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General Information
Symbol
Dmel\Tlrv1
Species
D. melanogaster
Name
FlyBase ID
FBal0016843
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Tl1-RXA, TlRxA, Tll-RXA
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Polytene chromosomes normal.
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Tlr3/Tlrv1 flies do not exhibit significantly different survival rates in response to Staphylococcus aureus infection, as compared to control flies.
Tlr3/Tlrv1 flies infected with Pythium insidiosum show significantly lower survival rates than wild-type. As evidenced by histopathological studies, injected P. insidiosum zoospores germinate rapidly in fly hemolymph to form hyphae that subsequently disseminate and invade the thorax, abdomen and head of the mutants. No histopathological alterations are found in wild-type flies after P. insidiosum infection.
Mutant flies show no significant difference in mortality compared to wild-type flies after infection with either Providencia rettgeri or Providencia burhodogranariea.
Tlr3/Tlrv1 flies show a reduced survival rate compared to control flies after infection with either S. aureus or A. fumigatus.
Infection with the S. aureus 'ItaS' mutant causes earlier death than infection with its parent RN4220 strain in Tlrv1/Tlr3 flies, similar to the findings with wild type flies.
Adult females transheterozygous for Tlr3/Tlrv1 display increased sensitivity to infection with various strains of Candida albicans: the survival rate of infected flies is significantly decreased compared to wild-type. Tlr3/Tlrv1 also show significantly higher post-infection fungal load, which unlike in wild-type flies progressively increases with time when infected with a wild-type strain of C. albicans.
The ability of Tlr2/Tlrv1 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
The concentration of circulating hemocytes in Tlrv1/Tlr3 larvae is reduced compared to controls.
Level of Drs induction of bacterially challenged Tlr3/Tlrv1 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Inducibility of all antimicrobial genes by bacterial challenge in imd1/imd1; Tlr3/Tlrv1 double mutants is severely reduced. Septic injury (pricking with a needle under nonsterile conditions) or infection with E.coli does not noticeably affect Tlr3/Tlrv1 survival, infection with A.fumigatus results in death after 2-3 days clearly associated with uncontrolled fungal development. 40% homozygous double mutant flies survive after septic injury but only a few individuals survive 3 days postinfection with E.coli. Infection of Tlr3/Tlrv1 mutants with A.fumigatus causes 8% survival 3 days postinfection, infection with E.coli causes survival rates similar to wild type.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Tlrv1 is a non-enhancer of visible phenotype of upd1GMR.PB
NOT Suppressor of
Statement
Reference
Tlrv1 is a non-suppressor of visible phenotype of upd1GMR.PB
Phenotype Manifest In
NOT Enhancer of
Statement
Reference
Tlrv1 is a non-enhancer of eye phenotype of upd1GMR.PB
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Tlrv1 is a non-suppressor of eye phenotype of upd1GMR.PB
Tlr3/Tlrv1 is a non-suppressor of lamellocyte phenotype of mxcG43
Tlr3/Tlrv1 is a non-suppressor of podocyte phenotype of mxcG43
Additional Comments
Genetic Interactions
Statement
Reference
The addition of spz4 or Tlrv1/Tlr3 enhances the susceptibility of RelE20 mutants to E.coli infection, but has no affect on susceptibility to A.fumigatus injection or natural infection by B.bassiana.
The increased concentration of circulating hemocytes seen in mxcG43 larvae is suppressed by Tlrv1/Tlr3, but the numbers of podocytes and lamellocytes are still increased in the double mutants compared to wild type.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (11)
References (28)