FlyBase Allele Report: Dmel\vtd[4]

General Information

Symbol

Dmel\vtd⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0018067

Feature type

allele

Associated gene

Dmel\vtd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Deletion of vtd sequences including exons 1 and 2 and part of intron 2.

(Hallson et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle (with vtd^80Fh-35)

(Hallson et al., 2008)

lethal (with vtd^3-1)

(Schulze et al., 2001)

lethal (with vtd^5-1)

(Schulze et al., 2001)

lethal (with vtd^5-3)

(Schulze et al., 2001)

lethal (with vtd^80Fh-1)

(Schulze et al., 2001)

lethal (with vtd^80Fh-6)

(Schulze et al., 2001)

lethal | recessive

(Kennison and Tamkun, 1988)

lethal - all die before end of pupal stage (with vtd^80Fh-35)

(Schulze et al., 2001)

lethal - all die before end of pupal stage (with vtd^80Fh-36)

(Schulze et al., 2001)

lethal - all die during embryonic stage (with vtd^80Fh-5)

(Schulze et al., 2001)

lethal - all die during embryonic stage | recessive

(Schulze et al., 2001)

some die during embryonic stage (with vtd^80Fh-5)

(Schulze et al., 2001)

some die during embryonic stage | recessive

(Schulze et al., 2001)

some die during pupal stage (with vtd^80Fh-35)

(Schulze et al., 2001)

some die during pupal stage (with vtd^80Fh-36)

(Schulze et al., 2001)

Phenotype Manifest In

imaginal disc (with vtd^80Fh-35)

(Hallson et al., 2008)

Detailed Description

Statement

Reference

Imaginal discs are not evident in vtd^80Fh-35/vtd⁴ third instar larvae.

Metaphase chromosome spreads of vtd^80Fh-35/vtd⁴ third larval instar neuroblasts consist of individual sister chromatids that are not conjoined at the centromere. In addition, the chromosome complements are often aneuploid.

(Hallson et al., 2008)

Dead embryos are morphologically normal.

(Schulze et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

vtd⁴ is a suppressor of visible phenotype of Pc⁴

(Schulze et al., 2001)

vtd⁴/vtd[+] is a suppressor of visible phenotype of hh^Mrt

(Schulze et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

vtd⁴ is a suppressor of sex comb phenotype of Pc⁴

(Strübbe et al., 2011)

vtd⁴ is a suppressor of sex comb | ectopic phenotype of Pc⁴

(Schulze et al., 2001)

vtd⁴/vtd[+] is a suppressor of wing vein phenotype of hh^Mrt

(Schulze et al., 2001)

vtd⁴/vtd[+] is a suppressor of wing phenotype of hh^Mrt

(Schulze et al., 2001)

vtd⁴ is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

vtd^3-1

(Schulze et al., 2001)

vtd^5-1

(Schulze et al., 2001)

vtd^5-3

(Schulze et al., 2001)

vtd^80Fh-35

(Schulze et al., 2001)

vtd^80Fh-36

(Schulze et al., 2001)

vtd^80Fh-5

(Schulze et al., 2001)

vtd^80Fh-6

(Schulze et al., 2001)

vtd^80Fh-1

(Schulze et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5050

Eip74EF^v4 vtd⁴/TM3, st²⁴ Sb¹

Kyoto

108010

Eip74EF^v4 vtd⁴/TM3, st²⁴ Sb¹

Notes on Origin

Discoverer

Induced with: Eip74EF^v4.

(Kennison, 1999.2.11)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

vtd⁴

(Pherson et al., 2019, Strübbe et al., 2011, Hallson et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close