Adults exhibit severely reduced wings, a complete margin surrounds the wing. Defects are due to dominant loss of wing tissue and homeotic phenotype. Wing reduction can be suppressed by Egfrunspecified
, suppression is variable.
Heterozygotes have a severe reduction of wing and haltere. vgW
flies have a more severe phenotype than a vg
null allele; as well as affecting the wing blade and wing hinge regions, the entire notum region is missing. This genotype is also semi-lethal and female sterile. Heterozygotes raised at 29o
C show homeotic transformations; the wings have anterior to posterior transformations resulting in a double posterior wing, the halteres show a weak transformation to wing, and occasional postnotum to notum transformations are seen.
One dose removes entire wing margin.
Homozygous embryos die prior to the migration of nuclei to form the syncytial blastoderm. Heterozygotes have a variable wing phenotype with duplications and deletions; usually the anterior margin and costa is deleted, the ventral hinge is present but not duplicated, and the axillary cord is present and duplicated. As the size of the duplicated wing increases the alar lobe and posterior row become duplicated and the dorsal hinge appears but is not duplicated. The sensillae of the dorsal radius are sometimes present in one copy, and are sometimes duplicated. The halteres are often missing, or are transformed into wing. The thorax often shows bristle misarrangements and small local duplications, and some flies have abnormal legs. Occasionally some metathorax to mesothorax transformation is seen. A large number of heterozygotes die as pupae, these tend to have the more extreme wing phenotypes. Heterozygous third instar haltere discs are generally larger than wild-type. Third instar wing discs show a variable phenotype; some are small with reduced presumptive wing blade areas, while others have duplications of the folds normally seen in wild-type discs. vgW
flies have no wings or halteres, but the thorax is present. vgW
flies and vgW
flies have a more extreme semi-lethal phenotype, with the dorsal mesothorax often being deleted. vgW
flies are lethal and fail to emerge as adults. Viable in combination with Df(2R)vg-S
flies have a slightly different phenotype to vgW
flies, with more disrupted wings. These sometimes have holes with the dorsal and ventral wing blades fused around the hole. Wing margin is often seen in the transformed haltere, and legs are sometimes defective. UbxCbx-1
completely inhibits the homoeosis normally seen in vgW
flies; there is no wing blade in the capitellum, the haltere forms but is incomplete, the hinge sensillae are present, but the hairy regions in the anterior margin of the scabellum and pedicel are deleted. The normal posterior part of the wing is not seen, but the duplicated posterior wing tissue found in vgW
flies is present in vgW UbxCbx-1
Heterozygotes lack wings, or have blistery wing buds filled with sap. One or both halteres are missing, and occasionally they are modified into wings or hairy structures. vgW
flies completely lack wings and halteres and the scutellum is deformed. The postscutellar bristles are usually absent. Development is slow, and only 20-30% of flies eclose. Viability and fertility is reduced.
homozygous lethal; dominant with homeotic effect; vgW
/+ is wingless or has tiny buds, no halteres (or one); female fertile and viable