Allele Dmel\rho^ve-1

General Information
Symbol	Dmel\rho^ve-1	Species	D. melanogaster
Name		FlyBase ID	FBal0017855
Feature type	allele	Associated gene	Dmel\rho
Also Known As	rho^ve, ve¹, rho^ve1

Allele class	loss of function allele
Mutagen	spontaneous
Recent Updates
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FB2013_03	Stocks FBst0043636
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Sturtevant et al., 1993, Sawamoto et al., 1994, Milan et al., 1997)
Mutagen	spontaneous (Lindsley and Zimm, 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Mutation within the promoter region. (Sturtevant et al., 1993)
Carried on aberration	Df(3L)BSC12 (Deal and Cook, 2002.1.22) Df(3L)BSC13 (Deal and Cook, 2002.2.25) Df(3L)BSC14 (Deal and Cook, 2002.2.24) Df(3L)BSC15 (Deal and Cook, 2002.2.24) Df(3L)BSC23 (Deal et al., 2002.11.12) Df(3L)BSC33 (Andrade and Cook, 2003.4.2) Df(3L)BSC35 (Andrade and Cook, 2003.6.2) Df(3L)BSC46 (Andrade and Cook, 2003.12.11) TM1-mr (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Lindsley and Zimm, 1992, Kotarski et al., 1998, de Celis, 1997, Yano et al., 2005) visible (Rendina et al., 2010) visible \| recessive (Roch et al., 1998, Guichard et al., 1999, Sturtevant et al., 1993)
Phenotype Manifest In
	segment border muscle \| ectopic (Bidet et al., 2003) wing vein (Lindsley and Zimm, 1992, Sturtevant et al., 1993, de Celis, 1997, Ralston and Blair, 2005, Tjota et al., 2011) wing vein \| distal (de Celis, 1997) wing vein L1 (Murray et al., 1995) wing vein L2 (Murray et al., 1995, Sawamoto et al., 1994, Marenda et al., 2004) wing vein L3 (Murray et al., 1995, Sawamoto et al., 1994, Yano et al., 2005, Gallio et al., 2002, Ragab et al., 2006, Marenda et al., 2004, Li et al., 2007) wing vein L3 \| distal (Rendina et al., 2010) wing vein L4 (Murray et al., 1995, Sawamoto et al., 1994, Guichard et al., 1999, Yano et al., 2005, Gallio et al., 2002, Ragab et al., 2006, Marenda et al., 2004, Li et al., 2007, Rendina et al., 2010) wing vein L5 (Murray et al., 1995, Sawamoto et al., 1994, Guichard et al., 1999, Yano et al., 2005, Gallio et al., 2002, Ragab et al., 2006, Marenda et al., 2004, Li et al., 2007, Rendina et al., 2010, Tjota et al., 2011) wing vein L5 (with Df(3L)ru-22) (Tjota et al., 2011) wing vein L6 (Murray et al., 1995)
Detailed Description
	Statement Reference Homozygous rho[ve-1] flies exhibit truncated wing veins. (Tjota et al., 2011) Homozygotes lack the distal portion of wing vein L3 and lack most of the L4 and L5 wing veins. (Rendina et al., 2010) Homozygous rho[ve-1] mutants show loss of partial L3, L4 and L5 and weakened L2-L4 M veins, whereas heterozygous rho[ve-1] exhibit only a weakened distal portion of L5 vein. (Li et al., 2007) rho^ve-1 flies show a partial loss of wing veins L3, L4 and L5. (Ragab et al., 2006) The initial development of most veins in the wing is disrupted in rho^ve-1 mutants. (Ralston and Blair, 2005) rho^ve-1 mutants are viable, exhibiting partial loss of L3-L5 wing veins. (Yano et al., 2005) Homozygotes show incomplete wing veins L2, L3, L4 and L5. (Marenda et al., 2004) Mutant embryos show duplication of the segmental border muscle and a complete loss of lateral adult muscle precursors. (Bidet et al., 2003) rho^ve-1 mutant flies show loss of the distal ends of wing veins, particularly L3, L4 and L5. (Gallio et al., 2002) The interactions between rho^ve-1/rho^ve-1 and emc^D or emc¹/emc¹¹ are additive. The interactions between rho^ve-1/rho⁹ and emc^D or emc¹/emc¹¹ are additive. emc¹ clones in rho^ve-1 vn¹ wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins. (Baonza and Garcia-Bellido, 1999) In a e¹, rho^ve-1 double mutant, in which all of the longitudinal veins are truncated or eliminated, ectopic melanin only develops in proximal areas that truncate before reaching the margin. (True et al., 1999) Germline clones fail to rescue the female sterile phenotype of Fs(3)Apc. (Sapir et al., 1998) Homozygotes lack the distal ends of all longitudinal wing veins. (de Celis, 1997) Wings lack the longitudinal veins. (Murray et al., 1995) rho^ve-1 supresses the vein defects of bs mutations although L2 to L5 remain truncated distally. (Fristrom et al., 1994) Wings have shortened longitudinal veins that do not reach the wing margin. (Sawamoto et al., 1994) Lack distal segments of wing veins especially veins L4 and L5. Homozygous phenotype is strongly suppressed by heterozygous rho^Wk. (Sturtevant et al., 1993) Wing veins do not reach margins. (Lindsley and Zimm, 1992)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference rho^ve-1 has visible phenotype, enhanceable by aos^hs.PSa (Sawamoto et al., 1994)
Suppressed by
Statement Reference rho⁹/rho^ve-1, vn^M2/vn¹ has visible phenotype, suppressible by bs⁰³²⁶⁷/bs² (Roch et al., 1998)
NOT suppressed by
Statement Reference rho^ve-1 has viable phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005) rho^ve-1 has visible phenotype, non-suppressible by Bap170^hfl1/Bap170[+] (Rendina et al., 2010)
Enhancer of
Statement Reference rho^ve-1/rho[+] is an enhancer of size defective \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) rho^ve-1/rho[+] is an enhancer of visible \| dominant phenotype of sog^EP7 (Araujo et al., 2003) rho^ve-1/rho[+] is an enhancer of visible \| dominant phenotype of sog^EP11 (Araujo et al., 2003) rho^ve-1 is an enhancer of visible phenotype of aos^hs.PSa (Sawamoto et al., 1994)
Suppressor of
Statement Reference rho^ve-1/rho[+] is a suppressor \| partially of increased cell number \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) rho^ve-1/rho[+] is a suppressor of visible \| heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) rho^ve-1/rho[+] is a suppressor of visible \| recessive phenotype of px¹ (Wessendorf et al., 1992) rho^ve-1/rho⁺ is a suppressor of visible phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) rho^ve-1/rho^ve-1 is a suppressor \| partially of visible phenotype of H^C2.Scer\UAS, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002) rho^ve-1/rho^ve-1 is a suppressor of visible \| recessive phenotype of px⁷² (Wessendorf et al., 1992, Wessendorf et al., 1992)
Other
Statement Reference pk³⁰, rho^ve-1, vn¹ has planar polarity defective phenotype (Hogan et al., 2011) pk³⁰, rho^ve-1, vn¹ has visible phenotype (Hogan et al., 2011) rho⁹/rho^ve-1, vn^M2/vn¹ has visible phenotype (Roch et al., 1998) rho^ve-1, vn¹ has visible \| recessive phenotype (Martin-Blanco et al., 1999, Milan et al., 1997, Milan et al., 1997, Martin-Blanco et al., 1999) rho^ve-1, vn¹ has visible phenotype (Wolfgang et al., 1996, Wolfgang et al., 1996)
Phenotype Manifest In
Enhanced by
Statement Reference rho^ve-1 has wing vein L3 phenotype, enhanceable by Pc⁴ (Marenda et al., 2004) rho^ve-1 has wing vein L5 phenotype, enhanceable by brm² (Marenda et al., 2004) rho^ve-1 has wing vein L5 phenotype, enhanceable by Df(2R)ED3921 (Ragab et al., 2006) rho^ve-1 has wing vein phenotype, enhanceable by aos^hs.PSa (Sawamoto et al., 1994) rho^ve-1 has wing vein phenotype, enhanceable by Egfr^t1/Egfr^f1 (Guichard et al., 1999)
NOT Enhanced by
Statement Reference rho^ve-1 has phenotype, non-enhanceable by ast^K6 (Kotarski et al., 1998) rho^ve-1 has wing vein L3 phenotype, non-enhanceable by Df(2R)ED3921 (Ragab et al., 2006) rho^ve-1 has wing vein L4 phenotype, non-enhanceable by Df(2R)ED3921 (Ragab et al., 2006)
Suppressed by
Statement Reference brm², rho^ve-1 has wing vein L5 phenotype, suppressible by Snr1^E1 (Marenda et al., 2004) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by Eps-15^e75 (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by Hrs^v28 (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by Rbsn-5^40-3 (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible by Rab5² (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible by shrb^G5 (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible by Vps20^I3 (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible by Vps25^A3 (Tjota et al., 2011) Df(3L)ru-22/rho^ve-1 has wing vein L5 phenotype, suppressible by Vps28^B9 (Tjota et al., 2011) rho⁹/rho^ve-1, vn^M2/vn¹ has wing vein phenotype, suppressible by bs⁰³²⁶⁷/bs² (Roch et al., 1998) rho^ve-1, vn¹ has wing vein phenotype, suppressible \| partially by ash2^S112411/ash2^S112411 (Angulo et al., 2004, Angulo et al., 2004, Angulo et al., 2004) rho^ve-1, vn¹ has wing vein phenotype, suppressible by dpp^Scer\UAS.cSa/Scer\GAL4^C-580 (de Celis, 1997) rho^ve-1 has phenotype, suppressible by bs^Px (Sturtevant and Bier, 1995) rho^ve-1 has phenotype, suppressible by gra¹ (Lindsley and Zimm, 1992) rho^ve-1 has posterior crossvein phenotype, suppressible \| partially by rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 has wing vein L2 phenotype, suppressible by kst¹ (Tjota et al., 2011) rho^ve-1 has wing vein L3 phenotype, suppressible \| partially by rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 has wing vein L3 phenotype, suppressible by kst¹ (Tjota et al., 2011) rho^ve-1 has wing vein L3 phenotype, suppressible by Pstu\aarA^Scer\UAS.cGa/Scer\GAL4^Bx-MS1096 (Gallio et al., 2002) rho^ve-1 has wing vein L4 phenotype, suppressible \| partially by rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 has wing vein L4 phenotype, suppressible by kst¹ (Tjota et al., 2011) rho^ve-1 has wing vein L4 phenotype, suppressible by Pstu\aarA^Scer\UAS.cGa/Scer\GAL4^Bx-MS1096 (Gallio et al., 2002) rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by Eps-15^e75 (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by Hrs^v28 (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by kst¹ (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by Rbsn-5^40-3 (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 has wing vein L5 phenotype, suppressible \| partially by shrb^G5 (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible by Pstu\aarA^Scer\UAS.cGa/Scer\GAL4^Bx-MS1096 (Gallio et al., 2002) rho^ve-1 has wing vein L5 phenotype, suppressible by Rab5² (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible by Snr1^R3/Snr1^E1 (Marenda et al., 2004) rho^ve-1 has wing vein L5 phenotype, suppressible by Vps20^I3 (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible by Vps25^A3 (Tjota et al., 2011) rho^ve-1 has wing vein L5 phenotype, suppressible by Vps28^B9 (Tjota et al., 2011) rho^ve-1 has wing vein phenotype, suppressible by AnxB9^{dsRNA.Scer\UAS}/Scer\GAL4^Bx-MS1096 (Tjota et al., 2011) rho^ve-1 has wing vein phenotype, suppressible by bs² (Sturtevant and Bier, 1995) rho^ve-1 has wing vein phenotype, suppressible by bs¹¹ (Sturtevant and Bier, 1995) rho^ve-1 has wing vein phenotype, suppressible by bs^ba (Sturtevant and Bier, 1995)
NOT suppressed by
Statement Reference rho^ve-1, vn¹ has wing vein phenotype, non-suppressible by osa^Scer\UAS.cCa/Scer\GAL4^salm-459.2 (Terriente-Félix and de Celis, 2009) rho^ve-1 has wing vein L3 \| distal phenotype, non-suppressible by Bap170^hfl1/Bap170[+] (Rendina et al., 2010) rho^ve-1 has wing vein L3 phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005) rho^ve-1 has wing vein L4 phenotype, non-suppressible by Bap170^hfl1/Bap170[+] (Rendina et al., 2010) rho^ve-1 has wing vein L4 phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005) rho^ve-1 has wing vein L5 phenotype, non-suppressible by Bap170^hfl1/Bap170[+] (Rendina et al., 2010) rho^ve-1 has wing vein L5 phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005)
Enhancer of
Statement Reference rho^ve-1/rho[+] is an enhancer of wing blade phenotype of sl² (Murillo-Maldonado et al., 2011) rho^ve-1/rho[+] is an enhancer of wing vein \| ectopic phenotype of sl² (Murillo-Maldonado et al., 2011) rho^ve-1/rho[+] is an enhancer of wing vein phenotype of sog^EP7 (Araujo et al., 2003) rho^ve-1/rho[+] is an enhancer of wing vein phenotype of sog^EP11 (Araujo et al., 2003) rho^ve-1 is an enhancer of wing vein phenotype of aos^hs.PSa (Sawamoto et al., 1994)
NOT Enhancer of
Statement Reference rho^ve-1/vn¹ is a non-enhancer of wing vein \| ectopic phenotype of bwk^Δ11, cic^D49 (Roch et al., 2002) rho^ve-1 is a non-enhancer of wing disc phenotype of ft^k07918 (Garoia et al., 2000)
Suppressor of
Statement Reference rho^ve-1/rho[+] is a suppressor \| partially of photoreceptor cell R7 \| adult stage phenotype of sl² (Murillo-Maldonado et al., 2011) rho^ve-1/rho[+] is a suppressor of wing \| heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) rho^ve-1/rho[+] is a suppressor of wing phenotype of px¹ (Wessendorf et al., 1992) rho^ve-1/rho[+] is a suppressor of wing vein \| ectopic \| heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) rho^ve-1/rho⁺ is a suppressor of wing vein \| ectopic phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) rho^ve-1/rho^ve-1 is a suppressor of wing phenotype of px⁷² (Wessendorf et al., 1992, Wessendorf et al., 1992) rho^ve-1/rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of H^C2.Scer\UAS, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002) rho^ve-1/rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of H^Scer\UAS.cNa, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002) rho^ve-1/rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of Snr1^R3/Snr1^E1 (Marenda et al., 2004, Marenda et al., 2004) rho^ve-1/Scer\GAL4^e22c is a suppressor \| partially of posterior crossvein phenotype of Scer\GAL4^e22c, Ubqn^{dsRNA.Ex2.Scer\UAS} (Li et al., 2007) rho^ve-1/Scer\GAL4^e22c is a suppressor \| partially of wing vein L3 phenotype of Scer\GAL4^e22c, Ubqn^{dsRNA.Ex2.Scer\UAS} (Li et al., 2007) rho^ve-1/Scer\GAL4^e22c is a suppressor \| partially of wing vein L4 phenotype of Scer\GAL4^e22c, Ubqn^{dsRNA.Ex2.Scer\UAS} (Li et al., 2007) rho^ve-1/Scer\GAL4^e22c is a suppressor \| partially of wing vein L5 phenotype of Scer\GAL4^e22c, Ubqn^{dsRNA.Ex2.Scer\UAS} (Li et al., 2007) rho^ve-1 is a suppressor \| partially of posterior crossvein phenotype of rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 is a suppressor \| partially of wing vein L3 phenotype of rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 is a suppressor \| partially of wing vein L4 phenotype of rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 is a suppressor \| partially of wing vein L5 phenotype of rho^ve-1 (Li et al., 2007, Li et al., 2007) rho^ve-1 is a suppressor of wing phenotype of bs^A48 (Fristrom et al., 1994) rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of bs^A48 (Fristrom et al., 1994) rho^ve-1 is a suppressor of wing vein phenotype of tkv¹/tkv⁸ (de Celis, 1997)
NOT Suppressor of
Statement Reference rho^ve-1/rho^ve-1 is a non-suppressor of wing & microchaeta \| ectopic phenotype of H^C2.Scer\UAS, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002) rho^ve-1 is a non-suppressor of wing disc phenotype of ft^k07918 (Garoia et al., 2000)
Other
Statement Reference aos^hs.PSa, rho^ve-1 has wing vein L2 phenotype (Sawamoto et al., 1994, Sawamoto et al., 1994) aos^hs.PSa, rho^ve-1 has wing vein L4 phenotype (Sawamoto et al., 1994, Sawamoto et al., 1994) aos^hs.PSa, rho^ve-1 has wing vein L5 phenotype (Sawamoto et al., 1994, Sawamoto et al., 1994) bs¹¹, rho^ve-1 has wing vein L2 phenotype (Fristrom et al., 1994) bs¹¹, rho^ve-1 has wing vein L3 phenotype (Fristrom et al., 1994) bs¹¹, rho^ve-1 has wing vein L4 phenotype (Fristrom et al., 1994) bs¹¹, rho^ve-1 has wing vein L5 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L2 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L3 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L4 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L5 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L2 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L3 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L4 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L5 phenotype (Fristrom et al., 1994) Df(2R)ED3921, rho^ve-1 has wing vein L2 phenotype (Ragab et al., 2006) h¹, rho^ve-1 has wing phenotype (Biehs et al., 1998, Biehs et al., 1998) h¹, rho^ve-1 has wing sensillum \| ectopic phenotype (Biehs et al., 1998, Biehs et al., 1998) pk³⁰, rho^ve-1, vn¹ has wing hair phenotype (Hogan et al., 2011) pk³⁰, rho^ve-1, vn¹ has wing vein phenotype (Hogan et al., 2011) rho⁹/rho^ve-1, vn¹ has wing vein phenotype (Roch et al., 1998) rho⁹/rho^ve-1, vn^M2/vn¹ has wing vein phenotype (Roch et al., 1998) rho⁹/rho^ve-1, vn^M2 has wing vein phenotype (Roch et al., 1998) rho^ve-1, vn¹ has crossvein phenotype (Milan et al., 1997, Milan et al., 1997) rho^ve-1, vn¹ has wing phenotype (Wolfgang et al., 1996, Wolfgang et al., 1996) rho^ve-1, vn¹ has wing vein phenotype (de Celis, 1997, Martin-Blanco et al., 1999, Milan et al., 1997, Ralston and Blair, 2005, Milan et al., 1997, Martin-Blanco et al., 1999, Ralston and Blair, 2005, Terriente-Félix and de Celis, 2009) Scer\GAL4^Bx-MS1096, Zzzz\lef^Scer\UAS.cGa, rho^ve-1 has wing vein phenotype (Guichard et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference rho[ve-1], vn[1] double mutant wings retain wild-type hair polarity and ridge orientation. Wings of homozygous pk[30], rho[ve-1] and vn[1] triple mutant flies lack veins L2-5. Wing anterior hairs of these mutants consistently have a posterior component to their polarity and posterior hairs have an anterior component to their polarity. (Hogan et al., 2011) One copy of rho[ve-1] enhances the reduction in wing blade area seen in homozygous sl[2] males. One copy of rho[ve-1] significantly enhances the ectopic wing vein phenotype seen in sl[2] homozygotes. One copy of rho[ve-1] partially suppresses the percentage of sl[2] mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced. (Murillo-Maldonado et al., 2011) Introduction of one copy of kst[1] into a homozygous rho[ve-1] background completely suppresses the wing vein defect for L2-L4 and partially suppresses the defects in L5. A kst[2] heterozygous background results in a similar, but milder suppression. A reduction in the level of AnnIX, through expression of AnnIX[dsRNA.Scer\UAS] in the wing blade, under the control of Scer\GAL4[Bx-MS1096], restores wing vein formation in a rho[ve-1] background. A Rab5[2] heterozygous background leads to full suppression of the L5 wing vein defect in rho[ve-1]/Df(3L)ru-22 kst[1] mutants and 90% suppression in rho[ve-1]/rho[ve-1] kst[1] flies. A Rbsn-5[40-3] heterozygous background leads to just under 40% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst[1] and rho[ve-1]/rho[ve-1] kst[1] flies. A Hrs[v28] heterozygous background leads to approximately 30% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst[1] and rho[ve-1]/rho[ve-1] kst[1] flies. An Eps-15[e75] heterozygous background leads to approximately 70% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst[1] and rho[ve-1]/rho[ve-1] kst[1] flies. A Vps28[B9] heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst[1] and rho[ve-1]/rho[ve-1] kst[1] flies. A Vps25[A3] heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in rho[ve-1]/rho[ve-1] kst[1] flies. A Vps20[I3] heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in rho[ve-1]/Df(3L)ru-22 kst[1] flies. A shrb[G5] heterozygous background leads to almost full suppression of the L5 wing vein defect in rho[ve-1]/Df(3L)ru-22 kst[1] mutants and 80% suppression in rho[ve-1]/rho[ve-1] kst[1] flies. (Tjota et al., 2011) The loss of wing veins seen in rho[ve-1] homozygotes is not suppressed by Bap170[hfl1]/+. (Rendina et al., 2010) Wing veins do not develop in rho[ve-1], vn[1] animals. Overexpression of osa[Scer\UAS.cCa] in the wing under the control of Scer\GAL4[salm-459.2] cannot induce vein formation in a rho[ve-1], vn[1] mutant background. (Terriente-Félix and de Celis, 2009) Expression of Ubqn[dsRNA.Ex2.Scer\UAS] by Scer\GAL4[e22c] in a heterozygous rho[ve-1] background leads to a normal anterior cross vein and partially restored posterior cross vein and L5 vein, while the distal portion of L4 and L3-4 M veins corresponding to the posterior portion of the wing remains weakened, compared with Ubqn[dsRNA.Ex2.Scer\UAS]; Scer\GAL4[e22c] single mutants. (Li et al., 2007) Df(2R)ED3921; rho^ve-1 flies show an enhancement of L5 vein loss compared to rho^ve-1 flies single mutants and partial loss of L2, a phenotype not seen in rho^ve-1 flies. There is no significant enhancement of L4 and L3 loss. (Ragab et al., 2006) The wings of rho^ve-1 vn¹ double mutants examined at 19, 21 or 24 hours after pupariation (AP) lack most longitudinal veins, with only the most proximal vein tissue intact 19 and 21 hours AP. (Ralston and Blair, 2005) rho^ve-1 double mutants, heterozygous for frc^RY34 exhibit the same phenotype as rho^ve-1 mutants. (Yano et al., 2005) rho[ve-1] vn[1] double homozygotes lack wing veins. This phenotype is partially suppressed by ash2[S112411] /ash2[S112411]. The degree of suppression varies from development of L2 only to almost complete rescue, albeit with some abnormalities such as extra crossvein material or proximal fusions between L2 and L3 or L4 and L5. In 25% of cases, hollow, tube like wings are formed, probably due to detachment of dorsal and ventral layers. (Angulo et al., 2004) brm² enhances the loss of wing vein L5 seen in rho^ve-1 homozygotes. Snr1^E1/Snr1^R3 suppresses the loss of wing vein L5 seen in rho^ve-1 homozygotes and rho^ve-1 suppresses the Snr1^E1/Snr1^R3 extra wing vein phenotype. Snr1^E1 suppresses the shortened L5 wing vein that results from the interaction between rho^ve-1 and brm². (Marenda et al., 2004) The addition of bwk^Δ11 and vn¹ fails to enhance the extra wing vein phenotype seen in cic^D49/bwk^Δ11 animals. (Roch et al., 2002) When Egfr^f1/Egfr^t1 flies are raised at the non-permissive temperature (29^oC) in a rho^ve-1/rho^ve-1 background, there is an enhancement of the usual rho^ve-1 homozygous wing vein phenotype. (Guichard et al., 1999) vn¹ rho^ve-1 flies completely lack wing veins. (Martin-Blanco et al., 1999) h¹ rho^ve-1 / h¹ rho^ve-1 flies have ectopic bristles running between longitudinal veins. (Biehs et al., 1998) rho^ve-1/ast^K6 double heterozygotes do not have a visible phenotype. The phenotype of rho^ve-1 homozygotes is not dominantly altered by ast^K6. (Kotarski et al., 1998) rho⁹, vn^M2/rho^ve-1, vn¹ double mutants lack wing veins. bs⁰³²⁶⁷/bs²; rho⁹, vn^M2/rho^ve-1, vn¹ triple mutants show an almost wild type wing vein pattern. (Roch et al., 1998) vn¹ rho^ve-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn¹ rho^ve-1 double homozygotes when dpp^Scer\UAS.cSa is expressed in these flies using Scer\GAL4^C-580. rho^ve-1 suppresses the differentiation of thicker veins seen in tkv¹/tkv⁸ flies, and results in fewer veins in combination with either dpp^s4/dpp^s8 or tkv¹/tkv⁸. (de Celis, 1997) rho^ve-1 vn¹ double mutant flies lack all the longitudinal veins and crossveins of the wing blade. Dorsal and ventral implants of rho^ve-1 vn¹ imaginal disc tissue into wild-type imaginal discs fail to differentiate veins. (Milan et al., 1997) vn¹ rho^ve-1 flies lack wing veins. (Wolfgang et al., 1996) rho^ve-1 homozygotes which are also expressing argos^hs.PSa (using heat pulses from the second and third larval instar to pupal stage) lack most of wing veins L2-L4 and the entire L5 vein is eliminated. The campaniform sensilla on vein L3 usually remain intact. (Sawamoto et al., 1994)
Xenogenetic Interactions
Statement Reference Moderate expression of Zzzz\lef[Scer\UAS.cGa] under the control of Scer\GAL4[Bx-MS1096] in rho[ve-1] heterozygotes results in wing vein loss, while moderate Zzzz\lef[Scer\UAS.cGa] expression (with Scer\GAL4[Bx-MS1096]) alone doesn't have this phenotype. (Guichard et al., 2006) Loss of the distal tips of wing veins seen in rho^ve-1 mutant flies is suppressed by Pstu\aarA^Scer\UAS.cGa; Scer\GAL4^Bx-MS1096. (Gallio et al., 2002)
Complementation & Rescue Data
Comments
Stocks ( 43 )
Bloomington	628 rho^ve-1 2399 Df(3L)R-G5, rho^ve-1/TM6 1029 rho^ve-1 Coa¹/TM6 629 rho^ve-1 h¹ th¹ 479 mwh¹ rho^ve-1 h¹ 43636 mwh¹ rho^ve-1 mu2¹
Kyoto	106017 rho^ve-1 107310 Df(3L)R-G5, rho^ve-1/TM6 101596 Df(3L)R-G5, rho^ve-1 / TM6 106176 rho^ve-1 Coa¹/TM6 105933 mwh¹ rho^ve-1 h¹ 101936 bw¹ ; rho^ve-1 st¹
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Notes on Origin
Discoverer	Duncan, Jan. 1934.

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Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	rho-1^veinlet (Gallio et al., 2002) rho¹ (Yan et al., 2004) rho^ve1 (Yano et al., 2005, Kotarski et al., 1998) Rho^ve1 (Bidet et al., 2003) rho^ve-1 (Li et al., 2007, Pilgram et al., 2011, Hogan et al., 2011, Murillo-Maldonado et al., 2011, Oishi et al., 2006) rho^ve (Ragab et al., 2006, Ralston and Blair, 2005, Marenda et al., 2004, Guichard et al., 2002, Brentrup et al., 2000, Martin-Blanco et al., 1999, Guichard et al., 1999, Biehs et al., 1998, Lunde et al., 1998, Murray et al., 1995, Sturtevant and Bier, 1995, Sturtevant et al., 1994, Sawamoto et al., 1994, Fristrom et al., 1994, Sturtevant et al., 1993, Angulo et al., 2004, Terriente-Félix and de Celis, 2009, Guichard et al., 2006, Rendina et al., 2010, Ajuria et al., 2011, Tjota et al., 2011) rho^VE (Wolfgang et al., 1996) ve (Baonza and Garcia-Bellido, 1999) ve¹ (Johannes and Preiss, 2002, Sotillos and Campuzano, 2000, Garoia et al., 2000, Roch et al., 1998, Sapir et al., 1998, Milan et al., 1997, de Celis, 1997, Lindsley and Zimm, 1992, Wessendorf et al., 1992, Duncan, 1935)
Name Synonym	rhomboid^ve (Tjota et al., 2011) veinlet (Urban, 2006)
Secondary FlyBase IDs

References ( 61 )

Generate a list of	All references relating to this allele ( 61 )

List References by type	Research paper ( 49 ) Review ( 1 ) Personal communication to FlyBase ( 9 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 5 )
	Ajuria et al., 2011, Development 138(5): 915--924 Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila. [FBrf0212975] Hogan et al., 2011, PLoS Genet. 7(2): e1001305 Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the fat/dachsous pathway. [FBrf0213159] Murillo-Maldonado et al., 2011, PLoS ONE 6(11): e28067 Insulin Receptor-Mediated Signaling via Phospholipase C-γ Regulates Growth and Differentiation in Drosophila. [FBrf0216849] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Tjota et al., 2011, J. Cell Sci. 124(17): 2914--2926 Annexin B9 binds to {beta}H-spectrin and is required for multivesicular body function in Drosophila. [FBrf0215049] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Dmel\rhove-1

Allele Dmel\rho^ve-1