Allele Dmel\trx³

General Information
Symbol	Dmel\trx³	Species	D. melanogaster
Name		FlyBase ID	FBal0017167
Feature type	allele	Associated gene	Dmel\trx

Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Gindhart and Kaufman, 1995)
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Breen, 1999) visible \| dominant (Kankel et al., 2004) visible \| dominant \| homeotic (Breen, 1999)
Phenotype Manifest In
	abdominal tergite 1 (Breen, 1999) abdominal tergite 2 (Breen, 1999) abdominal tergite 3 (Breen, 1999) adult abdominal segment 4 \| ectopic (Kankel et al., 2004) adult abdominal segment 5 (Kankel et al., 2004) adult head (Breen, 1999) adult thorax \| anterior (Breen, 1999) antenna (Breen, 1999) arista (Breen, 1999) epidermis (Breen, 1999) maxillary palpus (Breen, 1999) prothoracic segment (Breen, 1999) prothoracic segment \| ventral (Breen, 1999)
Detailed Description
	Statement Reference 9.3% of heterozygotes show transformation of segment A5 to A4. (Kankel et al., 2004) 20.8% of heterozygous adults show at least one transformation phenotype. trx³ may be slightly antimorphic. trx³/trx^Z11 adults occasionally developed small heads, anterior thoracic segments, abnormal antennae with reduced aristae and reduced or absent maxillary palps. They also often develop A1 tergites with dark pigmentation and large Uab-like bristles at their posterior borders. The flies have patches of small bristles in the A2 and A3 tergites that are normally only found in the A1 tergite. Transformation of ventral T1 to ventral T2 is seen, and sternopleural bristles are present on T1. (Breen, 1999) Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter. (Fauvarque et al., 1995) Suppressor of the Dlw¹/Dlw⁺ ventral to dorsal wing transformation. (Tiong et al., 1995) Like trx². About 75% of the trx¹/trx³ transheterozygotes are lethals, larval and pupal (Ingham, 1981). recessive; lethal in homozygotes or with trx² or trx^D
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference trx³ has visible \| dominant \| homeotic phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷ (Kankel et al., 2004) trx³ has visible \| dominant \| homeotic phenotype, enhanceable by Gug⁵¹⁹/Gug[+] (Kankel et al., 2004) trx³ has visible \| dominant \| homeotic phenotype, enhanceable by Gug²²⁹⁵/Gug[+] (Kankel et al., 2004) trx³ has visible \| dominant \| homeotic phenotype, enhanceable by Gug³³³³/Gug[+] (Kankel et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference trx³ has adult abdominal segment 4 \| ectopic phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷ (Kankel et al., 2004) trx³ has adult abdominal segment 4 \| ectopic phenotype, enhanceable by Gug⁵¹⁹/Gug[+] (Kankel et al., 2004) trx³ has adult abdominal segment 4 \| ectopic phenotype, enhanceable by Gug²²⁹⁵/Gug[+] (Kankel et al., 2004) trx³ has adult abdominal segment 4 \| ectopic phenotype, enhanceable by Gug³³³³/Gug[+] (Kankel et al., 2004) trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug[+]/Gug¹⁷⁵⁷ (Kankel et al., 2004) trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug⁵¹⁹/Gug[+] (Kankel et al., 2004) trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug²²⁹⁵/Gug[+] (Kankel et al., 2004) trx³ has adult abdominal segment 5 phenotype, enhanceable by Gug³³³³/Gug[+] (Kankel et al., 2004)
NOT Enhancer of
Statement Reference trx³ is a non-enhancer of phenotype of w^T3 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T13.5 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T26 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T30 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T33.1.24j (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T40 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T42.1 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T43 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T44 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T53.3 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T66.1 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T69.3 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T72.1 (Fauvarque and Dura, 1993) trx³ is a non-enhancer of phenotype of w^T72.2 (Fauvarque and Dura, 1993)
NOT Suppressor of
Statement Reference trx³ is a non-suppressor of phenotype of w^T3 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T13.5 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T26 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T30 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T33.1.24j (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T40 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T42.1 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T43 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T44 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T53.3 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T66.1 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T69.3 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T72.1 (Fauvarque and Dura, 1993) trx³ is a non-suppressor of phenotype of w^T72.2 (Fauvarque and Dura, 1993)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Ingham (1981).

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	trx³
Name Synonym
Secondary FlyBase IDs

References ( 13 )
Research paper	Kankel et al., 2004, Genetics 168(1): 161--180 A screen for genes that interact with the Drosophila pair-rule segmentation gene fushi tarazu. [FBrf0180288] Rusch and Kaufman, 2000, Genetics 156(1): 183--194 Regulation of proboscipedia in Drosophila by homeotic selector genes. [FBrf0130058] Breen, 1999, Genetics 152(1): 319--344 Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes. [FBrf0108148] Fauvarque et al., 1995, Mech. Dev. 52(2-3): 343--355 Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. [FBrf0083917] Gindhart and Kaufman, 1995, Genetics 139(2): 797--814 Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene sex combs reduced. [FBrf0080053] Harding et al., 1995, Genetics 140(4): 1339--1352 A screen for modifiers of Deformed function in Drosophila. [FBrf0083173] Kapoun and Kaufman, 1995, Genetics 140(2): 643--658 Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairing. [FBrf0082203] Tiong et al., 1995, Development 121(6): 1649--1656 Dorsal wing, a locus that affects dorsoventral wing patterning in Drosophila. [FBrf0079523] Fauvarque and Dura, 1993, Genes Dev. 7(8): 1508--1520 polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. [FBrf0058522] Breen and Harte, 1991, Mech. Dev. 35: 113--127 Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila. [FBrf0054607] Mazo et al., 1990, Proc. Natl. Acad. Sci. U.S.A. 87: 2112--2116 The trithorax gene, a trans-acting regulator of the Bithorax complex in Drosophila, encodes a protein with zinc-binding domains. [FBrf0052831] Ingham, 1985, J. Embryol. exp. Morphol. 89: 349--365 A clonal analysis of the requirement for the trithorax gene in the diversification of segments in Drosophila. [FBrf0043006] Ingham, 1981, Rouxs Arch. Dev. Biol. 190(6): 365--369 Trithorax: a new homoeotic mutation of Drosophila melanogaster. [FBrf0037315]

Allele Dmel\trx3

Allele Dmel\trx³