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General Information
Symbol
Dmel\rhove-1
Species
D. melanogaster
Name
FlyBase ID
FBal0017855
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rhove, ve1, rhove1
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Mutation within the promoter region.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The rhove-1 mutant phenotype is characterized by distal gaps in the longitudinal veins.
13.2% of heterozygous females have a truncated L5 wing vein.
Homozygous rhove-1 flies exhibit truncated wing veins.
Homozygotes lack the distal portion of wing vein L3 and lack most of the L4 and L5 wing veins.
Homozygous rhove-1 mutants show loss of partial L3, L4 and L5 and weakened L2-L4 M veins, whereas heterozygous rhove-1 exhibit only a weakened distal portion of L5 vein.
rhove-1 flies show a partial loss of wing veins L3, L4 and L5.
The initial development of most veins in the wing is disrupted in rhove-1 mutants.
rhove-1 mutants are viable, exhibiting partial loss of L3-L5 wing veins.
Homozygotes show incomplete wing veins L2, L3, L4 and L5.
Mutant embryos show duplication of the segmental border muscle and a complete loss of lateral adult muscle precursors.
rhove-1 mutant flies show loss of the distal ends of wing veins, particularly L3, L4 and L5.
The interactions between rhove-1/rhove-1 and emcD or emc1/emc11 are additive. The interactions between rhove-1/rho9 and emcD or emc1/emc11 are additive. emc1 clones in rhove-1 vn1 wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins.
In a e1, rhove-1 double mutant, in which all of the longitudinal veins are truncated or eliminated, ectopic melanin only develops in proximal areas that truncate before reaching the margin.
Germline clones fail to rescue the female sterile phenotype of Fs(3)Apc.
Homozygotes lack the distal ends of all longitudinal wing veins.
Wings lack the longitudinal veins.
rhove-1 supresses the vein defects of bs mutations although L2 to L5 remain truncated distally.
Wings have shortened longitudinal veins that do not reach the wing margin.
Lack distal segments of wing veins especially veins L4 and L5. Homozygous phenotype is strongly suppressed by heterozygous rhoWk.
Wing veins do not reach margins.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
rhove-1 has visible phenotype, enhanceable by CycGHR7
rhove-1 has visible phenotype, enhanceable by vn1
rhove-1 has visible phenotype, enhanceable by aoshs.PSa
Suppressed by
Statement
Reference
rho9/rhove-1, vnM2/vn1 has visible phenotype, suppressible by bs03267/bs2
NOT suppressed by
Statement
Reference
rhove-1 has visible phenotype, non-suppressible by Bap170hfl1/Bap170[+]
rhove-1 has viable phenotype, non-suppressible by frcRY34/frc[+]
Enhancer of
Statement
Reference
rhove-1/rho[+] is an enhancer of size defective | adult stage phenotype of sl2
rhove-1/rho[+] is an enhancer of visible | dominant phenotype of sogEP7
rhove-1/rho[+] is an enhancer of visible | dominant phenotype of sogEP11
rhove-1 is an enhancer of visible phenotype of aoshs.PSa
Suppressor of
Statement
Reference
vn[+], rhove-1, vn1, rho+ is a suppressor of visible phenotype of Chmp1GD11219, Scer\GAL4Bx-MS1096
rhove-1/rho[+] is a suppressor of visible | heat sensitive phenotype of HC2.hs
rhove-1/rhove-1 is a suppressor of visible | recessive phenotype of px72
rhove-1/rho[+] is a suppressor of visible | recessive phenotype of px1
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
rhove-1 has wing vein | adult stage phenotype, enhanceable by CycGHR7
rhove-1 has wing vein L4 | adult stage phenotype, enhanceable by vn1
rhove-1 has wing vein L5 phenotype, enhanceable by Df(2R)ED3921
rhove-1 has wing vein L5 phenotype, enhanceable by brm2
rhove-1 has wing vein L3 phenotype, enhanceable by Pc4
rhove-1 has wing vein phenotype, enhanceable by Egfrt1/Egfrf1
rhove-1 has wing vein phenotype, enhanceable by aoshs.PSa
NOT Enhanced by
Statement
Reference
rhove-1 has wing vein L3 phenotype, non-enhanceable by Df(2R)ED3921
rhove-1 has wing vein L4 phenotype, non-enhanceable by Df(2R)ED3921
rhove-1 has phenotype, non-enhanceable by astK6
Suppressed by
Statement
Reference
rhove-1 has wing vein L5 phenotype, suppressible | partially by kst1
rhove-1 has wing vein L2 phenotype, suppressible by kst1
rhove-1 has wing vein L3 phenotype, suppressible by kst1
rhove-1 has wing vein L4 phenotype, suppressible by kst1
rhove-1 has wing vein L5 phenotype, suppressible by Rab52
Df(3L)ru-22/rhove-1 has wing vein L5 phenotype, suppressible by Rab52
rhove-1 has wing vein L5 phenotype, suppressible | partially by Rbsn-540-3
rhove-1 has wing vein L5 phenotype, suppressible | partially by Hrsv28
rhove-1 has wing vein L5 phenotype, suppressible | partially by Eps-15e75
rhove-1 has wing vein L5 phenotype, suppressible by Vps28B9
rhove-1 has wing vein L5 phenotype, suppressible by Vps25A3
rhove-1 has wing vein L5 phenotype, suppressible by Vps20I3
rhove-1 has wing vein L5 phenotype, suppressible | partially by shrbG5
Df(3L)ru-22/rhove-1 has wing vein L5 phenotype, suppressible by shrbG5
rhove-1 has wing vein L4 phenotype, suppressible | partially by rhove-1
rhove-1 has wing vein L5 phenotype, suppressible | partially by rhove-1
rhove-1 has wing vein L3 phenotype, suppressible | partially by rhove-1
rhove-1 has posterior crossvein phenotype, suppressible | partially by rhove-1
brm2, rhove-1 has wing vein L5 phenotype, suppressible by Snr1E1
rhove-1 has wing vein L5 phenotype, suppressible by Snr1R3/Snr1E1
rho9/rhove-1, vnM2/vn1 has wing vein phenotype, suppressible by bs03267/bs2
rhove-1, vn1 has wing vein phenotype, suppressible by dppUAS.cSa/Scer\GAL4C-580
rhove-1 has phenotype, suppressible by bsPx
rhove-1 has wing vein phenotype, suppressible by bsba
rhove-1 has wing vein phenotype, suppressible by bs11
rhove-1 has wing vein phenotype, suppressible by bs2
rhove-1 has phenotype, suppressible by gra1
NOT suppressed by
Statement
Reference
rhove-1 has wing vein L3 | distal phenotype, non-suppressible by Bap170hfl1/Bap170[+]
rhove-1 has wing vein L4 phenotype, non-suppressible by Bap170hfl1/Bap170[+]
rhove-1 has wing vein L5 phenotype, non-suppressible by Bap170hfl1/Bap170[+]
rhove-1 has wing vein L3 phenotype, non-suppressible by frcRY34/frc[+]
rhove-1 has wing vein L4 phenotype, non-suppressible by frcRY34/frc[+]
rhove-1 has wing vein L5 phenotype, non-suppressible by frcRY34/frc[+]
Enhancer of
Statement
Reference
rhove-1/rho[+] is an enhancer of wing blade phenotype of sl2
rhove-1/rho[+] is an enhancer of wing vein | ectopic phenotype of sl2
rhove-1/rho[+] is an enhancer of wing vein phenotype of sogEP11
rhove-1/rho[+] is an enhancer of wing vein phenotype of sogEP7
rhove-1 is an enhancer of wing vein phenotype of aoshs.PSa
NOT Enhancer of
Statement
Reference
rhove-1/vn1 is a non-enhancer of wing vein | ectopic phenotype of bwkΔ11, cicD49
rhove-1 is a non-enhancer of wing disc phenotype of ftk07918
Suppressor of
Statement
Reference
rhove-1 is a suppressor | partially of wing vein L4 phenotype of rhove-1
rhove-1 is a suppressor | partially of wing vein L5 phenotype of rhove-1
rhove-1 is a suppressor | partially of wing vein L3 phenotype of rhove-1
rhove-1 is a suppressor | partially of posterior crossvein phenotype of rhove-1
rhove-1/rho[+] is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs
rhove-1/rho[+] is a suppressor of wing | heat sensitive phenotype of HC2.hs
rhove-1 is a suppressor of wing vein phenotype of tkv1/tkv8
rhove-1 is a suppressor of wing vein | ectopic phenotype of bsA48
rhove-1 is a suppressor of wing phenotype of bsA48
rhove-1/rhove-1 is a suppressor of wing phenotype of px72
rhove-1/rho[+] is a suppressor of wing phenotype of px1
NOT Suppressor of
Statement
Reference
rhove-1/rhove-1 is a non-suppressor of wing & microchaeta | ectopic phenotype of HC2.UAS, Scer\GAL4en-e16E
rhove-1 is a non-suppressor of wing disc phenotype of ftk07918
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
rhove-1,vn1 double mutants almost completely lack veins in the adult wing. This phenotype was not changed in rhove-1,vn1,CycGHR7 triple mutants. The vein loss phenotype of rhove-1 is slightly enhanced in rhove-1,CycGHR7 double mutants but the effect is limited to L4 vein.
rhove-1, vn1 double mutant wings retain wild-type hair polarity and ridge orientation. Wings of homozygous pk30, rhove-1 and vn1 triple mutant flies lack veins L2-5. Wing anterior hairs of these mutants consistently have a posterior component to their polarity and posterior hairs have an anterior component to their polarity.
One copy of rhove-1 enhances the reduction in wing blade area seen in homozygous sl2 males. One copy of rhove-1 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes. One copy of rhove-1 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced.
Introduction of one copy of kst1 into a homozygous rhove-1 background completely suppresses the wing vein defect for L2-L4 and partially suppresses the defects in L5. A kst2 heterozygous background results in a similar, but milder suppression. A reduction in the level of AnnIX, through expression of AnnIXdsRNA.Scer\UAS in the wing blade, under the control of Scer\GAL4Bx-MS1096, restores wing vein formation in a rhove-1 background. A Rab52 heterozygous background leads to full suppression of the L5 wing vein defect in rhove-1/Df(3L)ru-22 kst1 mutants and 90% suppression in rhove-1/rhove-1 kst1 flies. A Rbsn-540-3 heterozygous background leads to just under 40% suppression of the L5 wing vein defect in both rhove-1/Df(3L)ru-22 kst1 and rhove-1/rhove-1 kst1 flies. A Hrsv28 heterozygous background leads to approximately 30% suppression of the L5 wing vein defect in both rhove-1/Df(3L)ru-22 kst1 and rhove-1/rhove-1 kst1 flies. An Eps-15e75 heterozygous background leads to approximately 70% suppression of the L5 wing vein defect in both rhove-1/Df(3L)ru-22 kst1 and rhove-1/rhove-1 kst1 flies. A Vps28B9 heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in both rhove-1/Df(3L)ru-22 kst1 and rhove-1/rhove-1 kst1 flies. A Vps25A3 heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in rhove-1/rhove-1 kst1 flies. A Vps20I3 heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in rhove-1/Df(3L)ru-22 kst1 flies. A shrbG5 heterozygous background leads to almost full suppression of the L5 wing vein defect in rhove-1/Df(3L)ru-22 kst1 mutants and 80% suppression in rhove-1/rhove-1 kst1 flies.
The loss of wing veins seen in rhove-1 homozygotes is not suppressed by Bap170hfl1/+.
Wing veins do not develop in rhove-1, vn1 animals. Overexpression of osaScer\UAS.cCa in the wing under the control of Scer\GAL4salm-459.2 cannot induce vein formation in a rhove-1, vn1 mutant background.
Expression of UbqndsRNA.Ex2.Scer\UAS by Scer\GAL4e22c in a heterozygous rhove-1 background leads to a normal anterior cross vein and partially restored posterior cross vein and L5 vein, while the distal portion of L4 and L3-4 M veins corresponding to the posterior portion of the wing remains weakened, compared with UbqndsRNA.Ex2.Scer\UAS; Scer\GAL4e22c single mutants.
Df(2R)ED3921; rhove-1 flies show an enhancement of L5 vein loss compared to rhove-1 flies single mutants and partial loss of L2, a phenotype not seen in rhove-1 flies. There is no significant enhancement of L4 and L3 loss.
The wings of rhove-1 vn1 double mutants examined at 19, 21 or 24 hours after pupariation (AP) lack most longitudinal veins, with only the most proximal vein tissue intact 19 and 21 hours AP.
rhove-1 double mutants, heterozygous for frcRY34 exhibit the same phenotype as rhove-1 mutants.
rhove-1 vn1 double homozygotes lack wing veins. This phenotype is partially suppressed by ash2S112411 /ash2S112411. The degree of suppression varies from development of L2 only to almost complete rescue, albeit with some abnormalities such as extra crossvein material or proximal fusions between L2 and L3 or L4 and L5. In 25% of cases, hollow, tube like wings are formed, probably due to detachment of dorsal and ventral layers.
brm2 enhances the loss of wing vein L5 seen in rhove-1 homozygotes. Snr1E1/Snr1R3 suppresses the loss of wing vein L5 seen in rhove-1 homozygotes and rhove-1 suppresses the Snr1E1/Snr1R3 extra wing vein phenotype. Snr1E1 suppresses the shortened L5 wing vein that results from the interaction between rhove-1 and brm2.
The addition of bwkΔ11 and vn1 fails to enhance the extra wing vein phenotype seen in cicD49/bwkΔ11 animals.
When Egfrf1/Egfrt1 flies are raised at the non-permissive temperature (29oC) in a rhove-1/rhove-1 background, there is an enhancement of the usual rhove-1 homozygous wing vein phenotype.
vn1 rhove-1 flies completely lack wing veins.
h1 rhove-1 / h1 rhove-1 flies have ectopic bristles running between longitudinal veins.
rhove-1/astK6 double heterozygotes do not have a visible phenotype. The phenotype of rhove-1 homozygotes is not dominantly altered by astK6.
rho9, vnM2/rhove-1, vn1 double mutants lack wing veins. bs03267/bs2; rho9, vnM2/rhove-1, vn1 triple mutants show an almost wild type wing vein pattern.
rhove-1 vn1 double mutant flies lack all the longitudinal veins and crossveins of the wing blade. Dorsal and ventral implants of rhove-1 vn1 imaginal disc tissue into wild-type imaginal discs fail to differentiate veins.
vn1 rhove-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn1 rhove-1 double homozygotes when dppScer\UAS.cSa is expressed in these flies using Scer\GAL4C-580. rhove-1 suppresses the differentiation of thicker veins seen in tkv1/tkv8 flies, and results in fewer veins in combination with either dpps4/dpps8 or tkv1/tkv8.
vn1 rhove-1 flies lack wing veins.
rhove-1 homozygotes which are also expressing argoshs.PSa (using heat pulses from the second and third larval instar to pupal stage) lack most of wing veins L2-L4 and the entire L5 vein is eliminated. The campaniform sensilla on vein L3 usually remain intact.
Xenogenetic Interactions
Statement
Reference
Moderate expression of Zzzz\lefScer\UAS.cGa under the control of Scer\GAL4Bx-MS1096 in rhove-1 heterozygotes results in wing vein loss, while moderate Zzzz\lefScer\UAS.cGa expression (with Scer\GAL4Bx-MS1096) alone doesn't have this phenotype.
Loss of the distal tips of wing veins seen in rhove-1 mutant flies is suppressed by Pstu\aarAScer\UAS.cGa; Scer\GAL4Bx-MS1096.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (42)
Notes on Origin
Discoverer
Duncan, Jan. 1934.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (12)
References (67)