|Feature type||allele||Associated gene||Dmel\rho|
|Also Known As||rhove, ve1, rhove1|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Mutation within the promoter region.
|Carried on aberration|
|Phenotype Manifest In|
Homozygotes lack the distal portion of wing vein L3 and lack most of the L4 and L5 wing veins.
Homozygous rho[ve-1] mutants show loss of partial L3, L4 and L5 and weakened L2-L4 M veins, whereas heterozygous rho[ve-1] exhibit only a weakened distal portion of L5 vein.
The initial development of most veins in the wing is disrupted in rhove-1 mutants.
Homozygotes show incomplete wing veins L2, L3, L4 and L5.
Mutant embryos show duplication of the segmental border muscle and a complete loss of lateral adult muscle precursors.
rhove-1 mutant flies show loss of the distal ends of wing veins, particularly L3, L4 and L5.
The interactions between rhove-1/rhove-1 and emcD or emc1/emc11 are additive. The interactions between rhove-1/rho9 and emcD or emc1/emc11 are additive. emc1 clones in rhove-1 vn1 wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins.
In a e1, rhove-1 double mutant, in which all of the longitudinal veins are truncated or eliminated, ectopic melanin only develops in proximal areas that truncate before reaching the margin.
Homozygotes lack the distal ends of all longitudinal wing veins.
Wings lack the longitudinal veins.
Wings have shortened longitudinal veins that do not reach the wing margin.
Lack distal segments of wing veins especially veins L4 and L5. Homozygous phenotype is strongly suppressed by heterozygous rhoWk.
Wing veins do not reach margins.
|NOT suppressed by|
|Phenotype Manifest In|
|NOT Enhanced by|
|NOT suppressed by|
|NOT Enhancer of|
rhove-1/rho+ is a suppressor of wing vein | ectopic phenotype of Scer\GAL4tub.PU, cswN308D.Scer\UAS.P\T
rhove-1/Scer\GAL4e22c is a suppressor | partially of posterior crossvein phenotype of Scer\GAL4e22c, UbqndsRNA.Ex2.Scer\UAS
rhove-1/Scer\GAL4e22c is a suppressor | partially of wing vein L3 phenotype of Scer\GAL4e22c, UbqndsRNA.Ex2.Scer\UAS
rhove-1/Scer\GAL4e22c is a suppressor | partially of wing vein L4 phenotype of Scer\GAL4e22c, UbqndsRNA.Ex2.Scer\UAS
rhove-1/Scer\GAL4e22c is a suppressor | partially of wing vein L5 phenotype of Scer\GAL4e22c, UbqndsRNA.Ex2.Scer\UAS
|NOT Suppressor of|
rhove-1/rhove-1 is a non-suppressor of wing & microchaeta | ectopic phenotype of HC2.Scer\UAS, Scer\GAL4en-e16E
rho[ve-1], vn double mutant wings retain wild-type hair polarity and ridge orientation. Wings of homozygous pk, rho[ve-1] and vn triple mutant flies lack veins L2-5. Wing anterior hairs of these mutants consistently have a posterior component to their polarity and posterior hairs have an anterior component to their polarity.
One copy of rho[ve-1] enhances the reduction in wing blade area seen in homozygous sl males. One copy of rho[ve-1] significantly enhances the ectopic wing vein phenotype seen in sl homozygotes. One copy of rho[ve-1] partially suppresses the percentage of sl mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced.
Introduction of one copy of kst into a homozygous rho[ve-1] background completely suppresses the wing vein defect for L2-L4 and partially suppresses the defects in L5. A kst heterozygous background results in a similar, but milder suppression. A reduction in the level of AnnIX, through expression of AnnIX[dsRNA.Scer\UAS] in the wing blade, under the control of Scer\GAL4[Bx-MS1096], restores wing vein formation in a rho[ve-1] background. A Rab5 heterozygous background leads to full suppression of the L5 wing vein defect in rho[ve-1]/Df(3L)ru-22 kst mutants and 90% suppression in rho[ve-1]/rho[ve-1] kst flies. A Rbsn-5[40-3] heterozygous background leads to just under 40% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst and rho[ve-1]/rho[ve-1] kst flies. A Hrs[v28] heterozygous background leads to approximately 30% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst and rho[ve-1]/rho[ve-1] kst flies. An Eps-15[e75] heterozygous background leads to approximately 70% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst and rho[ve-1]/rho[ve-1] kst flies. A Vps28[B9] heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in both rho[ve-1]/Df(3L)ru-22 kst and rho[ve-1]/rho[ve-1] kst flies. A Vps25[A3] heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in rho[ve-1]/rho[ve-1] kst flies. A Vps20[I3] heterozygous background leads to approximately 90% suppression of the L5 wing vein defect in rho[ve-1]/Df(3L)ru-22 kst flies. A shrb[G5] heterozygous background leads to almost full suppression of the L5 wing vein defect in rho[ve-1]/Df(3L)ru-22 kst mutants and 80% suppression in rho[ve-1]/rho[ve-1] kst flies.
Wing veins do not develop in rho[ve-1], vn animals. Overexpression of osa[Scer\UAS.cCa] in the wing under the control of Scer\GAL4[salm-459.2] cannot induce vein formation in a rho[ve-1], vn mutant background.
Expression of Ubqn[dsRNA.Ex2.Scer\UAS] by Scer\GAL4[e22c] in a heterozygous rho[ve-1] background leads to a normal anterior cross vein and partially restored posterior cross vein and L5 vein, while the distal portion of L4 and L3-4 M veins corresponding to the posterior portion of the wing remains weakened, compared with Ubqn[dsRNA.Ex2.Scer\UAS]; Scer\GAL4[e22c] single mutants.
Df(2R)ED3921; rhove-1 flies show an enhancement of L5 vein loss compared to rhove-1 flies single mutants and partial loss of L2, a phenotype not seen in rhove-1 flies. There is no significant enhancement of L4 and L3 loss.
The wings of rhove-1 vn1 double mutants examined at 19, 21 or 24 hours after pupariation (AP) lack most longitudinal veins, with only the most proximal vein tissue intact 19 and 21 hours AP.
rho[ve-1] vn double homozygotes lack wing veins. This phenotype is partially suppressed by ash2[S112411] /ash2[S112411]. The degree of suppression varies from development of L2 only to almost complete rescue, albeit with some abnormalities such as extra crossvein material or proximal fusions between L2 and L3 or L4 and L5. In 25% of cases, hollow, tube like wings are formed, probably due to detachment of dorsal and ventral layers.
brm2 enhances the loss of wing vein L5 seen in rhove-1 homozygotes. Snr1E1/Snr1R3 suppresses the loss of wing vein L5 seen in rhove-1 homozygotes and rhove-1 suppresses the Snr1E1/Snr1R3 extra wing vein phenotype. Snr1E1 suppresses the shortened L5 wing vein that results from the interaction between rhove-1 and brm2.
The addition of bwkΔ11 and vn1 fails to enhance the extra wing vein phenotype seen in cicD49/bwkΔ11 animals.
When Egfrf1/Egfrt1 flies are raised at the non-permissive temperature (29oC) in a rhove-1/rhove-1 background, there is an enhancement of the usual rhove-1 homozygous wing vein phenotype.
rhove-1/astK6 double heterozygotes do not have a visible phenotype. The phenotype of rhove-1 homozygotes is not dominantly altered by astK6.
rho9, vnM2/rhove-1, vn1 double mutants lack wing veins. bs03267/bs2; rho9, vnM2/rhove-1, vn1 triple mutants show an almost wild type wing vein pattern.
vn1 rhove-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn1 rhove-1 double homozygotes when dppScer\UAS.cSa is expressed in these flies using Scer\GAL4C-580. rhove-1 suppresses the differentiation of thicker veins seen in tkv1/tkv8 flies, and results in fewer veins in combination with either dpps4/dpps8 or tkv1/tkv8.
rhove-1 vn1 double mutant flies lack all the longitudinal veins and crossveins of the wing blade. Dorsal and ventral implants of rhove-1 vn1 imaginal disc tissue into wild-type imaginal discs fail to differentiate veins.
Moderate expression of Zzzz\lef[Scer\UAS.cGa] under the control of Scer\GAL4[Bx-MS1096] in rho[ve-1] heterozygotes results in wing vein loss, while moderate Zzzz\lef[Scer\UAS.cGa] expression (with Scer\GAL4[Bx-MS1096]) alone doesn't have this phenotype.
|Complementation & Rescue Data|
|Stocks ( 43 )|
|Notes on Origin|
Duncan, Jan. 1934.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 11 )|
(Ragab et al., 2006, Ralston and Blair, 2005, Marenda et al., 2004, Guichard et al., 2002, Brentrup et al., 2000, Martin-Blanco et al., 1999, Guichard et al., 1999, Biehs et al., 1998, Lunde et al., 1998, Murray et al., 1995, Sturtevant and Bier, 1995, Sturtevant et al., 1994, Sawamoto et al., 1994, Fristrom et al., 1994, Sturtevant et al., 1993, Angulo et al., 2004, Terriente-Félix and de Celis, 2009, Guichard et al., 2006, Rendina et al., 2010, Ajuria et al., 2011, Tjota et al., 2011)
|Secondary FlyBase IDs|
|References ( 61 )|
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|Recent research papers ( 5 )|
|Recent reviews (0)|
|All reviews listed in FlyBase were published before 2011|