FB2025_01 , released February 20, 2025
Allele: Dmel\uncl5
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General Information
Symbol
Dmel\uncl5
Species
D. melanogaster
Name
FlyBase ID
FBal0017615
Feature type
allele
Associated gene
uncl
Associated Insertion(s)
Carried in Construct
Also Known As
R-10-10, unclR-10-10
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Perrimon et al., 1989, Schalet and Lefevre, 1973)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethality occurs during pupal or adult stages. Homozygous germline clones display no maternal effect. Embryos derived from heterozygous mothers do not exhibit CNS or PNS defects and adults are unable to walk due to lack of coordination.

      (Perrimon et al., 1989)

      uncl5 sol1 double heterozygotes have a normal optomotor response and normal viability.

      (Miklos et al., 1987)

      Most mutant flies die just before eclosion. Those that survive have uncoordinated leg movements and die soon afterward. Hemizygous females have the same phenotype as hemizygous males and homozygous females.

      (Schalet, 1972)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Lifschytz.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      R-10
      (Zusman et al., 1985)
      R-10-10
      (Perrimon et al., 1989, Kramers et al., 1983, Schalet and Lefevre, 1973, Schalet, 1972, Lifschytz and Falk, 1969)
      l(1)R-10-10
      (Munoz, 1992.12.16)
      uncl5
      unclR-10-10
      (Perrimon et al., 1989, Miklos et al., 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)