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General Information
Symbol
Dmel\vg1
Species
D. melanogaster
Name
FlyBase ID
FBal0017868
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
vgBG, vg
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a complete 412 element in the same transcriptional orientation as vg.

Insertion of an 8kb 412 in intron 3 and an insertion of 6kb of unknown DNA at the 3' end of intron 2.

Insertion of a 412 element.

412 insertion into intronic region.

412 element insert.

412 insertion (8 kb) at + 8kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990).

Insertion components
412{}vg1
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes lack halteres and wings are almost always small and stumpy and do not extend beyond the scutellum.

In vg1 wing discs, much of the wing pouch anlagen fails to develop.

Of the indirect flight muscles in vg1 mutants, the dorsal medial muscles are severely reduced and the dorso-ventral muscles (lateral oblique dorsal muscles and tergosternal muscles) are minimal or completely missing.

Heterozygotes have normal wing tissue.

Significant cell death is seen in the third larval instar wing disc (in contrast to wild type).

The formation of ectopic wing-like outgrowths caused by expression of vgScer\UAS.cZa under the control of Scer\GAL4ptc-559.1 is more strongly reduced in a vg1 homozygous background than in a vg1 heterozygous background.

vgWR2 produces a weak vg phenotype in combination with vg83b27.

Wing length increases with increasing temperature.

Flies have reduced wings and halteres.

No effect on the faf eye phenotype.

ctL32; su(Hw)e2 flies heterozygous for vg1 display a significant ct wing phenotype.

Wing imaginal discs are smaller than wild type due to cell death.

Only 4/1692 wings with clones of l(2)gl4 clones in a vg1 background show clonal restoration of pattern.

Most of the wing is missing, only some of the most proximal structures remain.

Homozygotes display high sensitivity to fluorodeoxyuridine (FUdR), an inhibitor of thymidylate synthetase and high resistance to aminopterin.

No interaction with mw2.

Homozygotes have no wings.

Strong vg phenotype. Transheterozygotes with vg83b27 exhibit wing bubbles and unequal wing deficiencies.

Homozygotes display an extreme vg phenotype when in the P-cytotype or M-cytotype.

Homozygotes have vestigial wings.

Nfa-do-vg/Nfa-do-vg; vg1/+ produces some wing notching. vg1/+ is strongly scalloped in combination with Ma1. wings, halteres reduced; small wing discs map location

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

vg83b27/vg1 has visible phenotype, enhanceable by 10381038

vg83b27/vg1 has visible phenotype, enhanceable by 12971297

vg83b27/vg1 has visible phenotype, enhanceable by 15771577

vg83b27/vg1 has visible phenotype, enhanceable by 23352335

vg83b27/vg1 has visible phenotype, enhanceable by 836836

vg83b27/vg1 has visible phenotype, enhanceable by In(2LR)789

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)550

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)75

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)805

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)835

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)84

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)88

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)B9b

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)B9c

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No3

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No5

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No6

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)P1C

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)PIIA

vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)PIIB

vg83b27/vg1 has visible phenotype, enhanceable by Tp(2;3)P10.C

vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E338/+

vg1 has visible | dominant phenotype, enhanceable by +/T(2;3)Nipped-C138.2

vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D341.1/+

vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D263.3/+

vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E43/+

NOT Enhanced by
Statement
Reference

vg83b27/vg1 has visible phenotype, non-enhanceable by za

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

vg83b27/vg1 has visible phenotype, non-suppressible by za

NOT Suppressor of
Statement
Reference

vg1 is a non-suppressor of visible phenotype of Scer\GAL4Bx-MS1096, hng1KK103642

Other
Statement
Reference

Nipped-A[+]/Nipped-A323, vg1 has visible | dominant phenotype

Nipped-A[+]/Nipped-A222.3, vg1 has visible | dominant phenotype

Nipped-A[+]/Nipped-A394.2, vg1 has visible | dominant phenotype

M(3)80[+]/M(3)801, vg1 has visible | dominant phenotype

M(3)801, vg[+]/vg1 has visible | dominant | heat sensitive phenotype

M(3)80[+]/M(3)801, vg1 has visible | dominant | heat sensitive phenotype

Phenotype Manifest In
Enhanced by
Statement
Reference

vg83b27/vg1 has haltere phenotype, enhanceable by 10381038

vg83b27/vg1 has wing phenotype, enhanceable by 10381038

vg83b27/vg1 has haltere phenotype, enhanceable by 12971297

vg83b27/vg1 has wing phenotype, enhanceable by 12971297

vg83b27/vg1 has haltere phenotype, enhanceable by 15771577

vg83b27/vg1 has wing phenotype, enhanceable by 15771577

vg83b27/vg1 has haltere phenotype, enhanceable by 23352335

vg83b27/vg1 has wing phenotype, enhanceable by 23352335

vg83b27/vg1 has haltere phenotype, enhanceable by 836836

vg83b27/vg1 has wing phenotype, enhanceable by 836836

vg83b27/vg1 has haltere phenotype, enhanceable by In(2LR)789

vg83b27/vg1 has wing phenotype, enhanceable by In(2LR)789

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)550

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)550

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)75

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)805

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)805

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)835

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)835

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)84

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)88

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)88

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)B9b

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)B9b

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)B9c

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)B9c

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No3

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No3

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No5

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No5

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No6

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No6

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)P1C

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)P1C

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)PIIA

vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)PIIA

vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)PIIB

vg83b27/vg1 has haltere phenotype, enhanceable by Tp(2;3)P10.C

vg83b27/vg1 has wing phenotype, enhanceable by Tp(2;3)P10.C

vg1 has wing phenotype, enhanceable by Df(2R)Nipped-E338/+

vg1 has phenotype, enhanceable by Nipped-A222.3

vg1 has phenotype, enhanceable by Nipped-A323

vg1 has phenotype, enhanceable by Nipped-A394.2

vg1 has phenotype, enhanceable by RpL3845-72

vg1 has wing phenotype, enhanceable by +/T(2;3)Nipped-C138.2

vg1 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1/+

vg1 has wing phenotype, enhanceable by Df(2R)Nipped-D263.3/+

vg1 has wing phenotype, enhanceable by Df(2R)Nipped-E43/+

vg1 has wing phenotype, enhanceable by Nfa-do-vg/N[+]

NOT Enhanced by
Statement
Reference

vg83b27/vg1 has wing phenotype, non-enhanceable by T(2;3)PIIB

vg83b27/vg1 has wing phenotype, non-enhanceable by za

vg1 has phenotype, non-enhanceable by Nipped-A2

vg1 has phenotype, non-enhanceable by Nipped-B292.1

vg1 has phenotype, non-enhanceable by Nipped-B359.1

vg1 has phenotype, non-enhanceable by Nipped-B407

vg1 has phenotype, non-enhanceable by Nipped-B4

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

vg83b27/vg1 has wing phenotype, non-suppressible by za

vg1 has phenotype, non-suppressible by su(Hw)2

Enhancer of
Statement
Reference

vg79d5/vg1 is an enhancer of wing phenotype of sdETX4

vg1 is an enhancer of wing phenotype of Nnd-1

vg[+]/vg1 is an enhancer of wing margin phenotype of sno71e3

vg[+]/vg1 is an enhancer of wing phenotype of ctL32, su(Hw)e2

NOT Enhancer of
Statement
Reference

vg1 is a non-enhancer of phenotype of Nspl-1

Suppressor of
Statement
Reference

vg1 is a suppressor | partially of wing | pharate adult stage phenotype of l(2)gd11

vg1 is a suppressor | partially of wing | pharate adult stage phenotype of l(2)gd13

vg1 is a suppressor | partially of wing | pharate adult stage phenotype of ft8

NOT Suppressor of
Statement
Reference

vg1 is a non-suppressor of wing hinge phenotype of Scer\GAL4Bx-MS1096, hng1KK103642

vg1 is a non-suppressor of phenotype of Nspl-1

vg1 is a non-suppressor of phenotype of NAx-E2

Other
Additional Comments
Genetic Interactions
Statement
Reference

A vg1 mutant background has no effect on the wing hinge phenotype seen when hng1KK103642 is expressed under the control of Scer\GAL4Bx-MS1096.

Flies heterozygous for both vg1 and ebi2g1, ebi2g2 or ebiE4 display wing notching and wing venation phenotypes that are not observed in any single heterozygote.

za has no effect on the complementation seen between vg1 and vg83b27.

sdETX4, vg1/vg79d5 wings are very small and deformed. The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) significantly rescues the wing defects.

vg1/+ CG6194P0997/CG6194P0997 flies show loss of wing margin tissue.

Suppresses the expansion of the wing pouch caused by expression of spis.Scer\UAS under the control of Scer\GAL4dpp.blk1.

Heterozygotes show a cut wing phenotype in combination with mutants in the 'Nipped' genes. Has no effect on the eye phenotype of Nspl-1.

Cell death is also abundant in l(2)gd11 vg1 and ft8 vg1 wing imaginal discs. Pharate adult wings of l(2)gd11 vg1, l(2)gd13 vg1 and ft8 vg1 double mutants are partially restored compared to the single homozygotes. At a high growth temperature, 29oC, wings of homozygotes and l(2)gd11 vg1 double mutants are more normal due to improved cell viability.

vg1; M(3)801 heterozygotes have nicks in the wing at 29oC.

vg1/+ ; M(3)801/+ flies show no novel phenotypes at 22oC, but at 29oC they show apical wing notches.

Xenogenetic Interactions
Statement
Reference

Expression of BacA\p35Scer\UAS.cHa under the control of Scer\GAL4vg.PU partially suppresses the vg1 wing phenotype.

Complementation and Rescue Data
Partially complements
Comments

vg1/vg83b27 transheterozygotes have less severe wing defects than either homozygote and halteres are usually present in the transheterozygotes (they are absent in either homozygote).

Images (1)
Stocks (27)
Notes on Origin
Discoverer

Morgan, Dec. 1910.

Comments
Comments

412 insertion causes truncation of the vg transcript.

Strong vg allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (55)