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General Information
Symbol
Dmel\tkv1
Species
D. melanogaster
Name
FlyBase ID
FBal0016818
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
tkv1 heterozygous females show the expected mating-induced increase in germline stem cells in the germarium.
tkv1/Df(2L)tkv3 results in thickened wing veins.
mesothoracic tergum & macrochaeta | ectopic tkv1 flies occasionally display ectopic bristles anterior to the anterior dorso-central bristle, when raised at 18oC.
tkv1/tkv7 animals survive until the third larval instar and show a dramatic reduction in neuromuscular junction (NMJ) size compared to wild type. tkv1/tkv8 animals show a significant reduction in neuromuscular junction (NMJ) size compared to wild type; the number of synaptic boutons/muscle surface area at muscle 6/7 is 71.6 +/- 1.9% of wild type. The evoked excitatory junctional potential (EJP) (measured at muscle 6 of segment A3) shows a decrease in amplitude in tkv1/tkv8 animals compared to wild type. Quantal content is reduced compared to wild type.
Heterozygotes show a quantitative effect on wing shape in intervein regions B and C compared to wild type.
tkv1/tkv8 flies have variable thickening of the wing veins, particularly in regions close to the cross veins and at the distal ends of all longitudinal veins. tkv1/tkv7 flies have some wing vein thickening, and lack distal stretches of vein LIV.
Thickened vein mutant.
Thickening and abnormal branching of the wing veins in the region of intersection with the crossveins and near the ends of the longitudinal veins.
Homozygotes have a weak phenotype, hemizygotes have thickening of longitudinal and transverse veins.
homozygous viable with thick veins Veins thickened and branched in region of crossveins, near end of L2, and elsewhere. Sometimes a blister near posterior crossvein in female; L4 sometimes shortened, especially in female. Female more extreme than male. Easier to identify at 19oC. RK2.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
tkv1/tkv[+] is an enhancer of visible | dominant phenotype of sogEP11
tkv1/tkv[+] is an enhancer of visible | dominant phenotype of sogEP7
Suppressor of
Statement
Reference
Other
Statement
Reference
NPFRsk8, tkv1/tkv[+] has decreased cell number | oogenesis | oogenesis | conditional phenotype
Phenotype Manifest In
Enhanced by
Statement
Reference
tkv1 has mesothoracic tergum & macrochaeta | ectopic phenotype, enhanceable by pad1
tkv1 has wing vein phenotype, enhanceable by Snr1E1/Snr1E1
tkv1 has wing vein phenotype, enhanceable by Snr1E1/Snr1[+]
tkv1/tkv8 has wing vein phenotype, enhanceable by Nnd-3
Suppressed by
Statement
Reference
tkv1/tkv8 has phenotype, suppressible by dpps4/dpps8
tkv1/tkv8 has wing vein phenotype, suppressible by rhove-1
tkv1/tkv8 has wing vein phenotype, suppressible by NAx-1
Enhancer of
Statement
Reference
tkv1 is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of pad1
tkv1/tkv[+] is an enhancer of wing vein phenotype of sogEP11
tkv1/tkv[+] is an enhancer of wing vein phenotype of sogEP7
tkv1/tkv8 is an enhancer of wing vein | ectopic phenotype of Ras64BAct5C.PC
tkv1/tkv8 is an enhancer of wing vein phenotype of dpps4/dpps8
tkv1/tkv8 is an enhancer of wing vein phenotype of rhohs.PSt
NOT Enhancer of
Statement
Reference
tkv1 is a non-enhancer of wing | somatic clone phenotype of ftk07918
Suppressor of
Statement
Reference
tkv1/tkv7 is a suppressor of eye disc phenotype of spin10403
tkv1/tkv7 is a suppressor of glial cell phenotype of spin10403
tkv1/tkv[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, cswN308D.UASp
tkv1 is a suppressor of eye phenotype of upd1GMR.PB
NOT Suppressor of
Statement
Reference
tkv1 is a non-suppressor of wing | somatic clone phenotype of ftk07918
Other
Additional Comments
Genetic Interactions
Statement
Reference
NPFRsk8, tkv1 double heterozygous females fail to show the expected mating-induced increase in germline stem cells in the germarium, as compared to heterozygous controls.
The glial overmigration phenotype seen in spin10403 eye discs is significantly suppressed if the animals are also carrying tkv1/tkv7.
tkv1 pad1 double mutants show an enhanced ectopic bristle phenotype compared to either single mutant; there are particularly more ectopic bristles present around the presutal suture.
The tkv1/tkv1 wing vein phenotype is enhanced by Snr1E1/+ at 25oC, and is further enhanced by Snr1E1/Snr1E1 at 25oC.
The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpps4 tkv1/dpps8 tkv8 double mutant flies. rhove-1 suppresses the differentiation of thicker veins seen in tkv1/tkv8 flies. The differentiation of thicker veins seen in rhohs.PSt flies is strongly increased in combination with tkv1/tkv8. The ectopic vein phenotype of Ras64BAct5C.PC flies is increased in combination with tkv1/tkv8. tkv1/tkv8 NAx-1 double mutant flies show pronounced wing vein loss. The thickening of veins seen in tkv1/tkv8 flies is strongly enhanced in combination with Nnd-3 and is suppressed in combination with NAx-1.
shn1 enhances the wing vein thickening of tkv1/Df(2L)tkv2. Some tkv1/Df(2L)tkv2, shn1 flies are missing terminal leg claws.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Nichols-Skoog, 25th Feb. 1933.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
References (23)