FlyBase Allele Report: Dmel\tkv[7]

Third instar larvae heterozygous for tkv⁷ show no significant differences in the number or size of neuromuscular junction boutons compared to wild-type controls.

(Zhang et al., 2017)

The neuromuscular junction synapses of homozygous tkv⁷/tkv^k16713 mutants are undergrown but the total number of boutons is similar to heterozygous controls.

(Zhao et al., 2015)

tkv⁷/+ mutant wings show thickened, bifurcated L2, L3 and L4 veins, and incomplete anterior crossveins.

(Dahal et al., 2012)

The anterior and posterior crossveins are absent and the distal end of vein L4 is lost in tkv⁴²⁷/tkv⁷ wings.

(Liu et al., 2011)

tkv¹/tkv⁷ animals survive until the third larval instar and show a dramatic reduction in neuromuscular junction (NMJ) size compared to wild type.

(McCabe et al., 2004)

The average number of crystal cells per embryo is significantly reduced in homozygous stage 13-14 embryos compared to wild type.

(Milchanowski et al., 2004)

When homozygous clones are made in the developing wing disc, clones in the medial wing pouch survive 36 hours, but are lost within 48 hours of induction. In lateral areas survival is greater, but clones are still small compared to wild-type twin spots. When homozygous tkv⁷ wing discs are made (in a Minute background) about 30% of discs show an aberrant morphology. tkv⁷ cells show a cell cycle profile with a very reduced S phase fraction, and an increased G1 fraction. However, mutant cells are not detectably different in size to controls.

(Martin-Castellanos and Edgar, 2002)

tkv^k16713/tkv⁷ larvae show a significant decrease in bouton number at the neuromuscular junction.

(Sweeney and Davis, 2002)

tkv⁷/tkv⁴²⁷ flies have ectopic vein fragments around the distal part of vein L2. Does not suppress the phenotype caused by tkv^CA.Scer\UAS expressed under the control of Scer\GAL4^71B.

(Adachi-Yamada et al., 1999)

A fraction of tkv⁷/tkv⁴²⁷ flies show a small notching of the wing tip. The number of dying cells in the late third larval instar tkv⁷/tkv⁴²⁷ wing disc is increased compared to wild type; a cluster of dying cells appears in the primordial wing tip.

(Adachi-Yamada et al., 1999)

The Malpighian tubules of homozygous embryos elongate properly to the two cell circumference, although they are located abnormally in the embryo, coiling around their point of origin from the hindgut.

(Jack and Myette, 1999)

Eggs from tkv⁷/tkv³ females fertilised with tkv⁷ sperm develop into ventralised embryos comparable to a dpp null mutant.

(Jazwinska et al., 1999)

Homozygous clones induced in the pleura cause no mutant phenotype.

(Kopp et al., 1999)

Eggs laid by tkv⁷/+ show 97.2% wild type dorsal appendages, 0.5% broad dorsal appendages and short egg length, 05% broad dorsal appendages and normal egg length and 1.9% abnormal dorsal appendages with short egg length.

(Mantrova et al., 1999)

Epidermal cells initially appear to elongate normally in dorsal closure, but their migration becomes directed in an anterior-posterior direction, instead of dorsally. Cells of several segments are drawn together into points of focus in regions of the leading edge, pulling the intervening segments apart. This results in epidermal bunching. The embryos have a dorsal open phenotype.

(Ricos et al., 1999)

Many tracheal dorsal branches are reduced or absent in the embryo. Where dorsal branches do form they never fuse.

(Steneberg et al., 1999)

Embryos derived from a cross of tkv³/tkv⁷ females to tkv⁷ Df(2L)OD16/+ males differentiate 3 classes of cuticle; 25% (of putative genotype tkv⁷/tkv⁷ Df(2L)OD16) have a phenotype identical to that of dpp null mutants, 25% (of putative genotype tkv³/tkv⁷ Df(2L)OD16) are ventralised with expansion of ventral denticle bands and internalised fusion of the filzkorper, and the remaining embryos (which contain a wild-type copy of tkv) differentiate more weakly ventralised cuticles. Injection of embryos derived from a cross of tkv³/tkv⁷ females to tkv⁷ Df(2L)OD16/+ males with sax::tkv^{sax.EC.tkv.IC} RNA rescues amnioserosa formation in 91% of embryos that contain a paternal copy of tkv⁷. Injection of embryos derived from a cross of tkv⁷ Df(2L)OD16/tkv³ females to tkv⁷ Df(2L)OD16/+ males with sax::tkv^{sax.EC.tkv.IC} RNA results in 53% of embryos with restored amnioserosa formation and 47% of embryos without amnioserosa formation.

(Neul and Ferguson, 1998)

Homozygous embryos derived from tkv⁷/tkv³ females lack the dorsal vessel.

(Yin and Frasch, 1998)

Tracheal tree defects consisting mainly of a failure to develop some particular branches in the dorsoventral axis. Other tracheal branches form in the anteroposterior axis, though they display an occasional gap.

(Llimargas and Casanova, 1997)

tkv¹/tkv⁷ flies have some wing vein thickening, and lack distal stretches of vein LIV.

(de Celis, 1997)

P{tkv^Brk25D1} has suboptimal levels of expression sufficient to rescue the lethality of tkv⁷/Df(2L)tkv2 through embryonic and larval development. Rescued adults display defects in the wing (cleft in the notum and reduction/deletion of the scutellum) and leg (duplication of ventral structures and loss of dorsal and distal structures) patterning.

(Morimura et al., 1996)

Thickened vein mutant.

(Sturtevant and Bier, 1995)

Heterozygous females that are also heterozygous for dpp^hr56 or dpp^hr27, show markedly reduced viability (for dpp^hr56) or lethality (for dpp^hr27). The enhancement of the mutant phenotype extends to the phenotype of the embryos produced. Transheterozygotes of tkv⁷ and sax¹ are virtually sterile.

(Nellen et al., 1994)

The presence of tkv⁷ in the mother causes dpp^hr27 to behave as a dominant lethal in the zygote.

(Penton et al., 1994)

Homozygotes display dorsally open cuticle, severe defective head and contracted epidermis giving the cuticle a rounded appearance. Lethal when heterozygous with tkv⁶. Female transheterozygotes with tkv¹ are viable and display a wing phenotype, portions of veins and crossveins are lost, transheterozygotes with Df(2L)tkv3 display extremely thickened veins. Adult Df(2L)tkv3/tkv⁷ females lay eggs, embryos from these females crossed to wild type males die showing a moderately ventralised phenotype.

(Terracol and Lengyel, 1994)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tkv⁷/tkv⁴²⁷ has visible phenotype, enhanceable by puc^E69

(Adachi-Yamada et al., 1999)

tkv⁷/tkv⁴²⁷ has visible phenotype, enhanceable by hep^CA

(Adachi-Yamada et al., 1999)

NOT Enhanced by

Statement

Reference

tkv⁷ has increased cell death | embryonic stage phenotype, non-enhanceable by raw¹

(Yang and Su, 2011)

NOT suppressed by

Statement

Reference

tkv⁷ has increased cell death | embryonic stage phenotype, non-suppressible by raw¹

(Yang and Su, 2011)

Enhancer of

Statement

Reference

tkv⁷ is an enhancer of increased occurrence of cell division | adult stage | conditional phenotype of Mov10¹⁸/Mov10^KO.tdTomato

(Takemura et al., 2021)

tkv⁷/tkv[+] is an enhancer of visible | adult stage phenotype of Irk2^UAS.cDa, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

tkv⁷/tkv[+] is an enhancer of visible | adult stage phenotype of Irk2^DN.UAS, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

NOT Enhancer of

Statement

Reference

tkv⁷/tkv[+] is a non-enhancer of visible phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

Suppressor of

Statement

Reference

tkv⁷ is a suppressor | partially of increased size | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

tkv⁷/tkv[+] is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

tkv⁷/tkv[+] is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

tkv⁷/tkv[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Nlg4^UAS.cZa, Scer\GAL4^elav.PU

(Zhang et al., 2017)

tkv⁷/tkv[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rab8¹/Rab8^B229

(West et al., 2015)

tkv^k16713/tkv⁷ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rab8¹/Rab8^B229

(West et al., 2015)

tkv⁷/tkv[+] is a suppressor of abnormal neuroanatomy | larval stage phenotype of Acsl⁰⁵⁸⁴⁷/Acsl^KO

(Liu et al., 2014)

tkv⁷/tkv[+] is a suppressor of abnormal neuroanatomy phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv⁷/sax^KG07525 is a suppressor of abnormal neuroanatomy phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv¹/tkv⁷ is a suppressor of abnormal neuroanatomy phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv^k16713/tkv⁷ is a suppressor of abnormal neuroanatomy phenotype of spict^mut

(Wang et al., 2007)

tkv⁷/tkv[+] is a suppressor | partially of abnormal neuroanatomy phenotype of spict^mut

(Wang et al., 2007)

tkv⁷/tkv[+] is a suppressor | partially of visible phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Bangi and Wharton, 2006)

tkv⁷/tkv[+] is a suppressor of visible phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Bangi and Wharton, 2006)

tkv⁷/tkv[+] is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

tkv⁷/tkv[+] is a suppressor of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

tkv^k16713/tkv⁷ is a suppressor of abnormal neuroanatomy phenotype of spin^k09905/spin¹⁰⁴⁰³

(Sweeney and Davis, 2002)

tkv⁷/tkv[+] is a suppressor of abnormal neuroanatomy phenotype of spin^k09905/spin¹⁰⁴⁰³

(Sweeney and Davis, 2002)

NOT Suppressor of

Statement

Reference

tkv⁷/tkv[+] is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of brat^2L-192-9/brat¹¹

(Shi et al., 2013)

Other

Statement

Reference

myd[+]/myd^3PM71, tkv⁷ has abnormal flight phenotype

(Sidisky et al., 2021)

Nlg4^KO10, tkv⁷/tkv[+] has abnormal neuroanatomy | third instar larval stage phenotype

(Zhang et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

tkv⁷/tkv⁴²⁷ has wing phenotype, enhanceable by puc^E69

(Adachi-Yamada et al., 1999)

tkv⁷/tkv⁴²⁷ has wing disc phenotype, enhanceable by puc^E69

(Adachi-Yamada et al., 1999)

tkv⁷/tkv⁴²⁷ has wing phenotype, enhanceable by hep^CA

(Adachi-Yamada et al., 1999)

Suppressed by

Statement

Reference

tkv⁷ has embryo | dorsal closure stage phenotype, suppressible by Ack^UAS.cSa/Scer\GAL4^hs.PB

(Zahedi et al., 2008)

tkv⁷ has embryo | dorsal closure stage phenotype, suppressible by Ack^UAS.cSa/Scer\GAL4^c381

(Zahedi et al., 2008)

puc^E69/puc[+], tkv⁷/tkv⁴²⁷ has wing disc phenotype, suppressible by hep^r75

(Adachi-Yamada et al., 1999)

puc^E69, tkv⁷/tkv⁴²⁷ has wing disc phenotype, suppressible by hep^r75

(Adachi-Yamada et al., 1999)

tkv⁷ has embryo | dorsal closure stage phenotype, suppressible by Scer\GAL4^hs.PB/Cdc42^V12.UAS

(Ricos et al., 1999)

Enhancer of

Statement

Reference

tkv⁷ is an enhancer of adult midgut | conditional phenotype of Mov10¹⁸/Mov10^KO.tdTomato

(Takemura et al., 2021)

tkv⁷/tkv[+] is an enhancer of wing phenotype of Irk2^DN.UAS, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

NOT Enhancer of

Statement

Reference

tkv⁷/tkv[+] is a non-enhancer of eye phenotype of Caf1-105^NIG.12892R, Scer\GAL4^ey.PH

(Yu et al., 2013)

tkv⁷/tkv[+] is a non-enhancer of wing vein phenotype of Irk2^UAS.cDa, Scer\GAL4^Bx-MS1096

(Dahal et al., 2012)

tkv⁷ is a non-enhancer of embryo | dorsal phenotype of raw¹

(Yang and Su, 2011)

tkv⁷/tkv[+] is a non-enhancer of dorsal appendage phenotype of bwk¹⁵¹, cic⁰⁸⁴⁸²

(Tran and Berg, 2003)

Suppressor of

Statement

Reference

tkv⁷ is a suppressor | partially of wing disc anterior compartment | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

tkv⁷/tkv[+] is a suppressor | partially of wing vein phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

tkv⁷/tkv[+] is a suppressor | partially of wing phenotype of Scer\GAL4^A9, anchor^GD3613

(Wang et al., 2018)

tkv⁷/tkv[+] is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Nlg4^UAS.cZa, Scer\GAL4^RapGAP1-OK6

(Zhang et al., 2017)

tkv⁷/tkv[+] is a suppressor | partially of germarium phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

tkv⁷/tkv[+] is a suppressor | partially of spectrosome phenotype of Cul2^GD8913, Scer\GAL4^ptc.PU

(Ayyub et al., 2015)

tkv⁷/tkv[+] is a suppressor of NMJ bouton | third instar larval stage phenotype of Rab8¹/Rab8^B229

(West et al., 2015)

tkv^k16713/tkv⁷ is a suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rab8¹/Rab8^B229

(West et al., 2015)

tkv^k16713/tkv⁷ is a suppressor of NMJ bouton | third instar larval stage phenotype of Rab8¹/Rab8^B229

(West et al., 2015)

tkv⁷/tkv[+] is a suppressor of embryonic/larval neuromuscular junction phenotype of S6KL¹⁴⁰

(Zhao et al., 2015)

tkv⁷/tkv[+] is a suppressor of NMJ bouton | increased number phenotype of S6KL¹⁴⁰

(Zhao et al., 2015)

tkv⁷/tkv[+] is a suppressor of neuromuscular junction phenotype of Acsl⁰⁵⁸⁴⁷/Acsl^KO

(Liu et al., 2014)

tkv⁷/tkv[+] is a suppressor of NMJ bouton | increased number phenotype of Acsl⁰⁵⁸⁴⁷/Acsl^KO

(Liu et al., 2014)

tkv⁷/tkv[+] is a suppressor of larval abdominal 2 neuron phenotype of Acsl⁰⁵⁸⁴⁷/Acsl^KO

(Liu et al., 2014)

tkv⁷/tkv[+] is a suppressor of larval abdominal 3 neuron phenotype of Acsl⁰⁵⁸⁴⁷/Acsl^KO

(Liu et al., 2014)

tkv⁷/tkv[+] is a suppressor of wing vein phenotype of Ctdnep1^G0269

(Liu et al., 2011)

tkv⁷/tkv[+] is a suppressor of eye disc phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv⁷/tkv[+] is a suppressor of glial cell phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv⁷/sax^KG07525 is a suppressor of eye disc phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv⁷/sax^KG07525 is a suppressor of glial cell phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv¹/tkv⁷ is a suppressor of eye disc phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv¹/tkv⁷ is a suppressor of glial cell phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv^k16713/tkv⁷ is a suppressor of embryonic/larval neuromuscular junction phenotype of spict^mut

(Wang et al., 2007)

tkv⁷/tkv[+] is a suppressor | partially of embryonic/larval neuromuscular junction phenotype of spict^mut

(Wang et al., 2007)

tkv⁷/tkv[+] is a suppressor | partially of wing vein phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Bangi and Wharton, 2006)

tkv⁷/tkv[+] is a suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Bangi and Wharton, 2006)

tkv⁷/tkv[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

tkv⁷/tkv[+] is a suppressor of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

tkv⁷ is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li and Li, 2003)

tkv⁷/tkv[+] is a suppressor of bouton | increased number phenotype of spin^k09905/spin¹⁰⁴⁰³

(Sweeney and Davis, 2002)

tkv^k16713/tkv⁷ is a suppressor of bouton | increased number phenotype of spin^k09905/spin¹⁰⁴⁰³

(Sweeney and Davis, 2002)

tkv⁷/tkv[+] is a suppressor of neuromuscular junction phenotype of spin^k09905/spin¹⁰⁴⁰³

(Sweeney and Davis, 2002)

tkv^k16713/tkv⁷ is a suppressor of neuromuscular junction phenotype of spin^k09905/spin¹⁰⁴⁰³

(Sweeney and Davis, 2002)

NOT Suppressor of

Statement

Reference

tkv⁷/tkv[+] is a non-suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of DAAM^Ex68

(Migh et al., 2018)

tkv⁷/tkv[+] is a non-suppressor of NMJ bouton | larval stage phenotype of DAAM^Ex68

(Migh et al., 2018)

tkv⁷/tkv[+] is a non-suppressor of larval LL1 motor neuron | larval stage phenotype of DAAM^Ex68

(Migh et al., 2018)

tkv⁷/tkv[+] is a non-suppressor of NMJ bouton | increased number | third instar larval stage phenotype of brat^2L-192-9/brat¹¹

(Shi et al., 2013)

tkv⁷ is a non-suppressor of embryo | dorsal phenotype of raw¹

(Yang and Su, 2011)

tkv⁷/tkv[+] is a non-suppressor of dorsal appendage phenotype of bwk¹⁵¹, cic⁰⁸⁴⁸²

(Tran and Berg, 2003)

tkv⁷ is a non-suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

Other

Statement

Reference

Nlg4^KO10, tkv⁷/tkv[+] has NMJ bouton | third instar larval stage phenotype

(Zhang et al., 2017)

Ack^10b, tkv⁷/tkv[+] has embryo | dorsal closure stage phenotype

(Zahedi et al., 2008)

Mef2⁴²⁴, tkv⁷ has egg phenotype

(Mantrova et al., 1999)

Mef2⁴²⁴, tkv⁷ has dorsal appendage phenotype

(Mantrova et al., 1999)

sax¹, tkv⁷ has egg phenotype

(Twombly et al., 1996)

sax¹, tkv⁷ has dorsal appendage phenotype

(Twombly et al., 1996)

tkv¹/tkv⁷, vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

myd^3PM71/+, tkv⁷/+ double heterozygotes show a decrease in flight ability.

(Sidisky et al., 2021)

Addition of tkv⁷/+ to animals expressing anchor^GD3613 under the control of Scer\GAL4^A9 partially suppresses the thickened wing vein phenotype, but does not suppress the increased wing size phenotype.

(Wang et al., 2018)

The increased bouton and satellite bouton number characteristic for third instar larvae expressing two copies of Nlg4^Scer\UAS.cZa under the control of Scer\GAL4^RapGAP1-OK6 is suppressed by combination with a single copy of tkv⁷.

Although none of the larvae heterozygous for either Nlg4^KO10 or tkv⁷ display any significant difference in the number or size of boutons on neuromuscular junctions compared to controls, tkv⁷/+;Nlg4^KO10/+ double heterozygotes all show reduced bouton number and increased bouton size.

(Zhang et al., 2017)

The increased number of spectrosome-containing cells in germaria characteristic for adult females expressing Cul2^GD8913 RNAi under the control of the Scer\GAL4^ptc.PU can be partially rescued by combination with either dpp^hr92, dpp^hr56 or tkv⁷ in a heterozygous state or by knocking-down dpp by co-expression of either dpp^JF01090 or dpp^JF01091 RNAi.

(Ayyub et al., 2015)

When present in the genetic background, heterozygous tkv⁷ reduces the synaptic overgrowth in Rab8¹/Rab8^B229 mutants.

When present in the genetic background, trans-heterozygous tkv⁷/tkv^k16713 reduces the synaptic overgrowth in Rab8¹/Rab8^B229 mutants.

(West et al., 2015)

One copy of tkv⁷ completely suppresses the increase in total bouton number seen in S6KL¹⁴⁰ mutants.

(Zhao et al., 2015)

tkv⁷/+ significantly suppresses synaptic overgrowth of Acsl⁰⁵⁸⁴⁷/Acsl^KO mutants.

(Liu et al., 2014)

The neuromuscular junction overgrowth phenotype (increased total number of boutons and increased number of satellite boutons) of brat¹¹/brat^2L-192-9 larvae is not suppressed by tkv⁷/+.

(Shi et al., 2013)

One copy of tkv⁷ does not enhance the small eye phenotype seen when Caf1-105^NIG.12892R is expressed under the control of Scer\GAL4^ey.PH.

(Yu et al., 2013)

One copy of tkv⁷ enhances the wing defects seen when Irk2^DN.Scer\UAS is expressed under the control of Scer\GAL4^Bx-MS1096. Total wing defects in females expressing the P{UAS-Irk2.DN}5.2 insertion line are increased from 46% to 72% of wings. Total wing defects in females expressing the stronger P{UAS-Irk2.DN}5.1 line are increased from 94% to 99% of wings.

One copy of tkv⁷ does not enhance the wing vein defects seen when Irk2^Scer\UAS.cDa is expressed under the control of Scer\GAL4^Bx-MS1096.

(Dahal et al., 2012)

The aberrant wing vein phenotype seen in Dd^G0269/Y animals is suppressed by tkv⁷/+.

(Liu et al., 2011)

The glial overmigration phenotype seen in spin¹⁰⁴⁰³ eye discs is significantly suppressed if the animals are also heterozygous for tkv⁷.

The glial overmigration phenotype seen in spin¹⁰⁴⁰³ eye discs is significantly suppressed if the animals are also carrying tkv⁷/sax^KG07525 or tkv¹/tkv⁷.

(Yuva-Aydemir et al., 2011)

The defects in dorsal closure seen in homozygous tkv⁷ embryos are partially suppressed by expression of Ack^Scer\UAS.cSa under the control of either Scer\GAL4^c381 or Scer\GAL4^hs.PB.

tkv⁷/+ ; Ack^10b/Ack^10b embryos show dorsal closure defects at a relatively low frequency, but which is significantly higher than the frequency seen in either tkv⁷/+ or Ack^10b/Ack^10b single mutant embryos.

(Zahedi et al., 2008)

spict^mut neuromuscular junction overgrowth phenotypes are fully suppressed in tkv⁷/tkv^k16713 mutants. The synaptic undergrowth phenotypes in larvae homozygous for spict^mut in a tkv⁷/tkv^k16713 background are indistinguishable from that of tkv⁷/tkv^k16713 mutants alone. In addition, a heterozygous tkv⁷ background partially suppresses the neuromuscular junction expansion of spict^mut larvae.

(Wang et al., 2007)

Expression of gbb^Scer\UAS.cKa, under the control of Scer\GAL4^A9, in a tkv⁷/+ background suppresses the extra wing vein phenotype of Scer\GAL4^A9>gbb^Scer\UAS.cKa flies. Around 80% of Scer\GAL4^A9>gbb^Scer\UAS.cKa; tkv⁷/+ wings show a very mild vein phenotype, while around 20% appear wild type.

A tkv⁷/+ background strongly suppresses the wing phenotype of Scer\GAL4^A9>@dpp^Scer\UAS.cHa

@ flies so that almost 50% of wings appear wild type.

(Bangi and Wharton, 2006)

The mutant dorsal appendage phenotype seen in bwk¹⁵¹/bwk⁰⁸⁴⁸² eggs is not significantly modified by tkv⁷/+.

(Tran and Berg, 2003)

One copy of tkv⁷ suppresses the increased bouton number seen at the neuromuscular junction in spin¹⁰⁴⁰³/spin^k09905 animals. spin¹⁰⁴⁰³/spin^k09905 animals which are also mutant for tkv⁷/tkv^k16713 show a further decrease in bouton number.

(Sweeney and Davis, 2002)

The tkv⁷/tkv⁴²⁷ wing phenotype is significantly enhanced by a single copy of puc^E69 or hep^CA, and in the case of hep^CA a wide region of the wing blade is lost, leaving only the base of the wing. The appearance of the apoptotic cluster in the wing discs of tkv⁷/tkv⁴²⁷ larvae is more apparent if the larvae are also heterozygous for puc^E69. The appearance of the cluster of apoptotic cells is suppressed in hep^r75/Y ; tkv⁷/tkv⁴²⁷ ; puc^E69/+ larvae.

(Adachi-Yamada et al., 1999)

Eggs laid by Mef2⁴²⁴/tkv⁷ females show 48.3% wild type dorsal appendages, 11.6% reduced dorsal appendages, 21.5% broad dorsal appendages and short egg length, 2.9% broad dorsal appendages and normal egg length, 12.2% abnormal dorsal appendages with short egg length and 1.2% cup-like eggs with no dorsal appendages and cup-like shape.

(Mantrova et al., 1999)

The dorsal closure phenotypes of tkv⁷ embryos are rescued by Cdc42^V12.Scer\UAS expressed under the control of Scer\GAL4^hs.PB.

(Ricos et al., 1999)

Does not suppress the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

42% of the eggs produced by tkv⁷/sax¹ females have reduced dorsal appendages and 31% are short with fused appendages. The opercula are shifted towards the anterior pole, and appear to lack normal follicle cell imprint patterns.

(Twombly et al., 1996)

tkv⁴, tkv⁵, tkv⁷, tkv⁴²⁷ and Df(2L)tkv2 fail to complement dpp short vein alleles for the wing vein defect.

(Penton et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tkv^xtr

(Gibson and Perrimon, 2005)

Rescued by

tkv⁸/tkv⁷ is rescued by tkv^Ubi-p63E.PB

(Brummel et al., 1994)

Comments

tkv^Ubi-p63E.PB rescues the inviable mutant phenotype of tkv⁷/tkv⁸.

(Brummel et al., 1994)

Allelism with tkv indicated by location, failure to complement lethal and viable tkv alleles and thick vein and abnormal thorax phenotype over Tp(2;3)tkv (Szidonya and Reuter, 1988).

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

3242

tkv⁷ cn¹ bw¹ speck¹/CyO

98445

w^*; tkv⁷ P{neoFRT}40A/In(2LR)Gla, wg^Gla-1 PPO1^Bc Egfr^E1

Kyoto

106937

tkv⁷ cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Nusslein-Volhard.

Comments

Null allele.

(Horsfield et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Tkv⁷

(Sidisky et al., 2021, West et al., 2015)

str^IO

(Tearle and Nusslein-Volhard, 1987)

tkv7

(Zhang et al., 2017)

tkv^IO78

(Sturtevant and Bier, 1995)

tkv^IO

(Yin and Frasch, 1998, de Celis, 1997, Terracol and Lengyel, 1994)

tkv^O1

(Jazwinska et al., 1999)

tkv^str-I

(Eulenberg and Schuh, 1997, Affolter et al., 1994, Nellen et al., 1994)

tkv^strID

(Ricos et al., 1999, Jiang and Struhl, 1996)

tkv^strl

(Marty et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (78)

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