FlyBase Allele Report: Dmel\trx[E2]

General Information

Symbol

Dmel\trx^E2

Species

D. melanogaster

Name

FlyBase ID

FBal0017174

Feature type

allele

Associated gene

Dmel\trx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

gamma ray

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

enhancer of variegation | dominant, with P{hsp26-pt-T}39C-27

(Boivin et al., 2003)

homeotic | adult stage

(Umer et al., 2019)

increased cell death | somatic clone | third instar larval stage

(Kanda et al., 2013)

increased cell number

(Tauc et al., 2021)

increased cell number | somatic clone

(Janody et al., 2004)

increased occurrence of cell division

(Tauc et al., 2021)

lethal (with trx^lac1)

(Fauvarque et al., 2001)

lethal (with trx^lac2)

(Fauvarque et al., 2001)

lethal | recessive

(Kennison and Tamkun, 1988)

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-enhancer of variegation, with P{wA}4-4

(Boivin et al., 2003)

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-suppressor of variegation, with P{wA}4-4

(Boivin et al., 2003)

visible | adult stage | dominant

(Bi et al., 2022)

visible | adult stage | somatic clone

(Kanda et al., 2013)

visible | dominant

(Rougeot et al., 2013)

visible | dominant | homeotic

(Ruhf et al., 2001)

visible | homeotic

(Ragab, 2006, Klymenko and Muller, 2004)

visible | homeotic (with trx¹)

(Rudenko et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

trx^E2/trx^E2 somatic clones show similar levels of intestinal stem cell proliferation as controls.

(Gervais et al., 2019)

trx^E2 heterozygous adults show occasional homeotic transformation in the abdomen (A5 to A4 transformation, indicated by loss of pigmentation in A5).

(Umer et al., 2019)

trx^E2 mutant somatic clones show a growth disadvantage compared to the wild-type cells as the trx^E2 mutant tissue is relatively underrepresented in the mosaic adult eyes. Eyes composed almost entirely of the mutant tissue (generated by mitotic recombination with a chromosome bearing a recessive cell-lethal mutation) are much smaller than in controls. trx^E2 homozygous clones in the third instar larval eye discs display high levels of apoptosis (detected by Casp3 antibody staining).

(Kanda et al., 2013)

53.9% of heterozygous females have ectopic wing veins.

(Rougeot et al., 2013)

Developmental apoptosis is trx^E2 embryos is similar to wild type.

(González and Busturia, 2009)

trx^E2 flies show a haltere to wing transformation.

(Ragab, 2006)

Homozygous mutant clones in the central region of the eye disc cause a delay in photoreceptor differentiation, but clones at the posterior or lateral margins of the disc show a strong loss of photoreceptor differentiation accompanied by overgrowth.

(Janody et al., 2004)

Larval cuticles of trx^E2 somatic clone mutant embryos show only mild homeotic transformations.

(Klymenko and Muller, 2004)

trx^E2/+ enhances the telomeric position effect (TPE) of P{hsp26-pt-T}39C-27. trx^E2/+ has no effect on the telomeric position effect (TPE) of P{hsp26-pt-T}39C-5 or P{wA}4-4.

(Boivin et al., 2003)

trx¹/trx^E2 flies show transformations of wing to haltere; 57% show strong transformation, 34% show weak transformation and 9% show no transformation.

(Rudenko et al., 2003)

Heterozygotes do not have a held-out wing phenotype.

(Calgaro et al., 2002)

Transformation of abdominal segment A6 to A5.

(Ruhf et al., 2001)

No effect on the eye pigment phenotype of w^T81.

(Netter et al., 1998)

Pairing sensitive repression is unchanged in iab-7 PRE lines that carry trx^E2.

(Hagstrom et al., 1997)

Heterozygous adults sometimes display homeotic transformation of thoracic and abdominal segments.

(Dingwall et al., 1995)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is lighter.

(Fauvarque et al., 1995)

Suppressor of the Dlw¹/Dlw⁺ ventral to dorsal wing transformation.

(Tiong et al., 1995)

trx^E2, brm² double heterozygotes frequently display homeotic transformations: fifth abdominal segment is transformed to a more anterior identity and haltere to wing.

(Tamkun et al., 1992)

dominant; suppresses extra sex combs in Pc⁴/+

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

trx^E2 has visible | adult stage | dominant phenotype, enhanceable by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

trx^E2 has visible | adult stage | dominant phenotype, enhanceable by Df(3R)Exel8157/+

(Bi et al., 2022)

trx^E2 has homeotic | adult stage phenotype, enhanceable by enok¹/enok[+]

(Umer et al., 2019)

trx^E2 has homeotic | adult stage phenotype, enhanceable by enok[+]/enok²

(Umer et al., 2019)

brm², trx[+]/trx^E2 has visible | dominant phenotype, enhanceable by Bap60[+]/Bap60¹

(Möller et al., 2005)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by JIL-1[+]/JIL-1^z2

(Zhang et al., 2003)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Asx[+]/Asx¹³

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Asx³/Asx[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by E(z)[+]/E(z)⁵

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Psc[+]/Psc¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Sce[+]/Sce^D1

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)2¹/Su(z)2[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)2^Arp1/Su(z)2[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)4[+]/Su(z)4¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)6[+]/Su(z)6¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Su(z)7[+]/Su(z)7¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Trl[+]/Trl^R85

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Kdm5^k06801/lid[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by sxc[+]/sxc¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by E(Pc)[+]/E(Pc)¹

(Gildea et al., 2000)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawc^EF520

(Zorin et al., 1999)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+

(Zorin et al., 1999)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by lawc[+]/lawc^EF520

(Zorin et al., 1999)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by Df(1)RA2/+

(Zorin et al., 1999)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)^T16/mod(mdg4)[+]

(Gerasimova and Corces, 1998)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^ul

(Gerasimova and Corces, 1998)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^T6

(Gerasimova and Corces, 1998)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)^T16/mod(mdg4)[+]

(Gerasimova and Corces, 1998)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^ul

(Gerasimova and Corces, 1998)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, enhanceable by mod(mdg4)[+]/mod(mdg4)^T6

(Gerasimova and Corces, 1998)

Suppressed by

Statement

Reference

trx^E2 has increased cell number phenotype, suppressible by Pc¹

(Tauc et al., 2021)

trx^E2 has visible | dominant phenotype, suppressible by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

trx^E2 has visible | dominant phenotype, suppressible by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

trx^E2 has visible | dominant phenotype, suppressible by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

brm[+]/brm², trx^E2 has homeotic | dominant phenotype, suppressible by CG9007[+]/upSET^e00365

(Rincon-Arano et al., 2012)

brm[+]/brm², trx^E2 has homeotic | dominant phenotype, suppressible by upSET^MB08950/CG9007[+]

(Rincon-Arano et al., 2012)

trx^E2/trx¹ has visible | homeotic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^87Bg-6

(Rudenko et al., 2003)

trx^E2/trx¹ has visible | homeotic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B¹

(Rudenko et al., 2003)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

trx^E2 has visible | homeotic phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by M(2)21AB[+]/Sams¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by Pc³/Pc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by Pcl⁷/Pcl[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by esc¹⁰/esc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by esc²¹/esc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by esc⁹/esc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxc¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by mxc[+]/mxc^M1

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by ph-d[+]/ph-d⁵⁰³

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by pho^b/pho[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype, suppressible by sxc[+]/sxc⁴

(Gildea et al., 2000)

NOT suppressed by

Statement

Reference

trx^E2 has visible | homeotic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

trx^E2/trx¹ has visible | homeotic phenotype, non-suppressible by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Rudenko et al., 2003)

Enhancer of

Statement

Reference

trx[+]/trx^E2 is an enhancer of visible | dominant phenotype of brm[+]/brm², tara^L4

(Calgaro et al., 2002)

trx[+]/trx^E2 is an enhancer of visible | homeotic phenotype of Dsp1¹

(Decoville et al., 2001)

trx^E2 is an enhancer of visible | homeotic phenotype of brm², lawc^p1

(Zorin et al., 1999)

trx[+], trx^E2, brm[+], brm² is an enhancer of visible | homeotic phenotype of lawc^p1

(Zorin et al., 1999)

trx^E2 is an enhancer of abnormal body color phenotype of brm², mod(mdg4)^ul, y²

(Gerasimova and Corces, 1998)

NOT Enhancer of

Statement

Reference

trx[+]/trx^E2 is a non-enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

trx[+]/trx^E2 is a non-enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

trx^E2 is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

trx[+]/trx^E2 is a suppressor of visible | dominant phenotype of gcm^Pyx

(Popkova et al., 2012)

trx[+]/trx^E2 is a suppressor | partially of increased cell death phenotype of RYBP^UAS.cBa, Scer\GAL4^nub-AC-62

(González and Busturia, 2009)

trx[+]/trx^E2 is a suppressor of abnormal eye color phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

trx^E2 is a suppressor of visible | homeotic phenotype of esc⁶

(Klymenko and Muller, 2004)

NOT Suppressor of

Statement

Reference

trx[+]/trx^E2 is a non-suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

trx[+]/trx^E2 is a non-suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

trx^E2 is a non-suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

trx^E2 is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Other

Statement

Reference

brm[+]/brm², trx^E2 has homeotic | dominant phenotype

(Rincon-Arano et al., 2012)

Rm62[+]/Rm62⁰¹⁰⁸⁶, trx^E2 has visible phenotype

(Lamiable et al., 2010)

fs(1)h⁴, trx[+]/trx^E2 has visible phenotype

(Florence and Faller, 2008)

RYBP^KG08683, trx^E2 has visible | dominant phenotype

(González et al., 2008)

RYBP[+]/RYBP^KG08683, trx^E2 has visible | dominant phenotype

(González et al., 2008)

brm², trx[+]/trx^E2 has visible | dominant phenotype

(Möller et al., 2005, Calgaro et al., 2002)

brm[+]/brm², trx^E2 has visible | dominant | homeotic phenotype

(Zhang et al., 2003)

brm², trx[+]/trx^E2 has visible | dominant | homeotic phenotype

(Zhang et al., 2003)

brm², tara¹/tara[+], trx[+]/trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm², tara^L4/tara[+], trx[+]/trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹, trx[+]/trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹/tara[+], trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara^L4/tara[+], trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002)

brm², trx^E2 has visible | dominant phenotype

(Calgaro et al., 2002, Vazquez et al., 1999)

brm², trx^E2 has visible | homeotic phenotype

(Zorin et al., 1999, Gerasimova and Corces, 1998, Tamkun et al., 1992)

Phenotype Manifest In

Enhanced by

Statement

Reference

trx^E2 has abdominal tergite phenotype, enhanceable by CtBP[+]/CtBP^87De-10

(Bi et al., 2022)

trx^E2 has adult abdominal segment 4 phenotype, enhanceable by enok¹/enok[+]

(Umer et al., 2019)

trx^E2 has adult abdominal segment 5 phenotype, enhanceable by enok¹/enok[+]

(Umer et al., 2019)

trx^E2 has adult abdominal segment 5 phenotype, enhanceable by enok[+]/enok²

(Umer et al., 2019)

trx^E2 has adult abdominal segment 4 phenotype, enhanceable by enok[+]/enok²

(Umer et al., 2019)

brm², trx[+]/trx^E2 has humeral bristle phenotype, enhanceable by Bap60[+]/Bap60¹

(Möller et al., 2005)

brm[+]/brm², trx^E2 has adult abdominal segment 5 | ectopic | male phenotype, enhanceable by JIL-1[+]/JIL-1^z2

(Zhang et al., 2003)

brm[+]/brm², trx^E2 has adult abdominal segment 6 | male phenotype, enhanceable by JIL-1[+]/JIL-1^z2

(Zhang et al., 2003)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Asx[+]/Asx¹³

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Asx³/Asx[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by E(z)[+]/E(z)⁵

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Psc[+]/Psc¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Sce[+]/Sce^D1

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)2¹/Su(z)2[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)2^Arp1/Su(z)2[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)4[+]/Su(z)4¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)6[+]/Su(z)6¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Su(z)7[+]/Su(z)7¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Trl[+]/Trl^R85

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by Kdm5^k06801/lid[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by sxc[+]/sxc¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, enhanceable by E(Pc)[+]/E(Pc)¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has haltere phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

brm[+]/brm², trx^E2 has metathoracic leg phenotype, enhanceable by lawc^p1/lawc[+]

(Zorin et al., 1999)

trx^E2 has phenotype, enhanceable by Snr1^R3

(Dingwall et al., 1995)

NOT Enhanced by

Statement

Reference

trx^E2 has abdominal tergite phenotype, non-enhanceable by Df(3R)Exel8157/+

(Bi et al., 2022)

trx^E2 has phenotype, non-enhanceable by Alh^unspecified

(Perrin et al., 2003)

Suppressed by

Statement

Reference

trx^E2 has enteroendocrine cell | increased number phenotype, suppressible by Pc¹

(Tauc et al., 2021)

trx^E2 has wing vein | ectopic phenotype, suppressible by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

trx^E2 has wing vein | ectopic phenotype, suppressible by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

trx^E2 has wing vein | ectopic phenotype, suppressible by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

brm[+]/brm², trx^E2 has metathoracic leg phenotype, suppressible by CG9007[+]/upSET^e00365

(Rincon-Arano et al., 2012)

brm[+]/brm², trx^E2 has metathoracic leg phenotype, suppressible by upSET^MB08950/CG9007[+]

(Rincon-Arano et al., 2012)

trx^E2/trx¹ has wing phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^87Bg-6

(Rudenko et al., 2003)

trx^E2/trx¹ has haltere | ectopic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B^87Bg-6

(Rudenko et al., 2003)

trx^E2/trx¹ has wing phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B¹

(Rudenko et al., 2003)

trx^E2/trx¹ has haltere | ectopic phenotype, suppressible | partially by Pp1-87B[+]/Pp1-87B¹

(Rudenko et al., 2003)

brm[+]/brm², trx^E2 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

brm[+]/brm², trx^E2 has haltere phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

brm², trx[+]/trx^E2 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

brm², trx[+]/trx^E2 has haltere phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

trx^E2 has abdominal segment 6 phenotype, suppressible by dom¹⁴/dom[+]

(Ruhf et al., 2001)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by M(2)21AB[+]/Sams¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by Pc³/Pc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by Pcl⁷/Pcl[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by esc¹⁰/esc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by esc²¹/esc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by esc⁹/esc[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc¹

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by mxc[+]/mxc^M1

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by ph-d[+]/ph-d⁵⁰³

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by pho^b/pho[+]

(Gildea et al., 2000)

brm[+]/brm², trx^E2 has adult metathoracic segment phenotype, suppressible by sxc[+]/sxc⁴

(Gildea et al., 2000)

NOT suppressed by

Statement

Reference

trx^E2 has haltere phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

trx^E2 has wing | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

trx^E2 has phenotype, non-suppressible by Alh^unspecified

(Perrin et al., 2003)

trx^E2/trx¹ has wing phenotype, non-suppressible by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Rudenko et al., 2003)

trx^E2/trx¹ has haltere | ectopic phenotype, non-suppressible by Pp1-87B^UAS.Tag:HA/Scer\GAL4^arm.PS

(Rudenko et al., 2003)

Enhancer of

Statement

Reference

trx[+]/trx^E2 is an enhancer of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

trx[+]/trx^E2 is an enhancer of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

trx^E2 is an enhancer of wing phenotype of sd^Fab-X

(Bantignies et al., 2003)

trx[+]/trx^E2 is an enhancer of wing phenotype of brm[+]/brm², tara^L4

(Calgaro et al., 2002)

trx[+]/trx^E2 is an enhancer of haltere phenotype of Dsp1¹

(Decoville et al., 2001)

trx[+]/trx^E2 is an enhancer of wing | ectopic phenotype of Dsp1¹

(Decoville et al., 2001)

trx[+], trx^E2, brm[+], brm² is an enhancer of arista phenotype of lawc^p1

(Zorin et al., 1999)

trx^E2 is an enhancer of arista phenotype of brm², lawc^p1

(Zorin et al., 1999)

trx[+], trx^E2, brm[+], brm² is an enhancer of phenotype of mod(mdg4)^ul

(Gerasimova and Corces, 1998)

trx^E2 is an enhancer of adult cuticle | male phenotype of brm², mod(mdg4)^ul, y²

(Gerasimova and Corces, 1998)

NOT Enhancer of

Statement

Reference

trx[+]/trx^E2 is a non-enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

trx[+]/trx^E2 is a non-enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

trx^E2 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

trx^E2 is a non-enhancer of wing vein | ectopic phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

trx^E2 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, osa^UAS.cCa

(Collins et al., 1999)

Suppressor of

Statement

Reference

trx[+]/trx^E2 is a suppressor of chaeta | increased number phenotype of gcm^Pyx

(Popkova et al., 2012)

trx[+]/trx^E2 is a suppressor | partially of wing disc | third instar larval stage phenotype of RYBP^UAS.cBa, Scer\GAL4^nub-AC-62

(González and Busturia, 2009)

trx^E2 is a suppressor of embryonic/first instar larval cuticle phenotype of esc⁶

(Klymenko and Muller, 2004)

trx^E2 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

trx^E2 is a suppressor of phenotype of Abd-B^Fab7-P18.1

(Mihaly et al., 1997)

trx^E2 is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

trx[+]/trx^E2 is a non-suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

trx[+]/trx^E2 is a non-suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

trx^E2 is a non-suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

trx^E2 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

trx^E2 is a non-suppressor of wing vein | ectopic phenotype of Snr1^R3/Snr1^E1

(Marenda et al., 2004)

trx^E2/brm² is a non-suppressor of wing phenotype of Scer\GAL4^OK386, nej^UAS.cMa

(Bantignies et al., 2000)

trx^E2 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, osa^UAS.cCa

(Collins et al., 1999)

Other

Statement

Reference

brm[+]/brm², trx^E2 has metathoracic leg phenotype

(Rincon-Arano et al., 2012)

Rm62[+]/Rm62⁰¹⁰⁸⁶, trx^E2 has haltere phenotype

(Lamiable et al., 2010)

Rm62[+]/Rm62⁰¹⁰⁸⁶, trx^E2 has adult abdominal segment 6 phenotype

(Lamiable et al., 2010)

fs(1)h⁴, trx[+]/trx^E2 has metathoracic leg phenotype

(Florence and Faller, 2008)

fs(1)h⁴, trx[+]/trx^E2 has haltere phenotype

(Florence and Faller, 2008)

fs(1)h⁴, trx[+]/trx^E2 has prothoracic leg phenotype

(Florence and Faller, 2008)

fs(1)h⁴, trx[+]/trx^E2 has adult segment phenotype

(Florence and Faller, 2008)

RYBP^KG08683, trx^E2 has adult abdominal segment 5 phenotype

(González et al., 2008)

RYBP[+]/RYBP^KG08683, trx^E2 has adult abdominal segment 5 phenotype

(González et al., 2008)

brm², trx[+]/trx^E2 has humeral bristle phenotype

(Möller et al., 2005)

brm², trx[+]/trx^E2 has adult abdominal segment 6 | male phenotype

(Zhang et al., 2003)

brm², trx[+]/trx^E2 has adult abdominal segment 5 | ectopic | male phenotype

(Zhang et al., 2003)

brm[+]/brm², trx^E2 has adult abdominal segment 6 | male phenotype

(Zhang et al., 2003)

brm[+]/brm², trx^E2 has adult abdominal segment 5 | ectopic | male phenotype

(Zhang et al., 2003)

brm², tara¹/tara[+], trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², tara^L4/tara[+], trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹, trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara¹/tara[+], trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm[+]/brm², tara^L4/tara[+], trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², trx[+]/trx^E2 has wing phenotype

(Calgaro et al., 2002)

brm², trx^E2 has adult abdominal segment 5 phenotype

(Vazquez et al., 1999)

brm², trx^E2 has metathoracic leg phenotype

(Zorin et al., 1999)

brm², trx^E2 has haltere phenotype

(Zorin et al., 1999)

brm², trx[+]/trx^E2 has abdominal segment 5 phenotype

(Tamkun et al., 1992)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is not affected by combination with a single copy of trx^E2.

(Morimoto et al., 2016)

The penetrance of the ectopic wing vein phenotype seen in trx^E2/+ females (53.9% penetrance) is reduced if they are also heterozygous for one of EloA^G4930 (10.4% penetrance), EloC^SH1520 (5.4%) or EloC^SH1299 (16.7%).

(Rougeot et al., 2013)

56% of brm² trx^E2 double heterozygotes have an apical bristle on the third leg (usually found on the second leg). Heterozygosity for either upSET^e00365 or upSET^MB08950 reduces the penetrance of this phenotype to 9% or 4% respectively.

(Rincon-Arano et al., 2012)

7.7% of Rm62⁰¹⁰⁸⁶/trx^E2 double heterozygous males show transformation of abdominal segment A6 into A5. 6.6% of the double heterozygotes show transformation of haltere into wing.

(Lamiable et al., 2010)

The increased apoptosis seen in Scer\GAL4^nub-AC-62 RYBP^Scer\UAS.cBa wing discs is diminished in a trx^E2/+ background.

(González and Busturia, 2009)

21% of fs(1)h⁴/+;trx^E2/+ adults show segmental deletions, and 41% show transformations of haltere to wing and T1 or T3 leg and plura to T2 identity.

(Florence and Faller, 2008)

52% of RYBP^KG08683/+ ; trx^E2/+ males show depigmentation of the fifth abdominal segment. 95% of RYBP^KG08683/RYBP^KG08683 ; trx^E2/+ males show depigmentation of the fifth abdominal segment.

(González et al., 2008)

Df(2R)ED3921 fails to suppress the haltere to wing transformation of trx^E2 flies.

(Ragab, 2006)

trx^E2/+ largely rescues the wing defects seen in RYBP^Scer\UAS.cBa; Scer\GAL4^sd-SG29.1 animals.

(Bejarano et al., 2005)

5% of brm² trx^E2 double heterozygotes show loss of humeral bristles. The penetrance of this phenotype is increased to 15% by Bap60¹/+.

Bap60¹/+ ; trx^E2/+ double heterozygotes do not show loss of humeral bristles.

(Möller et al., 2005)

trx^E2 esc⁶ double mutants show partial suppression of homeotic transformations in embryonic/first instar larval cuticle (i.e. thoracic denticle belts are comparable to those found in wild-type embryos), but the head is abnormal and abdominal segments are still partly transformed towards the eighth abdominal segment.

(Klymenko and Muller, 2004)

Pp1-87B^87Bg-6 dominantly suppresses the transformation of wing to haltere seen in trx¹/trx^E2 flies; 36% show strong transformation, 42% show weak transformation and 22% show no transformation.

Pp1-87B¹ dominantly suppresses the transformation of wing to haltere seen in trx¹/trx^E2 flies; 31% show strong transformation, 39% show weak transformation and 30% show no transformation.

Expression of Pp1-87B^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^arm.PS has no effect on the transformation of wing to haltere seen in trx¹/trx^E2 flies.

(Rudenko et al., 2003)

brm² trx^E2 double heterozygous males show a low frequency of A6 to A5 transformation; the frequency is 9% if brm² trx^E2 is maternally derived and 17% if brm² trx^E2 is paternally derived. The frequency of A6 to A5 transformation seen in brm² trx^E2 double heterozygous males is increased if they also carry JIL-1^z2; the frequency is 65% if JIL-1^z2 is maternally derived and brm² trx^E2 is paternally derived and is 75% in the reciprocal cross.

(Zhang et al., 2003)

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

2% of trx^E2 tara^L4 double heterozygotes have a held-out wing phenotype. 1% of trx^E2 tara¹ double heterozygotes have a held-out wing phenotype. 5% of trx^E2 brm² double heterozygotes have a held-out wing phenotype. 45% of trx^E2 brm² tara^L4 triple heterozygotes have a held-out wing phenotype. 38% of trx^E2 brm² tara¹ triple heterozygotes have a held-out wing phenotype.

(Calgaro et al., 2002)

The frequency of transformation of halteres into wings seen in Dsp1¹/Y flies is enhanced by trx^E2/+. The enhancement is dramatically reduced if the female parents are heterozygous rather than homozygous for Dsp1¹.

(Decoville et al., 2001)

The abdominal segment A6 to A5 transformation and the haltere to wing transformation of brm²/+, trx^E2/+ is dominantly suppressed by dom¹⁴.

(Ruhf et al., 2001)

35.3% of trx^E2 brm² double heterozygotes show T3 to T2 transformations. The penetrance of this phenotype is enhanced by one copy of lid^k06801, sxc¹, Sce^D1, E(z)⁵, Trl^R85, Su(z)4¹, Su(z)7¹, Su(z)6¹, E(Pc)¹, Su(z)2¹, Su(z)2^Arp1, Psc¹, Asx³ or Asx¹³ and suppressed by one copy of Pc³, ph-d⁵⁰³, Pcl⁷, pho^b, mxc^M1, mxc¹, esc⁹, esc¹⁰, esc²¹, sxc⁴ or M(2)21AB¹.

(Gildea et al., 2000)

Mutant heterozygotes show a moderate enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes. In trx^E2/+, Scer\GAL4^hs.PB, w^Fab-7.5F24 flies, an embryonic heat shock pulse leads to eyes lighter than with w^Fab-7.5F24 alone.

(Cavalli, 1999)

The addition of trx^E2 does not affect the variable eye size phenotype seen in osa^Scer\UAS.cCa/Scer\GAL4^ey.PH flies.

(Collins et al., 1999)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

brm² trx^E2 double heterozygotes show partial transformation of the 5th abdominal segment to fourth abdominal segment, but do not hold out their wings at any significantly higher frequency than that seen in brm²/+ single heterozygotes.

(Vazquez et al., 1999)

The frequency and severity of homeotic transformations (such as haltere to wing or third leg to second leg transformations) in brm² trx^E2 double heterozygotes is dominantly enhanced by lawc^p1. The enhancement is stronger in a lawc^p1 maternal background. The arista to leg transformation characteristic of lawc^p1 is also enhanced in these flies. The frequency of homeotic transformations in brm² trx^E2 double heterozygotes is dominantly enhanced by lawc^EF520 or Df(1)RA2.

(Zorin et al., 1999)

10.0% of trx^E2 brm² double heterozygous adults show a homeotic phenotype. This is increased to 56.5% if the flies are also heterozygous for mod(mdg4)^T16, 24.9% if the flies are also heterozygous for mod(mdg4)^ul and 35.7% if the flies are also heterozygous for mod(mdg4)^T6. The combination brm² trx^E2 dominantly enhances the effect of mod(mdg4)^ul on the y² phenotype.

(Gerasimova and Corces, 1998)

Suppresses the transformation of A6 to A7 seen in Abd-B^Fab7-P18.1 heterozygotes, but does not alter the phenotype of Abd-B^Fab7-12 heterozygotes.

(Mihaly et al., 1997)

Snr1 mutations enhance the abdominal transformations.

(Dingwall et al., 1995)

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is not affected by combination with a single copy of trx^E2.

(Morimoto et al., 2016)

Complementation and Rescue Data

Fails to complement

trx^lac1

(Fauvarque et al., 2001)

trx^lac2

(Fauvarque et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (5)