FlyBase Allele Report: Dmel\tor[rv66]

Embryos from tor^rv66 homozygous mothers exhibit a fully penetrant posterior "terminal class mutant" phenotype by the end of embryogenesis, in which some posterior structures are missing (including abdominal segment 8, telson, and/or filzkorper), but do not exhibit any obvious defects in ventral cells during ventral furrow formation, as compared to controls.

(Johnson et al., 2017)

tor^rv66 mutant homozygotes show a significant delay in reaching pupariation compared with heterozygous controls. The L2-L3 transition is delayed by ~7 hours. Adult flies are increased in size compared to controls.

(Johnson et al., 2013)

Embryos derived from homozygous females lack the abdominal segment 8 denticle belts.

(Ding et al., 2010)

tor^rv66 partially suppresses the cuticle defects seen in embryos derived from tor^12D/+ females.

(Li and Li, 2003)

Embryos derived from tor^rv66 homozygous mothers show defective gastrulation and completely lack the posterior midgut primordium. In contrast to wild-type pole cells that are internalized during gastrulation, pole cells from the vast majority of these embryos do not enter the embryo at gastrulation and are left outside. In wild-type embryos, pole cells become spherical as they start migrating at stage 4, then become elongated after cellularization and start to move out of the pole cell cluster. Pole cells in embryos derived from tor^rv66 mothers do become spherical at stage 4, suggesting that they start to migrate, but then remain this shape and stay in a tightly-packed cluster without further movement. Pole cells from cellularization stage tor^rv66 embryos hardly disperse and are slow in translocation movements when observed in Schneider culture medium, while pole cells from wild-type embryos are more active in both dispersion and translocation. tor^rv66 mutant soma can provide a normal environment for pole cell migration as transplanted wild-type pole cells can successfully migrate to the somatic gonad in tor^rv66 host embryos.

(Li et al., 2003)

Embryos from homozygous females lack terminal structures.

(Casanova et al., 1994)

All structures posterior to abdominal segment 7 fail to develop.

(Lu et al., 1993)

In embryos from homozygous mothers no PMG is formed though the AMG and visceral mesoderm form normally. The AMG migrates far into the posterior of the embryo, well beyond the point that the PMG would have migrated to, were it to be present, and makes its transition to an epithelium.

(Reuter et al., 1993)

Embryos derived from homozygous females fail to form a posterior midgut.

(Leptin et al., 1992)

Little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm.

(Pignoni et al., 1992)

Embryos carrying the hb^Δ transcripts do not express kni and form no abdominal segments.

(Wharton and Struhl, 1991)

The ventral furrow extends over the whole length of the embryo in embryos derived from tor^rv66 homozygous females.

(Leptin and Grunewald, 1990)

Embryos derived from homozygous females lack the labrum anteriorly, and the head is reduced in size. Posteriorly, A8 and the telson are deleted.

(Stevens et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tor^rv66 has embryonic/larval segmentation phenotype | embryonic stage | maternal effect phenotype, enhanceable by fog^S4

(Johnson et al., 2017)

tor^rv66 has abnormal developmental rate phenotype, enhanceable by tsl^Δ

(Johnson et al., 2013)

Suppressed by

Statement

Reference

tor^rv66 has abnormal size phenotype, suppressible by tsl^Δ

(Johnson et al., 2013)

Enhancer of

Statement

Reference

tor^rv66 is an enhancer of abnormal developmental rate phenotype of tsl^Δ

(Johnson et al., 2013)

NOT Suppressor of

Statement

Reference

tor^rv66 is a non-suppressor of abnormal size phenotype of tsl^Δ

(Johnson et al., 2013)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

tor^rv66 has abdominal segment 8 | embryonic stage | maternal effect phenotype, non-enhanceable by fog^S4

(Johnson et al., 2017)

tor^rv66 has telson | embryonic stage | maternal effect phenotype, non-enhanceable by fog^S4

(Johnson et al., 2017)

tor^rv66 has filzkorper | embryonic stage | maternal effect phenotype, non-enhanceable by fog^S4

(Johnson et al., 2017)

Suppressed by

Statement

Reference

tor^rv66 has embryonic/first instar larval cuticle phenotype, suppressible by 14-3-3ζ^hs.PL

(Li et al., 1997)

NOT suppressed by

Statement

Reference

tor^rv66 has abdominal 8 ventral denticle belt | maternal effect phenotype, non-suppressible by Raf^Hsp83.PD

(Ding et al., 2010)

tor^rv66 has abdominal 8 ventral denticle belt | maternal effect phenotype, non-suppressible by Raf^ΔN114.Hsp83

(Ding et al., 2010)

Suppressor of

Statement

Reference

tor^rv66/tor^rv66 is a suppressor | maternal effect | partially of embryonic/larval cuticle | maternal effect | embryonic stage phenotype of fog^S4

(Johnson et al., 2017)

tor^rv66 is a suppressor of embryonic segment phenotype of tsl^tor.PF

(Furriols et al., 1998)

NOT Suppressor of

Statement

Reference

tor^rv66 is a non-suppressor of phenotype of cic¹

(Jimenez et al., 2000)

Other

Statement

Reference

fog^S4, tor^rv66 has embryonic head | maternal effect phenotype

(Johnson et al., 2017)

fog^S4, tor^rv66 has embryonic/larval cuticle | ventral | maternal effect | embryonic stage phenotype

(Johnson et al., 2017)

Raf::tor^13D.hs.sev, tor^rv66 has filzkorper phenotype

(Li et al., 1998)

Raf^Su3, tor^rv66 has filzkorper phenotype

(Li et al., 1998)

Raf^Su3, tor^rv66 has embryonic abdominal segment 8 phenotype

(Li et al., 1998)

Hsap\RAF1^Δ305.hs, tor^rv66 has abdomen phenotype

(Casanova et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

The patterning and cuticle defects exhibited by late embryos from tor^rv66 homozygous mothers are enhanced by the zygotic hemizygosity for fog^S4, as the embryos additionally miss head structures and exhibit a penetrant posterior-ventral cuticle hole phenotype, as compared to controls.

(Johnson et al., 2017)

tsl^Δ tor^rv66 double mutants show a dramatically extended larval period compared to either mutant alone, with flies pupating 83 hours after controls. Double mutant adult flies are similar in size to tsl^Δ mutants alone.

(Johnson et al., 2013)

The lack of the abdominal segment 8 denticle belts seen in embryos derived from homozygous tor^rv66 females is not rescued by either phl^Hsp83.PD or phl^ΔN114.Hsp83.

(Ding et al., 2010)

The phenotype of embryos derived from homozygous cic¹ females is not altered if the females are also homozygous for tor^rv66.

(Jimenez et al., 2000)

Embryos derived from tor^rv66 females carrying tsl^tor.PF show no rescue of the tor^rv66 phenotype and do not show deletions of the middle segments ("splice" phenotype seen in wild-type embryos carrying tsl^tor.PF).

(Furriols et al., 1998)

Animals doubly mutant for phl^Su3 and tor^rv66 are completely non-viable and resemble tor^rv66 mutants.

(Li et al., 1998)

Overexpression of 14-3-3ζ^hs.PL partly rescues the cuticle of embryos derived from tor^rv66 females.

(Li et al., 1997)

Xenogenetic Interactions

Statement

Reference

Heat induced expression of Hsap\RAF1^Δ305.hs in tor^rv66 embryos deletes the middle body segments. 5-20% embryos also show terminal structures.

(Casanova et al., 1994)

Complementation and Rescue Data

Rescued by

tor^rv66 is rescued by tor^+t11.5

(Gayko et al., 1999)

Comments

Mutant phenotype can be rescued by injection of a mammalian activated p21^ras, p21^v-ras.

(Lu et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

92605

Adc^b-1 pr¹ tor^rv66 cn¹/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

Notes on Origin

Discoverer

Klingler.

Revertant.

Comments

Used to eliminate tor expression from endogenous tor gene in studies on consequences of ectopic expression of tor.

(Casanova and Struhl, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

tor^XR

(Grillo et al., 2012)

tor^rv66

torXR

(Grillo et al., 2012)

torso^XR1

(Ding et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (38)

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