Allele Dmel\trx^E2

General Information
Symbol	Dmel\trx^E2	Species	D. melanogaster
Name		FlyBase ID	FBal0017174
Feature type	allele	Associated gene	Dmel\trx

Allele class	amorphic allele - genetic evidence
Mutagen	gamma ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Gindhart and Kaufman, 1995)
Mutagen	gamma ray (Kennison and Tamkun, 1988)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	enhancer of variegation \| dominant, with P{hsp26-pt-T}39C-27 (Boivin et al., 2003) increased cell number \| somatic clone (Janody et al., 2004) lethal (with trx^lac1) (Fauvarque et al., 2001) lethal (with trx^lac2) (Fauvarque et al., 2001) lethal \| recessive (Kennison and Tamkun, 1988) non-enhancer of variegation, with P{hsp26-pt-T}39C-5 (Boivin et al., 2003) non-enhancer of variegation, with P{wA}4-4 (Boivin et al., 2003) non-suppressor of variegation, with P{hsp26-pt-T}39C-5 (Boivin et al., 2003) non-suppressor of variegation, with P{wA}4-4 (Boivin et al., 2003) visible \| dominant \| homeotic (Ruhf et al., 2001) visible \| homeotic (Ragab, 2006, Klymenko and Muller, 2004) visible \| homeotic (with trx¹) (Rudenko et al., 2003)
Phenotype Manifest In
	abdominal segment 6 (Ruhf et al., 2001) embryonic/first instar larval cuticle \| somatic clone (Klymenko and Muller, 2004) eye \| somatic clone (Janody et al., 2004) eye disc \| somatic clone (Janody et al., 2004) haltere (Ragab, 2006) haltere \| ectopic (with trx¹) (Rudenko et al., 2003) photoreceptor cell \| somatic clone (Janody et al., 2004) wing (with trx¹) (Rudenko et al., 2003) wing \| ectopic (Ragab, 2006)
Detailed Description
	Statement Reference trx^E2 flies show a haltere to wing transformation. (Ragab, 2006) Homozygous mutant clones in the central region of the eye disc cause a delay in photoreceptor differentiation, but clones at the posterior or lateral margins of the disc show a strong loss of photoreceptor differentiation accompanied by overgrowth. (Janody et al., 2004) Larval cuticles of trx^E2 somatic clone mutant embryos show only mild homeotic transformations. (Klymenko and Muller, 2004) trx^E2/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-27. trx^E2/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5 or P{wA}4-4. (Boivin et al., 2003) trx[1]/trx[E2] flies show transformations of wing to haltere; 57% show strong transformation, 34% show weak transformation and 9% show no transformation. (Rudenko et al., 2003) Heterozygotes do not have a held-out wing phenotype. (Calgaro et al., 2002) Transformation of abdominal segment A6 to A5. (Ruhf et al., 2001) No effect on the eye pigment phenotype of w^T81. (Netter et al., 1998) Pairing sensitive repression is unchanged in iab-7 PRE lines that carry trx^E2. (Hagstrom et al., 1997) Heterozygous adults sometimes display homeotic transformation of thoracic and abdominal segments. (Dingwall et al., 1995) Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter. (Fauvarque et al., 1995) Suppressor of the Dlw¹/Dlw⁺ ventral to dorsal wing transformation. (Tiong et al., 1995) trx^E2, brm² double heterozygotes frequently display homeotic transformations: fifth abdominal segment is transformed to a more anterior identity and haltere to wing. (Tamkun et al., 1992) dominant; suppresses extra sex combs in Pc⁴/+
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Asx[+]/Asx¹³ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Asx³/Asx[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Df(1)RA2/+ (Zorin et al., 1999) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by E(Pc)[+]/E(Pc)¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by E(z)[+]/E(z)⁵ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by JIL-1[+]/JIL-1^z2 (Zhang et al., 2003) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by lawc[+]/lawc^EF520 (Zorin et al., 1999) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by lawc^p1/lawc[+] (Zorin et al., 1999) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by lid^k06801/lid[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^T6 (Gerasimova and Corces, 1998) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^ul (Gerasimova and Corces, 1998) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by mod(mdg4)^T16/mod(mdg4)[+] (Gerasimova and Corces, 1998) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Psc[+]/Psc¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Sce[+]/Sce^D1 (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Su(z)2¹/Su(z)2[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Su(z)2^Arp1/Su(z)2[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Su(z)4[+]/Su(z)4¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Su(z)6[+]/Su(z)6¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Su(z)7[+]/Su(z)7¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by sxc[+]/sxc¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Trl[+]/Trl^R85 (Gildea et al., 2000) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by Df(1)RA2/+ (Zorin et al., 1999) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by lawc[+]/lawc^EF520 (Zorin et al., 1999) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by lawc^p1/lawc[+] (Zorin et al., 1999) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^T6 (Gerasimova and Corces, 1998) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^ul (Gerasimova and Corces, 1998) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, enhanceable by mod(mdg4)^T16/mod(mdg4)[+] (Gerasimova and Corces, 1998) brm², trx[+]/trx^E2 has visible \| dominant phenotype, enhanceable by Bap60[+]/Bap60¹ (Moeller et al., 2005)
Suppressed by
Statement Reference brm[+]/brm², trx^E2 has homeotic \| dominant phenotype, suppressible by CG9007[+]/upSET^e00365 (Rincon-Arano et al., 2012) brm[+]/brm², trx^E2 has homeotic \| dominant phenotype, suppressible by upSET^MB08950/CG9007[+] (Rincon-Arano et al., 2012) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by esc⁹/esc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by esc¹⁰/esc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by esc²¹/esc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by M(2)21AB[+]/Sam-S¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by mxc[+]/mxc¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by mxc[+]/mxc^M1 (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by Pc³/Pc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by Pcl⁷/Pcl[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by ph-d[+]/ph-d⁵⁰³ (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by pho^b/pho[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by sxc[+]/sxc⁴ (Gildea et al., 2000) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001) trx^E2/trx¹ has visible \| homeotic phenotype, suppressible \| partially by Pp1-87B[+]/Pp1-87B¹ (Rudenko et al., 2003) trx^E2/trx¹ has visible \| homeotic phenotype, suppressible \| partially by Pp1-87B[+]/Pp1-87B^87Bg-6 (Rudenko et al., 2003) trx^E2 has visible \| homeotic phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001)
NOT suppressed by
Statement Reference trx^E2/trx¹ has visible \| homeotic phenotype, non-suppressible by Pp1-87B^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^arm.PS (Rudenko et al., 2003) trx^E2 has visible \| homeotic phenotype, non-suppressible by Df(2R)ED3921 (Ragab, 2006)
Enhancer of
Statement Reference trx[+], trx^E2, brm[+], brm² is an enhancer of visible \| homeotic phenotype of lawc^p1 (Zorin et al., 1999) trx[+]/trx^E2 is an enhancer of eye color defective phenotype of w^YGfPfMG (Poux et al., 2002) trx[+]/trx^E2 is an enhancer of visible \| dominant phenotype of brm[+]/brm², tara^L4 (Calgaro et al., 2002) trx[+]/trx^E2 is an enhancer of visible \| homeotic phenotype of Dsp1¹ (Decoville et al., 2001) trx^E2 is an enhancer of body color defective phenotype of brm², mod(mdg4)^ul, y² (Gerasimova and Corces, 1998) trx^E2 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.813 (Bloyer et al., 2003) trx^E2 is an enhancer of eye color defective phenotype of w¹¹¹⁸, w^{mC.ph-p.813bis} (Bloyer et al., 2003) trx^E2 is an enhancer of eye color defective phenotype of w^Fab-7.5F24 (Cavalli, 1999) trx^E2 is an enhancer of visible \| homeotic phenotype of brm², lawc^p1 (Zorin et al., 1999)
NOT Enhancer of
Statement Reference trx^E2 is a non-enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-d.826 (Bloyer et al., 2003) trx^E2 is a non-enhancer of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.812 (Bloyer et al., 2003) trx^E2 is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005)
Suppressor of
Statement Reference trx[+]/trx^E2 is a suppressor of visible \| dominant phenotype of gcm^Pyx (Popkova et al., 2012) trx^E2 is a suppressor of visible \| homeotic phenotype of esc⁶ (Klymenko and Muller, 2004)
NOT Suppressor of
Statement Reference trx^E2 is a non-suppressor of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-d.826 (Bloyer et al., 2003) trx^E2 is a non-suppressor of eye color defective phenotype of w¹¹¹⁸, w^mC.ph-p.812 (Bloyer et al., 2003) trx^E2 is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005) trx^E2 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa (Secombe et al., 2007)
Other
Statement Reference brm[+]/brm², tara¹, trx[+]/trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002) brm[+]/brm², tara¹/tara[+], trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002) brm[+]/brm², tara^L4/tara[+], trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002) brm[+]/brm², trx^E2 has homeotic \| dominant phenotype (Rincon-Arano et al., 2012) brm[+]/brm², trx^E2 has visible \| dominant \| homeotic phenotype (Zhang et al., 2003) brm², tara¹/tara[+], trx[+]/trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002) brm², tara^L4/tara[+], trx[+]/trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002) brm², trx[+]/trx^E2 has visible \| dominant \| homeotic phenotype (Zhang et al., 2003) brm², trx[+]/trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002, Moeller et al., 2005) brm², trx^E2 has visible \| dominant phenotype (Calgaro et al., 2002, Vazquez et al., 1999) brm², trx^E2 has visible \| homeotic phenotype (Zorin et al., 1999, Gerasimova and Corces, 1998, Gerasimova and Corces, 1998, Zorin et al., 1999, Tamkun et al., 1992) fs(1)h⁴, trx[+]/trx^E2 has visible phenotype (Florence and Faller, 2008) Rm62[+]/Rm62⁰¹⁰⁸⁶, trx^E2 has visible phenotype (Lamiable et al., 2010) RYBP[+]/RYBP^KG08683, trx^E2 has visible \| dominant phenotype (González et al., 2008) RYBP^KG08683, trx^E2 has visible \| dominant phenotype (González et al., 2008)
Phenotype Manifest In
Enhanced by
Statement Reference brm[+]/brm², trx^E2 has adult abdominal segment 5 \| ectopic \| male phenotype, enhanceable by JIL-1[+]/JIL-1^z2 (Zhang et al., 2003) brm[+]/brm², trx^E2 has adult abdominal segment 6 \| male phenotype, enhanceable by JIL-1[+]/JIL-1^z2 (Zhang et al., 2003) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Asx[+]/Asx¹³ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Asx³/Asx[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by E(Pc)[+]/E(Pc)¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by E(z)[+]/E(z)⁵ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by lid^k06801/lid[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Psc[+]/Psc¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Sce[+]/Sce^D1 (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)2¹/Su(z)2[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)2^Arp1/Su(z)2[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)4[+]/Su(z)4¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)6[+]/Su(z)6¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)7[+]/Su(z)7¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by sxc[+]/sxc¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Trl[+]/Trl^R85 (Gildea et al., 2000) brm[+]/brm², trx^E2 has haltere phenotype, enhanceable by lawc^p1/lawc[+] (Zorin et al., 1999) brm[+]/brm², trx^E2 has metathoracic leg phenotype, enhanceable by lawc^p1/lawc[+] (Zorin et al., 1999) brm², trx[+]/trx^E2 has humeral bristle phenotype, enhanceable by Bap60[+]/Bap60¹ (Moeller et al., 2005) trx^E2 has phenotype, enhanceable by Snr1^R3 (Dingwall et al., 1995)
NOT Enhanced by
Statement Reference trx^E2 has phenotype, non-enhanceable by Alh^unspecified (Perrin et al., 2003)
Suppressed by
Statement Reference brm[+]/brm², trx^E2 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by esc⁹/esc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by esc¹⁰/esc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by esc²¹/esc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by M(2)21AB[+]/Sam-S¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc¹ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc^M1 (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by Pc³/Pc[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by Pcl⁷/Pcl[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by ph-d[+]/ph-d⁵⁰³ (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by pho^b/pho[+] (Gildea et al., 2000) brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc⁴ (Gildea et al., 2000) brm[+]/brm², trx^E2 has haltere phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001) brm[+]/brm², trx^E2 has metathoracic leg phenotype, suppressible by CG9007[+]/upSET^e00365 (Rincon-Arano et al., 2012) brm[+]/brm², trx^E2 has metathoracic leg phenotype, suppressible by upSET^MB08950/CG9007[+] (Rincon-Arano et al., 2012) brm², trx[+]/trx^E2 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001) brm², trx[+]/trx^E2 has haltere phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001) trx^E2/trx¹ has haltere \| ectopic phenotype, suppressible \| partially by Pp1-87B[+]/Pp1-87B¹ (Rudenko et al., 2003) trx^E2/trx¹ has haltere \| ectopic phenotype, suppressible \| partially by Pp1-87B[+]/Pp1-87B^87Bg-6 (Rudenko et al., 2003) trx^E2/trx¹ has wing phenotype, suppressible \| partially by Pp1-87B[+]/Pp1-87B¹ (Rudenko et al., 2003) trx^E2/trx¹ has wing phenotype, suppressible \| partially by Pp1-87B[+]/Pp1-87B^87Bg-6 (Rudenko et al., 2003) trx^E2 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+] (Ruhf et al., 2001)
NOT suppressed by
Statement Reference trx^E2/trx¹ has haltere \| ectopic phenotype, non-suppressible by Pp1-87B^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^arm.PS (Rudenko et al., 2003) trx^E2/trx¹ has wing phenotype, non-suppressible by Pp1-87B^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^arm.PS (Rudenko et al., 2003) trx^E2 has haltere phenotype, non-suppressible by Df(2R)ED3921 (Ragab, 2006) trx^E2 has phenotype, non-suppressible by Alh^unspecified (Perrin et al., 2003) trx^E2 has wing \| ectopic phenotype, non-suppressible by Df(2R)ED3921 (Ragab, 2006)
Enhancer of
Statement Reference trx[+], trx^E2, brm[+], brm² is an enhancer of arista phenotype of lawc^p1 (Zorin et al., 1999) trx[+], trx^E2, brm[+], brm² is an enhancer of phenotype of mod(mdg4)^ul (Gerasimova and Corces, 1998) trx[+]/trx^E2 is an enhancer of haltere phenotype of Dsp1¹ (Decoville et al., 2001) trx[+]/trx^E2 is an enhancer of pigment cell phenotype of w^YGfPfMG (Poux et al., 2002) trx[+]/trx^E2 is an enhancer of wing \| ectopic phenotype of Dsp1¹ (Decoville et al., 2001) trx[+]/trx^E2 is an enhancer of wing phenotype of brm[+]/brm², tara^L4 (Calgaro et al., 2002) trx^E2 is an enhancer of adult cuticle \| male phenotype of brm², mod(mdg4)^ul, y² (Gerasimova and Corces, 1998) trx^E2 is an enhancer of arista phenotype of brm², lawc^p1 (Zorin et al., 1999) trx^E2 is an enhancer of pigment cell phenotype of w^Fab-7.5F24 (Cavalli, 1999) trx^E2 is an enhancer of wing phenotype of sd^Fab-X (Bantignies et al., 2003)
NOT Enhancer of
Statement Reference trx^E2 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005) trx^E2 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, osa^Scer\UAS.cCa (Collins et al., 1999) trx^E2 is a non-enhancer of wing vein \| ectopic phenotype of Snr1^R3/Snr1^E1 (Marenda et al., 2004)
Suppressor of
Statement Reference trx[+]/trx^E2 is a suppressor of chaeta \| supernumerary phenotype of gcm^Pyx (Popkova et al., 2012) trx^E2 is a suppressor of embryonic/first instar larval cuticle phenotype of esc⁶ (Klymenko and Muller, 2004) trx^E2 is a suppressor of eye phenotype of CycE^JP (Brumby et al., 2002) trx^E2 is a suppressor of phenotype of Abd-B^Fab7-P18.1 (Mihaly et al., 1997) trx^E2 is a suppressor of phenotype of Pc⁴ (Kennison and Tamkun, 1988) trx^E2 is a suppressor of phenotype of w^Fab-7-Ab (Dejardin and Cavalli, 2004) trx^E2 is a suppressor of phenotype of w^Fab-7-ΔZ (Dejardin and Cavalli, 2004)
NOT Suppressor of
Statement Reference trx^E2/brm² is a non-suppressor of wing phenotype of Scer\GAL4^OK386, nej^Scer\UAS.cMa (Bantignies et al., 2000) trx^E2 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Armstrong et al., 2005) trx^E2 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, osa^Scer\UAS.cCa (Collins et al., 1999) trx^E2 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, dm^Scer\UAS.cZa (Secombe et al., 2007) trx^E2 is a non-suppressor of wing vein \| ectopic phenotype of Snr1^R3/Snr1^E1 (Marenda et al., 2004)
Other
Statement Reference brm[+]/brm², tara¹, trx[+]/trx^E2 has wing phenotype (Calgaro et al., 2002) brm[+]/brm², tara¹/tara[+], trx^E2 has wing phenotype (Calgaro et al., 2002) brm[+]/brm², tara^L4/tara[+], trx^E2 has wing phenotype (Calgaro et al., 2002) brm[+]/brm², trx^E2 has adult abdominal segment 5 \| ectopic \| male phenotype (Zhang et al., 2003) brm[+]/brm², trx^E2 has adult abdominal segment 6 \| male phenotype (Zhang et al., 2003) brm[+]/brm², trx^E2 has metathoracic leg phenotype (Rincon-Arano et al., 2012) brm², tara¹/tara[+], trx[+]/trx^E2 has wing phenotype (Calgaro et al., 2002) brm², tara^L4/tara[+], trx[+]/trx^E2 has wing phenotype (Calgaro et al., 2002) brm², trx[+]/trx^E2 has abdominal segment 5 phenotype (Tamkun et al., 1992) brm², trx[+]/trx^E2 has adult abdominal segment 5 \| ectopic \| male phenotype (Zhang et al., 2003) brm², trx[+]/trx^E2 has adult abdominal segment 6 \| male phenotype (Zhang et al., 2003) brm², trx[+]/trx^E2 has humeral bristle phenotype (Moeller et al., 2005) brm², trx[+]/trx^E2 has wing phenotype (Calgaro et al., 2002) brm², trx^E2 has adult abdominal segment 5 phenotype (Vazquez et al., 1999, Vazquez et al., 1999) brm², trx^E2 has haltere phenotype (Zorin et al., 1999, Zorin et al., 1999) brm², trx^E2 has metathoracic leg phenotype (Zorin et al., 1999, Zorin et al., 1999) brm², trx^E2 has wing phenotype (Calgaro et al., 2002) fs(1)h⁴, trx[+]/trx^E2 has adult segment phenotype (Florence and Faller, 2008) fs(1)h⁴, trx[+]/trx^E2 has haltere phenotype (Florence and Faller, 2008) fs(1)h⁴, trx[+]/trx^E2 has metathoracic leg phenotype (Florence and Faller, 2008) fs(1)h⁴, trx[+]/trx^E2 has prothoracic leg phenotype (Florence and Faller, 2008) Rm62[+]/Rm62⁰¹⁰⁸⁶, trx^E2 has adult abdominal segment 6 phenotype (Lamiable et al., 2010) Rm62[+]/Rm62⁰¹⁰⁸⁶, trx^E2 has haltere phenotype (Lamiable et al., 2010) RYBP[+]/RYBP^KG08683, trx^E2 has adult abdominal segment 5 phenotype (González et al., 2008) RYBP^KG08683, trx^E2 has adult abdominal segment 5 phenotype (González et al., 2008)
Additional Comments
Genetic Interactions
Statement Reference 56% of brm[2] trx[E2] double heterozygotes have an apical bristle on the third leg (usually found on the second leg). Heterozygosity for either upSET[e00365] or upSET[MB08950] reduces the penetrance of this phenotype to 9% or 4% respectively. (Rincon-Arano et al., 2012) 7.7% of Rm62[01086]/trx[E2] double heterozygous males show transformation of abdominal segment A6 into A5. 6.6% of the double heterozygotes show transformation of haltere into wing. (Lamiable et al., 2010) 21% of fs(1)h[4]/+;trx[E2]/+ adults show segmental deletions, and 41% show transformations of haltere to wing and T1 or T3 leg and plura to T2 identity. (Florence and Faller, 2008) 52% of RYBP[KG08683]/+ ; trx[E2]/+ males show depigmentation of the fifth abdominal segment. 95% of RYBP[KG08683]/RYBP[KG08683] ; trx[E2]/+ males show depigmentation of the fifth abdominal segment. (González et al., 2008) Df(2R)ED3921 fails to suppress the haltere to wing transformation of trx^E2 flies. (Ragab, 2006) trx[E2]/+ largely rescues the wing defects seen in RYBP[Scer\UAS.cBa]; Scer\GAL4[sd-SG29.1] animals. (Bejarano et al., 2005) 5% of brm[2] trx[E2] double heterozygotes show loss of humeral bristles. The penetrance of this phenotype is increased to 15% by Bap60[1]/+. Bap60[1]/+ ; trx[E2]/+ double heterozygotes do not show loss of humeral bristles. (Moeller et al., 2005) trx^E2 esc⁶ double mutants show partial suppression of homeotic transformations in embryonic/first instar larval cuticle (i.e. thoracic denticle belts are comparable to those found in wild-type embryos), but the head is abnormal and abdominal segments are still partly transformed towards the eighth abdominal segment. (Klymenko and Muller, 2004) Pp1-87B[87Bg-6] dominantly suppresses the transformation of wing to haltere seen in trx[1]/trx[E2] flies; 36% show strong transformation, 42% show weak transformation and 22% show no transformation. Pp1-87B[1] dominantly suppresses the transformation of wing to haltere seen in trx[1]/trx[E2] flies; 31% show strong transformation, 39% show weak transformation and 30% show no transformation. Expression of Pp1-87B[Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[arm.PS] has no effect on the transformation of wing to haltere seen in trx[1]/trx[E2] flies. (Rudenko et al., 2003) brm² trx^E2 double heterozygous males show a low frequency of A6 to A5 transformation; the frequency is 9% if brm² trx^E2 is maternally derived and 17% if brm² trx^E2 is paternally derived. The frequency of A6 to A5 transformation seen in brm² trx^E2 double heterozygous males is increased if they also carry JIL-1^z2; the frequency is 65% if JIL-1^z2 is maternally derived and brm² trx^E2 is paternally derived and is 75% in the reciprocal cross. (Zhang et al., 2003) Mutant weakly suppresses the CycE^JP rough eye phenotype. (Brumby et al., 2002) 2% of trx^E2 tara^L4 double heterozygotes have a held-out wing phenotype. 1% of trx^E2 tara¹ double heterozygotes have a held-out wing phenotype. 5% of trx^E2 brm² double heterozygotes have a held-out wing phenotype. 45% of trx^E2 brm² tara^L4 triple heterozygotes have a held-out wing phenotype. 38% of trx^E2 brm² tara¹ triple heterozygotes have a held-out wing phenotype. (Calgaro et al., 2002) The frequency of transformation of halteres into wings seen in Dsp1¹/Y flies is enhanced by trx^E2/+. The enhancement is dramatically reduced if the female parents are heterozygous rather than homozygous for Dsp1¹. (Decoville et al., 2001) The abdominal segment A6 to A5 transformation and the haltere to wing transformation of brm²/+, trx^E2/+ is dominantly suppressed by dom¹⁴. (Ruhf et al., 2001) 35.3% of trx^E2 brm² double heterozygotes show T3 to T2 transformations. The penetrance of this phenotype is enhanced by one copy of lid^k06801, sxc¹, Sce^D1, E(z)⁵, Trl^R85, Su(z)4¹, Su(z)7¹, Su(z)6¹, E(Pc)¹, Su(z)2¹, Su(z)2^Arp1, Psc¹, Asx³ or Asx¹³ and suppressed by one copy of Pc³, ph-d⁵⁰³, Pcl⁷, pho^b, mxc^M1, mxc¹, esc⁹, esc¹⁰, esc²¹, sxc⁴ or M(2)21AB¹. (Gildea et al., 2000) Mutant heterozygotes show a moderate enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes. In trx^E2/+, Scer\GAL4^hs.PB, w^Fab-7.5F24 flies, an embryonic heat shock pulse leads to eyes lighter than with w^Fab-7.5F24 alone. (Cavalli, 1999) The addition of trx^E2 does not affect the variable eye size phenotype seen in osa^Scer\UAS.cCa/Scer\GAL4^ey.PH flies. (Collins et al., 1999) Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies. (Staehling-Hampton et al., 1999) brm² trx^E2 double heterozygotes show partial transformation of the 5th abdominal segment to fourth abdominal segment, but do not hold out their wings at any significantly higher frequency than that seen in brm²/+ single heterozygotes. (Vazquez et al., 1999) The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in brm² trx^E2 double heterozygotes is dominantly enhanced by lawc^p1. The enhancement is stronger in a lawc^p1 maternal background. The arista to leg transformation characteristic of lawc^p1 is also enhanced in these flies. The frequency of homeotic transformations in brm² trx^E2 double heterozygotes is dominantly enhanced by lawc^EF520 or Df(1)RA2. (Zorin et al., 1999) 10.0% of trx^E2 brm² double heterozygous adults show a homeotic phenotype. This is increased to 56.5% if the flies are also heterozygous for mod(mdg4)^T16, 24.9% if the flies are also heterozygous for mod(mdg4)^ul and 35.7% if the flies are also heterozygous for mod(mdg4)^T6. The combination brm² trx^E2 dominantly enhances the effect of mod(mdg4)^ul on the y² phenotype. (Gerasimova and Corces, 1998) Suppresses the transformation of A6 to A7 seen in Abd-B^Fab7-P18.1 heterozygotes, but does not alter the phenotype of Abd-B^Fab7-12 heterozygotes. (Mihaly et al., 1997) Snr1 mutations enhance the abdominal transformations. (Dingwall et al., 1995) Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype. (Kennison and Tamkun, 1988)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	trx^lac1 (Fauvarque et al., 2001) trx^lac2 (Fauvarque et al., 2001)
Comments
Stocks ( 5 )
Bloomington	24160 y¹; P{neoFRT}82B trx^E2/TM6C, Sb¹ Tb¹ 3622 brm² trx^E2 ca¹/TM6B, Tb¹ ca¹ 3621 ru¹ h¹ th¹ st¹ trx^E2 ca¹/TM6B, Tb¹ ca¹
Kyoto	107135 brm² trx^E2 ca¹/TM6B, Tb¹ ca¹ 107134 ru¹ h¹ th¹ st¹ trx^E2 ca¹/TM6B, Tb¹ ca¹
Notes on Origin
Discoverer	Kennison, Tamkun.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	trx^e2 (Klymenko and Muller, 2004, Gildea et al., 2000) trx^E2 (de Navas et al., 2006, Moeller et al., 2005, Bejarano et al., 2005, Vázquez et al., 2008, González et al., 2008, Florence and Faller, 2008, Rudenko et al., 2003, Lamiable et al., 2010, Melicharek et al., 2008, Rincon-Arano et al., 2012, Popkova et al., 2012) Trx^E2 (Secombe et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 60 )

Generate a list of	All references relating to this allele ( 60 )

List References by type	Research paper ( 58 ) Supplementary material ( 1 ) Review ( 1 )
Recent research papers ( 2 )
	Popkova et al., 2012, PLoS Genet. 8(12): e1003159 Polycomb controls gliogenesis by regulating the transient expression of the gcm/glide fate determinant. [FBrf0220515] Rincon-Arano et al., 2012, Cell 151(6): 1214--1228 UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions. [FBrf0220189] Show all research papers ...
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	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\trxE2

Allele Dmel\trx^E2