Allele Dmel\w¹

General Information
Symbol	Dmel\w¹	Species	D. melanogaster
Name		FlyBase ID	FBal0018074
Feature type	allele	Created / Updated	2006-05-15/2006-05-15
Associated gene	Dmel\w

Allele class	amorph, loss of function, hypomorph
Mutagen	spontaneous
Nature of the Allele
Allele class	amorph (Judd, 1995) loss of function (Sabl and Birchler, 1993) hypomorph (Lloyd et al., 2002)
Mutagen	spontaneous (Zachar and Bingham, 1982, Driver et al., 1989)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference 5kb Doc insert at +3.71; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end. Insertion of 4.9kb Doc element, close to the site of transcription initiation. 13bp of w sequence from +3700 to +3688 is duplicated, and is present at both ends of the Doc insertion (nucleotide positions as in FBrf0041384). The Doc element is inserted in the same orientation as the direction of w transcription. (Driver et al., 1989) Insertion of Doc element into the proximal region of w. (O'Hare, 1991) Insertion of Doc element at +3700bp. (Dalby and O'Hare, 1991) Doc element inserted into w promoter region. (O'Hare et al., 1991) Insertion of a 5.7kb Doc element. (Sabl and Birchler, 1993) Insertion of a Doc element. (Judd, 1995)
Assay mode
Caused by insertion	Doc{}w¹ (Sabl and Birchler, 1993, Dalby and O'Hare, 1991, O'Hare, 1991, O'Hare et al., 1991, Judd, 1995, Driver et al., 1989)
Carried on aberration	FM7h-N^Placr (FlyBase Curators, 2006-, Heitzler, 1997) FM6-w¹ (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) FM4-w¹B⁺ (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) FM7i (FlyBase Curators, 2006-, Heitzler, 1997) FM7j-B¹ (FlyBase Curators, 2006-, Roote, 2001.12.11) FM7j (FlyBase Curators, 2006-, Heitzler, 1997) FM4-wfB (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28) Bwinscy (FlyBase Curators, 2006-, Sekelsky et al., 1999) FM0 (FlyBase Curators, 2006-, Lindsley and Zimm, 1992, Bloomington Drosophila Stock Center, 1998.5.16) FM7w (FlyBase Curators, 2006-, Sekelsky et al., 1999) winscy (FlyBase Curators, 2006-, Lindsley and Zimm, 1992) FM7h (FlyBase Curators, 2006-) Binsinscy (FlyBase Curators, 2006-, Lindsley and Zimm, 1992) FM6-vAa (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| recessive (Gehring et al., 1984, ) eye color defective (Smolik-Utlaut and Gelbart, 1987, Gehring et al., 1984, Lloyd et al., 2002, Plough and Ives, 1934) eye color defective \| recessive (Pastink et al., 1987, Kaufman, 1969) eye color defective, with w^{enh.Fab-7.1.2} (Schweinsberg et al., 2004) eye color defective, with w^{enh.Fab-7.1.2.m3-4} (Schweinsberg et al., 2004) eye color defective, with w^{enh.Fab-7.1.2.m1-5} (Schweinsberg et al., 2004) eye color defective, with w^{enh.Fab-7.1.2.m1-2} (Schweinsberg et al., 2004)
Phenotype Manifest In
	pigment cell, with w^{enh.Fab-7.1.2.m3-4} (Schweinsberg et al., 2004) pigment cell, with w^{enh.Fab-7.1.2.m1-2} (Schweinsberg et al., 2004) pigment cell, with w^{enh.Fab-7.1.2} (Schweinsberg et al., 2004) pigment cell, with w^{enh.Fab-7.1.2.m1-5} (Schweinsberg et al., 2004) pigment cell (Smolik-Utlaut and Gelbart, 1987, Gehring et al., 1984, Pastink et al., 1987, Lloyd et al., 2002, Plough and Ives, 1934, Zachar and Bingham, 1982, Kaufman, 1969) ocellus pigment granule (Gehring et al., 1984, ) testis pigment cell (Gehring et al., 1984, ) Malpighian tubule (Gehring et al., 1984, )
Detailed Description
	Statement Reference Eye colour: white. Ocellus colour: colourless. Testis colour: colourless. Malpighian tubule colour: colourless. Eye colour: brown at eclosion, darker after 4-5 days, as w¹/w^sp1. Eye colour: bleach white. (Zachar and Bingham, 1982) Eye colour: white. Ocellus colour: colourless. Testis colour: colourless. Malpighian tubule colour: colourless. (Gehring et al., 1984) White eye colour, suppresses z¹. (Smolik-Utlaut and Gelbart, 1987) Eye colour: w^sp1/w¹ flies have brown eyes at eclosion, which become somewhat darker with age. (Pastink et al., 1987) Bleach white eyes. (O'Hare et al., 1991) Eye colour: The w^cf2 eye colour is not diluted when w^cf2 is in transheterozygous combination with w¹. (Kaufman, 1969) Eye colour: w^dil/w¹ flies have darker eyes than g¹ and lighter eyes than pn¹. (Plough and Ives, 1934) Homozygotes have white eyes with only <1% red pigment (compared to 100% pigment in wild type). (Lloyd et al., 2002)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference w¹/w^e(g) is an enhancer of eye color defective phenotype of g^53d (Lloyd et al., 2002) w¹/w^e(g) is an enhancer of eye color defective phenotype of g² (Lloyd et al., 2002) w¹/w^e(g) is an enhancer of eye color defective phenotype of g^50e (Lloyd et al., 2002)
Other
Statement Reference su(f)⁴/su(f)¹, w¹ has eye color defective phenotype (Schalet, 1972)
Phenotype Manifest In
NOT suppressed by
Statement Reference w¹ has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Enhancer of
Statement Reference w¹/w^e(g) is an enhancer of pigment cell phenotype of g^53d (Lloyd et al., 2002) w¹/w^e(g) is an enhancer of pigment cell phenotype of g² (Lloyd et al., 2002) w¹/w^e(g) is an enhancer of pigment cell phenotype of g^50e (Lloyd et al., 2002)
Suppressor of
Statement Reference w¹ is a suppressor of phenotype of z¹ (Judd, 1995)
Other
Statement Reference su(f)⁴/su(f)¹, w¹ has pigment cell phenotype (Schalet, 1972)
Additional Comments
Genetic Interactions
Statement Reference w¹ su(f)⁴/w^a su(f)¹ females have a w¹ phenotype at 24-25^oC. w^a su(f)⁴/Y males have an eye colour intermediate between that of w¹ and w^a at 17-18^oC. (Schalet, 1972) A suppressor of the repression on w by z¹. (Judd, 1995) Flies with a w¹/w^e(g) mutant genotype enhance the eye colour defective phenotype of g², g^50e and g^53d homozygous mutants leading to a greater reduction of red pigment in the eye. (Lloyd et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	w^sp1
Partially complements	w^sp1 (Green, 1959)
Rescued by	w¹ is rescued by w^+t12 (Gehring et al., 1984)
Partially rescued by	w¹ is partially rescued by w^+tAR (Lloyd et al., 2002) w¹ is partially rescued by w^+mC (Lloyd et al., 2002) w¹ is partially rescued by w^HSBJ (Lloyd et al., 2002)
Comments
Stocks ( 1720 )
Bloomington	145 w¹ 2390 w¹ 1495 y¹ w¹ 3132 w¹; vg¹ 5298 w¹ dsh¹ 24619 w¹; P{UAS-fh.A}1
Kyoto	101196 w¹ 105757 w¹ 107303 w¹ 106349 y¹ w¹ 101198 w¹ ct¹ 101202 w¹ sn³
	More stocks available...
Notes on Origin
Discoverer	Morgan, March 1910.

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	w (Schalet, 1972, Plough and Ives, 1934, Pastink et al., 1987) w1 (Soriano et al., 1997) w¹
Name Synonym
Secondary FlyBase IDs

References ( 59 )

Generate a list of	All references relating to this allele ( 59 )

List References by type	Research paper ( 50 ) Personal communication to FlyBase ( 3 ) Abstract ( 2 ) FlyBase analysis ( 1 ) Book ( 2 ) Stock list ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2006 Show research papers ...

Allele Dmel\w1

Allele Dmel\w¹