|Feature type||allele||Associated gene||Dmel\Tl|
|Also Known As||Tlr632, Tl632, Tollr632|
|Allele class||hypomorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Polytene chromosomes normal.
|Phenotype Manifest In|
Tl[r3]/Tl[rv1] flies show a reduced survival rate compared to control flies after infection with either S. aureus or A. fumigatus.
Infection with the S. aureus 'ItaS' mutant causes earlier death than infection with its parent RN4220 strain in Tl[rv1]/Tl[r3] flies, similar to the findings with wild type flies.
Injection of Tl[r3] mutant fruit flies, with either Rhizopus or Mucor spp. results in a higher mortality rate at 48 hours (95%) when compared with injection of wild-type fruit flies. Infection of Tl[r3] mutant fruit flies, with C. bertholletaie causes hyperacute mortality (as in wild-type).
Tlr3/Tlrv1 mutant males survive well 10 days post-infection with E.coli, with an 85% survival rate, compared to 96% in wounded controls. Females also survived equally well. Tlr3/Tlrv1 mutant males can withstand B.bassiana fungal infection to a greater level than Tlr3/Tlrv1 mutant females.
The ability of hemizygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. The ability of Tlr2/Tlr3 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
Shows brain tumours when heterozygous with the MBT chromosome. Shows third larval instar lethality when heterozygous with the MBT chromosome.
Level of Drs induction of bacterially challenged Tlr3/Tlrv1 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Inducibility of all antimicrobial genes by bacterial challenge in imd1/imd1; Tlr3/Tlrv1 double mutants is severely reduced. Septic injury (pricking with a needle under nonsterile conditions) or infection with E.coli does not noticeably affect Tlr3/Tlrv1 survival, infection with A.fumigatus results in death after 2-3 days clearly associated with uncontrolled fungal development. 40% homozygous double mutant flies survive after septic injury but only a few individuals survive 3 days postinfection with E.coli. Infection of Tlr3/Tlrv1 mutants with A.fumigatus causes 8% survival 3 days postinfection, infection with E.coli causes survival rates similar to wild type.
Dorsalized embryos at the restrictive temperature.
Embryos derived from females are dorsalised.
dppHin embryos derived from dl1 mothers have a weak dorsalizing phenotype: numerous ventral like setae.
temperature-sensitive for the maternal effect, showing stronger dorsalization of the embryonic pattern at 29oC than at 18oC; also temperature-sensitive for viability. TSP for the maternal effect begins slightly before pole cell formation and ends in midsyncytial blastoderm in the offspring of Tlr7 females. TSP for zygotic viability begins late in embryogenesis and extends into the second larval instar in Tlr5 and Tlr6 mutants. recessive
|Phenotype Manifest In|
|NOT Suppressor of|
The addition of spz4 or Tlrv1/Tlr3 enhances the susceptibility of RelE20 mutants to E.coli and M.luteus infection.
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 9 )|
(Sorrentino et al., 2004, Remillieux-Leschelle et al., 2002, De Gregorio et al., 2002, Hedengren et al., 2000, Levashina et al., 1999, Manfruelli et al., 1999, Levashina et al., 1998, Nicolas et al., 1998, Lemaitre et al., 1997, Lemaitre et al., 1996, Lemaitre et al., 1995, Roth et al., 1991, Gerttula et al., 1988, Carroll et al., 1987, Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985, Chen et al., 2010, Buchon et al., 2009, Chamilos et al., 2009, Chamilos et al., 2008, Chen et al., 2010)
|Secondary FlyBase IDs|
|References ( 34 )|
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|Recent research papers ( 1 )|