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General Information
Symbol
Dmel\ttk1
Species
D. melanogaster
Name
FlyBase ID
FBal0017203
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

ttk cDNA of the TTK69 isoform lacks the distal 80% of the 3' UTR sequence, owing to a readthrough into P-element sequences.

P-element insertion into last intron.

P-element insertion 0.45kb from the 3' end of the coding region of the 4.5kb cDNA within an intron.

Insertion components
P{PZ}ttk1
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ttk1/ttk1 flies are viable and develop with no aberrant muscle development.

ttk1 mutant eyes have supernumerary R7 cells in some ommatidia, though the eyes are overtly the same as wild type by SEM. The number and appearance of cone cells in each ommatidium of ttk1 pupal eye discs are normal.

Eggs laid by ttktwp/ttk1 or homozygous ttk1 mothers exhibit a weak dorsal appendage phenotype, with 12% show some defect. Only 40% of eggs laid by ttk1/ttk1e11 mothers are wild-type,, the rest exhibit a dorsal appendage phenotype, 3% having only the nub of an appendage.

Shows a semidominant double bristle phenotype - similar to that caused by overexpression of the TTK69 isoform.

CNS development is normal.

Rough eye phenotype due to supernumerary R7 cells. Mutant phenotype can be enhanced by ttk00219.

The compound eye of ttkbose1/ttk1 flies is similar to wild-type.

Many ommatidia contain supernumerary R7 cells and decreased numbers of R1-R6 cells.

embryonic lethal no effect on ftz gene expression.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

ttk1 is an enhancer of phenotype of phylhs.sev

NOT Enhancer of
Statement
Reference

ttk[+]/ttk1 is a non-enhancer of wing margin bristle | ectopic phenotype of h41

Suppressor of
Statement
Reference

ttk[+]/ttk1 is a suppressor | partially of ommatidium phenotype of SosJC2, sev6

ttk[+]/ttk1 is a suppressor | partially of photoreceptor cell R7 phenotype of SosJC2, sev6

ttk[+]/ttk1 is a suppressor | partially of ommatidium phenotype of SosJC2/Sos[+], sev6

ttk[+]/ttk1 is a suppressor | partially of photoreceptor cell R7 phenotype of SosJC2/Sos[+], sev6

NOT Suppressor of
Statement
Reference

ttk[+]/ttk1 is a non-suppressor of wing margin bristle | ectopic phenotype of h41

Other
Additional Comments
Genetic Interactions
Statement
Reference

svspa-pol ttk1 double mutant eyes show a much stronger rough eye phenotype than either single mutant: the surface of the eye is nearly flat with irregularly spaced bristles. Only a few malformed ommatidia, many of which have open holes at their apices, are visible. Photoreceptors in the remaining ommatidia have strongly deformed rhabdomeres. svspa-pol ttk1 pupal eye discs have no cone cells.

The addition of or ttk1/+ to h41/+ animals does not lead to a significant ectopic wing margin bristle phenotype.

The partial lethality due to runScer\UAS.cLa; Scer\GAL4nos.PG (3% viable) is partially suppressed by maternal heterozygosity for ttk1 (rescues to 19% viable).

In sev6 hemizygotes that are also heterozygous for SosJC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly suppressed by ttk1.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Comments

94% of the ommatidia in ttk1/ttk1e11 flies were wild-type, as opposed to 50-60% in ttk1 homozygotes. There are 65% of normal ommatidia in ttk1/ttkrM730 flies and most mutant ommatidia contain ectopic photoreceptors.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

ttk1 is a loss of function allele for the TTK88 isoform and a gain of function allele for the TTK69 isoform.

Despite extensive outcrossing of the ttk1 stock, the identity of which was confirmed by analysis of its DNA, it no longer shows a large fraction, but less than 1%, of ommatidia with supernumerary R7 cells. A possible explanation might be that in the original stock a mutation closely coupled with ttk1, but later lost, was responsible for the large fraction (~40%) of ommatidia with supernumerary R7 cells and reduced number (~20%) of outer photoreceptor cells (see FBrf0058514 and FBrf0087523).

Disrupts the mRNA encoding ttk protein p88. Mutant phenotype can be restored to wild type by Js P-element mobilisation.

Mutation affects the p88 ttk protein.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (23)