Allele Dmel\w^DZL

General Information
Symbol	Dmel\w^DZL	Species	D. melanogaster
Name	Dominant zeste-like	FlyBase ID	FBal0018236
Feature type	allele	Associated gene	Dmel\w

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	spontaneous
Recent Updates
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FB2013_03
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Nature of the Allele
Allele class
Mutagen	spontaneous (Zachar and Bingham, 1982)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site X:2,696,296..2,696,304 (Collins et al., 1983, Bingham and Zachar, 1985, Rabinow et al., 1991, Harden and Ashburner, 1990, Bhadra et al., 1997, Zachar and Bingham, 1982)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion of FB sequences into the upstream regulatory region of w. (Bhadra et al., 1997) Caused by a foldback element upstream of the normal regulatory sequences of w. (Rabinow et al., 1991) Insertion of FB element. (Harden and Ashburner, 1990) Insertion of a composite transposon 5-6kb 5' to w, resulting in a novel transcription unit that is expressed in the head. The transposon consists of a 6.5kb portion, originating at cytological locus 21D, flanked by two FB transposons. (Bingham and Zachar, 1985) Insertion of a 13 kb FB-element at map position +9.8 relative to the transcription start site of w. (Collins et al., 1983) FB insertion between coordinates +9.5 and +10, using coordinate system of FBrf0038648 where coordinate 0 is the copia insert of w^a. (Zachar and Bingham, 1982) Physical analysis of w^DZL shows that the mutant phenotype results from the insertion (proximal to white) of a complex transposable element made up of sequences normally found at 21D ('unique segment sequences') flanked by sequences of two FB transposons (Levis et al., 1982; Zachar and Bingham, 1982; Bingham and Zachar, 1985). A transcript 1.3 kb larger than the major (2.6 kb) w⁺ transcript is found in w^DZL adult heads and head precursor tissues; this is a composite transcript, made up of sequences from the major w⁺ transcript and from the w^DZL unique segment (Bingham and Zachar, 1985; Zachar, Chapman and Bingham, 1985). In w^DZL flies, a reduction in the levels of the w⁺ transcript is observed in adult head and head precursor tissues, but not in abdominal tissues. Revertants of w^DZL show loss of most of the unique segments of the insertion with 1.9 and 6.2 kb of the insertion remaining (Levis and Rubin, 1982; Zachar and Bingham, 1982). 13kb FB insertion map site (kb): +9.77; Origin = insertion of w^a copia; '-' values to left (telomere) end; '+' values to right (centromere) end.
Caused by insertion	FB{}w^DZL (Collins et al., 1983, Bingham and Zachar, 1985, Rabinow et al., 1991, Harden and Ashburner, 1990, Bhadra et al., 1997, Zachar and Bingham, 1982)
Caused by aberration	Dp(2;1)w^DZL
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective \| dominant (Bingham, 1980, Bingham, 1981) visible \| dominant (Bingham, 1980, Bingham, 1981)
Phenotype Manifest In
	pigment cell (Bingham, 1980, Bingham, 1981)
Detailed Description
	Statement Reference Eye colour: z-like. Shows some interaction with Inr-a mutants. (Rabinow et al., 1991) Eye colour: dull red brown, in z⁺ males. Eye colour: yellow, in heterozygous or homozygous females. Eye colour: wild-type in In(1)w^DZL-1/w^DZL, T(1;3)w^DZL/w^DZL females. Eye colour: wild-type in In(1)w^DZL-3/w^DZL females. (Bingham, 1981) Eye colour: dull red brown, in z⁺ males. Eye colour: yellow, in z¹ males and in homo- and heterozygous females (z⁺ or z¹) when X's synapsed. Malpighian tubule colour: wild-type. Testis colour: wild-type. (Bingham, 1980)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference w^DZL has eye color defective phenotype, enhanceable by Low¹ (Bhadra et al., 1997)
Phenotype Manifest In
Enhanced by
Statement Reference w^DZL has phenotype, enhanceable by Wow^ems1 (Birchler et al., 1994) w^DZL has phenotype, enhanceable by Wow^hd1 (Birchler et al., 1994) w^DZL has phenotype, enhanceable by Wow^γb (Birchler et al., 1994) w^DZL has phenotype, enhanceable by Wow^γe (Birchler et al., 1994) w^DZL has pigment cell phenotype, enhanceable by Low¹ (Bhadra et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference Female progeny of w⁺ crossed to w^DZL, Wow^- have reduced eye pigment. When z¹ w^DZL are crossed to Wow mutants, Wow has no effect on the eye color of sons. (Birchler et al., 1994)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 3 )
Bloomington	3603 w^DZL 3604 sc¹ z¹ w^DZL
Kyoto	101137 In(1)sc⁸, sc⁸ w^DZL
Notes on Origin
Discoverer	Bingham.

Comments
	Unstable. (Harden and Ashburner, 1990) Unstable mutation that creates revertants that carry internal deletion of the FB element. (Zachar and Bingham, 1982) Located in or immediately proximal to the rightmost set of previously-defined w mutant sites Mutable allele; spontaneous mutations are observed at a frequency of 0.5 to 1.5%. (Bingham, 1981) w^DZL shows synapsis-dependent dominance over w⁺. It is a highly mutable allele (like w^c), giving rise spontaneously to w⁺ and w^- derivatives with a frequency of 0.5-1.5%. (Bingham, 1980)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	w^DZL
Name Synonym	Dominant zeste-like
Secondary FlyBase IDs

References ( 18 )
Research paper	Bhadra et al., 1997, Genetics 146(3): 903--917 A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats. [FBrf0094158] Birchler et al., 1994, Genetics 137(4): 1057--1070 Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster. [FBrf0074960] Rabinow et al., 1991, Genetics 129: 463--480 A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. [FBrf0054158] Harden and Ashburner, 1990, Genetics 126: 387--400 Characterization of the FB-NOF transposable element of Drosophila melanogaster. [FBrf0051943] Bingham and Zachar, 1985, Cell 40: 819--825 Evidence that two mutations, w^DZL and z¹, affecting synapsis-dependent genetic behavior of white are transcriptional regulatory mutations. [FBrf0042055] Ryo et al., 1985, Genetics 110: 441--451 Comparison of somatic reversions between the ivory allele and transposon-caused mutant alleles at the white locus of Drosophila melanogaster after larval treatment with X rays and ethyl methanesulfonate. [FBrf0042640] Zachar et al., 1985, Cold Spring Harbor Symp. Quant. Biol. 50: 337--346 On the molecular basis of transvection effects and the regulation of transcription. [FBrf0042164] Gehring et al., 1984, EMBO J. 3: 2077--2085 Functional analysis of the white⁺ gene of Drosophila by P-factor-mediated transformation. [FBrf0040771] Hazelrigg et al., 1984, Cell 36: 469--481 Transformation of white locus DNA in Drosophila: Dosage compensation, zeste interaction, and position effects. [FBrf0040489] O'Hare et al., 1984, J. Mol. Biol. 180: 437--455 DNA sequence of the white locus of Drosophila melanogaster. [FBrf0041384] Collins et al., 1983, Yb. Carnegie Instn, Wash. 82: 180--182 Transposable genetic elements and the white locus of Drosophila. [FBrf0063381] McGinnis and Beckendorf, 1983, Nucleic Acids Res. 11: 737--751 Association of a Drosophila transposable element of the roo family with chromosomal deletion breakpoints. [FBrf0040067] Levis and Rubin, 1982, Cell 30: 543--550 The unstable w^DZL mutation of Drosophila is caused by a 13 kilobase insertion that is imprecisely excised in phenotypic revertants. [FBrf0037613] Levis et al., 1982, Cell 30: 551--565 FB elements are the common basis for the instability of the w^DZL and w^c Drosophila mutations. [FBrf0037614] Levis et al., 1982, Proc. Natl. Acad. Sci. U.S.A. 79(2): 564--568 Physical map of the white locus of Drosophila melanogaster. [FBrf0038648] Zachar and Bingham, 1982, Cell 30: 529--541 Regulation of white locus expression: The structure of mutant alleles at the white locus of Drosophila melanogaster. [FBrf0037612] Bingham, 1981, Cold Spring Harbor Symp. Quant. Biol. 45(2): 519--525 A novel dominant mutant allele at the white locus of Drosophila melanogaster is mutable. [FBrf0036017] Bingham, 1980, Genetics 95(2): 341--353 The regulation of white locus expression: A dominant mutant allele at the white locus of Drosophila melanogaster. [FBrf0034850]

Allele Dmel\wDZL

Allele Dmel\w^DZL