Allele Dmel\tor^rv66

General Information
Symbol	Dmel\tor^rv66	Species	D. melanogaster
Name		FlyBase ID	FBal0016988
Feature type	allele	Associated gene	Dmel\tor
Also Known As	tor^XR1

Allele class	loss of function allele, amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate, X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Stevens et al., 1990, Sprenger and Nusslein-Volhard, 1992, Pignoni et al., 1992, Lu et al., 1993) loss of function allele (Casanova et al., 1994, Li et al., 1997)
Mutagen	ethyl methanesulfonate X ray (Sprenger et al., 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	tor^11D (Sprenger et al., 1989)
Nature of the lesion	Statement Reference 10.5kb deletion encompassing the tor gene. (Lu et al., 1993) 9.5 kb deletion. (Pignoni et al., 1992) 9.5kb deletion within the tor locus. (Sprenger et al., 1989) 9.5 kb deletion
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| maternal effect \| recessive (Reuter et al., 1993)
Phenotype Manifest In
	abdomen \| posterior (Casanova et al., 1994) abdominal 8 ventral denticle belt \| maternal effect (Ding et al., 2010) abdominal 11 anal tuft \| embryonic stage (Lu et al., 1993) embryonic/first instar larval cuticle (Li et al., 1997) embryonic/first instar larval cuticle \| maternal effect (with tor^12D) (Li and Li, 2003) embryonic/larval midgut \| embryonic stage \| posterior (Lu et al., 1993) embryonic abdominal segment 8 (Lu et al., 1993, Stevens et al., 1990, Li et al., 1998) embryonic anal pad (Lu et al., 1993) embryonic head (Stevens et al., 1990) embryonic telson (Lu et al., 1993, Stevens et al., 1990) filzkorper (Li et al., 1998) filzkorper \| embryonic stage (Lu et al., 1993) gastrula embryo (Li et al., 2003) labrum \| embryonic stage (Stevens et al., 1990) pole cell \| ectopic \| maternal effect (Li et al., 2003) posterior midgut primordium (Leptin et al., 1992) posterior midgut primordium \| maternal effect (Reuter et al., 1993) salivary gland common duct primordium \| maternal effect (Li et al., 2003)
Detailed Description
	Statement Reference Embryos derived from homozygous females lack the abdominal segment 8 denticle belts. (Ding et al., 2010) tor^rv66 partially suppresses the cuticle defects seen in embryos derived from tor^12D/+ females. (Li and Li, 2003) Embryos derived from tor^rv66 homozygous mothers show defective gastrulation and completely lack the posterior midgut primordium. In contrast to wild-type pole cells that are internalized during gastrulation, pole cells from the vast majority of these embryos do not enter the embryo at gastrulation and are left outside. In wild-type embryos, pole cells become spherical as they start migrating at stage 4, then become elongated after cellularization and start to move out of the pole cell cluster. Pole cells in embryos derived from tor^rv66 mothers do become spherical at stage 4, suggesting that they start to migrate, but then remain this shape and stay in a tightly-packed cluster without further movement. Pole cells from cellularization stage tor^rv66 embryos hardly disperse and are slow in translocation movements when observed in Schneider culture medium, while pole cells from wild-type embryos are more active in both dispersion and translocation. tor^rv66 mutant soma can provide a normal environment for pole cell migration as transplanted wild-type pole cells can successfully migrate to the somatic gonad in tor^rv66 host embryos. (Li et al., 2003) Embryos from homozygous females lack terminal structures. (Casanova et al., 1994) All structures posterior to abdominal segment 7 fail to develop. (Lu et al., 1993) In embryos from homozygous mothers no PMG is formed though the AMG and visceral mesoderm form normally. The AMG migrates far into the posterior of the embryo, well beyond the point that the PMG would have migrated to, were it to be present, and makes its transition to an epithelium. (Reuter et al., 1993) Embryos derived from homozygous females fail to form a posterior midgut. (Leptin et al., 1992) Little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm. (Pignoni et al., 1992) Embryos carrying the hb^Δ transcripts do not express kni and form no abdominal segments. (Wharton and Struhl, 1991) The ventral furrow extends over the whole length of the embryo in embryos derived from tor^rv66 homozygous females. (Leptin and Grunewald, 1990) Embryos derived from homozygous females lack the labrum anteriorly, and the head is reduced in size. Posteriorly, A8 and the telson are deleted. (Stevens et al., 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference tor^rv66 has embryonic/first instar larval cuticle phenotype, suppressible \| partially by 14-3-3ζ^hs.PL (Li et al., 1997)
NOT suppressed by
Statement Reference tor^rv66 has abdominal 8 ventral denticle belt \| maternal effect phenotype, non-suppressible by phl^Hsp83.PD (Ding et al., 2010) tor^rv66 has abdominal 8 ventral denticle belt \| maternal effect phenotype, non-suppressible by phl^ΔN114.Hsp83 (Ding et al., 2010)
Suppressor of
Statement Reference tor^rv66 is a suppressor of embryonic segment phenotype of tsl^tor.PF (Furriols et al., 1998)
NOT Suppressor of
Statement Reference tor^rv66 is a non-suppressor of phenotype of cic¹ (Jimenez et al., 2000)
Other
Statement Reference Hsap\RAF1^Δ305.hs, tor^rv66 has abdomen phenotype (Casanova et al., 1994) phl::tor^13D.hs.sev, tor^rv66 has filzkorper phenotype (Li et al., 1998) phl^Su3, tor^rv66 has embryonic abdominal segment 8 phenotype (Li et al., 1998) phl^Su3, tor^rv66 has filzkorper phenotype (Li et al., 1998) tor^rv66, trk^{C-108.T:SS-ea} has filzkorper phenotype (Casali and Casanova, 2001, Casali and Casanova, 2001)
Additional Comments
Genetic Interactions
Statement Reference The lack of the abdominal segment 8 denticle belts seen in embryos derived from homozygous tor[rv66] females is not rescued by either phl[Hsp83.PD] or phl[ΔN114.Hsp83]. (Ding et al., 2010) Filzkorper are not seen in embryos laid by tor^rv66 females when trk^C-108.T:ea RNA is injected into the posterior pole. (Casali and Casanova, 2001) The phenotype of embryos derived from homozygous cic¹ females is not altered if the females are also homozygous for tor^rv66. (Jimenez et al., 2000) Embryos derived from tor^rv66 females carrying tsl^tor.PF show no rescue of the tor^rv66 phenotype and do not show deletions of the middle segments ("splice" phenotype seen in wild-type embryos carrying tsl^tor.PF). (Furriols et al., 1998) Animals doubly mutant for phl^Su3 and tor^rv66 are completely non-viable and resemble tor^rv66 mutants. (Li et al., 1998) Overexpression of 14-3-3ζ^hs.PL partly rescues the cuticle of embryos derived from tor^rv66 females. (Li et al., 1997)
Xenogenetic Interactions
Statement Reference Heat induced expression of Hsap\RAF1^Δ305.hs in tor^rv66 embryos deletes the middle body segments. 5-20% embryos also show terminal structures. (Casanova et al., 1994)
Complementation & Rescue Data
Rescued by	tor^rv66 is rescued by tor^+t11.5 (Gayko et al., 1999)
Comments	Mutant phenotype can be rescued by injection of a mammalian activated p21^ras, p21^v-ras. (Lu et al., 1993)
Stocks ( 0 )

Notes on Origin
Discoverer	Klingler.
	Revertant.
Comments
	Used to eliminate tor expression from endogenous tor gene in studies on consequences of ectopic expression of tor. (Casanova and Struhl, 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	tor^rv66 tor^XR1 (Li et al., 2003, Martinho et al., 2004, Stevens et al., 2003, Li and Li, 2003, Casali and Casanova, 2001, Jimenez et al., 2000, Gayko et al., 1999, Li et al., 1998, Furriols et al., 1998, Li et al., 1997, Dahanukar and Wharton, 1996, Cleghon et al., 1996, Liaw et al., 1995, Hou et al., 1995, Casanova et al., 1994, Edgar et al., 1994, Reuter et al., 1993, Sprenger and Nusslein-Volhard, 1993, Klingler and Gergen, 1993, Liaw and Lengyel, 1993, Lu et al., 1993, Pignoni et al., 1992, Leptin et al., 1992, Sprenger and Nusslein-Volhard, 1992, Casanova, 1991, Wharton and Struhl, 1991, Stevens et al., 1990, Leptin and Grunewald, 1990, Sprenger et al., 1989, Driever et al., 1989, ) tor^XR (Grillo et al., 2012) torso^XR1 (Ding et al., 2010) torXR (Grillo et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 34 )

Generate a list of	All references relating to this allele ( 34 )

List References by type	Research paper ( 32 ) Review ( 1 ) Letter ( 1 )
Recent research papers ( 1 )
	Grillo et al., 2012, Sci. Rep. 2: 762 Conserved and divergent elements in Torso RTK activation in Drosophila development. [FBrf0219757] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\torrv66

Allele Dmel\tor^rv66