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General Information
Symbol
Dmel\tup2
Species
D. melanogaster
Name
FlyBase ID
FBal0017280
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G18864524A

Reported nucleotide change:

G?A

Comment:

G to A mutation in the AG acceptor splice site of the second intron.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

The G to A mutation is in the AG acceptor splice site of the second intron.

This mutation is predicted to result in a severely truncated protein.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

tupJQ3 fails to complement tup2 as judged by the increase in scutellar macrochaetae.

Homozygous clones in the lateral-posterior region of the notum can result in ectopic structures, such as ectopic sclerites and an ectopic tegula-like structure, bearing macrochaetae and sensilla trichoidea. Homozygous clones can also result in protrusions of the notum cuticle and also to small, tubercle-like disruptions with a corrugated appearance and roundish contour.

tup2 die as embryos with a prominent dorsal hole.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

tup[+]/tup2 is an enhancer of thorax phenotype of ChiE

Additional Comments
Genetic Interactions
Statement
Reference

tup2 enhances the excess scutellar bristle and thoracic cleft phenotype of ChiE flies when heterozygous.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

tupJQ3 fails to complement tup2 as judged by the increase in scutellar macrochaetae.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Both midgut primordia extend normally along the visceral mesoderm and the yolk is completely engulfed by the endoderm.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)