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General Information
Symbol
Dmel\tkv6
Species
D. melanogaster
Name
FlyBase ID
FBal0016823
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
tkvSz15
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G5221401A

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Splice acceptor mutation of CAG to CAA, affecting C75 and K76 (figure 1).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Splice acceptor mutation of CAG to CAA, in the extracellular domain.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes have thickened wing veins. All other imaginal disc-derived structures appear normal. tkv6/Df(2L)tkv2 flies are phenotypically identical to tkv6 homozygotes. tkvD17/tkv6 flies have defects in the notum and legs. tkv6/tkv6 embryos form three midgut constrictions.

Clones within an adult wing that intersects the margin causes formation of triple row in an area that normally produces dorsal row.

Homozygotes display weak head defects, wrinkled dorsal epidermis and internalised and often disorganised filzkorper. Lethal when heterozygous with tkv4, tkv5, tkv7 and tkv8, but not with Df(2L)tkv2. Female transheterozygotes with Df(2L)tkv2 are viable and display a wing phenotype, wing veins are very thick and short along the proximal distal axis, transheterozygotes with Df(2L)tkv3 display wing veins that are very thick and short along the proximal distal axis. Adult Df(2L)tkv3/tkv6 and tkv1/tkv6 females lay eggs, some of the embryos from these females crossed to wild type males die showing a weakly ventralised phenotype.

Viable with strong tkv phenotype over Tp(2;3)tkv (Szidonya and Reuter, 1988). homozygous lethal; hemizygous viable with thick veins;

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

tkv6 has phenotype, enhanceable by put135

Enhancer of
Statement
Reference
Other
Statement
Reference

shn1, tkv6 has leg phenotype

Additional Comments
Genetic Interactions
Statement
Reference

shn1 dominantly enhances the wing vein defects of tkv6 flies, and also produces defects in proximal/distal patterning of the leg in these flies; distal elements such as claws and distal tarsal segments are deleted in tkv6 shn1; tkv6 flies. The phenotype is dominantly enhanced by E(tkv)D1D1 or E(tkv)D2D2; tkv6 flies carrying one copy of E(tkv)D1D1 or E(tkv)D2D2 have defects in the notum. The phenotype is dominantly enhanced by MadD3, MadD14, MadD15, MadD16, MadD24, gbbD4, gbbD8, gbbD20, MedD5, putD13 or putD18; tkv6 flies carrying one copy of MadD3, MadD14, MadD15, MadD16, MadD24, gbbD4, gbbD8, gbbD20, MedD5, putD13 or putD18 have defects in the notum and legs. No interaction with dpps5, shn1, sax5, MadP1, MadP1 or put135 is seen in double heterozygous flies. tkv6 gbbD4/tkv6 gbbD8 embryos form only one midgut constriction. gbbD4/tkv6 gbbD8 embryos have head defects and an excessive ventral curvature. gbbD4/tkv6 gbbD8 embryos derived from homozygous tkv6 females have a dorsal open phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Szidonya.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)