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Allele Dmel\tkv⁸

General Information
Symbol	Dmel\tkv8	Species	D. melanogaster
Name		FlyBase ID	FBal0016825
Feature type	allele	Associated gene	Dmel\tkv
Also Known As	tkvstrII, tkvstr-II, tkv-, tkvIIB, tkvIIB09
Map ( GBrowse )
Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Nellen et al., 1994, Burke and Basler, 1996) loss of function allele (de Celis, 1997, Vincent et al., 1997, Riesgo-Escovar and Hafen, 1997)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987, Terracol and Lengyel, 1994)
Mutations Mapped to the Genome
Type Location Additional Notes References point mutation 2L:5,221,353..5,221,353 reported_pr_change=C144@ comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=C5221353A pr_change=C156|tkv-PC,C112|tkv-PB,C90|tkv-PD,C144|tk v-PA (Nellen et al., 1994)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: C144@. The predicted product terminates immediately N-terminal to the conserved cysteine cluster in the extracellular domain. (Nellen et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (de Celis, 1997) lethal | embryonic stage (Terracol and Lengyel, 1994) lethal | embryonic stage | recessive (Affolter et al., 1994) mitotic cell cycle defective | somatic clone (Vrailas and Moses, 2006) neuroanatomy defective (with tkv1) (McCabe et al., 2004) neurophysiology defective (with tkv1) (McCabe et al., 2004) viable (with tkv1) (McCabe et al., 2004)
Phenotype Manifest In
	adult head & cuticle | somatic clone (Burke and Basler, 1996) adult midgut precursor cell | somatic clone (Mathur et al., 2010) amnioserosa (Wada et al., 2007) bouton (with tkv1) (McCabe et al., 2004) cephalopharyngeal skeleton (Affolter et al., 1994) embryonic/first instar larval cuticle (Terracol and Lengyel, 1994) embryonic/first instar larval cuticle | dorsal (Torres-Vazquez et al., 2001, Simin et al., 1998) embryonic/larval dorsal branch (Wappner et al., 1997, Llimargas and Casanova, 1999) embryonic/larval dorsal branch 1 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 2 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 3 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 4 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 5 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 6 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 7 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 8 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 9 | embryonic stage (Affolter et al., 1994) embryonic/larval dorsal branch 10 | embryonic stage (Affolter et al., 1994) embryonic/larval lateral trunk (Wappner et al., 1997) embryonic/larval lateral trunk | embryonic stage (Affolter et al., 1994) embryonic/larval trachea (Llimargas and Casanova, 1999, Llimargas and Casanova, 1997) embryonic/larval tracheal system (Vincent et al., 1997) embryonic dorsal epidermis (Riesgo-Escovar and Hafen, 1997, Affolter et al., 1994, Wada et al., 2007) embryonic epidermis (Terracol and Lengyel, 1994) embryonic head (Terracol and Lengyel, 1994, Simin et al., 1998) eye | somatic clone (Burke and Basler, 1996) eye disc | somatic clone (Vrailas and Moses, 2006) eye photoreceptor cell | somatic clone (Burke and Basler, 1996) female germline stem cell (Xie and Spradling, 1998) female germline stem cell | somatic clone (Zhu and Xie, 2003) filamentous actin (Wada et al., 2007) ganglionic branch 0 | embryonic stage (Affolter et al., 1994) ganglionic branch 1 | embryonic stage (Affolter et al., 1994) ganglionic branch 2 | embryonic stage (Affolter et al., 1994) ganglionic branch 3 | embryonic stage (Affolter et al., 1994) ganglionic branch 4 | embryonic stage (Affolter et al., 1994) ganglionic branch 5 | embryonic stage (Affolter et al., 1994) ganglionic branch 6 | embryonic stage (Affolter et al., 1994) ganglionic branch 7 | embryonic stage (Affolter et al., 1994) ganglionic branch 8 | embryonic stage (Affolter et al., 1994) ganglionic branch 9 | embryonic stage (Affolter et al., 1994) gastric caecum (Affolter et al., 1994) male germline stem cell | germline clone (Kawase et al., 2004) midgut constriction 2 (Affolter et al., 1994) neuromuscular junction (with tkv1) (McCabe et al., 2004) ommatidium | cell non-autonomous | somatic clone (Burke and Basler, 1996) secondary pigment cell | pupal stage P7 | somatic clone (Cordero et al., 2007) stage 13 embryo (Wada et al., 2007) stage 14 embryo (Wada et al., 2007) stage 15 embryo (Wada et al., 2007) tarsal segment | dorsal (Theisen et al., 1996) tarsal segment | ventral (Theisen et al., 1996) trachea (Affolter et al., 1994) ventral thoracic disc (Kubota et al., 2000) visceral mesoderm & parasegment 7 (Affolter et al., 1994) wing disc (Kubota et al., 2000) wing vein (Sturtevant and Bier, 1995, de Celis, 1997)
Detailed Description
	Statement Reference Clones of tkv[8]-mutant cells cause premature differentiation of the adult midgut precursor cells into large, polyploid, enterocyte-like cells compared with wild-type cells. (Mathur et al., 2010) Clones of tkv[8] homozygous cells in the pupal retina have defects in the apical profiles and packing of secondary pigment cells relative to tertiary pigment cells. Single, isolated tkv[4] homozygous secondary pigment cells in the pupal retina have a restricted apical profile compared to neighbouring wild-type inter-ommatidial cells which expand apically to fill the unoccuppied space. (Cordero et al., 2007) tkv8 mutant embryos show a delay in dorsal closure and rapture of the dorsal epidermis-peripheral amnioserosa interface, along with discontinuation of F-actin accumulation in the leading edge. The mutants also exhibit rupture of the amino serosa-dorsal epidermis interface. In tkv8 mutants the F-actin cable is absent in the peripheral amnioserosa, suggesting that specification is incomplete. Time-lapse recording reveals that the progression and removal of the peripheral amnioserosa is delayed. (Wada et al., 2007) Somatic clones of tkv[8] homozygous cells in the late third instar eye disc are much smaller than wild-type twin spots. However, many of the cells in these clones go on to express neuronal differentiation markers. Mutant cells enter the S phase in the second mitotic wave, but the G2/M transition of this mitosis is disrupted. (Vrailas and Moses, 2006) When neutral marked clones are induced in the ovary, the proportion of germaria carrying marked somatic stem cells 3 weeks after clone induction is around 70% of that seen one week after clone induction. For tkv8 homozygous clones, the equivalent figure is around 25%. However, the number of resulting clones in the ovarian follicle cells is only slightly reduced compared to controls and these clones have no fewer cells than their twin-spots. (Kirilly et al., 2005) Clones of male tkv8 homozygous germline stem cells are still present in only 1.3X% of testes one week after clone induction and none are present two weeks after clone induction. This is in contrast to wild-type control clones, which are present in 82% of testes one week after clone induction and 64% two weeks after clone induction. (Kawase et al., 2004) tkv1/tkv8 animals show a significant reduction in neuromuscular junction (NMJ) size compared to wild type; the number of synaptic boutons/muscle surface area at muscle 6/7 is 71.6 +/- 1.9% of wild type. The evoked excitatory junctional potential (EJP) (measured at muscle 6 of segment A3) shows a decrease in amplitude in tkv1/tkv8 animals compared to wild type. Quantal content is reduced compared to wild type. (McCabe et al., 2004) R8 photoreceptor differentiation is normal in somatic clones of tkv8 mutant cells. (Fu and Baker, 2003) Only 2.5% of ovarioles carry mutant tkv8 germline stem cell (GSC) clones, compared to 11.2% of ovarioles carrying wild-type GSC clones, and many tkv8 GSCs are lost before adulthood. (Zhu and Xie, 2003) Homozygous clones in the adult abdomen do not show any effect on polarity. (Lawrence et al., 2002) Mutant embryos have a "dorsal open" cuticle phenotype. (Torres-Vazquez et al., 2001) Wing discs are lost completely and the number of proximal leg disc cells is reduced in mutant embryos. The leg phenotype is sometimes variable. (Kubota et al., 2000) The dorsal branches of the tracheal system do not develop in homozygous embryos, and the more ventral branches are absent or severely affected. Some tracheal cells invaginate in stage 12 embryos but others remain in an intermediate position between the epidermis and the branches that are formed. (Llimargas and Casanova, 1999) Homozygous embryos show a dorsal-open phenotype, with severe head defects and large holes in the dorsal cuticle. (Simin et al., 1998) Clonal analysis in the germarium reveals that mutant stem cells are lost more rapidly than wild type, though there is no effect on the formation of 16 cell cysts or their subsequent development. Stem cell half life is 0.69 weeks (wild type being 4.6 weeks). Stem cell division rate relative to control is 0.29. (Xie and Spradling, 1998) tkv1/tkv8 flies have variable thickening of the wing veins, particularly in regions close to the cross veins and at the distal ends of all longitudinal veins. (de Celis, 1997) Tracheal tree defects consisting mainly of a failure to develop some particular branches in the dorsoventral axis. Other tracheal branches form in the anteroposterior axis, though they display an occasional gap. (Llimargas and Casanova, 1997) Embryos exhibit a partial dorsal closure phenotype, leading edge cells are extremely elongated but adjacent more ventral epithelial cells fail to stretch. Most dorsal cuticle is turned inwards and the mouth hooks are retained inside the embryo. (Riesgo-Escovar and Hafen, 1997) Dorsal branches of the tracheal system are lacking and ganglion branches and the lateral trunk are severely affected. (Vincent et al., 1997) Mutant embryos show absence of the dorsal branch and lateral trunks. The visceral branch forms normally. (Wappner et al., 1997) Small homozygous clones are observed in the adult eye; photoreceptor differentiation occurs relatively normally, 25% ommatidia are missing one or more photoreceptor cell and the normal precise hexagonal array of the ommatidia is disrupted in the clone and surrounding wild type tissue. Eye is significantly reduced in size or completely missing and the surrounding head cuticle is missing (loss of head cuticle is not caused by put clones). (Burke and Basler, 1996) Dorsal clones induced in second instar larvae in the tarsus convert dorsal cells to ventral or ventrolateral cell fates. Clones often produce outgrowths that include normal neighbours, some of which have been respecified to ventral fates. Ventral clones induced in second instar larvae in the tarsus produce excessive ventral-most structures (peg-like bristles). Tarsal clones cause polarity disruptions in neighbouring normal cells. (Theisen et al., 1996) Thickened vein mutant. (Sturtevant and Bier, 1995) Embryos show a dorsal hole. Parts of the dorsal hypoderm in the trunk region are missing. Cephalopharyngeal skeleton is severely disrupted or absent and its remains are forced out of the body cavity. Embryos fail to form the second midgut constriction, and later the gastric caeca are missing. Visceral mesoderm of parasegment 7 is absent. Tracheal system shows a complete absence of dorsally directed trachea, ganglionic branches and lateral trunk. The remaining tracheal lumen is only established in a rudimentary fashion. (Affolter et al., 1994) Homozygotes display dorsally open cuticle, severe defective head and contracted epidermis giving the cuticle a rounded appearance. Lethal when heterozygous with tkv6. Female transheterozygotes with tkv1 are viable and display a wing phenotype, wing veins are very thick and short along the proximal distal axis, transheterozygotes with Df(2L)tkv3 display extremely thickened wing veins. Adult Df(2L)tkv3/tkv8 females are very weak, possess atrophic ovaries and do not lay eggs in the few days they survive beyond eclosion. (Terracol and Lengyel, 1994) Nondefective in gonad assembly. (Warrior, 1994) homozygous lethal
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference tkv8 has lethal | recessive phenotype, non-enhanceable by lilliunspecified (Su et al., 2001)
Enhancer of
Statement Reference tkv8/tkv[+] is an enhancer of increased cell number | pupal stage phenotype of Scer\GAL4GMR.PF, pyd3.dsRNA.Scer\UAS (Seppa et al., 2008)
Suppressor of
Statement Reference tkv8/tkv[+] is a suppressor of visible | dominant phenotype of sogEP7 (Araujo et al., 2003) tkv8/tkv[+] is a suppressor of visible | dominant phenotype of sogEP11 (Araujo et al., 2003) tkv8/tkv[+] is a suppressor of visible | recessive phenotype of magu2 (Vuilleumier et al., 2010) tkv8/tkv[+] is a suppressor of visible phenotype of Scer\GAL4A9, dppScer\UAS.cHa (Bangi and Wharton, 2006) tkv8/tkv[+] is a suppressor of visible phenotype of Scer\GAL4A9, gbbScer\UAS.cKa (Bangi and Wharton, 2006)
Other
Statement Reference Chc[+]/Chc1, tkv8 has visible | dominant | heat sensitive phenotype (Gonzalez-Gaitan and Jackle, 1999) Chc1, tkv8/tkv[+] has visible | dominant phenotype (Gonzalez-Gaitan and Jackle, 1999) smo3, tkv8 has mitotic cell cycle defective | somatic clone phenotype (Baonza and Freeman, 2005) tkv8, witHA3/wit[+] has neuroanatomy defective | dominant phenotype (McCabe et al., 2004) tkv8/tkv[+], witHA3 has neuroanatomy defective phenotype (McCabe et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference tkv1/tkv8 has wing vein phenotype, enhanceable by Nnd-3 (de Celis, 1997) tkv8 has inter-ommatidial cell | ectopic | pupal stage P7 phenotype, enhanceable by shg[+]/shgR69 (Cordero et al., 2007)
Suppressed by
Statement Reference tkv1/tkv8 has phenotype, suppressible by dpps4/dpps8 (de Celis, 1997) tkv1/tkv8 has wing vein phenotype, suppressible by NAx-1 (de Celis, 1997) tkv1/tkv8 has wing vein phenotype, suppressible by rhove-1 (de Celis, 1997) tkv8 has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by brkXH (Torres-Vazquez et al., 2001)
Enhancer of
Statement Reference tkv1/tkv8 is an enhancer of wing vein | ectopic phenotype of Ras64BAct5C.PC (de Celis, 1997) tkv1/tkv8 is an enhancer of wing vein phenotype of dpps4/dpps8 (de Celis, 1997) tkv1/tkv8 is an enhancer of wing vein phenotype of rhohs.PSt (de Celis, 1997) tkv8/tkv[+] is an enhancer of inter-ommatidial cell | ectopic | pupal stage P7 phenotype of shgR69 (Cordero et al., 2007) tkv8/tkv[+] is an enhancer of inter-ommatidial precursor cell | supernumerary | pupal stage phenotype of Scer\GAL4GMR.PF, pyd3.dsRNA.Scer\UAS (Seppa et al., 2008) tkv8 is an enhancer | somatic clone of photoreceptor cell R8 & eye disc | somatic clone phenotype of smo3 (Fu and Baker, 2003)
Suppressor of
Statement Reference tkv8/tkv[+] is a suppressor of wing phenotype of Scer\GAL4A9, dppScer\UAS.cHa (Bangi and Wharton, 2006) tkv8/tkv[+] is a suppressor of wing vein L5 phenotype of magu2 (Vuilleumier et al., 2010) tkv8/tkv[+] is a suppressor of wing vein phenotype of Scer\GAL4A9, gbbScer\UAS.cKa (Bangi and Wharton, 2006) tkv8/tkv[+] is a suppressor of wing vein phenotype of sogEP7 (Araujo et al., 2003) tkv8/tkv[+] is a suppressor of wing vein phenotype of sogEP11 (Araujo et al., 2003) tkv8 is a suppressor of ventral ectoderm phenotype of brkXH (Torres-Vazquez et al., 2001)
Other
Statement Reference arm2, tkv8 has embryonic/larval tracheal system phenotype (Llimargas, 2000, Llimargas, 2000) brkXH, tkv8 has filzkorper phenotype (Torres-Vazquez et al., 2001, Torres-Vazquez et al., 2001) Chc[+]/Chc1, tkv8 has wing phenotype (Gonzalez-Gaitan and Jackle, 1999) Chc[+]/Chc1, tkv8 has wing vein phenotype (Gonzalez-Gaitan and Jackle, 1999) Chc1, tkv8/tkv[+] has wing phenotype (Gonzalez-Gaitan and Jackle, 1999) Chc1, tkv8/tkv[+] has wing vein phenotype (Gonzalez-Gaitan and Jackle, 1999) put135, tkv8 has tracheal pit phenotype (Wappner et al., 1997, Wappner et al., 1997) Scer\GAL4btl.PS, tkv8, wgScer\UAS.cLa has embryonic/larval dorsal trunk phenotype (Llimargas, 2000, Llimargas, 2000) Scer\GAL4btl.PS, tkv8, wgScer\UAS.cLa has embryonic/larval tracheal system phenotype (Llimargas, 2000, Llimargas, 2000) smo3, tkv8 has eye disc | somatic clone phenotype (Baonza and Freeman, 2005) smo3, tkv8 has photoreceptor cell phenotype (Greenwood and Struhl, 1999, Greenwood and Struhl, 1999) tkv8, witHA3/wit[+] has bouton phenotype (McCabe et al., 2004) tkv8, witHA3/wit[+] has neuromuscular junction phenotype (McCabe et al., 2004) tkv8, witHA3 has bouton phenotype (McCabe et al., 2004) tkv8, witHA3 has neuromuscular junction phenotype (McCabe et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference Heterozygous tkv[8] suppresses the adult wing patterning defects of homozygous magu[2] mutants. (Vuilleumier et al., 2010) One copy of tkv[8] strongly enhances the increase in inter-ommatidial precursor cell number seen when pyd[3.dsRNA.Scer\UAS] is expressed under the control of Scer\GAL4[GMR.PF]. (Seppa et al., 2008) tkv[8]/+ almost completely suppresses the abberant arrangement of inter-ommatidial cells seen in the pupal and adult retinas of In(1)rst[3]/Y animals. The retinas of tkv[8]/+ or shg[R69]/+ animals at 42 hours APF have only very occasional inter-ommatidial patterning defects (the occasional extra or misplaced cell). This phenotype is dramatically enhanced in tkv[8]/shg[R69] transheterozygotes. (Cordero et al., 2007) Marker analysis shows that some photoreceptor differentiation begins in some fraction of the cells in smo[3] tkv[8] double homozygous cones in the late third instar eye disc. (Vrailas and Moses, 2006) In smo[3], tkv[8] double mutant eye disc clones, BrdU incorporation, a marker of S phase, is abolished in the second mitotic wave. (Baonza and Freeman, 2005) The number of synaptic boutons/muscle surface area at muscle 6/7 in tkv8/witHA3 double heterozygotes is 88.8 +/- 2.4 % of wild type. (McCabe et al., 2004) R8 photoreceptor differentiation fails in tkv8; smo3 double mutant clones, whereas it is only delayed in smo3 single mutant clones. (Fu and Baker, 2003) Ommatidial clusters situated posterior to smo3; tkv8 double mutant clones differentiate properly, but over-rotate at a much higher frequency than those situated in other regions of the same eye disc, with many of them reaching 110o-120o. (Chou and Chien, 2002) The tkv8 "dorsal open" cuticle phenotype is rescued in brkXH ; tkv8 double mutant embryos. These double mutant larvae differentiate a contiguous dorsal epidermis, but the Filzkorper are reduced and are more ventralised than brkXH single mutant embryos. (Torres-Vazquez et al., 2001) The disc phenotype of tkv8 Egfrf6 and tkv8 ; rho6 double mutant embryos is a simple addition of each single mutant phenotype, in which wing discs are lost completely and leg discs are severely reduced. (Kubota et al., 2000) When wgScer\UAS.cLa is expressed under the control of Scer\GAL4btl.PS in a tkv8 background a huge dorsal trunk is formed and no other tracheal branches are usually formed. The formation of all tracheal branches except the transverse connective and visceral branch is impaired in arm2 ; tkv8 double mutants. (Llimargas, 2000) At 25oC, Chc1/+, tkv8/+ double heterozygotes show thickened veins and wing reduction phenotypes. At 29oC only wing remnants develop. (Gonzalez-Gaitan and Jackle, 1999) Cells in tkv8 smo3 double mutant clones in the eye disc cannot differentiate as photoreceptors. (Greenwood and Struhl, 1999) The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpps4 tkv1/dpps8 tkv8 double mutant flies. rhove-1 suppresses the differentiation of thicker veins seen in tkv1/tkv8 flies. The differentiation of thicker veins seen in rhohs.PSt flies is strongly increased in combination with tkv1/tkv8. The ectopic vein phenotype of Ras64BAct5C.PC flies is increased in combination with tkv1/tkv8. tkv1/tkv8 NAx-1 double mutant flies show pronounced wing vein loss. The thickening of veins seen in tkv1/tkv8 flies is strongly enhanced in combination with Nnd-3 and is suppressed in combination with NAx-1. (de Celis, 1997) tkv8 put135 double mutants exhibit cells that remain in the original position in the tracheal pit and do not migrate. (Wappner et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	tkv1/tkv8 is rescued by Scer\GAL4elav.PLu/tkvScer\UAS.T:Ivir\HA1 (McCabe et al., 2004) tkv8/tkv7 is rescued by tkvUbi-p63E.PB (Brummel et al., 1994) tkv04415/tkv8 is rescued by tkvhs.PR (Jiang and Struhl, 1996)
Comments	tkv1/tkv8 flies are viable. (de Celis, 1997) Lethality of tkv04415/tkv8 can be rescued by tkvhs.PR. (Jiang and Struhl, 1996) tkvUbi-p63E.PB rescues the inviable mutant phenotype of tkv7/tkv8. (Brummel et al., 1994) Allelism with tkv indicated by location, failure to complement lethal and viable tkv alleles and thick vein and abnormal thorax phenotype over Tp(2;3)tkv (Szidonya and Reuter, 1988).
Stocks ( 1 )
Bloomington	34509 tkv8 cn1 bw1 sp1/CyO
Notes on Origin
Discoverer	Nusslein-Volhard.
External Crossreferences & Linkouts
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	strIIB09 (Warrior, 1994) strIIB (Tearle and Nusslein-Volhard, 1987, ) Tkv - (Mathur et al., 2010) tkv8 (Dudu, 2006, Vrailas et al., 2006, Bangi and Wharton, 2006, Kirilly et al., 2005, Wada et al., 2007, Vrailas and Moses, 2006, Cordero et al., 2007, Melicharek et al., 2008, Mathur et al., 2010, Seppa et al., 2008) tkv- (Lawrence et al., 2002, Weiss et al., 2010) tkvIIB09 (Theisen et al., 1996, Sturtevant and Bier, 1995) tkvIIB (de Celis, 1997, Terracol and Lengyel, 1994) tkvIIst (Baonza and Freeman, 2005) tkvstII (Baonza and Freeman, 2005) tkvstrII (Fu and Baker, 2003, Chou and Chien, 2002, Johannes and Preiss, 2002, Dorfman and Shilo, 2001, Greenwood and Struhl, 1999, Gonzalez-Gaitan and Jackle, 1999, Riesgo-Escovar and Hafen, 1997, Riesgo-Escovar and Hafen, 1997, Burke and Basler, 1996, Jiang and Struhl, 1996, Vuilleumier et al., 2010) tkvstr-II (Wappner et al., 1997, Vincent et al., 1997, Ruberte et al., 1995, Nellen et al., 1994, Affolter et al., 1994, Singh et al., 2006)
Name Synonym
Secondary FlyBase IDs
References ( 62 )
Generate a list of	All references relating to this allele ( 62 )
List References by type	Research paper  ( 59 ) Supplementary material  ( 2 ) Stock list  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...