embryos laid by Tlr2
mothers are dorsalised. They display differentiating amnioserosa tissue around the entire central region of the embryo. Leading edge (LE) and dorsal ectoderm are also formed in these embryos but their axial arrangement is reoriented nearly 90o
. Consequently LE cells are arrayed around the dorsal ventral circumference of the embryos, rather than in an anterior to posterior orientation. However, they remain in a single row configuration between amnioserosa and dorsal ectoderm cells. many embryos display a non-uniform distribution of amnioserosa and dorsal ectoderm.
Mutant embryos do not respond to injected purified polarizing activity (spz
Incompletely penetrant dominant dorsalization.
Dorsalized phenotype facilitates removal of perivitelline fluid.