Allele Dmel\rhove-1
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\rhove-1 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0017855 | |
| Feature type | allele | Created / Updated | 2006-08-22/2006-08-22 |
| Associated gene | Dmel\rho | ||
| Allele class | loss of function | ||
| Mutagen | spontaneous | ||
Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mapped Features and Mutations | |||
Type Symbol & Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference Mutation within the promoter region. | ||
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| Carried on aberration | |||
| Cytology | |||
Phenotypic Data
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Phenotypic Class
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Phenotype Manifest In
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Detailed Description
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Statement Reference Lack distal segments of wing veins especially veins L4 and L5. Homozygous phenotype is strongly suppressed by heterozygous rhoWk. Wing veins do not reach margins. Wings have shortened longitudinal veins that do not reach the wing margin. Wings lack the longitudinal veins. Homozygotes lack the distal ends of all longitudinal wing veins. Germline clones fail to rescue the female sterile phenotype of Fs(3)Apc. The interactions between rhove-1/rhove-1 and emcD or emc1/emc11 are additive. The interactions between rhove-1/rho9 and emcD or emc1/emc11 are additive. emc1 clones in rhove-1 vn1 wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins. rhove-1 mutant flies show loss of the distal ends of wing veins, particularly L3, L4 and L5. Mutant embryos show duplication of the segmental border muscle and a complete loss of lateral adult muscle precursors. Homozygotes show incomplete wing veins L2, L3, L4 and L5. The initial development of most veins in the wing is disrupted in rhove-1 mutants. rhove-1 mutants are viable, exhibiting partial loss of L3-L5 wing veins. rhove-1 flies show a partial loss of wing veins L3, L4 and L5. | |||
Interactions
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Phenotypic Class
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Phenotype Manifest In
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Suppressed by | |||
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Enhancer of | |||
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NOT Enhancer of | |||
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Suppressor of | |||
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NOT Suppressor of | |||
Statement Reference rhove-1/rhove-1 is a non-suppressor of wing & microchaeta | ectopic phenotype of HC2.Scer\UAS, Scer\GAL4en-e16E | |||
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Additional Comments
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Genetic Interactions
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Statement Reference rhove-1 homozygotes which are also expressing argoshs.PSa (using heat pulses from the second and third larval instar to pupal stage) lack most of wing veins L2-L4 and the entire L5 vein is eliminated. The campaniform sensilla on vein L3 usually remain intact. vn1 rhove-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn1 rhove-1 double homozygotes when dppScer\UAS.cSa is expressed in these flies using Scer\GAL4C-580. rhove-1 suppresses the differentiation of thicker veins seen in tkv1/tkv8 flies, and results in fewer veins in combination with either dpps4/dpps8 or tkv1/tkv8. brm2 enhances the loss of wing vein L5 seen in rhove-1 homozygotes. Snr1E1/Snr1R3 suppresses the loss of wing vein L5 seen in rhove-1 homozygotes and rhove-1 suppresses the Snr1E1/Snr1R3 extra wing vein phenotype. Snr1E1 suppresses the shortened L5 wing vein that results from the interaction between rhove-1 and brm2. Df(2R)ED3921; rhove-1 flies show an enhancement of L5 vein loss compared to rhove-1 flies single mutants and partial loss of L2, a phenotype not seen in rhove-1 flies. There is no significant enhancement of L4 and L3 loss. | |||
Xenogenetic Interactions
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Statement Reference Loss of the distal tips of wing veins seen in rhove-1 mutant flies is suppressed by Pstu\aarAScer\UAS.cGa; Scer\GAL4Bx-MS1096. | |||
Complementation & Rescue Data
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| Comments | |||
Stocks
( 44 ) | |||
| Bloomington | 628 1029 | ||
| Kyoto | 106017 107310 106176 105933 101936 | ||
Notes on Origin
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| Discoverer | Duncan, Jan. 1934. | ||
Synonyms & Secondary IDs
( 10 ) | |||
| Reported As | |||
| Symbol Synonym | rho-1veinlet rho1 rhove1 Rhove1 rhove-1 rhove (Ragab et al., 2006, Ralston and Blair, 2005, Marenda et al., 2004, Guichard et al., 2002, Brentrup et al., 2000, Martin-Blanco et al., 1999, Guichard et al., 1999, Biehs et al., 1998, Lunde et al., 1998, Murray et al., 1995, Sturtevant and Bier, 1995, Sturtevant et al., 1994, Sawamoto et al., 1994, Fristrom et al., 1994, Sturtevant et al., 1993) rhoVE | ||
| Name Synonym | veinlet | ||
| Secondary FlyBase IDs | |||
References
( 50 ) | |||
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Recent research papers ( 1 ) | |||
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Recent reviews ( 1 ) | |||
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Nature of the Allele