Allele Dmel\tor¹

General Information
Symbol	Dmel\tor¹	Species	D. melanogaster
Name		FlyBase ID	FBal0016909
Feature type	allele	Associated gene	Dmel\tor
Also Known As	tor^WK, tor^WK34

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Sprenger and Nusslein-Volhard, 1992, Sprenger et al., 1993)
Mutagen	ethyl methanesulfonate (Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:3,594,370..3,594,370 evidence=experimental pr_change=M522K na_change=T3594370A (Sprenger and Nusslein-Volhard, 1992)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: M522K. (Sprenger et al., 1993) Met at residue 522 (in the tyrosine kinase domain) replaced by Lys. (Sprenger and Nusslein-Volhard, 1992)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	abdominal segment 5 (Ambrosio et al., 1989) abdominal segment 6 (Ambrosio et al., 1989) abdominal segment 7 (Ambrosio et al., 1989) abdominal segment 8 (Ambrosio et al., 1989, Schupbach and Wieschaus, 1986) abdominal segment 9 (Ambrosio et al., 1989) abdominal segment 10 (Ambrosio et al., 1989) cephalic furrow (Ambrosio et al., 1989) cephalopharyngeal skeleton (Lehmann, 1988) embryonic/larval anus \| embryonic stage (Lehmann, 1988) embryonic/larval posterior spiracle \| embryonic stage (Lehmann, 1988) filzkorper (Lehmann, 1988) labrum (Ambrosio et al., 1989, Schupbach and Wieschaus, 1986) ocular segment (Ambrosio et al., 1989) telson (Ambrosio et al., 1989, Schupbach and Wieschaus, 1986) ventral furrow (Ambrosio et al., 1989)
Detailed Description
	Statement Reference Suppresses "splice" phenotype of tor^NRE, presumably because product is appropriately positioned to block diffusion of the tor ligand, even though it cannot transduce the terminal signal. (Casanova and Struhl, 1993) In tor¹ trk¹ embryos little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm. (Pignoni et al., 1992) Does not interact with RpII140^wimp maternal effect. (Parkhurst and Ish-Horowicz, 1991) Embryos derived from tor¹, trk¹ females lack A8 and filzkorper. Filzkorper are formed and segmentation is repressed in heat shocked embryos carrying tll^hs.PS and derived from tor¹, trk¹ females. (Steingrimsson et al., 1991) Embryos carrying the hb^Δ transcripts do not express kni and form no abdominal segments. (Wharton and Struhl, 1991) A hole is seen in the blastoderm layer below the pole cells in embryos. The ventral furrow is extended posteriorly. Segments A8 to the telson are deleted. Segments A5 to A7 are expanded. Some twisting of the germband is seen. Labral and acron-derived structures are deleted. There is cell death in the head and tail region. Cephalic furrow and anterior midgut invagination are shifted anteriorly. (Ambrosio et al., 1989) The anteriormost and posteriormost structures are lacking and the anterior pattern is shifted anteriorly. tor embryos display normal levels of bcd protein. (Driever and Nusslein-Volhard, 1988) Embryos derived from homozygous females lack the most anterior and posterior structures; the head skeleton is smaller than normal and the Filzkorper, anal plate and spiracles are missing. (Lehmann, 1988) Homozygous females produce embryos which have deletions of the most anterior head structures (labrum and chitinous mouth plates), and the most posterior abdominal structures (posterior midgut, telson and abdominal segment A8). (Schupbach and Wieschaus, 1986) recessive
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement Reference tor¹ is a non-suppressor of phenotype of arm³ (Cox et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	tor¹ is rescued by tor^+t11.5 (Cleghon et al., 1996)
Comments
Stocks ( 4 )
Bloomington	1764 tor¹ cn¹ exu¹ bw¹/CyO 3352 b¹ BicD¹ tor¹ cn¹/CyO 1574 vas¹ tor¹ cn¹ bw¹ sp¹/CyO 2620 vas¹ tor¹ cn¹ exu¹ bw¹/CyO
Notes on Origin
Discoverer	Wieschaus, Nusslein-Volhard.

Comments
	Transplantation of wild-type anterior cytoplasm into the anterior end of embryos derived from homozygous tor¹ females can rescue the mutant anterior structures. Transplantation of wild-type posterior cytoplasm into the posterior end of embryos derived from homozygous tor¹ females can rescue the mutant posterior structures. Cytoplasm transplanted from tor⁴ mutant donors has no rescuing effect. (Sugiyama and Okada, 1990) Germline mosaic analysis shows that tor is required in the germline. (Schupbach and Wieschaus, 1986)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	fs(2)torso^WK34 (Ambrosio et al., 1989) tor¹ tor^WK34 (Mohler, 1995, Riddihough and Ish-Horowicz, 1991, Parkhurst and Ish-Horowicz, 1991, Jack and McGinnis, 1990) tor^wk34 (Finkelstein and Perrimon, 1990) tor^WK (Hartmann et al., 2001, Gao et al., 1996, Cleghon et al., 1996, Sprenger and Nusslein-Volhard, 1993, Sprenger et al., 1993, Pignoni et al., 1992, Sprenger and Nusslein-Volhard, 1992, Struhl et al., 1992, Steingrimsson et al., 1991, Wharton and Struhl, 1991, Sugiyama and Okada, 1990, Hooper et al., 1989, Lehmann, 1988, Driever and Nusslein-Volhard, 1988, Tearle and Nusslein-Volhard, 1987, Schupbach and Wieschaus, 1986, )
Name Synonym
Secondary FlyBase IDs

References ( 27 )

Generate a list of	All references relating to this allele ( 27 )

List References by type	Research paper ( 24 ) Review ( 1 ) Stock list ( 1 ) Letter ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\tor1

Allele Dmel\tor¹