A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\vg1

General Information
SymbolDmel\vg1SpeciesD. melanogaster
NameFlyBase IDFBal0017868
Feature typealleleAssociated geneDmel\vg
Also Known AsvgBG, vg
Map ( GBrowse ) Untitled Document detailed view FBti0014741 FBti0014759 FBti0014751 FBti0014742 FBti0014752 FBti0014753 FBti0014740 FBti0014755 FBti0042154
Allele classgain of function allele, hypomorphic allele - genetic evidence
Mutagenspontaneous
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Insert stated as cause: undefined Intronic insertion.
Insertion of a complete 412 element in the same transcriptional orientation as vg.
Insertion of an 8kb 412 in intron 3 and an insertion of 6kb of unknown DNA at the 3' end of intron 2.
Insertion of a 412 element.
412 insertion into intronic region.
412 element insert.
412 insertion (8 kb) at + 8kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990).
 
Caused by insertion
Carried on aberration
Cytology
hide Phenotypic Data
hide Phenotypic Class
hide Phenotype Manifest In
hide Detailed Description
Statement
Reference
Homozygotes lack halteres and wings are almost always small and stumpy and do not extend beyond the scutellum.
In vg1 wing discs, much of the wing pouch anlagen fails to develop.
Of the indirect flight muscles in vg1 mutants, the dorsal medial muscles are severely reduced and the dorso-ventral muscles (lateral oblique dorsal muscles and tergosternal muscles) are minimal or completely missing.
Heterozygotes have normal wing tissue.
Significant cell death is seen in the third larval instar wing disc (in contrast to wild type).
The formation of ectopic wing-like outgrowths caused by expression of vgScer\UAS.cZa under the control of Scer\GAL4ptc-559.1 is more strongly reduced in a vg1 homozygous background than in a vg1 heterozygous background.
vgWR2 produces a weak vg phenotype in combination with vg83b27.
Wing length increases with increasing temperature.
Flies have reduced wings and halteres.
No effect on the faf eye phenotype.
ctL32; su(Hw)e2 flies heterozygous for vg1 display a significant ct wing phenotype.
Wing imaginal discs are smaller than wild type due to cell death.
Only 4/1692 wings with clones of l(2)gl4 clones in a vg1 background show clonal restoration of pattern.
Most of the wing is missing, only some of the most proximal structures remain.
Homozygotes display high sensitivity to fluorodeoxyuridine (FUdR), an inhibitor of thymidylate synthetase and high resistance to aminopterin.
No interaction with mw2.
Homozygotes have no wings.
Strong vg phenotype. Transheterozygotes with vg83b27 exhibit wing bubbles and unequal wing deficiencies.
Homozygotes display an extreme vg phenotype when in the P-cytotype or M-cytotype.
Homozygotes have vestigial wings.
Nfa-do-vg/Nfa-do-vg; vg1/+ produces some wing notching. vg1/+ is strongly scalloped in combination with Ma1. wings, halteres reduced; small wing discs map location
 
hide External Data
Linkouts
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hide Phenotypic Class
hideEnhanced by
Statement
Reference
vg1 has visible | dominant phenotype, enhanceable by +/T(2;3)Nipped-C138.2
vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D263.3/+
vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-D341.1/+
vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E43/+
vg1 has visible | dominant phenotype, enhanceable by Df(2R)Nipped-E338/+
vg83b27/vg1 has visible phenotype, enhanceable by 836836
vg83b27/vg1 has visible phenotype, enhanceable by 10381038
vg83b27/vg1 has visible phenotype, enhanceable by 12971297
vg83b27/vg1 has visible phenotype, enhanceable by 15771577
vg83b27/vg1 has visible phenotype, enhanceable by 23352335
vg83b27/vg1 has visible phenotype, enhanceable by In(2LR)789
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)75
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)84
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)88
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)550
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)805
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)835
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)B9b
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)B9c
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No3
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No5
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)No6
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)P1C
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)PIIA
vg83b27/vg1 has visible phenotype, enhanceable by T(2;3)PIIB
vg83b27/vg1 has visible phenotype, enhanceable by Tp(2;3)P10.C
hideNOT Enhanced by
Statement
Reference
vg83b27/vg1 has visible phenotype, non-enhanceable by za
hideSuppressed by
Statement
Reference
hideNOT suppressed by
Statement
Reference
vg83b27/vg1 has visible phenotype, non-suppressible by za
hideOther
Statement
Reference
M(3)80[+]/M(3)801, vg1 has visible | dominant | heat sensitive phenotype
M(3)80[+]/M(3)801, vg1 has visible | dominant phenotype
M(3)801, vg[+]/vg1 has visible | dominant | heat sensitive phenotype
Ma1, vg1 has visible | dominant phenotype
   
Nipped-A[+]/Nipped-A222.3, vg1 has visible | dominant phenotype
Nipped-A[+]/Nipped-A323, vg1 has visible | dominant phenotype
Nipped-A[+]/Nipped-A394.2, vg1 has visible | dominant phenotype
hide Phenotype Manifest In
hideEnhanced by
Statement
Reference
vg1 has phenotype, enhanceable by Nipped-A222.3
vg1 has phenotype, enhanceable by Nipped-A323
vg1 has phenotype, enhanceable by Nipped-A394.2
vg1 has phenotype, enhanceable by RpL3845-72
vg1 has wing phenotype, enhanceable by +/T(2;3)Nipped-C138.2
vg1 has wing phenotype, enhanceable by Df(2R)Nipped-D263.3/+
vg1 has wing phenotype, enhanceable by Df(2R)Nipped-D341.1/+
vg1 has wing phenotype, enhanceable by Df(2R)Nipped-E43/+
vg1 has wing phenotype, enhanceable by Df(2R)Nipped-E338/+
vg1 has wing phenotype, enhanceable by Nfa-do-vg/N[+]
 
vg83b27/vg1 has haltere phenotype, enhanceable by 836836
vg83b27/vg1 has haltere phenotype, enhanceable by 10381038
vg83b27/vg1 has haltere phenotype, enhanceable by 12971297
vg83b27/vg1 has haltere phenotype, enhanceable by 15771577
vg83b27/vg1 has haltere phenotype, enhanceable by 23352335
vg83b27/vg1 has haltere phenotype, enhanceable by In(2LR)789
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)75
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)88
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)550
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)805
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)835
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)B9b
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)B9c
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No3
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No5
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)No6
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)P1C
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)PIIA
vg83b27/vg1 has haltere phenotype, enhanceable by T(2;3)PIIB
vg83b27/vg1 has haltere phenotype, enhanceable by Tp(2;3)P10.C
vg83b27/vg1 has wing phenotype, enhanceable by 836836
vg83b27/vg1 has wing phenotype, enhanceable by 10381038
vg83b27/vg1 has wing phenotype, enhanceable by 12971297
vg83b27/vg1 has wing phenotype, enhanceable by 15771577
vg83b27/vg1 has wing phenotype, enhanceable by 23352335
vg83b27/vg1 has wing phenotype, enhanceable by In(2LR)789
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)84
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)88
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)550
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)805
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)835
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)B9b
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)B9c
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No3
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No5
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)No6
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)P1C
vg83b27/vg1 has wing phenotype, enhanceable by T(2;3)PIIA
vg83b27/vg1 has wing phenotype, enhanceable by Tp(2;3)P10.C
hideNOT Enhanced by
Statement
Reference
vg1 has phenotype, non-enhanceable by Nipped-A2
vg1 has phenotype, non-enhanceable by Nipped-B4
vg1 has phenotype, non-enhanceable by Nipped-B292.1
vg1 has phenotype, non-enhanceable by Nipped-B359.1
vg1 has phenotype, non-enhanceable by Nipped-B407
vg83b27/vg1 has wing phenotype, non-enhanceable by T(2;3)PIIB
vg83b27/vg1 has wing phenotype, non-enhanceable by za
hideSuppressed by
Statement
Reference
hideNOT suppressed by
Statement
Reference
vg1 has phenotype, non-suppressible by su(Hw)2
vg83b27/vg1 has wing phenotype, non-suppressible by za
hideEnhancer of
Statement
Reference
vg[+]/vg1 is an enhancer of wing margin phenotype of sno71e3
vg[+]/vg1 is an enhancer of wing phenotype of ctL32, su(Hw)e2
vg1 is an enhancer of wing phenotype of Nnd-1
vg79d5/vg1 is an enhancer of wing phenotype of sdETX4
hideNOT Enhancer of
Statement
Reference
vg1 is a non-enhancer of phenotype of Nspl-1
hideSuppressor of
Statement
Reference
vg1 is a suppressor | partially of wing | pharate adult stage phenotype of ft8
vg1 is a suppressor | partially of wing | pharate adult stage phenotype of l(2)gd11
vg1 is a suppressor | partially of wing | pharate adult stage phenotype of l(2)gd13
hideNOT Suppressor of
Statement
Reference
vg1 is a non-suppressor of phenotype of NAx-E2
vg1 is a non-suppressor of phenotype of Nspl-1
hideOther
Statement
Reference
Ma1, vg1 has wing phenotype
   
Nipped-A[+]/Nipped-A222.3, vg1 has wing phenotype
Nipped-A[+]/Nipped-A323, vg1 has wing phenotype
Nipped-A[+]/Nipped-A394.2, vg1 has wing phenotype
RpL38[+]/RpL3845-72, vg1 has wing phenotype
RpL3845-72, vg[+]/vg1 has wing phenotype
hide Additional Comments
hide Genetic Interactions
Statement
Reference
Flies heterozygous for both vg[1] and ebi[2g1], ebi[2g2] or ebi[E4] display wing notching and wing venation phenotypes that are not observed in any single heterozygote.
za has no effect on the complementation seen between vg1 and vg83b27.
sdETX4, vg1/vg79d5 wings are very small and deformed. The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) significantly rescues the wing defects.
vg1/+ CG6194P0997/CG6194P0997 flies show loss of wing margin tissue.
Suppresses the expansion of the wing pouch caused by expression of spis.Scer\UAS under the control of Scer\GAL4dpp.blk1.
Heterozygotes show a cut wing phenotype in combination with mutants in the 'Nipped' genes. Has no effect on the eye phenotype of Nspl-1.
Cell death is also abundant in l(2)gd11 vg1 and ft8 vg1 wing imaginal discs. Pharate adult wings of l(2)gd11 vg1, l(2)gd13 vg1 and ft8 vg1 double mutants are partially restored compared to the single homozygotes. At a high growth temperature, 29oC, wings of homozygotes and l(2)gd11 vg1 double mutants are more normal due to improved cell viability.
vg1; M(3)801 heterozygotes have nicks in the wing at 29oC.
vg1/+ ; M(3)801/+ flies show no novel phenotypes at 22oC, but at 29oC they show apical wing notches.
hide Xenogenetic Interactions
Statement
Reference
Expression of BacA\p35[Scer\UAS.cHa] under the control of Scer\GAL4[vg.PU] partially suppresses the vg[1] wing phenotype.
hide Complementation & Rescue Data
Partially complements
Partially rescued by
Not rescued by
Comments
vg1/vg83b27 transheterozygotes have less severe wing defects than either homozygote and halteres are usually present in the transheterozygotes (they are absent in either homozygote).
hide Stocks ( 30 )
Bloomington
432
3980
Kyoto
105910
107540
hide Notes on Origin
Discoverer
Morgan, Dec. 1910.
hide Comments
Strong vg allele.
412 insertion causes truncation of the vg transcript.
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym
Name Synonym
Secondary FlyBase IDs
hide References ( 53 )
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hide Recent research papers ( 1 )
Marygold et al., 2011, Fly 5(4): 291--303
Genetic characterization of ebi reveals its critical role in Drosophila wing growth. [FBrf0216882]