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General Information
Symbol
Dmel\vgW
Species
D. melanogaster
Name
wingless
FlyBase ID
FBal0017908
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Inversion breakpoint within the first intron of vg. This results in a fusion between the centromere distal part of vg and the inv region.
Fusion between inv and vg (first intron); proximal break at +2kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990)
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Adults exhibit severely reduced wings, a complete margin surrounds the wing. Defects are due to dominant loss of wing tissue and homeotic phenotype. Wing reduction can be suppressed by Egfrunspecified, suppression is variable.
Adults exhibit no wings.
Heterozygotes have a severe reduction of wing and haltere. vgW/Df(2R)vg-B flies have a more severe phenotype than a vg null allele; as well as affecting the wing blade and wing hinge regions, the entire notum region is missing. This genotype is also semi-lethal and female sterile. Heterozygotes raised at 29oC show homeotic transformations; the wings have anterior to posterior transformations resulting in a double posterior wing, the halteres show a weak transformation to wing, and occasional postnotum to notum transformations are seen.
One dose removes entire wing margin.
Homozygous embryos die prior to the migration of nuclei to form the syncytial blastoderm. Heterozygotes have a variable wing phenotype with duplications and deletions; usually the anterior margin and costa is deleted, the ventral hinge is present but not duplicated, and the axillary cord is present and duplicated. As the size of the duplicated wing increases the alar lobe and posterior row become duplicated and the dorsal hinge appears but is not duplicated. The sensillae of the dorsal radius are sometimes present in one copy, and are sometimes duplicated. The halteres are often missing, or are transformed into wing. The thorax often shows bristle misarrangements and small local duplications, and some flies have abnormal legs. Occasionally some metathorax to mesothorax transformation is seen. A large number of heterozygotes die as pupae, these tend to have the more extreme wing phenotypes. Heterozygous third instar haltere discs are generally larger than wild-type. Third instar wing discs show a variable phenotype; some are small with reduced presumptive wing blade areas, while others have duplications of the folds normally seen in wild-type discs. vgW/Df(2R)vg-C flies have no wings or halteres, but the thorax is present. vgW/Df(2R)vg-D flies and vgW/Df(2R)vg-B flies have a more extreme semi-lethal phenotype, with the dorsal mesothorax often being deleted. vgW/vgU flies are lethal and fail to emerge as adults. Viable in combination with Df(2R)vg-S. vgW/enLI034 flies have a slightly different phenotype to vgW flies, with more disrupted wings. These sometimes have holes with the dorsal and ventral wing blades fused around the hole. Wing margin is often seen in the transformed haltere, and legs are sometimes defective. UbxCbx-1 completely inhibits the homoeosis normally seen in vgW flies; there is no wing blade in the capitellum, the haltere forms but is incomplete, the hinge sensillae are present, but the hairy regions in the anterior margin of the scabellum and pedicel are deleted. The normal posterior part of the wing is not seen, but the duplicated posterior wing tissue found in vgW flies is present in vgW UbxCbx-1 flies.
Heterozygotes lack wings, or have blistery wing buds filled with sap. One or both halteres are missing, and occasionally they are modified into wings or hairy structures. vgW/vgunspecified flies completely lack wings and halteres and the scutellum is deformed. The postscutellar bristles are usually absent. Development is slow, and only 20-30% of flies eclose. Viability and fertility is reduced.
homozygous lethal; dominant with homeotic effect; vgW/+ is wingless or has tiny buds, no halteres (or one); female fertile and viable
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Shukla.
Comments
Comments
Homozygous lethal.
Analysis of vgW revertants indicates that inv sequences are required for the dominant wing and homeotic effects of vgW. It is difficult to determine inv activity in In(2R)vgW, but the possibility that invW has a neomorphic contribution to the vgW phenotype cannot be eliminated. The homozygous lethality of In(2R)vgW may be due to vgW or may be due to a second site lethal. No alteration in vgW dominance is seen in combination with zv77h, suggesting that the dominance is not produced by z-dependent transvection effects.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
vgW
Name Synonyms
wingless
Secondary FlyBase IDs
    References (10)