|Name||Dominant zeste-like||FlyBase ID||FBal0018236|
|Feature type||allele||Associated gene||Dmel\w|
|Map ( GBrowse )||
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Caused by a foldback element upstream of the normal regulatory sequences of w.
Insertion of a composite transposon 5-6kb 5' to w, resulting in a novel transcription unit that is expressed in the head. The transposon consists of a 6.5kb portion, originating at cytological locus 21D, flanked by two FB transposons.
Insertion of a 13 kb FB-element at map position +9.8 relative to the transcription start site of w.
FB insertion between coordinates +9.5 and +10, using coordinate system of FBrf0038648 where coordinate 0 is the copia insert of wa.
Physical analysis of wDZL shows that the mutant phenotype results from the insertion (proximal to white) of a complex transposable element made up of sequences normally found at 21D ('unique segment sequences') flanked by sequences of two FB transposons (Levis et al., 1982; Zachar and Bingham, 1982; Bingham and Zachar, 1985). A transcript 1.3 kb larger than the major (2.6 kb) w+ transcript is found in wDZL adult heads and head precursor tissues; this is a composite transcript, made up of sequences from the major w+ transcript and from the wDZL unique segment (Bingham and Zachar, 1985; Zachar, Chapman and Bingham, 1985). In wDZL flies, a reduction in the levels of the w+ transcript is observed in adult head and head precursor tissues, but not in abdominal tissues. Revertants of wDZL show loss of most of the unique segments of the insertion with 1.9 and 6.2 kb of the insertion remaining (Levis and Rubin, 1982; Zachar and Bingham, 1982). 13kb FB insertion map site (kb): +9.77; Origin = insertion of wa copia; '-' values to left (telomere) end; '+' values to right (centromere) end.
|Caused by insertion|
|Caused by aberration|
|Phenotype Manifest In|
Eye colour: dull red brown, in z+ males. Eye colour: yellow, in heterozygous or homozygous females. Eye colour: wild-type in In(1)wDZL-1/wDZL, T(1;3)wDZL/wDZL females. Eye colour: wild-type in In(1)wDZL-3/wDZL females.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 3 )|
|Notes on Origin|
Unstable mutation that creates revertants that carry internal deletion of the FB element.
Located in or immediately proximal to the rightmost set of previously-defined w mutant sites Mutable allele; spontaneous mutations are observed at a frequency of 0.5 to 1.5%.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 18 )|