Allele Dmel\w^apl

General Information
Symbol	Dmel\w^apl	Species	D. melanogaster
Name	apricot-like	FlyBase ID	FBal0018206
Feature type	allele	Associated gene	Dmel\w

Map ( GBrowse )	Untitled Document
Allele class	hypomorphic allele - genetic evidence
Mutagen	PM hybrid dysgenesis, P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Roseman et al., 1995)
Mutagen	P-element activity (Birchler and Hiebert, 1989, Rabinow et al., 1991) PM hybrid dysgenesis (Rabinow and Birchler, 1989, Csink et al., 1994, Birchler et al., 1994, Roseman et al., 1995, Frolov et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site X:2,690,518..2,690,530 (Csink et al., 1994, Bhadra et al., 1997, Rabinow et al., 1991)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AB110070

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	w¹ (Rabinow and Birchler, 1989, Birchler and Hiebert, 1989, Rabinow et al., 1991, Csink et al., 1994, Birchler et al., 1994, Roseman et al., 1995, Bhadra and Birchler, 1996, Frolov et al., 1998)
Nature of the lesion	Statement Reference P-element insertion into Doc element of w¹. (Rabinow et al., 1991) Reversion of Doc element. (Birchler and Hiebert, 1989) P-M hybrid dysgenic revertant of w¹. (Rabinow and Birchler, 1989) insertion mutant
Caused by insertion	Doc{}w¹ (Csink et al., 1994, Bhadra et al., 1997, Rabinow et al., 1991) P{}w^apl (Csink et al., 1994, Rabinow et al., 1991, Bhadra et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective (Bhadra et al., 1997) eye color defective \| recessive (Frolov et al., 1998)
Phenotype Manifest In
	pigment cell (Frolov et al., 1998)
Detailed Description
	Statement Reference Dosage compensation is almost equal in males and females in a su(Hw)^V/su(Hw)⁷ mutant background. (Roseman et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement Reference w^apl has eye color defective phenotype, non-enhanceable by Rga⁰³⁸³⁴ (Frolov et al., 1998)
NOT suppressed by
Statement Reference w^apl has eye color defective phenotype, non-suppressible by Rga⁰³⁸³⁴ (Frolov et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference w^apl has phenotype, enhanceable by E(w^a)¹ (Birchler and Hiebert, 1989)
NOT Enhanced by
Statement Reference w^apl has phenotype, non-enhanceable by Doa³ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa⁴ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa⁵ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa⁶ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa⁷ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa⁸ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa⁹ (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by Doa^HD (Rabinow and Birchler, 1989) w^apl has phenotype, non-enhanceable by In(3)Msu¹ (Csink et al., 1994) w^apl has phenotype, non-enhanceable by In(3)Msu² (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Mow^gamma (Bhadra and Birchler, 1996) w^apl has phenotype, non-enhanceable by Rm62^D (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Rm62^Dem (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Rm62^E (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Rm62^F (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Rm62^H (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Rm62^K (Csink et al., 1994) w^apl has phenotype, non-enhanceable by Ufo¹ (Bhadra et al., 1997) w^apl has phenotype, non-enhanceable by Wow^ems1 (Birchler et al., 1994) w^apl has phenotype, non-enhanceable by Wow^hd1 (Birchler et al., 1994) w^apl has phenotype, non-enhanceable by Wow^γb (Birchler et al., 1994) w^apl has phenotype, non-enhanceable by Wow^γe (Birchler et al., 1994)
NOT suppressed by
Statement Reference w^apl has phenotype, non-suppressible by Doa³ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa⁴ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa⁵ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa⁶ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa⁷ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa⁸ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa⁹ (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by Doa^HD (Rabinow and Birchler, 1989) w^apl has phenotype, non-suppressible by In(3)Msu¹ (Csink et al., 1994) w^apl has phenotype, non-suppressible by In(3)Msu² (Csink et al., 1994) w^apl has phenotype, non-suppressible by Inr-a^EMS3 (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^EMS4 (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^EMS5 (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^hd1 (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^γb (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^γc (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^γd (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Inr-a^γsc (Rabinow et al., 1991) w^apl has phenotype, non-suppressible by Mow^gamma (Bhadra and Birchler, 1996) w^apl has phenotype, non-suppressible by Rm62^D (Csink et al., 1994) w^apl has phenotype, non-suppressible by Rm62^Dem (Csink et al., 1994) w^apl has phenotype, non-suppressible by Rm62^E (Csink et al., 1994) w^apl has phenotype, non-suppressible by Rm62^F (Csink et al., 1994) w^apl has phenotype, non-suppressible by Rm62^H (Csink et al., 1994) w^apl has phenotype, non-suppressible by Rm62^K (Csink et al., 1994) w^apl has phenotype, non-suppressible by Ufo¹ (Bhadra et al., 1997) w^apl has phenotype, non-suppressible by Wow^ems1 (Birchler et al., 1994) w^apl has phenotype, non-suppressible by Wow^hd1 (Birchler et al., 1994) w^apl has phenotype, non-suppressible by Wow^γb (Birchler et al., 1994) w^apl has phenotype, non-suppressible by Wow^γe (Birchler et al., 1994)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Birchler.
	Revertant. (Csink et al., 1994)
Comments
	PM hybrid dysgenic revertant of w¹. (Bhadra and Birchler, 1996) mle⁴ has no effect on the dosage compensation of w^e, w^apl, w^F4-2, w^a2, Dp(1;1)w⁺61e19 or wⁱ. (Hiebert and Birchler, 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	w^apl
Name Synonym	apricot-like (Birchler and Hiebert, 1989)
Secondary FlyBase IDs

References ( 14 )
Research paper	Benevolenskaya et al., 1998, Mol. Gen. Genet. 260(2-3): 131--143 The sugarless mutation affects the expression of the white eye color gene in Drosophila melanogaster. [FBrf0105774] Frolov et al., 1998, Genetics 148(1): 317--329 Regena (Rga), a Drosophila homolog of the global negative transcriptional regulator CDC36 (NOT2) from yeast, modifies gene expression and suppresses position effect variegation. [FBrf0100562] Bhadra et al., 1997, Mol. Gen. Genet. 254(6): 621--634 A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster. [FBrf0094159] Bhadra and Birchler, 1996, Mol. Gen. Genet. 250(5): 601--613 Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila. [FBrf0086910] Roseman et al., 1995, Development 121(11): 3573--3582 A Drosophila insulator protein facilitates dosage compensation of the X chromosome mini-white gene located at autosomal insertion sites. [FBrf0084324] Birchler et al., 1994, Genetics 137(4): 1057--1070 Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. [FBrf0074960] Csink et al., 1994, Genetics 138(1): 153--163 The Lighten up (Lip) gene of Drosophila melanogaster, a modifier of retroelement expression, position effect variegation and white locus insertion alleles. [FBrf0076540] Csink et al., 1994, Genetics 136(2): 573--583 Mosaic suppressor, a gene in Drosophila that modifies retrotransposon expression and interacts with zeste. [FBrf0068460] Hiebert and Birchler, 1994, Genetics 136(3): 913--926 Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster. [FBrf0073338] Rabinow et al., 1991, Genetics 129: 463--480 A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. [FBrf0054158] Birchler and Hiebert, 1989, Genetics 122: 129--138 Interaction of the Enhancer of white-apricot with transposable element alleles at the white locus in Drosophila melanogaster. [FBrf0049880] Birchler et al., 1989, Genes Dev. 3: 73--84 Interaction of the mottler of white with transposable element alleles at the white locus in Drosophila melanogaster. [FBrf0049829] Rabinow and Birchler, 1989, EMBO J. 8: 879--889 A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. [FBrf0049635]
Abstract	Birchler, 1986, Genetics 113(1/2): s47 Dominant genetic enhancers interact with transposable element insertion mutants at the white locus in Drosophila. [FBrf0044510]

Allele Dmel\wapl

Allele Dmel\w^apl