instar larval stage phenotype of Mmp12
(Glasheen et al., 2010)
hide Phenotype Manifest In
hideSuppressor of
Statement
Reference
Tb+/Tb1 is a suppressor | partially of embryonic/larval dorsal trunk phenotype of Mmp12
(Glasheen et al., 2010)
Tb+/Tb1 is a suppressor | partially of embryonic/larval peripheral nervous system phenotype of GlcAT-Pbrv1
(Pandey et al., 2011)
Tb+/Tb1 is a suppressor | partially of ventral nerve cord | larval stage phenotype of GlcAT-Pbrv1
(Pandey et al., 2011)
hideNOT Suppressor of
Statement
Reference
Tb+/Tb1 is a non-suppressor of taenidium | larval stage phenotype of Mmp12
(Glasheen et al., 2010)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
A Tb[1] heterozygous background suppresses the ventral nerve cord extension found in GlcAT-P[brv1] homozygous mutant L3 larvae, however, these double mutants still exhibit extension compared to wild-type controls. This demonstrates that the ventral nerve cord extension correlates with the total length of the larva, suggesting that in GlcAT-P[brv1] mutants the ventral nerve cord expands as a consequence of increased tension from shorter peripheral nerves or trachea, possibly due to some growth retardation of larval peripheral nerves or trachea.
(Pandey et al., 2011)
One copy of Tb[1] in a Mmp1[2] mutant background partially rescues the tracheal break phenotype seen in Mmp1[2] homozygotes (55% of larva have tracheal breaks compared to 93%). The angle between the transverse connective and the dorsal trunk is reduced in Tb[1] Mmp1[2] double mutants compared to homozygous Mmp1[2] mutants but is still greater than in wild type. No homozygous Mmp1[2] larvae survive to pupariation, whereas 29% of Tb[1] Mmp1[2] double mutants survive beyond the larval stages. The failure of the taenidial distance to increase from the early to late third instar stages that is seen in Mmp1[2] mutants is still present in flies that also carry one copy of Tb[1].
(Glasheen et al., 2010)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Comments
hide Stocks ( 3053 )
Bloomington
624
Tb1
1794
TM1/TM6B, Tb1
2182
Df(3R)CP1/TM6B, Tb1
6548
Df(3L)XG1/TM6B, Tb1
7295
Df(3L)3C7/TM6B, Tb1
6556
Df(3L)XG12/TM6B, Tb1
7002
Df(3L)1-16/TM6B, Tb1
1917
Df(3R)red3l/TM6B, Tb1
Kyoto
106732
Df(3R)CP1/TM6B, Tb1
106780
Df(3R)Cha7/TM6B, Tb1
108428
Df(3R)GC14/TM6B, Tb1
107131
Df(3L)kto2/TM6B, Tb1
hide Notes on Origin
Discoverer
Auerbach.
hide Comments
"nitrogen mustard" was stated as tentative.
(Craymer, 1980)
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym
Tb
(Glasheen et al., 2010)
Tb1
(Guan, 2006, Guan et al., 2006, Pandey et al., 2011, Lattao et al., 2011)
Name Synonym
Secondary FlyBase IDs
hide References ( 17 )
Research paper
Pina and Pignoni, 2012, genesis 50(2): 119--123
Tubby-RFP Balancers for Developmental Analysis: FM7c 2xTb-RFP, CyO 2xTb-RFP, and TM3 2xTb-RFP. [FBrf0217414]
Lattao et al., 2011, Fly 5(4): 369--370
Tubby-tagged balancers for the Drosophila X and second chromosomes. [FBrf0216878]
Pandey et al., 2011, PLoS ONE 6(11): e28106
The Glucuronyltransferase GlcAT-P Is Required for Stretch Growth of Peripheral Nerves in Drosophila. [FBrf0216828]
Glasheen et al., 2010, Dev. Biol. 344(2): 772--783
A matrix metalloproteinase mediates airway remodeling in Drosophila. [FBrf0211435]
Guan et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(45): 16794--16799
Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. [FBrf0195309]
Basu et al., 1999, J. Cell Biol. 146(1): 13--28
Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. [FBrf0109303]
Craymer, 1980, D. I. S. 55: 197--200
[New mutants report.] [FBrf0063385]
Auerbach, 1943, D. I. S. 17: 48--50
Chemically induced mutations and rearrangements. [FBrf0005917]
Supplementary material
Guan, 2006, Proc. Natl. Acad. Sci. U.S.A. 103(45):
[FBrf0200374]
Personal communication to FlyBase
Beitel, 2007.4.20, P{Dfd-GMR-nvYFP} insertions and balancer variants.
P{Dfd-GMR-nvYFP} insertions and balancer variants. [FBrf0197896]
Beitel, 2005.3.25, P{Dfd-EYFP}3 insertion.
P{Dfd-EYFP}3 insertion. [FBrf0182566]
Beitel, 2004.9.21, Info from Greg Beitel.
Info from Greg Beitel. [FBrf0179869]
Kreber, 2004.7.20, T(2;3)SM6b-TM6B.
T(2;3)SM6b-TM6B. [FBrf0178900]
Bloomington Drosophila Stock Center, 2001.8.28, Balancer Variants.
Balancer Variants. [FBrf0138610]
Bloomington Drosophila Stock Center, 1999.7.19, New TM6C balancer for curation.
New TM6C balancer for curation. [FBrf0109360]
FlyBase analysis
FlyBase Curators, 2006-, Balancer summary information.
Balancer summary information. [FBrf0189689]
Book
Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
The Genome of Drosophila melanogaster. [FBrf0066905]