Allele Dmel\rho^ve-1

General Information
Symbol	Dmel\rho^ve-1	Species	D. melanogaster
Name		FlyBase ID	FBal0017855
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\rho

Allele class	loss of function
Mutagen	spontaneous
Nature of the Allele
Allele class	loss of function (Sturtevant et al., 1993, Sawamoto et al., 1994, Milan et al., 1997)
Mutagen	spontaneous (Lindsley and Zimm, 1992)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Mutation within the promoter region. (Sturtevant et al., 1993)
Assay mode
Carried on aberration	TM1-mr (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) Df(3L)BSC14 (Deal and Cook, 2002.2.24) Df(3L)BSC15 (Deal and Cook, 2002.2.24) Df(3L)BSC33 (Andrade and Cook, 2003.4.2) Df(3L)BSC13 (Deal and Cook, 2002.2.25) Df(3L)BSC46 (Andrade and Cook, 2003.12.11) Df(3L)BSC23 (Deal et al., 2002.11.12) Df(3L)BSC35 (Andrade and Cook, 2003.6.2) Df(3L)BSC12 (Deal and Cook, 2002.1.22)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Lindsley and Zimm, 1992, Kotarski et al., 1998, de Celis, 1997, Yano et al., 2005) visible \| recessive (Roch et al., 1998, Guichard et al., 1999, Sturtevant et al., 1993)
Phenotype Manifest In
	wing vein (Lindsley and Zimm, 1992, Sturtevant et al., 1993, de Celis, 1997, Ralston and Blair, 2005) wing vein L1 (Murray et al., 1995) wing vein L2 (Murray et al., 1995, Sawamoto et al., 1994, Marenda et al., 2004) wing vein L3 (Murray et al., 1995, Sawamoto et al., 1994, Yano et al., 2005, Gallio et al., 2002, Ragab et al., 2006, Marenda et al., 2004) wing vein L4 (Murray et al., 1995, Sawamoto et al., 1994, Guichard et al., 1999, Yano et al., 2005, Gallio et al., 2002, Ragab et al., 2006, Marenda et al., 2004) wing vein L5 (Murray et al., 1995, Sawamoto et al., 1994, Guichard et al., 1999, Yano et al., 2005, Gallio et al., 2002, Ragab et al., 2006, Marenda et al., 2004) wing vein L6 (Murray et al., 1995) segment border muscle \| ectopic (Bidet, 2003) wing vein \| distal (de Celis, 1997)
Detailed Description
	Statement Reference Lack distal segments of wing veins especially veins L4 and L5. Homozygous phenotype is strongly suppressed by heterozygous rho^Wk. (Sturtevant et al., 1993) Wing veins do not reach margins. (Lindsley and Zimm, 1992) rho^ve-1 supresses the vein defects of bs mutations although L2 to L5 remain truncated distally. (Fristrom et al., 1994) Wings have shortened longitudinal veins that do not reach the wing margin. (Sawamoto et al., 1994) Wings lack the longitudinal veins. (Murray et al., 1995) Homozygotes lack the distal ends of all longitudinal wing veins. (de Celis, 1997) Germline clones fail to rescue the female sterile phenotype of Fs(3)Apc. (Sapir et al., 1998) The interactions between rho^ve-1/rho^ve-1 and emc^D or emc¹/emc¹¹ are additive. The interactions between rho^ve-1/rho⁹ and emc^D or emc¹/emc¹¹ are additive. emc¹ clones in rho^ve-1 vn¹ wings differentiate as veins in positions possibly corresponding to those of wild-type veins. Vein differentiation in these clones frequently fails in distal regions of veins. (Baonza and Garcia-Bellido, 1999) In a e¹, rho^ve-1 double mutant, in which all of the longitudinal veins are truncated or eliminated, ectopic melanin only develops in proximal areas that truncate before reaching the margin. (True et al., 1999) rho^ve-1 mutant flies show loss of the distal ends of wing veins, particularly L3, L4 and L5. (Gallio et al., 2002) Mutant embryos show duplication of the segmental border muscle and a complete loss of lateral adult muscle precursors. (Bidet, 2003) Homozygotes show incomplete wing veins L2, L3, L4 and L5. (Marenda et al., 2004) The initial development of most veins in the wing is disrupted in rho^ve-1 mutants. (Ralston and Blair, 2005) rho^ve-1 mutants are viable, exhibiting partial loss of L3-L5 wing veins. (Yano et al., 2005) rho^ve-1 flies show a partial loss of wing veins L3, L4 and L5. (Ragab et al., 2006)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference rho^ve-1 has visible phenotype, enhanceable by argos^hs.PSa (Sawamoto et al., 1994)
Suppressed by
Statement Reference rho⁹/rho^ve-1, vn^M2/vn¹ has visible phenotype, suppressible by bs⁰³²⁶⁷/bs² (Roch et al., 1998)
NOT suppressed by
Statement Reference rho^ve-1 has viable phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005)
Enhancer of
Statement Reference rho^ve-1/rho[+] is an enhancer of visible \| dominant phenotype of sog^EP7 (Araujo et al., 2003) rho^ve-1/rho[+] is an enhancer of visible \| dominant phenotype of sog^EP11 (Araujo et al., 2003) rho^ve-1 is an enhancer of visible phenotype of argos^hs.PSa (Sawamoto et al., 1994)
Suppressor of
Statement Reference rho^ve-1/rho^ve-1 is a suppressor of visible \| recessive phenotype of px⁷² (Wessendorf et al., 1992, Wessendorf et al., 1992) rho^ve-1/rho[+] is a suppressor of visible \| recessive phenotype of px¹ (Wessendorf et al., 1992) rho^ve-1/rho[+] is a suppressor of visible \| conditional - heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) rho^ve-1/rho^ve-1 is a suppressor \| partially of visible phenotype of H^C2.Scer\UAS, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002)
Other
Statement Reference rho⁹/rho^ve-1, vn^M2/vn¹ has visible phenotype (Roch et al., 1998) rho^ve-1, vn¹ has visible \| recessive phenotype (Martin-Blanco et al., 1999, Milan et al., 1997, Milan et al., 1997, Martin-Blanco et al., 1999) rho^ve-1, vn¹ has visible phenotype (Wolfgang et al., 1996, Wolfgang et al., 1996)
Phenotype Manifest In
Enhanced by
Statement Reference rho^ve-1 has wing vein L5 phenotype, enhanceable by Df(2R)ED3921 (Ragab et al., 2006) rho^ve-1 has wing vein phenotype, enhanceable by argos^hs.PSa (Sawamoto et al., 1994) rho^ve-1 has wing vein L5 phenotype, enhanceable by brm² (Marenda et al., 2004) rho^ve-1 has wing vein L3 phenotype, enhanceable by Pc⁴ (Marenda et al., 2004) rho^ve-1 has wing vein phenotype, enhanceable by Egfr^t1/Egfr^f1 (Guichard et al., 1999)
NOT Enhanced by
Statement Reference rho^ve-1 has wing vein L3 phenotype, non-enhanceable by Df(2R)ED3921 (Ragab et al., 2006) rho^ve-1 has wing vein L4 phenotype, non-enhanceable by Df(2R)ED3921 (Ragab et al., 2006) rho^ve-1 has phenotype, non-enhanceable by ast^K6 (Kotarski et al., 1998)
Suppressed by
Statement Reference rho^ve-1 has phenotype, suppressible by gra¹ (Lindsley and Zimm, 1992) rho⁹/rho^ve-1, vn^M2/vn¹ has wing vein phenotype, suppressible by bs⁰³²⁶⁷/bs² (Roch et al., 1998) rho^ve-1, vn¹ has wing vein phenotype, suppressible by dpp^Scer\UAS.cSa/Scer\GAL4^C-580 (de Celis, 1997) rho^ve-1 has phenotype, suppressible by bs^Px (Sturtevant and Bier, 1995) rho^ve-1 has wing vein phenotype, suppressible by bs^ba (Sturtevant and Bier, 1995) rho^ve-1 has wing vein phenotype, suppressible by bs¹¹ (Sturtevant and Bier, 1995) rho^ve-1 has wing vein phenotype, suppressible by bs² (Sturtevant and Bier, 1995) rho^ve-1 has wing vein L4 phenotype, suppressible by Pstu\aarA^Scer\UAS.cGa/Scer\GAL4^Bx-MS1096 (Gallio et al., 2002) rho^ve-1 has wing vein L5 phenotype, suppressible by Pstu\aarA^Scer\UAS.cGa/Scer\GAL4^Bx-MS1096 (Gallio et al., 2002) rho^ve-1 has wing vein L3 phenotype, suppressible by Pstu\aarA^Scer\UAS.cGa/Scer\GAL4^Bx-MS1096 (Gallio et al., 2002) brm², rho^ve-1 has wing vein L5 phenotype, suppressible by Snr1^E1 (Marenda et al., 2004) rho^ve-1 has wing vein L5 phenotype, suppressible by Snr1^R3/Snr1^E1 (Marenda et al., 2004)
NOT suppressed by
Statement Reference rho^ve-1 has wing vein L3 phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005) rho^ve-1 has wing vein L4 phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005) rho^ve-1 has wing vein L5 phenotype, non-suppressible by frc^RY34/frc[+] (Yano et al., 2005)
Enhancer of
Statement Reference rho^ve-1/rho[+] is an enhancer of wing vein phenotype of sog^EP7 (Araujo et al., 2003) rho^ve-1/rho[+] is an enhancer of wing vein phenotype of sog^EP11 (Araujo et al., 2003) rho^ve-1 is an enhancer of wing vein phenotype of argos^hs.PSa (Sawamoto et al., 1994)
NOT Enhancer of
Statement Reference rho^ve-1/vn¹ is a non-enhancer of wing vein \| ectopic phenotype of bwk^Δ11, cic^D49 (Roch et al., 2002) rho^ve-1 is a non-enhancer of dorsal mesothoracic disc phenotype of ft^k07918 (Garoia et al., 2000)
Suppressor of
Statement Reference rho^ve-1/rho^ve-1 is a suppressor of wing phenotype of px⁷² (Wessendorf et al., 1992, Wessendorf et al., 1992) rho^ve-1/rho[+] is a suppressor of wing phenotype of px¹ (Wessendorf et al., 1992) rho^ve-1/rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of Snr1^R3/Snr1^E1 (Marenda et al., 2004, Marenda et al., 2004) rho^ve-1/rho[+] is a suppressor of wing vein \| ectopic \| conditional - heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) rho^ve-1/rho[+] is a suppressor of wing \| conditional - heat sensitive phenotype of H^C2.hs (Johannes and Preiss, 2002) rho^ve-1 is a suppressor of wing vein phenotype of tkv¹/tkv⁸ (de Celis, 1997) rho^ve-1/rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of H^C2.Scer\UAS, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002) rho^ve-1/rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of H^Scer\UAS.cNa, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002) rho^ve-1 is a suppressor of wing vein \| ectopic phenotype of bs^A48 (Fristrom et al., 1994) rho^ve-1 is a suppressor of wing phenotype of bs^A48 (Fristrom et al., 1994)
NOT Suppressor of
Statement Reference rho^ve-1 is a non-suppressor of dorsal mesothoracic disc phenotype of ft^k07918 (Garoia et al., 2000) rho^ve-1/rho^ve-1 is a non-suppressor of wing & microchaeta \| ectopic phenotype of H^C2.Scer\UAS, Scer\GAL4^en-e16E (Johannes and Preiss, 2002, Johannes and Preiss, 2002)
Other
Statement Reference Df(2R)ED3921, rho^ve-1 has wing vein L2 phenotype (Ragab et al., 2006) rho⁹/rho^ve-1, vn^M2/vn¹ has wing vein phenotype (Roch et al., 1998) rho^ve-1, vn¹ has wing vein phenotype (de Celis, 1997, Martin-Blanco et al., 1999, Milan et al., 1997, Ralston and Blair, 2005, Milan et al., 1997, Martin-Blanco et al., 1999, Ralston and Blair, 2005) rho^ve-1, vn¹ has wing phenotype (Wolfgang et al., 1996, Wolfgang et al., 1996) rho^ve-1, vn¹ has crossvein phenotype (Milan et al., 1997, Milan et al., 1997) bs¹¹, rho^ve-1 has wing vein L2 phenotype (Fristrom et al., 1994) bs¹¹, rho^ve-1 has wing vein L3 phenotype (Fristrom et al., 1994) bs¹¹, rho^ve-1 has wing vein L4 phenotype (Fristrom et al., 1994) bs¹¹, rho^ve-1 has wing vein L5 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L2 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L3 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L4 phenotype (Fristrom et al., 1994) bs¹², rho^ve-1 has wing vein L5 phenotype (Fristrom et al., 1994) rho⁹/rho^ve-1, vn^M2 has wing vein phenotype (Roch et al., 1998) h¹, rho^ve-1 has wing sensillum \| ectopic phenotype (Biehs et al., 1998, Biehs et al., 1998) h¹, rho^ve-1 has wing phenotype (Biehs et al., 1998, Biehs et al., 1998) argos^hs.PSa, rho^ve-1 has wing vein L2 phenotype (Sawamoto et al., 1994, Sawamoto et al., 1994) argos^hs.PSa, rho^ve-1 has wing vein L4 phenotype (Sawamoto et al., 1994, Sawamoto et al., 1994) argos^hs.PSa, rho^ve-1 has wing vein L5 phenotype (Sawamoto et al., 1994, Sawamoto et al., 1994) bs^A48, rho^ve-1 has wing vein L2 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L3 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L4 phenotype (Fristrom et al., 1994) bs^A48, rho^ve-1 has wing vein L5 phenotype (Fristrom et al., 1994) rho⁹/rho^ve-1, vn¹ has wing vein phenotype (Roch et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference rho^ve-1 homozygotes which are also expressing argos^hs.PSa (using heat pulses from the second and third larval instar to pupal stage) lack most of wing veins L2-L4 and the entire L5 vein is eliminated. The campaniform sensilla on vein L3 usually remain intact. (Sawamoto et al., 1994) vn¹ rho^ve-1 flies lack wing veins. (Wolfgang et al., 1996) vn¹ rho^ve-1 double homozygotes lack all longitudinal wing veins. Vein tissue differentiates in vn¹ rho^ve-1 double homozygotes when dpp^Scer\UAS.cSa is expressed in these flies using Scer\GAL4^C-580. rho^ve-1 suppresses the differentiation of thicker veins seen in tkv¹/tkv⁸ flies, and results in fewer veins in combination with either dpp^s4/dpp^s8 or tkv¹/tkv⁸. (de Celis, 1997) rho^ve-1 vn¹ double mutant flies lack all the longitudinal veins and crossveins of the wing blade. Dorsal and ventral implants of rho^ve-1 vn¹ imaginal disc tissue into wild-type imaginal discs fail to differentiate veins. (Milan et al., 1997) rho⁹, vn^M2/rho^ve-1, vn¹ double mutants lack wing veins. bs⁰³²⁶⁷/bs²; rho⁹, vn^M2/rho^ve-1, vn¹ triple mutants show an almost wild type wing vein pattern. (Roch et al., 1998) rho^ve-1/ast^K6 double heterozygotes do not have a visible phenotype. The phenotype of rho^ve-1 homozygotes is not dominantly altered by ast^K6. (Kotarski et al., 1998) h¹ rho^ve-1 / h¹ rho^ve-1 flies have ectopic bristles running between longitudinal veins. (Biehs et al., 1998) When Egfr^f1/Egfr^t1 flies are raised at the non-permissive temperature (29^oC) in a rho^ve-1/rho^ve-1 background, there is an enhancement of the usual rho^ve-1 homozygous wing vein phenotype. (Guichard et al., 1999) vn¹ rho^ve-1 flies completely lack wing veins. (Martin-Blanco et al., 1999) The addition of bwk^Δ11 and vn¹ fails to enhance the extra wing vein phenotype seen in cic^D49/bwk^Δ11 animals. (Roch et al., 2002) brm² enhances the loss of wing vein L5 seen in rho^ve-1 homozygotes. Snr1^E1/Snr1^R3 suppresses the loss of wing vein L5 seen in rho^ve-1 homozygotes and rho^ve-1 suppresses the Snr1^E1/Snr1^R3 extra wing vein phenotype. Snr1^E1 suppresses the shortened L5 wing vein that results from the interaction between rho^ve-1 and brm². (Marenda et al., 2004) The wings of rho^ve-1 vn¹ double mutants examined at 19, 21 or 24 hours after pupariation (AP) lack most longitudinal veins, with only the most proximal vein tissue intact 19 and 21 hours AP. (Ralston and Blair, 2005) rho^ve-1 double mutants, heterozygous for frc^RY34 exhibit the same phenotype as rho^ve-1 mutants. (Yano et al., 2005) Df(2R)ED3921; rho^ve-1 flies show an enhancement of L5 vein loss compared to rho^ve-1 flies single mutants and partial loss of L2, a phenotype not seen in rho^ve-1 flies. There is no significant enhancement of L4 and L3 loss. (Ragab et al., 2006)
Xenogenetic Interactions
Statement Reference Loss of the distal tips of wing veins seen in rho^ve-1 mutant flies is suppressed by Pstu\aarA^Scer\UAS.cGa; Scer\GAL4^Bx-MS1096. (Gallio et al., 2002)
Complementation & Rescue Data
Comments
Stocks ( 44 )
Bloomington	628 rho^ve-1 2399 Df(3L)R-G5, rho^ve-1/TM6 1029 rho^ve-1 Coa¹/TM6 889 T(3;4)A28, rho^ve-1 ca¹ 629 rho^ve-1 h¹ th¹ 479 mwh¹ rho^ve-1 h¹
Kyoto	106017 rho^ve-1 107310 Df(3L)R-G5, rho^ve-1/TM6 101596 Df(3L)R-G5, rho^ve-1 / TM6 106176 rho^ve-1 Coa¹/TM6 105933 mwh¹ rho^ve-1 h¹ 101936 bw¹ ; rho^ve-1 st¹
	More stocks available...
Notes on Origin
Discoverer	Duncan, Jan. 1934.

Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	rho-1^veinlet (Gallio et al., 2002) rho¹ (Yan et al., 2004) rho^ve1 (Yano et al., 2005, Kotarski et al., 1998) Rho^ve1 (Bidet, 2003) rho^ve-1 rho^ve (Ragab et al., 2006, Ralston and Blair, 2005, Marenda et al., 2004, Guichard et al., 2002, Brentrup et al., 2000, Martin-Blanco et al., 1999, Guichard et al., 1999, Biehs et al., 1998, Lunde et al., 1998, Murray et al., 1995, Sturtevant and Bier, 1995, Sturtevant et al., 1994, Sawamoto et al., 1994, Fristrom et al., 1994, Sturtevant et al., 1993) rho^VE (Wolfgang et al., 1996) ve (Baonza and Garcia-Bellido, 1999) ve¹ (Johannes and Preiss, 2002, Sotillos and Campuzano, 2000, Garoia et al., 2000, Roch et al., 1998, Sapir et al., 1998, Milan et al., 1997, de Celis, 1997, Lindsley and Zimm, 1992, Wessendorf et al., 1992, Duncan, 1935)
Name Synonym	veinlet (Urban, 2006)
Secondary FlyBase IDs

References ( 50 )

Generate a list of	All references relating to this allele ( 50 )

List References by type	Research paper ( 38 ) Review ( 1 ) Personal communication to FlyBase ( 9 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Ragab et al., 2006, Genetics 172(2): 1069--1078 High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila. [FBrf0190761] Show all research papers ...
Recent reviews ( 1 )
	Urban, 2006, Genes Dev. 20(22): 3054--3068 Rhomboid proteins: conserved membrane proteases with divergent biological functions. [FBrf0193506] Show all reviews ...

Allele Dmel\rhove-1

Allele Dmel\rho^ve-1