FB2025_01 , released February 20, 2025
Allele: Dmel\tor12D
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General Information
Symbol
Dmel\tor12D
Species
D. melanogaster
Name
FlyBase ID
FBal0016920
Feature type
allele
Associated gene
Dmel\tor
Associated Insertion(s)
Carried in Construct
Also Known As
torY9
Key Links
Genomic Maps

Allele class

gain of function allele

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Tearle and Nusslein-Volhard, 1987)

gain of function allele

(Li et al., 2003, Sprenger and Nusslein-Volhard, 1992, Stevens et al., 1990)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: W317R.

(Sprenger and Nusslein-Volhard, 1992)

Trp at residue 317 (in the extracellular domain) replaced by Arg.

(Sprenger and Nusslein-Volhard, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,707,594..7,707,594 [-]
Nucleotide change:

T7707594A

Reported nucleotide change:

T?A

Amino acid change:

W317R | tor-PA; W317R | tor-PD

Reported amino acid change:

W317R

(Sprenger and Nusslein-Volhard, 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from homozygous tor12D mutant females show expanded terminal regions at the expense of central body regions, as indicated by the deletion of several abdominal segments.

      (Grillo et al., 2011)

      The cuticle phenotype of tor12D is dosage sensitive; embryos derived from homozygous mothers show the strongest gain-of-function phenotype, while those from heterozygous or hemizygous females show progressively weaker phenotypes. Only a hollow shell of vitelline membrane can usually be found in cuticle preparations of embryos derived from homozygous females. There are no remnants of ventral denticle bands or the head skeleton. The Filzkorper, if present, appear diffuse and are mislocalised, usually in the centre of the embryo (class I phenotype). Embryos derived from heterozygous females also show a temperature sensitive cuticle phenotype. At 18oC, heterozygous females lay eggs with the most severe defects; most of the embryos have a remnant of a head skeleton, essentially all central structures are undifferentiated expect for an occasional strip of ventral denticle band and the Filzkorper is often a little enlarged (class II phenotype). At 21oC, most embryos derived from heterozygous females have an intact head skeleton and Filzkorper, and about four denticle bands are usually identifiable (class III phenotype). At 25oC, many embryos derived from heterozygous females hatch, forming nearly morphologically normal crawling larvae (sometimes one or two ventral denticle bands are missing) (class IV phenotype). torrv66 partially suppresses the cuticle defects seen in embryos derived from tor12D/+ females.

      (Li and Li, 2003)

      Embryos laid by heterozygous females lack most denticle belts and ectopic Filzkorper material is occasionally seen.

      (Li et al., 2002)

      Embryos laid by heterozygous females lack all ventral denticle belts and the filzkorper are slightly enlarged.

      (Li et al., 2000)

      Embryos derived from heterozygous females have a normal or enlarged head and telson, but the segmented region is disrupted and segments are variably deleted. Embryos derived from tor12D/+ ; tsl4/tsl4 females have the same phenotype as embryos derived from tor12D/+ females, indicating that tsl functions upstream of tor.

      (Stevens et al., 1990)

      semidominant

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)C144/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)S2590/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)TW137/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)b87e25/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)cact-255rv64/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)cl-h3/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)net-PMF/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by +/Df(2L)sc19-4

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2L)sc19-8/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2R)BSC11/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2R)CX1/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by +/Df(2R)X1

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2R)cn9/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(2R)stan1/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3L)AC1/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3L)M21/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3L)vin5/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3L)vin7/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3R)DG2/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3R)H-B79/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3R)ME15/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3R)by10/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(3R)p712/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by In(2LR)DTD16LDTD42R/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by +/In(2R)bwVDe2LCyR

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by T(Y;3)B81/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by T(1;3)scJ4/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(1)64c18/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(1)C246/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(1)JC19/+

      (Li and Li, 2003)

      tor12D has lethal | maternal effect | embryonic stage phenotype, suppressible by Df(1)lz-90b24/+

      (Li and Li, 2003)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, enhanceable by dppP23

      (Li and Li, 2003)
      Suppressed by
      Statement
      Reference

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by dppH46/dpp[+]

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by 14-3-3εΔ24

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by 14-3-3ζP1188

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Dsor1r1

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Hsp83e6D

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Madk00237

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Ras85DΔC40B

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Sose4G

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Stat92E06346

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by bowlL26

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by byn5

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by cswKN27

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by drkTZ160

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by hkbA321R1

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by lilli3E8

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Raf11

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by rl10

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by tkv7

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by tll1

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by tup1

      (Li and Li, 2003)

      tor12D has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible by Stat92E06346/Stat92E06346

      (Li et al., 2002)

      tor12D has phenotype, suppressible by Df(2L)TE29Aa-11/Btkk00206

      (Li et al., 2000)

      tor12D has ventral denticle belt phenotype, suppressible by Btkk00206/Btkk00206

      (Li et al., 2000)
      NOT suppressed by
      Statement
      Reference

      tor12D has ventral denticle belt | maternal effect phenotype, non-suppressible by hop2/hop2

      (Li et al., 2002)
      NOT Enhancer of
      Statement
      Reference

      tor12D is a non-enhancer of embryonic abdominal segment 8 | maternal effect phenotype of psqrum

      (Grillo et al., 2011)

      tor12D is a non-enhancer of filzkorper | maternal effect phenotype of psqrum

      (Grillo et al., 2011)
      NOT Suppressor of
      Statement
      Reference

      tor12D is a non-suppressor of embryonic abdominal segment 8 | maternal effect phenotype of psqrum

      (Grillo et al., 2011)

      tor12D is a non-suppressor of filzkorper | maternal effect phenotype of psqrum

      (Grillo et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      All embryos from homozygous psqrum tor12D double mutant females show terminal defects resembling the psqrum single mutant phenotype.

      (Grillo et al., 2011)

      The segmentation phenotype seen in embryos derived from tor12D/+ females is suppressed if the females also carry Stat92E06346 homozygous germline clones. These embryos have phenotypes similar to embryos derived from Stat92E homozygous germline clones.

      (Li et al., 2002)

      The tor12D maternal effect phenotype is partially suppressed by homozygosity for Btk29Ak00206; embryos show a significant increase in the number of ventral denticle belts. The tor12D phenotype is also partially suppressed by Btk29Ak00206/Df(2L)TE29Aa-11.

      (Li et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Klingler.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (22)