Polytene chromosomes normal.
abdomen | conditional (with Tlrv1)
cardioblast (with Tlr4)
embryo | dorsal ventral gradient (with TlrK344)
head | conditional (with Tlrv1)
hemolymph | conditional (with Tlrv1)
thorax | conditional (with Tlrv1)
Tlr3/Tlrv1 flies infected with Pythium insidiosum show significantly lower survival rates than wild-type. As evidenced by histopathological studies, injected P. insidiosum zoospores germinate rapidly in fly hemolymph to form hyphae that subsequently disseminate and invade the thorax, abdomen and head of the mutants. No histopathological alterations are found in wild-type flies after P. insidiosum infection.
Adult females transheterozygous for Tlr3/Tlrv1 display increased sensitivity to infection with various strains of Candida albicans: the survival rate of infected flies is significantly decreased compared to wild-type. Tlr3/Tlrv1 also show significantly higher post-infection fungal load, which unlike in wild-type flies progressively increases with time when infected with a wild-type strain of C. albicans.
The ability of hemizygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. The ability of Tlr2/Tlr3 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
Shows brain tumours when heterozygous with the MBT chromosome. Shows third larval instar lethality when heterozygous with the MBT chromosome.
Level of Drs induction of bacterially challenged Tlr3/Tlrv1 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Inducibility of all antimicrobial genes by bacterial challenge in imd1/imd1; Tlr3/Tlrv1 double mutants is severely reduced. Septic injury (pricking with a needle under nonsterile conditions) or infection with E.coli does not noticeably affect Tlr3/Tlrv1 survival, infection with A.fumigatus results in death after 2-3 days clearly associated with uncontrolled fungal development. 40% homozygous double mutant flies survive after septic injury but only a few individuals survive 3 days postinfection with E.coli. Infection of Tlr3/Tlrv1 mutants with A.fumigatus causes 8% survival 3 days postinfection, infection with E.coli causes survival rates similar to wild type.
Dorsalized embryos at the restrictive temperature.
Embryos derived from females are dorsalised.
temperature-sensitive for the maternal effect, showing stronger dorsalization of the embryonic pattern at 29oC than at 18oC; also temperature-sensitive for viability. TSP for the maternal effect begins slightly before pole cell formation and ends in midsyncytial blastoderm in the offspring of Tlr7 females. TSP for zygotic viability begins late in embryogenesis and extends into the second larval instar in Tlr5 and Tlr6 mutants. recessive
Tlr3/Df(3R)ro80b is an enhancer of increased cell death phenotype of spz2
Tlr3/Tlrv1 is an enhancer of abnormal immune response phenotype of RelE20
Tlr3, srn88 has lethal | pupal stage phenotype
Tlr3/Tlrv1 is a suppressor of embryonic/larval hemocyte phenotype of mxcG43
Tlr3/Tlrv1 is a non-suppressor of lamellocyte phenotype of mxcG43