G23361811A
E1423K | vir-PA
E1423K
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Amino acid replacement: E1423K.
Female-specific allele.
XX virts homozygotes develop as sterile intersexes at 29[o]C. The segmentation of the abdomen has features of both sexes. In general, the size and shape of the tergites are more female than male, and the pigmentation of the sixth tergite is more typical of males, covering more than the posterior 50% of the tergite. The sixth and seventh tergites are not fused, and the seventh tergite is reduced to small triangular plates. The sixth and seventh sternites are not fused, and the seventh sternite is smaller and has fewer bristles than in a normal female. The structures of the female genital primordium are poorly developed, the vaginal plates are small and have a reduced number of bristles. The male genital primordium is well developed, with all animals having a male genital arch amd parts of the penis and hypandrium. The anal plates are arranged laterally and have a bead-like form. They are sometimes connected at the dorsal side. The number of bristles is typical of males, but each plate carries a long bristle, which is typical of females. Rudiments of the female-specific ventral anal plate are sometimes found. The internal genitalia generally show a mixture of male and female derivatives. The gonads consistently develop as ovaries. At 25[o]C or below homozygous XX animals show normal female development, but are only weakly fertile, with the number of fertile females decreasing faster with age than for wild-type females. XY animals are unaffected by the mutation.
virunspecified/virts has lethal | female | larval stage phenotype, non-suppressible by SxlF1.hs
virunspecified/virts has lethal | female | larval stage phenotype, non-suppressible by SxlM1
virunspecified/virts has lethal | female | larval stage phenotype, non-suppressible by SxlM4
Df(2L)BSC209/+, virts has partially lethal - majority die | female phenotype
Df(2L)BSC209/+;virts/+ double heterozygous females show significantly reduced viability compared to Df(2L)BSC209 single heterozygotes.
virts/virts tra21/+ XX and virts/virts tra3/+ XX flies are pseudomales at 29[o]C, indicating that tra2 and tra are epistatic to vir. virts/virts trahs.PM/+ XX flies are phenotypically female at 29[o]C, suggesting that vir acts upstream of tra. These animals are sterile when tested at 29[o]C and 25[o]C. virts/virts dsx1/+ XX flies are sterile females with defective inner genitalia at 25[o]C. virts/virts dsxD/+ XX flies have a dsx phenotype at 25[o]C, and are strongly masculinised intersexes or almost pseudomales with poorly developed gonads at 29[o]C. virts/virts ix1/+ XX flies are females (which are generally fertile) at 25[o]C.
Schupbach.
The temperature-sensitive period is during the third larval instar.
msl-1 and mle are bound to the X chromosomes in homozygous females without resulting in hyperactivity of X-linked genes and concomitant reduction in viability. Salivary gland chromosomes of flies, with introduction of mle9 or msl-1γ222 into virts homozygous female larvae, show no evidence of H4Ac16 binding.