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General Information
Symbol
Dmel\tld14
Species
D. melanogaster
Name
FlyBase ID
FBal0016885
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
tld10E, tld10E95
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C24750913T

Reported nucleotide change:

C827T

Amino acid change:

S286F | tld-PA

Reported amino acid change:

S276F

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

point mutation
Nucleotide change:

C24750913T

Reported nucleotide change:

C?T

Amino acid change:

S286F | tld-PA

Reported amino acid change:

S276F

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: S276F. Nucleotide substitution: C827T. Mutation within the protease domain.

The mutation falls in the protease domain of the tld protein.

Amino acid replacement: S276F.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Neuromuscular junctions appear normal in structure and localisation in tld9/tld14 third instar larvae.

Homozygous embryos form some residual visceral mesoderm. The dorsal vessel is missing, except for a few residual cells.

Antagonistic activity towards dpp.

Strong ventralization. Dominantly enhances dpp phenotype.

Moderate ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

strong

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

tld1/tld14 has lethal phenotype, suppressible by sogY506

Phenotype Manifest In
Enhancer of
Statement
Reference

tld14 is an enhancer of phenotype of dpp98

tld14 is an enhancer of phenotype of dpp97

tld14 is an enhancer of phenotype of dpp99

tld14 is an enhancer of phenotype of dppe90

tld14 is an enhancer of phenotype of dpp100

tld14 is an enhancer of phenotype of dpp101

tld14 is an enhancer of phenotype of dpphr92

tld14 is an enhancer of phenotype of dpphr27

tld14 is an enhancer of phenotype of dppd-ho

tld14 is an enhancer of phenotype of dpphr89

tld14 is an enhancer of phenotype of dpp102

tld14 is an enhancer of phenotype of dpphr4

tld14 is an enhancer of phenotype of dpphr93

tld14 is an enhancer of phenotype of dpp103

Additional Comments
Genetic Interactions
Statement
Reference

Strong enhancer of all dpp alleles, except dppe87 and dpphr56.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Strong tld allele. Allelic series for tld antagonistic effect on dpp : tldB3 > tld14 = tld6 > tld1 > tld6P41 > tld9Q19.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (12)