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General Information
Symbol
Dmel\Tlr2
Species
D. melanogaster
Name
FlyBase ID
FBal0016837
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Tlr444, r444
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
T26840428A
Reported nucleotide change:
T3149A
Amino acid change:
F859I | Tl-PB; F859I | Tl-PC; F859I | Tl-PD
Reported amino acid change:
F859I
Comment:
This mutation is in the cytoplasmic domain of the protein.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Polytene chromosomes normal.
Nature of the lesion
Statement
Reference
Nucleotide substitution: T3149A. Amino acid replacement: F859I. This mutation is in the cytoplasmic domain of the protein.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Tlr3/Tlr2 mutant third instar larvae have more eve-positive neurons in the ventral nerve cord compared to wild-type controls.
The ability of hemizygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. The ability of Tlr2/Tlr3 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. The ability of Tlr2/Tlrv1 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
Shows brain tumours when heterozygous with the MBT chromosome.
embryos laid by Tlr2/Tlrv19 mothers are dorsalised. They display differentiating amnioserosa tissue around the entire central region of the embryo. Leading edge (LE) and dorsal ectoderm are also formed in these embryos but their axial arrangement is reoriented nearly 90o. Consequently LE cells are arrayed around the dorsal ventral circumference of the embryos, rather than in an anterior to posterior orientation. However, they remain in a single row configuration between amnioserosa and dorsal ectoderm cells. many embryos display a non-uniform distribution of amnioserosa and dorsal ectoderm.
Level of Drs induction of bacterially challenged Tlr2/Tl9QURE mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.
At 30oC there are errors in RP motoneuron number at 4 times the frequency seen at 18oC. The defects are similar to those seen for Tl null mutant combination Df(3R)Tl-X/Df(3R)ro-XB3 or hemizygotes. Loss of innervation of muscle fibers 6 and 7 is due to loss of RP3 motoneuron.
Females doubly heterozygous for spz4 and Tlr2 lay weakly dorsalized eggs at 29oC.
Embryos from homozygous females are strongly dorsalised at 29oC and weakly dorsalised at 18oC.
Female hemizygotes produce embryos that develop normally at 18oC but were strongly dorsalized at 29oC. Only 7% survived to adulthood at 29oC. Temperature sensitive period begins late embryogenesis and extended into second larval instar.
temperature-sensitive for the maternal effect, showing stronger dorsalization of the embryonic pattern at 29oC than at 18oC; also temperature-sensitive for viability. TSP for the maternal effect begins slightly before pole cell formation and ends in midsyncytial blastoderm in the offspring of Tlr7 females. TSP for zygotic viability begins late in embryogenesis and extends into the second larval instar in Tlr5 and Tlr6 mutants. recessive
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The zygotic semi-lethality of cact7 homozygotes is strongly suppressed by Tlr2/Df(3R)ro80b.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
Demonstrates zygotic haploinsufficiency.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (23)