Allele Dmel\Ubx^9.22

General Information
Symbol	Dmel\Ubx^9.22	Species	D. melanogaster
Name		FlyBase ID	FBal0017483
Feature type	allele	Associated gene	Dmel\Ubx
Also Known As	Ubx^9-22, Ubx⁹²²

Map ( GBrowse )
Allele class	amorphic allele - genetic evidence
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Limbourg-Bouchon et al., 1991)
Mutagen	X ray (Capdevila and Garcia-Bellido, 1981, Bender et al., 1983, Weinzierl et al., 1987)
Mutations Mapped to the Genome

Type Location Additional Notes References deletion 3R:12,484,640..12,486,220 comment=Position of mutation on reference sequence inferred by FlyBase curator based on author's statement. See Figure 2 of FBrf0046283. Mutation is a deletion of 1580bp which removes the splice acceptor site and much of the homeobox. evidence=experimental (Weinzierl et al., 1987)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name X05727 CAA29194

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion and associated frameshift producing a truncated protein that lacks the homeodomain and C-terminal sequences. (Mastick et al., 1995) Deletion of 1.6kb removing part of intron 3 and the common 3' exon up to and including the first 48 codons of the homeodomain. Inactivates all Ubx isoforms. (Subramaniam et al., 1994) Deletion of 16kb within the Ubx transcript. (Limbourg-Bouchon et al., 1991) 1.5kb deletion including the homeobox. (Castelli-Gair et al., 1990) Deletion in the homeobox. (Castelli-Gair and Garcia-Bellido, 1990) Deletion in the Ubx coding region. (Mathog, 1990) 1587bp deletion removing the final 1.4kb of the 50kb long intron, the splice acceptor site of the 3' exon and 48 codons of the homeobox. A sequence of 6 nucleotides is inserted between the deletion breakpoints. (Weinzierl et al., 1987) Deletion in the 3' Ubx exon. (Peifer and Bender, 1986)
Cytology	Polytene chromosomes normal. (Kerridge and Morata, 1982) Polytene chromosomes normal. (Bender et al., 1983) Polytene chromosomes normal. (Castelli-Gair and Garcia-Bellido, 1990)
Phenotypic Data
Phenotypic Class
	visible \| dominant (Burnette et al., 1999) wild-type (Bender and Hudson, 2000)
Phenotype Manifest In
	abdominal 1 ventral acute muscle 1 \| precursor (Michelson, 1994) abdominal 2 ventral acute muscle 1 \| precursor (Michelson, 1994) aorta primordium (Ponzielli et al., 2002) aorta primordium \| anterior (Ponzielli et al., 2002) denticle belt (Weinzierl et al., 1987) embryonic/larval lymph gland (Mandal et al., 2004) embryonic abdominal segment (Mandal et al., 2004) embryonic anterior Malpighian tubule (Bunt et al., 2010) embryonic dorsal vessel (Lovato et al., 2002) embryonic pericardial cell (Ponzielli et al., 2002) embryonic visceral muscle (LaBeau et al., 2009) haltere (Burnette et al., 1999) haltere (with Ubx^{HC71-1.HC166D.Dup.Rec.ry+}) (Bender and Hudson, 2000) haltere disc \| posterior compartment (with Ubx^pbx-1) (Crickmore and Mann, 2006) mesothoracic tergum (with Ubx^{HC71-1.HC166D.Dup.Rec.ry+}) (Bender and Hudson, 2000) spiracle (Bate and Martinez Arias, 1991) ventral thoracic disc (Bate and Martinez Arias, 1991) wing disc (Bate and Martinez Arias, 1991)
Detailed Description
	Statement Reference The anterior pair of Malpighian tubules do not migrate past the developing midgut in Ubx[9.22] mutant embryos. (Bunt et al., 2010) Homozygous Ubx[9.22] mutant embryos fail to develop the 2-3 most anterior pairs of alary muscles. (LaBeau et al., 2009) Ubx^9.22 clones within the haltere do not grow larger than their twin spots. The P compartment of Ubx^pbx-1/Ubx^9.22 haltere discs is increased in size relative to the disc, such that the P:A size ration is 1.45. This effect is not seen in Ubx^9.22/+ discs. (Crickmore and Mann, 2006) In stage-15 Ubx^9.22 mutant embryos the lymph gland is expanded posteriorly into the abdominal segments. (Mandal et al., 2004) Homozygous embryos frequently show a range of defects in dorsal vessel development, including incomplete dorsal migration of the cardiac precursors and minor morphological defects of the dorsal vessel, but there is still a clear distinction between the heart and the aorta in these animals. (Lovato et al., 2002) The aorta does not differentiate normally, particularly in the anterior region, in mutant embryos. Pericardiac cells are also disorganised in several positions, particularly in the anterior segments. (Ponzielli et al., 2002) When heterozygous with Ubx^{HC71-1.HC166D.Dup.Rec.ry+} the notum reduction phenotype is much more penetrant and severe. These animals also show an enlargement of the haltere, with anterior bristles, characteristic of a weak bx transformation. (Bender and Hudson, 2000) Haltere enlarged, average bristle number 0.9 (+-0.9 (SD); N=138). (Burnette et al., 1999) No gross morphological defects are seen in the central nervous system of Ubx^9.22 Abd-B^M1 double mutant embryos. (Hirth et al., 1998) Embryos lack the precursor for ventral muscle 26 in A1 and A2. (Michelson, 1994) Transformation of capitellum to wing. (Mortin et al., 1992) Elevated levels of ae transcript are found in parasegment 6. (Roder et al., 1992) Homozygous embryos have a set of extra leg discs, a rudimentary wing disc and two new sets of spiracles. (Bate and Martinez Arias, 1991) The phenotype of fu⁴¹ Ubx^9.22 double mutants can be interpreted as an addition of the corresponding single mutant phenotypes. (Limbourg-Bouchon et al., 1991) Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52. (Castelli-Gair and Garcia-Bellido, 1990) Transvection positive with Ubx^bx-34e. (Mathog, 1990) A2-A4 denticle belts are transformed into thoracic belts, and A5-A8 denticle belts are modified, having much more marked thoracic features in hemizygous embryos. (Casanova et al., 1988) Homozygotes complete embryogenesis and occasionally survive as third instar larvae. They have the characteristic Ubx phenotype of transformed denticle belts and three pairs of anterior spiracles. In Ubx^61d/Ubx^bxd-100 larvae A1 is transformed to T3, and a pair of presumptive leg neuromeres is formed in this transformed segment. In Ubx^9.22/Ubx^bxd-100 adults the commissures of the CNS in parasegment 6 are transformed to resemble those of parasegment 5. (Weinzierl et al., 1987) The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubx^9.22. (Capdevila and Garcia-Bellido, 1981)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Ubx^9.22 has visible phenotype, enhanceable by Df(2L)PJ17 (Bai and Tolias, 2000)
Phenotype Manifest In
Enhanced by
Statement Reference Ubx^9.22 has haltere phenotype, enhanceable by Df(2L)PJ17 (Bai and Tolias, 2000) Ubx^9.22 has haltere sensillum phenotype, enhanceable by crn³ (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by crn⁴ (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)64c18 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)C246 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)dm75e19 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)HC244 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)HF396 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)JC19 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)KA14 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)N19 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)sd72b (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(1)Sxl-bt (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)dp-79b (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)Mdh (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)PJ17 (Bai and Tolias, 2000) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)Prl (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TE29Aa-11 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TW84 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TW158 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(2L)TW203 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)29A6 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)brm11 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)fz-D21 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)fz-M21 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)pbl-NR (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)pbl-X1 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)Rdl-2 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)ri-79c (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3L)st-f13 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)9A99 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)Antp17 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)awd-KRB (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)by10 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)by62 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)crb87-4 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)crb87-5 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)Dl-BX12 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)l26c (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)M86D (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)ME15 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)M-Kx1 (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)ry506-85C (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(3R)X3F (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Df(4)G (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by Hrb27C[+]/Hrb27C¹⁰²⁸⁰ (Burnette et al., 1999) Ubx^9.22 has haltere sensillum phenotype, enhanceable by kz²⁶ (Burnette et al., 1999) Ubx^9.22 has macrochaeta \| ectopic phenotype, enhanceable by Df(2L)PJ17 (Bai and Tolias, 2000) Ubx^9.22 has phenotype, enhanceable by fl(2)d² (Burnette et al., 1999) Ubx^9.22 has phenotype, enhanceable by vir³ (Burnette et al., 1999)
Suppressed by
Statement Reference Ubx^pbx-1/Ubx^9.22 has haltere disc \| posterior compartment phenotype, suppressible \| partially by Scer\GAL4^Act5C.PU/tkv^Scer\UAS.cNa (Crickmore and Mann, 2006)
Additional Comments
Genetic Interactions
Statement Reference Expression of tkv^Scer\UAS.cNa under the control of Scer\GAL4^Act5C in a Ubx^pbx-1/Ubx^9.22 background reduces the size of the P compartment of haltere discs relative to that observed in Ubx^pbx-1/Ubx^9.22 discs (from 1.45 to 0.83), although this ratio is still greater than that of wild-type discs. (Crickmore and Mann, 2006) The addition of Df(2L)PJ17 to Ubx^9.22 flies enhances the haltere bristle phenotype seen in Ubx^9.22 alone. An average of 3.5 bristles per haltere are seen in Df(2L)PJ17,Ubx^9.22 flies, as opposed to none in wild-type and 0.9 per haltere in Ubx^9.22 flies alone. (Bai and Tolias, 2000) Hrb27C¹⁰²⁸⁰ enhances the haltere phenotype of Ubx^9.22/+ such that halteres are enlarged, and average bristle number 2.6 (+-1.5 (SD); N=46). (Burnette et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 7 )
Bloomington	3474 Ubx^9.22 Sb^sbd-1/TM1 3473 Ubx^9.22 Ubx^Cbx-1 Sb^sbd-1/TM1 1854 w^*; P{GawB}I-76-D, Ubx^9.22 e¹/TM6B, Tb⁺
Kyoto	107056 Ubx^9.22 Sb^sbd-1/TM1 106535 w^*; P{GawB}I-76-D, Ubx^9.22 e¹/TM6B, Tb⁺ 101717 Df(3R)abd-A-C1, mwh¹ jv¹ st¹ red¹ Sb^sbd-2 Ubx^9.22 e¹ / TM1, Me¹ kni^ri-1 Sb^sbd-l 102112 mwh¹ jv¹ st¹ red¹ Sb^sbd-2 e¹¹ ro¹ ca¹ Ubx^9.22 Abd-B^M1 / TM6B, Antp^Hu e¹ Tb¹ ca¹
Notes on Origin
Discoverer

Comments
	Ubx^9.22 homozygous germ line clones are viable and show no maternal effects. (Kerridge and Dura, 1982)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Ubx9.22 (Chauvet et al., 2000) Ubx^9-22 (Hirth et al., 1998, Casanova et al., 1988, Limbourg-Bouchon et al., 1991, Gonzalez-Reyes and Morata, 1990, Sanchez-Herrero and Morata, 1983, Kerridge and Morata, 1982, Kerridge and Dura, 1982, Capdevila and Garcia-Bellido, 1981, Crickmore and Mann, 2006, Crickmore and Mann, 2007) Ubx^9.22 (Stultz et al., 2006, Crickmore and Mann, 2006, LaBeau et al., 2009, Bunt et al., 2010) Ubx⁹²² (Chiang et al., 1995, Graba et al., 1994, Graba et al., 1995, Bate, 1993, Peifer and Bender, 1986)
Name Synonym
Secondary FlyBase IDs

References ( 53 )

Generate a list of	All references relating to this allele ( 53 )

List References by type	Research paper ( 48 ) Supplementary material ( 1 ) Review ( 3 ) Abstract ( 1 )
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Allele Dmel\Ubx9.22

Allele Dmel\Ubx^9.22