Allele Dmel\vg1
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\vg1 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0017868 | |
| Feature type | allele | Created / Updated | 2006-05-15/2006-05-15 |
| Associated gene | Dmel\vg | ||
| Allele class | hypomorph, gain of function | ||
| Mutagen | spontaneous | ||
Nature of the Allele
| |||
| Allele class | |||
| Mutagen | |||
| Mapped Features and Mutations | |||
Type Symbol & Location Additional Notes References | |||
| Associated Sequence Data | |||
| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Progenitor genotype | |||
| Nature of the lesion | Statement Reference 412 insertion (8 kb) at + 8kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990). 412 element insert. 412 insertion into intronic region. Insertion of a 412 element. Insertion of an 8kb 412 in intron 3 and an insertion of 6kb of unknown DNA at the 3' end of intron 2. Insert stated as cause: undefined Intronic insertion. | ||
| Assay mode | |||
| Caused by insertion | |||
| Carried on aberration | |||
| Cytology | |||
Phenotypic Data
| |||
Phenotypic Class
| |||
Phenotype Manifest In
| |||
Detailed Description
| |||
Statement Reference Nfa-do-vg/Nfa-do-vg; vg1/+ produces some wing notching. vg1/+ is strongly scalloped in combination with Ma1. wings, halteres reduced; small wing discs map location Homozygotes have vestigial wings. Homozygotes display an extreme vg phenotype when in the P-cytotype or M-cytotype. No interaction with mw2. Homozygotes have no wings. Homozygotes display high sensitivity to fluorodeoxyuridine (FUdR), an inhibitor of thymidylate synthetase and high resistance to aminopterin. Wing imaginal discs are smaller than wild type due to cell death. Most of the wing is missing, only some of the most proximal structures remain. Flies have reduced wings and halteres. No effect on the faf eye phenotype. Wing length increases with increasing temperature. The formation of ectopic wing-like outgrowths caused by expression of vgScer\UAS.cZa under the control of Scer\GAL4ptc-559.1 is more strongly reduced in a vg1 homozygous background than in a vg1 heterozygous background. In vg1 wing discs, much of the wing pouch anlagen fails to develop. Of the indirect flight muscles in vg1 mutants, the dorsal medial muscles are severely reduced and the dorso-ventral muscles (lateral oblique dorsal muscles and tergosternal muscles) are minimal or completely missing. Heterozygotes have normal wing tissue. Homozygotes lack halteres and wings are almost always small and stumpy and do not extend beyond the scutellum. | |||
Interactions
| |||
|
|||
Phenotypic Class
| |||
Enhanced by | |||
Statement Reference | |||
NOT Enhanced by | |||
Statement Reference | |||
NOT suppressed by | |||
Statement Reference | |||
Other | |||
Statement Reference | |||
Phenotype Manifest In
| |||
Enhanced by | |||
Statement Reference vg1 has phenotype, enhanceable by Nipped-A222.3 vg1 has phenotype, enhanceable by Nipped-A323 vg1 has phenotype, enhanceable by Nipped-A394.2 vg1 has phenotype, enhanceable by RpL3845-72 | |||
NOT Enhanced by | |||
Statement Reference vg1 has phenotype, non-enhanceable by Nipped-B292.1 vg1 has phenotype, non-enhanceable by Nipped-B359.1 vg1 has phenotype, non-enhanceable by Nipped-B407 | |||
Suppressed by | |||
Statement Reference | |||
NOT suppressed by | |||
Statement Reference | |||
Enhancer of | |||
Statement Reference | |||
NOT Enhancer of | |||
Statement Reference | |||
Suppressor of | |||
Statement Reference | |||
NOT Suppressor of | |||
Statement Reference | |||
Other | |||
Statement Reference | |||
Additional Comments
| |||
Genetic Interactions
| |||
Statement Reference Cell death is also abundant in l(2)gd11 vg1 and ft8 vg1 wing imaginal discs. Pharate adult wings of l(2)gd11 vg1, l(2)gd13 vg1 and ft8 vg1 double mutants are partially restored compared to the single homozygotes. At a high growth temperature, 29oC, wings of homozygotes and l(2)gd11 vg1 double mutants are more normal due to improved cell viability. Suppresses the expansion of the wing pouch caused by expression of spis.Scer\UAS under the control of Scer\GAL4dpp.blk1. Heterozygotes show a cut wing phenotype in combination with mutants in the 'Nipped' genes. Has no effect on the eye phenotype of Nspl-1. sdETX4, vg1/vg79d5 wings are very small and deformed. The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) significantly rescues the wing defects. | |||
Xenogenetic Interactions
| |||
Statement Reference | |||
Complementation & Rescue Data
| |||
| Partially complements | |||
| Partially rescued by | |||
| Not rescued by | |||
| Comments | |||
Stocks
( 29 ) | |||
| Bloomington | 432 3980 433 3132 3793 4070 | ||
| Kyoto | 105910 107540 | ||
Notes on Origin
| |||
| Discoverer | Morgan, Dec. 1910. | ||
Comments
| |||
Strong vg allele. | |||
Synonyms & Secondary IDs
( 4 ) | |||
| Reported As | |||
| Symbol Synonym | unnamed | ||
| Name Synonym | |||
| Secondary FlyBase IDs | |||
References
( 50 ) | |||
| Generate a list of | |||
| List References by type |
| ||
Recent research papers ( 1 ) | |||
| |||
Nature of the Allele