A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\vg1

General Information
SymbolDmel\vg1SpeciesD. melanogaster
NameFlyBase IDFBal0017868
Feature typealleleCreated / Updated2006-05-15/2006-05-15
Associated geneDmel\vg
Allele classhypomorph, gain of function
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      412 insertion (8 kb) at + 8kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990).
       
      412 element insert.
      412 insertion into intronic region.
      Insertion of a 412 element.
      Insertion of an 8kb 412 in intron 3 and an insertion of 6kb of unknown DNA at the 3' end of intron 2.
      Insertion of a complete 412 element in the same transcriptional orientation as vg.
      Insert stated as cause: undefined Intronic insertion.
      Assay mode
      Caused by insertion
      Carried on aberration
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      Nfa-do-vg/Nfa-do-vg; vg1/+ produces some wing notching. vg1/+ is strongly scalloped in combination with Ma1. wings, halteres reduced; small wing discs map location
       
      Homozygotes have vestigial wings.
      Homozygotes display an extreme vg phenotype when in the P-cytotype or M-cytotype.
      No interaction with mw2.
      Homozygotes have no wings.
      Strong vg phenotype. Transheterozygotes with vg83b27 exhibit wing bubbles and unequal wing deficiencies.
      Homozygotes display high sensitivity to fluorodeoxyuridine (FUdR), an inhibitor of thymidylate synthetase and high resistance to aminopterin.
      Wing imaginal discs are smaller than wild type due to cell death.
      Only 4/1692 wings with clones of l(2)gl4 clones in a vg1 background show clonal restoration of pattern.
      Most of the wing is missing, only some of the most proximal structures remain.
      Flies have reduced wings and halteres.
      No effect on the faf eye phenotype.
      ctL32; su(Hw)e2 flies heterozygous for vg1 display a significant ct wing phenotype.
      Wing length increases with increasing temperature.
      vgWR2 produces a weak vg phenotype in combination with vg83b27.
      The formation of ectopic wing-like outgrowths caused by expression of vgScer\UAS.cZa under the control of Scer\GAL4ptc-559.1 is more strongly reduced in a vg1 homozygous background than in a vg1 heterozygous background.
      In vg1 wing discs, much of the wing pouch anlagen fails to develop.
      Of the indirect flight muscles in vg1 mutants, the dorsal medial muscles are severely reduced and the dorso-ventral muscles (lateral oblique dorsal muscles and tergosternal muscles) are minimal or completely missing.
      Heterozygotes have normal wing tissue.
      Homozygotes lack halteres and wings are almost always small and stumpy and do not extend beyond the scutellum.
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      vg1 has visible | dominant phenotype, enhanceable by +/T(2;3)Nipped-C138.2
      vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D341.1/+
      vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D263.3/+
      vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E43/+
      vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E338/+
      vg83b27/vg1 has visible phenotype, enhanceable by 10381038
      vg83b27/vg1 has visible phenotype, enhanceable by 12971297
      vg83b27/vg1 has visible phenotype, enhanceable by 15771577
      vg83b27/vg1 has visible phenotype, enhanceable by 23352335
      vg83b27/vg1 has visible phenotype, enhanceable by 836836
      vg83b27/vg1 has visible phenotype, enhanceable by In(2LR)789
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)550
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)75
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)805
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)835
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)84
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)88
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)B9b
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)B9c
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No3
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No5
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No6
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)P1C
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)PIIA
      vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)PIIB
      vg83b27/vg1 has visible phenotype, enhanceable by Tp(2;3)P10.C
      hideNOT Enhanced by
      Statement
      Reference
      vg83b27/vg1 has visible phenotype, non-enhanceable by za
      hideNOT suppressed by
      Statement
      Reference
      vg83b27/vg1 has visible phenotype, non-suppressible by za
      hideOther
      Statement
      Reference
      M(3)801, vg[+]/vg1 has visible | dominant | conditional - heat sensitive phenotype
      Ma1, vg1 has visible | dominant phenotype
         
      M(3)80[+]/M(3)801, vg1 has visible | dominant | conditional - heat sensitive phenotype
      M(3)80[+]/M(3)801, vg1 has visible | dominant phenotype
      Nipped-A[+]/Nipped-A323, vg1 has visible | dominant phenotype
      Nipped-A[+]/Nipped-A222.3, vg1 has visible | dominant phenotype
      Nipped-A[+]/Nipped-A394.2, vg1 has visible | dominant phenotype
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      vg1 has wing phenotype, enhanceable by Nfa-do-vg/N[+]
       
      vg1 has wing phenotype, enhanceable by +/T(2;3)Nipped-C138.2
      vg1 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1/+
      vg1 has wing phenotype, enhanceable by Df(2R)Nipped-D263.3/+
      vg1 has wing phenotype, enhanceable by Df(2R)Nipped-E43/+
      vg1 has wing phenotype, enhanceable by Df(2R)Nipped-E338/+
      vg1 has phenotype, enhanceable by Nipped-A222.3
      vg1 has phenotype, enhanceable by Nipped-A323
      vg1 has phenotype, enhanceable by Nipped-A394.2
      vg1 has phenotype, enhanceable by RpL3845-72
      vg83b27/vg1 has haltere phenotype, enhanceable by 10381038
      vg83b27/vg1 has wing phenotype, enhanceable by 10381038
      vg83b27/vg1 has haltere phenotype, enhanceable by 12971297
      vg83b27/vg1 has wing phenotype, enhanceable by 12971297
      vg83b27/vg1 has haltere phenotype, enhanceable by 15771577
      vg83b27/vg1 has wing phenotype, enhanceable by 15771577
      vg83b27/vg1 has haltere phenotype, enhanceable by 23352335
      vg83b27/vg1 has wing phenotype, enhanceable by 23352335
      vg83b27/vg1 has haltere phenotype, enhanceable by 836836
      vg83b27/vg1 has wing phenotype, enhanceable by 836836
      vg83b27/vg1 has haltere phenotype, enhanceable by In(2LR)789
      vg83b27/vg1 has wing phenotype, enhanceable by In(2LR)789
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)550
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)550
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)75
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)805
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)805
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)835
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)835
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)84
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)88
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)88
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)B9b
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)B9b
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)B9c
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)B9c
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No3
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No3
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No5
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No5
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No6
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No6
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)P1C
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)P1C
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)PIIA
      vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)PIIA
      vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)PIIB
      vg83b27/vg1 has haltere phenotype, enhanceable by Tp(2;3)P10.C
      vg83b27/vg1 has wing phenotype, enhanceable by Tp(2;3)P10.C
      hideNOT Enhanced by
      Statement
      Reference
      vg1 has phenotype, non-enhanceable by Nipped-A2
      vg1 has phenotype, non-enhanceable by Nipped-B292.1
      vg1 has phenotype, non-enhanceable by Nipped-B359.1
      vg1 has phenotype, non-enhanceable by Nipped-B407
      vg1 has phenotype, non-enhanceable by Nipped-B4
      vg83b27/vg1 has wing phenotype, non-enhanceable by T(2;3)PIIB
      vg83b27/vg1 has wing phenotype, non-enhanceable by za
      hideSuppressed by
      Statement
      Reference
      hideNOT suppressed by
      Statement
      Reference
      vg83b27/vg1 has wing phenotype, non-suppressible by za
      vg1 has phenotype, non-suppressible by su(Hw)2
      hideEnhancer of
      Statement
      Reference
      vg79d5/vg1 is an enhancer of wing phenotype of sdETX4
      vg[+]/vg1 is an enhancer of wing phenotype of ctL32, su(Hw)e2
      vg1 is an enhancer of wing phenotype of Nnd-1
      vg[+]/vg1 is an enhancer of wing margin phenotype of sno71e3
      hideNOT Enhancer of
      Statement
      Reference
      vg1 is a non-enhancer of phenotype of Nspl-1
      hideSuppressor of
      Statement
      Reference
      vg1 is a suppressor | partially of wing & pharate adult phenotype of l(2)gd11
      vg1 is a suppressor | partially of wing & pharate adult phenotype of l(2)gd13
      vg1 is a suppressor | partially of wing & pharate adult phenotype of ft8
      hideNOT Suppressor of
      Statement
      Reference
      vg1 is a non-suppressor of phenotype of Nspl-1
      vg1 is a non-suppressor of phenotype of NAx-E2
      hideOther
      Statement
      Reference
      Ma1, vg1 has wing phenotype
         
      RpL3845-72, vg[+]/vg1 has wing phenotype
      RpL38[+]/RpL3845-72, vg1 has wing phenotype
      Nipped-A[+]/Nipped-A323, vg1 has wing phenotype
      Nipped-A[+]/Nipped-A222.3, vg1 has wing phenotype
      Nipped-A[+]/Nipped-A394.2, vg1 has wing phenotype
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      vg1/+ ; M(3)801/+ flies show no novel phenotypes at 22oC, but at 29oC they show apical wing notches.
      Cell death is also abundant in l(2)gd11 vg1 and ft8 vg1 wing imaginal discs. Pharate adult wings of l(2)gd11 vg1, l(2)gd13 vg1 and ft8 vg1 double mutants are partially restored compared to the single homozygotes. At a high growth temperature, 29oC, wings of homozygotes and l(2)gd11 vg1 double mutants are more normal due to improved cell viability.
      Suppresses the expansion of the wing pouch caused by expression of spis.Scer\UAS under the control of Scer\GAL4dpp.blk1.
      Heterozygotes show a cut wing phenotype in combination with mutants in the 'Nipped' genes. Has no effect on the eye phenotype of Nspl-1.
      vg1; M(3)801 heterozygotes have nicks in the wing at 29oC.
      sdETX4, vg1/vg79d5 wings are very small and deformed. The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) significantly rescues the wing defects.
      vg1/+ CG6194P0997/CG6194P0997 flies show loss of wing margin tissue.
      za has no effect on the complementation seen between vg1 and vg83b27.
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Partially complements
      Partially rescued by
      Not rescued by
      Comments
      vg1/vg83b27 transheterozygotes have less severe wing defects than either homozygote and halteres are usually present in the transheterozygotes (they are absent in either homozygote).
      hide Stocks ( 29 )
      Bloomington
      432
      3980
      Kyoto
      105910
      107540
      hide Notes on Origin
      Discoverer
      Morgan, Dec. 1910.
      hide Comments
      412 insertion causes truncation of the vg transcript.
      Strong vg allele.
      hide Synonyms & Secondary IDs ( 4 )
      Reported As
      Symbol Synonym
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 50 )
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        hide Recent research papers ( 1 )
        Mahoney et al., 2006, Genetics 172(4): 2309--2324
        Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. [FBrf0190744]