|Feature type||allele||Associated gene||Dmel\trc|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
comment=Position of mutation on reference sequence inferred by FlyBase curator. Difference in amino acid position due to slightly different predicted cds used by authors.
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: R395P.
|Phenotype Manifest In|
multidendritic neuron & dendrite
multidendritic neuron & dendrite | somatic clone
multidendritic neuron & dendrite | supernumerary
trc/Df(3L)BSC445 mutant third instar larvae show a significant increase in the proportion of dorsal midline ddaC dendrite length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type. Most of the dendritic crossings in these mutants are between enclosed dendrites and dendrites attached to the ECM and are thus non-contacting.
Females carrying homozygous follicle cell clones can produce round eggs.
trc/+ heterozygotes exhibit wild-type dendritic tiling, with wild-type levels of dendritic crossing points per υm.
trc1 mutants exhibit supernumerary terminal branching and defective dendritic tiling. Mutant larvae show an increase in terminal branch number, and the branches of ddaC neurons often overlap each other. This tiling defect can be seen independently from the overbranching defect. The crossing branches have rigid and straight trajectories. When somatic clones are made in the neurons, mutant ddaE, IdaA and ddaC dendrites display a 50% increase in the number of branches. Mutant clones also exhibit a tiling defect. In mutants, the v'ada and vdaB dendrites often invade neighbouring fields. Major branches as well as terminal branches overlap extensively.
trc1/trc8 mutant show a variable delay in developmental rate. trc1/trc8 mutant pupae can have multiply split laterals on the aristae. Laterals are seen to split at a wide range of developmental stages. As development proceeds, the distance from the proximal base of the lateral to the proximal most branch-point increases, as does the distance between the proximal and distal branch-points. An increase in the length of the arms distal to branch-points is also seen.
trc1/trc8 clones in the wing produce a weak multiple hair cell phenotype. Some hairs are split distally. The hairs appear clustered close together. In some cases the hairs are oriented almost orthogonally to the plane of the wing. trc1/Df(3L)kto2 larvae have an abnormal pattern of denticles, with the wild-type fairly precise rows of denticles being replaced by a more chaotic arrangement. At the level of the individual denticle, the predominant abnormality is splitting (more than 30% of denticles in some denticle bands show this phenotype). trc1/trc8 flies routinely show branching of one or more of the lateral extensions of the antenna.
Mutant wing and notum have rosettes of three or more short trichomes instead of single long hairs as in wild type. Useful as cell marker. Mutant cell autonomous in mitotic cells in a wild-type background, but not in a Minute background (Vinson and Adler, 1987, D. I. S. 66).
|Phenotype Manifest In|
stan[E59]/trc double heterozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type (neither single heterozygote shows this phenotype).
Class IV da neurons of Sin1[e03756]/+ ; trc/+, rictor[Δ2]/+ ; trc/+ and Tor[ΔP]/+ ; trc/+ double heterozygous larvae show defects in dendritic tiling, with a significantly higher number of dendritic branches crossing one another compared to wild type.
trc/+ tutl/+ double heterozygotes do not show any enhanced class I da neuron branching defects or class IV neuron dendrite self-avoidance defects compared to tutl/+ single heterozygotes.
Transheterozygotes for trc/hpo[MGH4] exhibit obvious iso-neuronal as well as hetero-neuronal tiling defects, including a significant increase in dendritic crossing-points compared to single mutants. Transheterozygotes for wts[x1]/trc do not show any significant dendritic phenotypes. Transheterozygotes for trc/hpo[KC202] exhibit obvious iso-neuronal as well as hetero-neuronal tiling defects, including a significant increase in dendritic crossing-points compared to single mutants.
|Complementation & Rescue Data|
|Not rescued by|
|Stocks ( 4 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 13 )|
|Personal communication to FlyBase|