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General Information
Symbol
Dmel\virts
Species
D. melanogaster
Name
FlyBase ID
FBal0018011
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
vir1ts, virts1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G23361811A

Amino acid change:

E1423K | vir-PA

Reported amino acid change:

E1423K

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E1423K.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Female-specific allele.

XX homozygotes are transformed into intersexes at 29oC. Females carrying vir2f homozygous germ line clones give rise to purely male offspring when mated to homozygous virts males.

Transheterozygotes with EMS induced vir mutations transform XX animals into intersexes at 29oC. Sxl+/Sxl+;virts/virts and Sxlf1/Sxl+;virts/vir+ are viable but doubly heterozygous Sxlf1/Sxl+;virts/virts females are lethal.

XX virts homozygotes develop as sterile intersexes at 29[o]C. The segmentation of the abdomen has features of both sexes. In general, the size and shape of the tergites are more female than male, and the pigmentation of the sixth tergite is more typical of males, covering more than the posterior 50% of the tergite. The sixth and seventh tergites are not fused, and the seventh tergite is reduced to small triangular plates. The sixth and seventh sternites are not fused, and the seventh sternite is smaller and has fewer bristles than in a normal female. The structures of the female genital primordium are poorly developed, the vaginal plates are small and have a reduced number of bristles. The male genital primordium is well developed, with all animals having a male genital arch amd parts of the penis and hypandrium. The anal plates are arranged laterally and have a bead-like form. They are sometimes connected at the dorsal side. The number of bristles is typical of males, but each plate carries a long bristle, which is typical of females. Rudiments of the female-specific ventral anal plate are sometimes found. The internal genitalia generally show a mixture of male and female derivatives. The gonads consistently develop as ovaries. At 25[o]C or below homozygous XX animals show normal female development, but are only weakly fertile, with the number of fertile females decreasing faster with age than for wild-type females. XY animals are unaffected by the mutation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

virunspecified/virts has lethal | female | larval stage phenotype, non-suppressible by SxlM1

virunspecified/virts has lethal | female | larval stage phenotype, non-suppressible by SxlM4

Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Df(2L)BSC209/+;virts/+ double heterozygous females show significantly reduced viability compared to Df(2L)BSC209 single heterozygotes.

The presence of SxlM1, SxlM4 or SxlF1.hs failed to rescue female lethality in vir transheterozygotes.

virts/virts tra21/+ XX and virts/virts tra3/+ XX flies are pseudomales at 29[o]C, indicating that tra2 and tra are epistatic to vir. virts/virts trahs.PM/+ XX flies are phenotypically female at 29[o]C, suggesting that vir acts upstream of tra. These animals are sterile when tested at 29[o]C and 25[o]C. virts/virts dsx1/+ XX flies are sterile females with defective inner genitalia at 25[o]C. virts/virts dsxD/+ XX flies have a dsx phenotype at 25[o]C, and are strongly masculinised intersexes or almost pseudomales with poorly developed gonads at 29[o]C. virts/virts ix1/+ XX flies are females (which are generally fertile) at 25[o]C.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The temperature-sensitive period is during the third larval instar.

msl-1 and mle are bound to the X chromosomes in homozygous females without resulting in hyperactivity of X-linked genes and concomitant reduction in viability. Salivary gland chromosomes of flies, with introduction of mle9 or msl-1γ222 into virts homozygous female larvae, show no evidence of H4Ac16 binding.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (8)