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General Information
Symbol
Dmel\vg21
Species
D. melanogaster
Name
FlyBase ID
FBal0017874
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion of a P-element which has a deletion of bases 382-2603 but is otherwise identical to a full P-element.
A P-element is inserted in the first intron of the vg transcription unit, not 5' to the start of vg transcription as previously thought. The insertion site is 423bp downstream of the vg transcription start site and the P-element has an internal deletion of nucleotides 381-2601. Transcription of the P-element is in the same orientation as that of vg.
vg transcription unit is fused to the P-element insert transcript.
Internally deleted P-element (5' breakpoint at nucleotide position 380 and 3' breakpoint at nucleotide position 2602) inserted in the 5' untranscribed region of vg.
Insertion of a 687bp P-element just upstream of the putative transcription start site, the 3' end is 20bp upstream of the first exon, in the same orientation as Ddc transcription.
Internally deleted P-element inserted in the 5' untranscribed region of vg.
Insertion of 7kb of unknown DNA at position 0 on the molecular map of the vg region (Williams, Mol. Gen. Genet. 221: 8).
0/7kb P-element insertion just upstream of the putative transcription start site.
P-element insertion near the 5' end of the vg transcription unit.
650bp P element insert.
P-element insertion at coordinate 0.
insert hybridizing to P sequences at 0kb ; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990).
Insertion components
P{}vg21
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Cryptic allele; homozygotes show no wing defect. vg21/Df(2R)vg-B animals show slight nicking of the wing.
Mutant phenotype shows cytotype-dependent expression. Heterozygotes with vg2a33 show moderate wing nicking. Homozygotes: wild type wing phenotype. Heterozygotes with Df(2R)vg-B in M cytotype: moderate wing phenotype. Heterozygotes with Df(2R)vg-B in cytotype: wild type wing phenotype.
Homozygotes have a wild type phenotype but a strap wing phenotype when in combination with most strong alleles of vg and in hemizygotes, a cryptic phenotype.
Homozygotes have a wild type phenotype and when heterozygous with a strong vg allele individuals have nicked or scalloped wings.
Homozygotes display high resistance to aminopterin.
Homozygotes display complete wing margins or only slight nicks at the distal tip of one wing.
"Wild type" phenotype, therefore a cryptic allele. vg1/vg21 heterozygotes exhibit a weak vg phenotype.
Homozygotes have a wild type phenotype, P-cytotype has no effect on the phenotype but the M-cytotype cause a moderate vg phenotype.
cytotype-dependent allele; homozygote normal; weak vg over vg1
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Df(2R)vg-B/vg21 has visible phenotype, suppressible | partially by P\TSal
Phenotype Manifest In
Suppressed by
Statement
Reference
Df(2R)vg-B/vg21 has wing phenotype, suppressible | partially by P\TSal
Additional Comments
Genetic Interactions
Statement
Reference
The presence of P\TSal partially suppresses the nicking of the wing that is seen in vg21/Df(2R)vg-B animals.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
?, 1988.
Comments
Comments
"of vg." was stated as revision.
Fusion of vg transcript to P-element transcript may be the reason for the cytotype dependence of the vg phenotype.
Transposase induced revertants demonstrate that deletions in the 3' region of the P-element result in a strong vg phenotype and deletions in the 5' region result in a revertant phenotype.
External Crossreferences and Linkouts ( 2 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (13)